ZA863108B - Process for preparing and purifying alpha-interferon - Google Patents

Process for preparing and purifying alpha-interferon

Info

Publication number
ZA863108B
ZA863108B ZA863108A ZA863108A ZA863108B ZA 863108 B ZA863108 B ZA 863108B ZA 863108 A ZA863108 A ZA 863108A ZA 863108 A ZA863108 A ZA 863108A ZA 863108 B ZA863108 B ZA 863108B
Authority
ZA
South Africa
Prior art keywords
interferon
preparing
purifying alpha
alpha
purifying
Prior art date
Application number
ZA863108A
Inventor
Gerhard Bodo
Ingrid Maurer-Fogy
Edgar Falkner
Silvia Jutta Lindner
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA863108B publication Critical patent/ZA863108B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The process yields a highly pure, non-immunogenic, homogeneous alpha -interferon which has antiviral and immunoregulatory activity.
ZA863108A 1985-04-27 1986-04-25 Process for preparing and purifying alpha-interferon ZA863108B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3515336A DE3515336C2 (en) 1985-04-27 1985-04-27 Process for the preparation and purification of â-interferon

Publications (1)

Publication Number Publication Date
ZA863108B true ZA863108B (en) 1987-12-30

Family

ID=6269344

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA863108A ZA863108B (en) 1985-04-27 1986-04-25 Process for preparing and purifying alpha-interferon

Country Status (20)

Country Link
EP (1) EP0203382B1 (en)
JP (1) JP2566919B2 (en)
KR (1) KR940010024B1 (en)
AT (1) ATE94588T1 (en)
AU (1) AU598460B2 (en)
CA (1) CA1340281C (en)
DE (2) DE3515336C2 (en)
DK (1) DK186486A (en)
ES (1) ES8707554A1 (en)
FI (1) FI861748A (en)
GR (1) GR861093B (en)
HU (1) HU202883B (en)
IE (1) IE61444B1 (en)
IL (1) IL78604A (en)
NO (1) NO166727C (en)
NZ (1) NZ215969A (en)
PH (1) PH30912A (en)
PT (1) PT82452B (en)
SU (1) SU1591814A3 (en)
ZA (1) ZA863108B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
DE3813124A1 (en) * 1988-04-15 1989-10-26 Krieg Benno Distillable buffer solutions and their uses
EP1104809A1 (en) * 1994-04-09 2001-06-06 F. Hoffmann-La Roche Ag Process for producing alpha-interferon
KR100369582B1 (en) * 1995-09-04 2003-04-03 동아제약 주식회사 Purification method of recombinant alpha-interferon
TW577894B (en) * 1998-11-12 2004-03-01 Schering Corp Methods for conversion of protein isoforms and products thereof
ITBO20010426A1 (en) * 2001-07-06 2003-01-06 Alfa Wassermann Spa PHARMACOLOGICALLY ACTIVE PROTEIN PURIFICATION PROCESS BY CATIONIC EXCHANGE CHROMATOGRAPHY
ATE489400T1 (en) 2002-09-06 2010-12-15 Genentech Inc PROTEIN EXTRACTION METHOD
GB0818228D0 (en) * 2008-10-06 2008-11-12 Avecia Biolog Ltd Purification process
CN114814000B (en) * 2022-03-30 2024-07-23 深圳科兴药业有限公司 Method for detecting content of recombinant human interferon

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA796175B (en) * 1978-11-24 1980-11-26 Hoffmann La Roche Purified proteins and process therefor
FI77877C (en) * 1979-04-20 1989-05-10 Technobiotic Ltd Process for the preparation and purification of human Le-shaped interferon protein.
ZA814375B (en) * 1980-07-01 1982-07-28 Hoffmann La Roche Interferons and process for their preparation
CH657141A5 (en) * 1980-07-01 1986-08-15 Hoffmann La Roche DNA SEQUENCES, RECOMBINANT EXPRESSION VECTORS FOR THE MICROBIAL PRODUCTION OF HUMAN LEUKOCYTE INTERFERON AND TRANSFORMED MICROORGANISMS.
US4364863A (en) * 1980-12-29 1982-12-21 Schering Corporation Extraction of interferon from bacteria
DE3220116A1 (en) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach MICROBIOLOGICALLY MANUFACTURED (ALPHA) AND SS INTERFERONES, DNA SEQUENCES CODING FOR THESE INTERFERONES, MICROORGANISMS CONTAINING THIS GENETIC INFORMATION, AND METHOD FOR THE PRODUCTION THEREOF
US4534906A (en) * 1982-11-01 1985-08-13 Genentech, Inc. Removal of impurities from human leukocyte interferon preparations
DE3382547D1 (en) * 1983-01-12 1992-05-27 Chiron Corp SECRETORIC EXPRESSION IN EUKARYOTS.
DE3306060A1 (en) * 1983-02-22 1984-08-23 Boehringer Ingelheim International GmbH, 6507 Ingelheim NEW IMMUNGLOBULIN-PRODUCING HYBRID CELL LINES, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
PT82452A (en) 1986-05-01
DE3515336A1 (en) 1987-01-22
NO861635L (en) 1986-10-28
PT82452B (en) 1988-11-30
ES8707554A1 (en) 1987-08-01
JPS61282098A (en) 1986-12-12
NZ215969A (en) 1990-08-28
DE3689008D1 (en) 1993-10-21
DK186486A (en) 1986-10-28
PH30912A (en) 1997-12-23
JP2566919B2 (en) 1996-12-25
CA1340281C (en) 1998-12-22
KR940010024B1 (en) 1994-10-20
FI861748A (en) 1986-10-28
DE3515336C2 (en) 1994-01-20
NO166727B (en) 1991-05-21
IE61444B1 (en) 1994-11-02
SU1591814A3 (en) 1990-09-07
IL78604A (en) 1991-11-21
AU5677586A (en) 1986-10-30
KR860008270A (en) 1986-11-14
ES554372A0 (en) 1987-08-01
EP0203382A2 (en) 1986-12-03
AU598460B2 (en) 1990-06-28
NO166727C (en) 1991-08-28
FI861748A0 (en) 1986-04-25
HU202883B (en) 1991-04-29
HUT41073A (en) 1987-03-30
EP0203382B1 (en) 1993-09-15
GR861093B (en) 1986-08-26
EP0203382A3 (en) 1988-04-27
IL78604A0 (en) 1986-08-31
IE861095L (en) 1986-10-27
ATE94588T1 (en) 1993-10-15
DK186486D0 (en) 1986-04-23

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