ZA884858B - Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activity - Google Patents
Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activityInfo
- Publication number
- ZA884858B ZA884858B ZA884858A ZA884858A ZA884858B ZA 884858 B ZA884858 B ZA 884858B ZA 884858 A ZA884858 A ZA 884858A ZA 884858 A ZA884858 A ZA 884858A ZA 884858 B ZA884858 B ZA 884858B
- Authority
- ZA
- South Africa
- Prior art keywords
- opiate
- dialkyl
- tertiary
- antagonistic activity
- phenylpiperidine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8701617 | 1987-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA884858B true ZA884858B (en) | 1989-03-29 |
Family
ID=19850283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA884858A ZA884858B (en) | 1987-07-09 | 1988-07-06 | Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activity |
Country Status (8)
Country | Link |
---|---|
US (1) | US5091393A (da) |
EP (1) | EP0299549A3 (da) |
JP (1) | JPS6429357A (da) |
AU (1) | AU615203B2 (da) |
DK (1) | DK374988A (da) |
IL (1) | IL87016A (da) |
NZ (1) | NZ225303A (da) |
ZA (1) | ZA884858B (da) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9710004D0 (en) * | 1997-05-17 | 1997-07-09 | Knoll Ag | Chemical process |
US6900228B1 (en) | 1998-03-10 | 2005-05-31 | Research Triangle Institute | Opiate compounds, methods of making and methods of use |
US20040033253A1 (en) * | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
US6541397B1 (en) * | 2002-03-29 | 2003-04-01 | Applied Materials, Inc. | Removable amorphous carbon CMP stop |
US7215258B2 (en) * | 2005-02-22 | 2007-05-08 | Research In Motion Limited | Handheld electronic device having reduced keyboard and multiple password access, and associated methods |
CA2680414A1 (en) * | 2007-03-12 | 2008-09-18 | Biolipox Ab | Piperidinones useful in the treatment of inflammation |
GB0722769D0 (en) * | 2007-11-21 | 2008-01-02 | Biolipox Ab | New compounds |
US8922398B2 (en) * | 2009-06-24 | 2014-12-30 | Blackberry Limited | Method of generating and providing a password to a handheld electronic device |
WO2011114103A1 (en) | 2010-03-18 | 2011-09-22 | Biolipox Ab | Pyrimidinones for use as medicaments |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR206937A1 (es) * | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
US4284635A (en) * | 1978-11-29 | 1981-08-18 | Eli Lilly And Company | Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines |
GB8400537D0 (en) * | 1984-01-10 | 1984-02-15 | Wyeth John & Brother Ltd | Piperidine derivatives |
US4593037A (en) * | 1984-07-26 | 1986-06-03 | Pfizer Inc. | 1,3-disubstituted piperidine compounds as neuroleptic agents |
ES2058265T3 (es) * | 1987-04-16 | 1994-11-01 | Lilly Co Eli | Piperidinas antagonistas de opiaceos. |
-
1988
- 1988-06-20 EP EP88201251A patent/EP0299549A3/en not_active Ceased
- 1988-07-06 IL IL87016A patent/IL87016A/xx unknown
- 1988-07-06 DK DK374988A patent/DK374988A/da unknown
- 1988-07-06 AU AU19020/88A patent/AU615203B2/en not_active Ceased
- 1988-07-06 NZ NZ225303A patent/NZ225303A/xx unknown
- 1988-07-06 ZA ZA884858A patent/ZA884858B/xx unknown
- 1988-07-06 JP JP63167009A patent/JPS6429357A/ja active Pending
-
1990
- 1990-05-29 US US07/528,895 patent/US5091393A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0299549A3 (en) | 1989-02-08 |
IL87016A0 (en) | 1988-12-30 |
IL87016A (en) | 1993-02-21 |
US5091393A (en) | 1992-02-25 |
AU615203B2 (en) | 1991-09-26 |
JPS6429357A (en) | 1989-01-31 |
NZ225303A (en) | 1991-02-26 |
DK374988A (da) | 1989-01-10 |
DK374988D0 (da) | 1988-07-06 |
AU1902088A (en) | 1989-01-12 |
EP0299549A2 (en) | 1989-01-18 |
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