ZA867805B - New conjugates of vinblastine and its derivatives,a process for their preparation and pharmaceutical compositions containing the same - Google Patents

New conjugates of vinblastine and its derivatives,a process for their preparation and pharmaceutical compositions containing the same

Info

Publication number
ZA867805B
ZA867805B ZA867805A ZA867805A ZA867805B ZA 867805 B ZA867805 B ZA 867805B ZA 867805 A ZA867805 A ZA 867805A ZA 867805 A ZA867805 A ZA 867805A ZA 867805 B ZA867805 B ZA 867805B
Authority
ZA
South Africa
Prior art keywords
vinblastine
derivatives
preparation
pharmaceutical compositions
same
Prior art date
Application number
ZA867805A
Inventor
Andre Benoit Lenon Trouet
Kandukuri Sivaprasade Bush Rao
Jean-Alfred Alphonse Hannart
Jean-Paul Dejonghe
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of ZA867805B publication Critical patent/ZA867805B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA867805A 1985-11-12 1986-10-15 New conjugates of vinblastine and its derivatives,a process for their preparation and pharmaceutical compositions containing the same ZA867805B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU86157A LU86157A1 (en) 1985-11-12 1985-11-12 NEW PROCESS FOR THE MANUFACTURE OF VINBLASTIN CONJUGATES AND DERIVATIVES THEREOF

Publications (1)

Publication Number Publication Date
ZA867805B true ZA867805B (en) 1987-06-24

Family

ID=19730582

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA867805A ZA867805B (en) 1985-11-12 1986-10-15 New conjugates of vinblastine and its derivatives,a process for their preparation and pharmaceutical compositions containing the same

Country Status (5)

Country Link
EP (1) EP0222722B1 (en)
JP (1) JPS62246599A (en)
DE (1) DE3688451D1 (en)
LU (1) LU86157A1 (en)
ZA (1) ZA867805B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006652A (en) * 1988-08-08 1991-04-09 Eli Lilly And Company Intermediates for antibody-vinca drug conjugates
US6319894B1 (en) * 1997-01-08 2001-11-20 The Picower Institute For Medical Research Complexes and combinations of fetuin with therapeutic agents
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2137210B (en) * 1983-03-30 1986-11-19 Lilly Industries Ltd Immunoglobulin conjugates
EP0124502B1 (en) * 1983-04-29 1991-06-12 OMNICHEM Société anonyme Conjugates of vinblastine and its derivatives, process for their preparation and pharmaceutical compositions containing these conjugates
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids

Also Published As

Publication number Publication date
EP0222722A3 (en) 1989-09-06
DE3688451D1 (en) 1993-06-24
EP0222722B1 (en) 1993-05-19
EP0222722A2 (en) 1987-05-20
LU86157A1 (en) 1987-06-26
JPS62246599A (en) 1987-10-27

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