ZA877859B - 5-nitrobenzo(de)isoquinoline-1.3-diones,their preparation and their use - Google Patents

5-nitrobenzo(de)isoquinoline-1.3-diones,their preparation and their use

Info

Publication number
ZA877859B
ZA877859B ZA877859A ZA877859A ZA877859B ZA 877859 B ZA877859 B ZA 877859B ZA 877859 A ZA877859 A ZA 877859A ZA 877859 A ZA877859 A ZA 877859A ZA 877859 B ZA877859 B ZA 877859B
Authority
ZA
South Africa
Prior art keywords
nitrobenzo
diones
isoquinoline
preparation
compounds
Prior art date
Application number
ZA877859A
Other languages
English (en)
Inventor
Miguel Brana Fernandez
Brana Fernandez Miguel
Jose Maria Berlanga Castellano
Maria Berlanga Castellano Jose
Marina Moran Moset
Moran Moset Marina
Erich Schlick
Schlick Erich
Gerhard Keilhauer
Keilhauer Gerhard
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of ZA877859B publication Critical patent/ZA877859B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
ZA877859A 1986-10-21 1987-10-20 5-nitrobenzo(de)isoquinoline-1.3-diones,their preparation and their use ZA877859B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863635711 DE3635711A1 (de) 1986-10-21 1986-10-21 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
ZA877859B true ZA877859B (en) 1989-06-28

Family

ID=6312114

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA877859A ZA877859B (en) 1986-10-21 1987-10-20 5-nitrobenzo(de)isoquinoline-1.3-diones,their preparation and their use

Country Status (9)

Country Link
US (1) US5552544A (OSRAM)
EP (1) EP0268093B1 (OSRAM)
JP (1) JPS63104963A (OSRAM)
AT (1) ATE76069T1 (OSRAM)
AU (1) AU592474B2 (OSRAM)
CA (1) CA1331382C (OSRAM)
DE (2) DE3635711A1 (OSRAM)
ES (1) ES2037055T3 (OSRAM)
ZA (1) ZA877859B (OSRAM)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3939372A1 (de) * 1989-11-29 1991-06-06 Knoll Ag Mitonafide-infusionsloesung
DE3942280A1 (de) * 1989-12-21 1991-06-27 Knoll Ag N-substituierte naphthalimide, ihre herstellung und verwendung
US5235045A (en) * 1992-03-19 1993-08-10 Microbiomed Corporation Non-azo naphthalimide dyes
US5766600A (en) * 1993-08-09 1998-06-16 Microbiomed Corporation Non-azo naphtalimide dyes and uses for same
JP2001503397A (ja) 1996-10-21 2001-03-13 アレリックス バイオファーマシューティカルズ インコーポレイテッド ニューロトロフィンアンタゴニスト組成物
DE19714161A1 (de) * 1997-04-05 1998-10-08 Emtec Magnetics Gmbh Magnetischer Aufzeichnungsträger
CZ20011782A3 (cs) * 1998-11-25 2001-09-12 Merck Patent Gmbh Derivát benzo[de]isochinolin-1,3-dionu, způsob jeho přípravy, jeho použití a farmaceutický prostředek, který ho obsahuje
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
US6492380B1 (en) 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6468990B1 (en) * 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
KR100718946B1 (ko) * 2000-11-06 2007-05-16 파르마 마르, 에스.에이. 효과적인 항종양 치료
DE10101319A1 (de) * 2001-01-09 2002-07-18 Schering Ag Morphometrisches Gewebe- oder Zellpräparat
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
US6693198B2 (en) * 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts
JP2005533088A (ja) * 2002-07-08 2005-11-04 ケムジェネックス・ファーマシューティカルズ・リミテッド アモナフィドを含むナフタルイミドの製造およびその医薬製剤
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
SI1689404T1 (sl) * 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
CN1897949A (zh) * 2003-11-14 2007-01-17 马尔药品公司 包含使用et－743和紫杉醇来治疗癌症的联合疗法
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CA2555718A1 (en) * 2004-05-05 2005-11-10 Unibioscreen S.A. Naphthalimide derivatives for the treatment of cancer
MX2007000360A (es) * 2004-07-09 2007-06-12 Pharma Mar Sa Marcadores moleculares de pronostico.
CA2583464A1 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
US20090117176A1 (en) * 2004-10-26 2009-05-07 Pharma Mar, S.A. Sociedad Unipersonal Anticancer Treatments
NZ554761A (en) 2004-10-29 2010-01-29 Pharma Mar Sa Formulations comprising ecteinascidin and a disaccharide
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
CN101304973A (zh) 2005-09-15 2008-11-12 佩因赛普托药物公司 调节神经营养蛋白介导的活性的方法
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CA2651197A1 (en) 2006-05-05 2007-11-15 Unibioscreen S.A. 5-urea substituted naphthalimide derivatives, methods of production and pharmaceutical compositions for treating cancer
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES459497A1 (es) * 1977-06-04 1978-04-16 Made Labor Sa Un metodo para la preparacion industrial de naftalimidas y sus derivados.
DE2944867A1 (de) * 1979-11-07 1981-05-27 Hoechst Ag, 6000 Frankfurt Kationische verbindungen der naphthalimid-reihe, verfahren zu deren herstellung und deren verwendung
US4614820A (en) * 1983-04-01 1986-09-30 Warner-Lambert Co. 3,6-disubstituted-1,8-naphthalimides
EP0125439B1 (en) * 1983-04-01 1990-01-24 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
DE3614414A1 (de) * 1986-04-29 1987-11-05 Knoll Ag Neue benzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
US4782064A (en) * 1986-07-21 1988-11-01 American Cyanamid Co. 2-heteroaryl-alkyl-1H-benz[de]-isoquinoline-1,3(2H)-diones

Also Published As

Publication number Publication date
JPS63104963A (ja) 1988-05-10
ATE76069T1 (de) 1992-05-15
EP0268093B1 (de) 1992-05-13
CA1331382C (en) 1994-08-09
AU592474B2 (en) 1990-01-11
AU7999087A (en) 1988-04-28
ES2037055T3 (es) 1993-06-16
US5552544A (en) 1996-09-03
EP0268093A1 (de) 1988-05-25
DE3635711A1 (de) 1988-04-28
DE3779053D1 (OSRAM) 1992-06-17

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