ZA861476B - 15(r)-5-fluroprostacyclins,pharmaceutical composition and antithrombotic methods and use thereof - Google Patents

15(r)-5-fluroprostacyclins,pharmaceutical composition and antithrombotic methods and use thereof

Info

Publication number
ZA861476B
ZA861476B ZA861476A ZA861476A ZA861476B ZA 861476 B ZA861476 B ZA 861476B ZA 861476 A ZA861476 A ZA 861476A ZA 861476 A ZA861476 A ZA 861476A ZA 861476 B ZA861476 B ZA 861476B
Authority
ZA
South Africa
Prior art keywords
fluroprostacyclins
pharmaceutical composition
antithrombotic
methods
antithrombotic methods
Prior art date
Application number
ZA861476A
Other languages
English (en)
Inventor
Stevan Wakefield Djuric
Robert Bruce Garland
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA861476B publication Critical patent/ZA861476B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
ZA861476A 1985-02-28 1986-02-27 15(r)-5-fluroprostacyclins,pharmaceutical composition and antithrombotic methods and use thereof ZA861476B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/706,806 US4616034A (en) 1985-02-28 1985-02-28 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof

Publications (1)

Publication Number Publication Date
ZA861476B true ZA861476B (en) 1987-05-27

Family

ID=24839120

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA861476A ZA861476B (en) 1985-02-28 1986-02-27 15(r)-5-fluroprostacyclins,pharmaceutical composition and antithrombotic methods and use thereof

Country Status (6)

Country Link
US (1) US4616034A (de)
EP (1) EP0193194B1 (de)
JP (1) JPS61205271A (de)
AU (1) AU5412886A (de)
DE (1) DE3676097D1 (de)
ZA (1) ZA861476B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719220A (en) * 1985-02-28 1988-01-12 G. D. Searle & Co. 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic methods of use thereof
US4808734A (en) * 1986-12-01 1989-02-28 Hoffmann-La Roche Inc. 16-cycloalkyl-7-fluoro-prostacyclins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
IT1088036B (it) * 1977-11-25 1985-06-04 Erba Carlo Spa 15-epi-prostaciclina e prostaciclina analoghi
US4324730A (en) * 1979-10-10 1982-04-13 The University Of Chicago Certain fluorine substituted PGI2 compounds
WO1981001002A1 (en) * 1979-10-10 1981-04-16 Univ Chicago Fluoro-substituted prostaglandins and prostacyclins
US4472428A (en) * 1980-12-09 1984-09-18 Teijin Limited Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore
EP0062303B1 (de) * 1981-04-02 1985-11-27 G.D. Searle & Co. 5-Fluor-PGI-Derivate
US4540801A (en) * 1981-04-02 1985-09-10 G. D. Searle & Co. 5 Fluoro PGI compounds
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物

Also Published As

Publication number Publication date
US4616034A (en) 1986-10-07
EP0193194B1 (de) 1990-12-12
EP0193194A2 (de) 1986-09-03
DE3676097D1 (de) 1991-01-24
AU5412886A (en) 1986-09-04
EP0193194A3 (en) 1987-09-02
JPS61205271A (ja) 1986-09-11

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