ZA893077B - Water-soluble preparations of coccidiostats - Google Patents

Water-soluble preparations of coccidiostats

Info

Publication number
ZA893077B
ZA893077B ZA893077A ZA893077A ZA893077B ZA 893077 B ZA893077 B ZA 893077B ZA 893077 A ZA893077 A ZA 893077A ZA 893077 A ZA893077 A ZA 893077A ZA 893077 B ZA893077 B ZA 893077B
Authority
ZA
South Africa
Prior art keywords
alkyl
hydrogen
water
independently
preparation
Prior art date
Application number
ZA893077A
Inventor
Dietrich Hiller
Hiller Dietrich
Theopil Hornykiewytsch
Hornykiewytsch Theopil
Wolfgang Raether
Raether Wolfgang
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA893077B publication Critical patent/ZA893077B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/116Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polymers & Plastics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Light Receiving Elements (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Active substance preparations characterised by a) up to 10000 ppm, based on the weight of the preparation, of one or more coccidiostats of the general formulae I and II <IMAGE> in which R<1>, R and R' are, independently of one another, hydrogen or C1-C4-alkyl, R<2> is together with R<3> a double bond or independently thereof hydrogen or C1-C4-alkyl, R<3> is together with R<2> a double bond or independently thereof hydrogen or C1-C4-alkyl, W is oxygen or sulphur, X is, in each case independently of one another, halogen such as fluorine, chlorine and bromine, C1-C4-alkyl, trifluoromethyl, cyano, thiocyanato, C1-C4-alkylthio, nitro or C1-C4-alkoxy, n is 0, 1, 2, 3 or 4, preferably 0 to 2, Y is hydrogen, C1-C6-alkyl, C1-C6-halogenoalkyl, benzyl, phenyl or phenyl which is substituted by at least one radical from the group comprising alkyl, alkoxy, halogenoalkyl, halogenoalkoxy, halogen, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkylthio, halogenoalkylsulphinyl and halogenoalkylsulphonyl, each with 1 to 4 C atoms in the alkyl radical, or is thienyl or halothienyl and Z is a direct bond or a divalent group of the formula O, S, SO, SO2, NH, NR<0> in which R<0> is hydrogen or C1-C4-alkyl, or C(CN)(R<+>) in which R<+> is hydrogen or methyl, b) a water-miscible, physiologically acceptable, anionic or non-ionic surfactant or a mixture of a plurality of these surfactants and c) 0 to 80% by weight, based on the preparation, of a physiologically acceptable, water-soluble organic solvent and d) 0 to 70% by weight, based on the preparation, of water, are suitable, by reason of their solubility in water, for the treatment of coccidiosis in livestock via the drinking water thereof.
ZA893077A 1988-04-28 1989-04-26 Water-soluble preparations of coccidiostats ZA893077B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3814323A DE3814323A1 (en) 1988-04-28 1988-04-28 WATER-SOLUBLE PREPARATIONS BY COCCIDIOSTATICA

Publications (1)

Publication Number Publication Date
ZA893077B true ZA893077B (en) 1989-12-27

Family

ID=6353066

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA893077A ZA893077B (en) 1988-04-28 1989-04-26 Water-soluble preparations of coccidiostats

Country Status (19)

Country Link
EP (1) EP0339555B1 (en)
JP (1) JPH01313430A (en)
KR (1) KR900015740A (en)
AT (1) ATE83661T1 (en)
AU (1) AU619004B2 (en)
BG (1) BG60542B2 (en)
BR (1) BR8901913A (en)
DD (1) DD283773A5 (en)
DE (2) DE3814323A1 (en)
DK (1) DK204689A (en)
ES (1) ES2043934T3 (en)
HU (1) HU205716B (en)
IL (1) IL90098A (en)
NZ (1) NZ228898A (en)
PH (1) PH27515A (en)
PL (1) PL279153A1 (en)
PT (1) PT90387B (en)
RU (1) RU1780510C (en)
ZA (1) ZA893077B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3288132B2 (en) * 1992-06-25 2002-06-04 サントリー株式会社 Substituted 1,2,4-triazine-3,5-dione and anticoccidial composition containing the same as an active ingredient
PL3759088T3 (en) 2018-02-26 2023-07-03 AlzeCure Pharma AB Triazine derivatives for treating diseases relating to neurotrophins
GB201810668D0 (en) 2018-06-28 2018-08-15 Stiftelsen Alzecure New compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361627A (en) * 1958-06-20 1968-01-02 Harris Trust And Savings Bank Phenothiazine compositions
DE3300793A1 (en) * 1983-01-12 1984-07-12 Bayer Ag, 5090 Leverkusen Coccidiosis
DE3408924A1 (en) * 1984-03-12 1985-09-26 Hoechst Ag, 6230 Frankfurt SUBSTITUTED 2-PHENYL-HEXAHYDRO-1,2,4-TRIAZINE-3,5-DIONE, METHOD FOR THE PRODUCTION THEREOF, MEANS CONTAINING IT AND THEIR USE
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
DE3531919A1 (en) * 1985-09-07 1987-03-19 Hoechst Ag SUBSTITUTED 2-PHENYL-HEXAHYDRO-1,2,4-TRIAZINE-3,5-DIONE, METHOD FOR THE PRODUCTION THEREOF, MEANS CONTAINING IT AND THEIR USE

Also Published As

Publication number Publication date
HUT51490A (en) 1990-05-28
DE3814323A1 (en) 1989-11-09
RU1780510C (en) 1992-12-07
KR900015740A (en) 1990-11-10
ATE83661T1 (en) 1993-01-15
AU3373589A (en) 1989-11-02
JPH01313430A (en) 1989-12-18
PT90387A (en) 1989-11-10
PL279153A1 (en) 1989-12-27
EP0339555A3 (en) 1990-01-31
EP0339555A2 (en) 1989-11-02
ES2043934T3 (en) 1994-01-01
BG60542B2 (en) 1995-08-28
NZ228898A (en) 1992-02-25
DK204689A (en) 1989-10-29
PT90387B (en) 1994-10-31
IL90098A (en) 1995-11-27
PH27515A (en) 1993-08-18
DD283773A5 (en) 1990-10-24
DE58903076D1 (en) 1993-02-04
DK204689D0 (en) 1989-04-27
AU619004B2 (en) 1992-01-16
EP0339555B1 (en) 1992-12-23
HU205716B (en) 1992-06-29
BR8901913A (en) 1989-11-28

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