ZA867495B - Novel polyoxgenated labdane derivatives,processes for their preparation and their use as medicaments - Google Patents

Novel polyoxgenated labdane derivatives,processes for their preparation and their use as medicaments

Info

Publication number
ZA867495B
ZA867495B ZA867495A ZA867495A ZA867495B ZA 867495 B ZA867495 B ZA 867495B ZA 867495 A ZA867495 A ZA 867495A ZA 867495 A ZA867495 A ZA 867495A ZA 867495 B ZA867495 B ZA 867495B
Authority
ZA
South Africa
Prior art keywords
polyoxgenated
medicaments
novel
processes
preparation
Prior art date
Application number
ZA867495A
Inventor
Yatendra Khandelwal
Noel John De Souza
Ramanujam Rajgopalan
Alihussein Nomandbh Dohadwalla
Richard Helmut Rupp
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA867495B publication Critical patent/ZA867495B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

Polyoxygenated labdane derivatives which carry one or more aminoacyl groups as substituents are suitable, due to their pharmacological properties, for use in the treatment of cardiac and circulatory diseases, hypertension, glaucoma, allergies, broncho- constriction and as immunomodulators.
ZA867495A 1985-10-02 1986-10-01 Novel polyoxgenated labdane derivatives,processes for their preparation and their use as medicaments ZA867495B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853535086 DE3535086A1 (en) 1985-10-02 1985-10-02 NEW POLYOXYGENATED LABDAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINES

Publications (1)

Publication Number Publication Date
ZA867495B true ZA867495B (en) 1987-05-27

Family

ID=6282512

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA867495A ZA867495B (en) 1985-10-02 1986-10-01 Novel polyoxgenated labdane derivatives,processes for their preparation and their use as medicaments

Country Status (14)

Country Link
EP (1) EP0217372B1 (en)
JP (1) JPS6289677A (en)
KR (1) KR870004051A (en)
AT (1) ATE60054T1 (en)
AU (1) AU606036B2 (en)
DE (2) DE3535086A1 (en)
DK (1) DK468186A (en)
ES (1) ES2019863B3 (en)
GR (1) GR3001559T3 (en)
HU (1) HU203234B (en)
IL (1) IL80201A0 (en)
IN (2) IN163242B (en)
PT (1) PT83478B (en)
ZA (1) ZA867495B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE62683T1 (en) * 1985-03-01 1991-05-15 Hoechst Roussel Pharma LABDAN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
US4963537A (en) * 1985-03-01 1990-10-16 Hoechst-Roussel Pharmaceuticals Inc. Labdane compounds, pharmaceutical compositions and use
JPS6310783A (en) * 1985-11-15 1988-01-18 Nippon Kayaku Co Ltd Novel forskolin derivative
AU591196B2 (en) * 1985-11-15 1989-11-30 Nippon Kayaku Kabushiki Kaisha Novel forskolin derivatives
DE3623300A1 (en) * 1986-07-11 1988-01-21 Hoechst Ag 7-ACYLOXY-6-AMINOACYLOXYPOLYOXYLABDANE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
US4920146A (en) * 1986-12-29 1990-04-24 Hoechst Roussel Pharmaceuticals Inc. Carbamoyloxylabdane compounds useful in reducing intraocular pressure
US5646175A (en) * 1987-12-28 1997-07-08 Hoechst Marion Roussel, Inc. Carbamoyloxylabdane compounds
IN166900B (en) * 1987-06-03 1990-08-04 Hoechst India
JP2504934B2 (en) * 1987-06-29 1996-06-05 日本化薬株式会社 1,6,7-Triacylforskolin derivative
JPH0684367B2 (en) * 1987-06-29 1994-10-26 日本化薬株式会社 New method for producing forskolin derivative
US5846992A (en) * 1987-10-08 1998-12-08 Hoechst Marion Roussel, Inc. Synergistic intraocular pressure lowering combinations
US4902696A (en) * 1987-10-08 1990-02-20 Hoechst-Roussel Pharmaceuticals, Inc. Synergistic intraocular pressure lowering combinations
US4883793A (en) * 1988-05-09 1989-11-28 Hoechst-Roussel Pharmaceuticals Inc. Hydrazinocarbonyloxylabdanes for treating cardiac failure
EP0447962A1 (en) * 1990-03-17 1991-09-25 Hoechst Aktiengesellschaft Labdanes and process for their preparation
YU128291A (en) * 1990-07-24 1994-09-09 Joechst Aktiengesellschaft PROCESS FOR PREPARATION OF 6- (3-SUBSTITUTED AMINOPROPIONYL) 7-DEACETYLFORSCOLIN DERIVATIVES
JP3557095B2 (en) * 1998-04-20 2004-08-25 高砂香料工業株式会社 Melanin production inhibitor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557784C2 (en) 1975-12-22 1986-04-17 Hoechst Ag, 6230 Frankfurt Forskolin, process for obtaining it and pharmaceutical preparations containing this compound
DE2640275A1 (en) 1976-09-08 1978-03-09 Hoechst Ag PHARMACOLOGICALLY EFFECTIVE SUBSTANCE FROM LABIATS
DE2654796A1 (en) * 1976-12-03 1978-06-08 Hoechst Ag POLYOXYGENATED LABDAN DERIVATIVES
FR2460397A1 (en) * 1979-07-05 1981-01-23 Ducellier & Cie ELECTRIC STARTER FOR INTERNAL COMBUSTION ENGINES IN PARTICULAR MOTOR VEHICLES
DE3502685A1 (en) 1985-01-26 1986-09-04 Hoechst Ag, 6230 Frankfurt FORSKOLIN, ITS ANALOGS AND DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF BY MEANS OF MICROBIAL CONVERSIONS AND THE USE OF THESE COMPOUNDS AS MEDICINAL PRODUCTS
DE3581725D1 (en) * 1984-12-14 1991-03-14 Hoechst Roussel Pharma AMINOACYLLABDANE, METHOD AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
ATE62683T1 (en) * 1985-03-01 1991-05-15 Hoechst Roussel Pharma LABDAN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
US4639443A (en) * 1985-03-01 1987-01-27 Hoechst-Roussel Pharmaceuticals Inc. Labdane compounds, pharmaceutical compositions and use
AU591196B2 (en) * 1985-11-15 1989-11-30 Nippon Kayaku Kabushiki Kaisha Novel forskolin derivatives

Also Published As

Publication number Publication date
ATE60054T1 (en) 1991-02-15
DE3676922D1 (en) 1991-02-21
HUT46319A (en) 1988-10-28
PT83478B (en) 1989-05-31
EP0217372B1 (en) 1991-01-16
EP0217372A3 (en) 1988-03-30
ES2019863B3 (en) 1991-07-16
IN163242B (en) 1988-08-27
DK468186A (en) 1987-04-03
HU203234B (en) 1991-06-28
JPS6289677A (en) 1987-04-24
KR870004051A (en) 1987-05-07
IN164680B (en) 1989-05-06
EP0217372A2 (en) 1987-04-08
AU6327086A (en) 1987-04-09
PT83478A (en) 1986-11-01
DK468186D0 (en) 1986-10-01
AU606036B2 (en) 1991-01-31
DE3535086A1 (en) 1987-04-16
IL80201A0 (en) 1986-12-31
GR3001559T3 (en) 1992-11-23

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