ZA89332B - Stabilization of cephalosporin derivatives by drying with a stabilizer and stable formulation forms containing cephalosporin derivatives - Google Patents

Stabilization of cephalosporin derivatives by drying with a stabilizer and stable formulation forms containing cephalosporin derivatives

Info

Publication number
ZA89332B
ZA89332B ZA89332A ZA89332A ZA89332B ZA 89332 B ZA89332 B ZA 89332B ZA 89332 A ZA89332 A ZA 89332A ZA 89332 A ZA89332 A ZA 89332A ZA 89332 B ZA89332 B ZA 89332B
Authority
ZA
South Africa
Prior art keywords
cephalosporin derivatives
stabilizer
stabilization
drying
forms containing
Prior art date
Application number
ZA89332A
Inventor
Detlev Schwabe
Schwabe Detlev
Richard Leeb
Leeb Richard
Herbert Westenberger
Westenberger Herbert
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA89332B publication Critical patent/ZA89332B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA89332A 1988-01-18 1989-01-16 Stabilization of cephalosporin derivatives by drying with a stabilizer and stable formulation forms containing cephalosporin derivatives ZA89332B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3801179A DE3801179A1 (en) 1988-01-18 1988-01-18 STABILIZATION OF CEPHALOSPORINE DERIVATIVES BY DRYING WITH A STABILIZER AND STABLE PREPARATION FORMS WITH CEPHALOSPORINE DERIVATIVES

Publications (1)

Publication Number Publication Date
ZA89332B true ZA89332B (en) 1989-09-27

Family

ID=6345430

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA89332A ZA89332B (en) 1988-01-18 1989-01-16 Stabilization of cephalosporin derivatives by drying with a stabilizer and stable formulation forms containing cephalosporin derivatives

Country Status (12)

Country Link
EP (1) EP0325112A1 (en)
JP (1) JPH01216996A (en)
KR (1) KR890011894A (en)
CN (1) CN1034670A (en)
AU (1) AU2853989A (en)
DE (1) DE3801179A1 (en)
DK (1) DK19489A (en)
HU (1) HUT49487A (en)
IE (1) IE890126L (en)
IL (1) IL88957A0 (en)
PT (1) PT89464A (en)
ZA (1) ZA89332B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19539574A1 (en) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Preparations and processes for stabilizing biological materials by means of drying processes without freezing
EP0913178A1 (en) * 1997-11-03 1999-05-06 Boehringer Mannheim Gmbh Process for the manufacture of dry, amorphous products comprising biologically active material by means of convection drying and products obtainable by the process
EP0913177A1 (en) 1997-11-03 1999-05-06 Roche Diagnostics GmbH Process for producing dry, amorphous products comprising biological active materials by means of convection drying technique, especially spray drying
EP1656930A1 (en) * 2004-11-10 2006-05-17 Basilea Pharmaceutica AG Stabilized freeze-dried formulation for cephalosporin derivatives
CN101590061B (en) * 2009-04-14 2010-09-29 深圳立健药业有限公司 Medicinal composition of cefotetan disodium
SI2968446T1 (en) 2013-03-13 2017-08-31 Theravance Biopharma Antibiotics Ip, Llc Hydrochloride salts of an antibiotic compound
KR101935186B1 (en) 2014-09-04 2019-01-03 시오노기세야쿠 가부시키가이샤 Pharmaceutical preparation comprising cephalosporin having catechol groups

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2017373A1 (en) * 1969-04-15 1971-04-22 Orsymonde S A , Paris Lyophilized products and processes for their manufacture
JPS5132723A (en) * 1974-09-11 1976-03-19 Toyama Chemical Co Ltd YOJOKAIGATACHUSHAYOSEIZAI NO SHINKISEIHO NARABINI SONOYOKAI YOSUI YOEKI
JPS5711909A (en) * 1980-06-23 1982-01-21 Shionogi & Co Ltd Stable freeze-dried preparation of beta-lactam
JPS6045514A (en) * 1983-08-22 1985-03-12 Shionogi & Co Ltd Stable antibacterial lyophilized pharmactical preparation
DE3577656D1 (en) * 1984-07-23 1990-06-21 Lilly Co Eli PHARMACEUTICAL COMPOSITIONS OF CEFTAZIDIM.
JP2690009B2 (en) * 1986-07-10 1997-12-10 エーザイ 株式会社 Cefalosporin injection

Also Published As

Publication number Publication date
DK19489D0 (en) 1989-01-17
DK19489A (en) 1989-07-19
IL88957A0 (en) 1989-08-15
CN1034670A (en) 1989-08-16
JPH01216996A (en) 1989-08-30
PT89464A (en) 1990-02-08
KR890011894A (en) 1989-08-23
HUT49487A (en) 1989-10-30
AU2853989A (en) 1989-07-20
IE890126L (en) 1989-07-18
EP0325112A1 (en) 1989-07-26
DE3801179A1 (en) 1989-07-27

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