AU598460B2 - Process preparing and purifying interferon - Google Patents

Process preparing and purifying interferon

Info

Publication number
AU598460B2
AU598460B2 AU56775/86A AU5677586A AU598460B2 AU 598460 B2 AU598460 B2 AU 598460B2 AU 56775/86 A AU56775/86 A AU 56775/86A AU 5677586 A AU5677586 A AU 5677586A AU 598460 B2 AU598460 B2 AU 598460B2
Authority
AU
Australia
Prior art keywords
process preparing
interferon
purifying interferon
purifying
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU56775/86A
Other versions
AU5677586A (en
Inventor
Gerhard Bodo
Edgar Falkner
Silvia Jutta Lindner
Ingrid Maurer-Fogy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU5677586A publication Critical patent/AU5677586A/en
Application granted granted Critical
Publication of AU598460B2 publication Critical patent/AU598460B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The process yields a highly pure, non-immunogenic, homogeneous alpha -interferon which has antiviral and immunoregulatory activity.
AU56775/86A 1985-04-27 1986-04-28 Process preparing and purifying interferon Ceased AU598460B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3515336A DE3515336C2 (en) 1985-04-27 1985-04-27 Process for the preparation and purification of â-interferon
DE3515336 1985-04-27

Publications (2)

Publication Number Publication Date
AU5677586A AU5677586A (en) 1986-10-30
AU598460B2 true AU598460B2 (en) 1990-06-28

Family

ID=6269344

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56775/86A Ceased AU598460B2 (en) 1985-04-27 1986-04-28 Process preparing and purifying interferon

Country Status (20)

Country Link
EP (1) EP0203382B1 (en)
JP (1) JP2566919B2 (en)
KR (1) KR940010024B1 (en)
AT (1) ATE94588T1 (en)
AU (1) AU598460B2 (en)
CA (1) CA1340281C (en)
DE (2) DE3515336C2 (en)
DK (1) DK186486A (en)
ES (1) ES8707554A1 (en)
FI (1) FI861748A (en)
GR (1) GR861093B (en)
HU (1) HU202883B (en)
IE (1) IE61444B1 (en)
IL (1) IL78604A (en)
NO (1) NO166727C (en)
NZ (1) NZ215969A (en)
PH (1) PH30912A (en)
PT (1) PT82452B (en)
SU (1) SU1591814A3 (en)
ZA (1) ZA863108B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
DE3813124A1 (en) * 1988-04-15 1989-10-26 Krieg Benno Distillable buffer solutions and their uses
EP1104809A1 (en) * 1994-04-09 2001-06-06 F. Hoffmann-La Roche Ag Process for producing alpha-interferon
KR100369582B1 (en) * 1995-09-04 2003-04-03 동아제약 주식회사 Purification method of recombinant alpha-interferon
TW577894B (en) * 1998-11-12 2004-03-01 Schering Corp Methods for conversion of protein isoforms and products thereof
ITBO20010426A1 (en) * 2001-07-06 2003-01-06 Alfa Wassermann Spa PHARMACOLOGICALLY ACTIVE PROTEIN PURIFICATION PROCESS BY CATIONIC EXCHANGE CHROMATOGRAPHY
ATE489400T1 (en) 2002-09-06 2010-12-15 Genentech Inc PROTEIN EXTRACTION METHOD
GB0818228D0 (en) * 2008-10-06 2008-11-12 Avecia Biolog Ltd Purification process
CN114814000B (en) * 2022-03-30 2024-07-23 深圳科兴药业有限公司 Method for detecting content of recombinant human interferon

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA796175B (en) * 1978-11-24 1980-11-26 Hoffmann La Roche Purified proteins and process therefor
FI77877C (en) * 1979-04-20 1989-05-10 Technobiotic Ltd Process for the preparation and purification of human Le-shaped interferon protein.
ZA814375B (en) * 1980-07-01 1982-07-28 Hoffmann La Roche Interferons and process for their preparation
CH657141A5 (en) * 1980-07-01 1986-08-15 Hoffmann La Roche DNA SEQUENCES, RECOMBINANT EXPRESSION VECTORS FOR THE MICROBIAL PRODUCTION OF HUMAN LEUKOCYTE INTERFERON AND TRANSFORMED MICROORGANISMS.
US4364863A (en) * 1980-12-29 1982-12-21 Schering Corporation Extraction of interferon from bacteria
DE3220116A1 (en) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach MICROBIOLOGICALLY MANUFACTURED (ALPHA) AND SS INTERFERONES, DNA SEQUENCES CODING FOR THESE INTERFERONES, MICROORGANISMS CONTAINING THIS GENETIC INFORMATION, AND METHOD FOR THE PRODUCTION THEREOF
US4534906A (en) * 1982-11-01 1985-08-13 Genentech, Inc. Removal of impurities from human leukocyte interferon preparations
DE3382547D1 (en) * 1983-01-12 1992-05-27 Chiron Corp SECRETORIC EXPRESSION IN EUKARYOTS.
DE3306060A1 (en) * 1983-02-22 1984-08-23 Boehringer Ingelheim International GmbH, 6507 Ingelheim NEW IMMUNGLOBULIN-PRODUCING HYBRID CELL LINES, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
PT82452A (en) 1986-05-01
DE3515336A1 (en) 1987-01-22
NO861635L (en) 1986-10-28
PT82452B (en) 1988-11-30
ES8707554A1 (en) 1987-08-01
JPS61282098A (en) 1986-12-12
NZ215969A (en) 1990-08-28
DE3689008D1 (en) 1993-10-21
DK186486A (en) 1986-10-28
PH30912A (en) 1997-12-23
JP2566919B2 (en) 1996-12-25
CA1340281C (en) 1998-12-22
KR940010024B1 (en) 1994-10-20
FI861748A (en) 1986-10-28
DE3515336C2 (en) 1994-01-20
NO166727B (en) 1991-05-21
IE61444B1 (en) 1994-11-02
SU1591814A3 (en) 1990-09-07
IL78604A (en) 1991-11-21
AU5677586A (en) 1986-10-30
KR860008270A (en) 1986-11-14
ES554372A0 (en) 1987-08-01
EP0203382A2 (en) 1986-12-03
ZA863108B (en) 1987-12-30
NO166727C (en) 1991-08-28
FI861748A0 (en) 1986-04-25
HU202883B (en) 1991-04-29
HUT41073A (en) 1987-03-30
EP0203382B1 (en) 1993-09-15
GR861093B (en) 1986-08-26
EP0203382A3 (en) 1988-04-27
IL78604A0 (en) 1986-08-31
IE861095L (en) 1986-10-27
ATE94588T1 (en) 1993-10-15
DK186486D0 (en) 1986-04-23

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired