ZA884858B - Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activity - Google Patents

Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activity

Info

Publication number
ZA884858B
ZA884858B ZA884858A ZA884858A ZA884858B ZA 884858 B ZA884858 B ZA 884858B ZA 884858 A ZA884858 A ZA 884858A ZA 884858 A ZA884858 A ZA 884858A ZA 884858 B ZA884858 B ZA 884858B
Authority
ZA
South Africa
Prior art keywords
opiate
dialkyl
tertiary
antagonistic activity
phenylpiperidine derivatives
Prior art date
Application number
ZA884858A
Other languages
English (en)
Inventor
Jacobus Antonius Joseph Hartog
Antonius Joseph Den Ha Jacobus
Ineke Van Wijngaarden
Van Wijngaarden Ineke
Martinus Theodorus Maria Tulp
Theodorus Maria Tulp Martinus
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of ZA884858B publication Critical patent/ZA884858B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA884858A 1987-07-09 1988-07-06 Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activity ZA884858B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8701617 1987-07-09

Publications (1)

Publication Number Publication Date
ZA884858B true ZA884858B (en) 1989-03-29

Family

ID=19850283

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA884858A ZA884858B (en) 1987-07-09 1988-07-06 Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activity

Country Status (8)

Country Link
US (1) US5091393A (da)
EP (1) EP0299549A3 (da)
JP (1) JPS6429357A (da)
AU (1) AU615203B2 (da)
DK (1) DK374988A (da)
IL (1) IL87016A (da)
NZ (1) NZ225303A (da)
ZA (1) ZA884858B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
US6541397B1 (en) * 2002-03-29 2003-04-01 Applied Materials, Inc. Removable amorphous carbon CMP stop
US7215258B2 (en) * 2005-02-22 2007-05-08 Research In Motion Limited Handheld electronic device having reduced keyboard and multiple password access, and associated methods
CA2680414A1 (en) * 2007-03-12 2008-09-18 Biolipox Ab Piperidinones useful in the treatment of inflammation
GB0722769D0 (en) * 2007-11-21 2008-01-02 Biolipox Ab New compounds
US8922398B2 (en) * 2009-06-24 2014-12-30 Blackberry Limited Method of generating and providing a password to a handheld electronic device
WO2011114103A1 (en) 2010-03-18 2011-09-22 Biolipox Ab Pyrimidinones for use as medicaments

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206937A1 (es) * 1974-09-06 1976-08-31 Lilly Co Eli Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina
US4284635A (en) * 1978-11-29 1981-08-18 Eli Lilly And Company Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines
GB8400537D0 (en) * 1984-01-10 1984-02-15 Wyeth John & Brother Ltd Piperidine derivatives
US4593037A (en) * 1984-07-26 1986-06-03 Pfizer Inc. 1,3-disubstituted piperidine compounds as neuroleptic agents
ES2058265T3 (es) * 1987-04-16 1994-11-01 Lilly Co Eli Piperidinas antagonistas de opiaceos.

Also Published As

Publication number Publication date
EP0299549A3 (en) 1989-02-08
IL87016A0 (en) 1988-12-30
IL87016A (en) 1993-02-21
US5091393A (en) 1992-02-25
AU615203B2 (en) 1991-09-26
JPS6429357A (en) 1989-01-31
NZ225303A (en) 1991-02-26
DK374988A (da) 1989-01-10
DK374988D0 (da) 1988-07-06
AU1902088A (en) 1989-01-12
EP0299549A2 (en) 1989-01-18

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