ZA859607B - Anthracycline derivatives,a microbiological process for their preparation,and their use as medicaments - Google Patents

Anthracycline derivatives,a microbiological process for their preparation,and their use as medicaments

Info

Publication number
ZA859607B
ZA859607B ZA859607A ZA859607A ZA859607B ZA 859607 B ZA859607 B ZA 859607B ZA 859607 A ZA859607 A ZA 859607A ZA 859607 A ZA859607 A ZA 859607A ZA 859607 B ZA859607 B ZA 859607B
Authority
ZA
South Africa
Prior art keywords
rod
roa
preparation
deoxyfucose
rhodinose
Prior art date
Application number
ZA859607A
Inventor
Christopher Milton Math Franco
Triptikumar Mukhopadhyay
Kalyanapuram Rajagopal Desikan
Bimal Naresh Ganguli
Hans-Wolfram Fehlhaber
Hans Peter Kraemer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA859607B publication Critical patent/ZA859607B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

1. Claims for the Contracting States BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A Compound of the formula I see diagramm : EP0186807,P11,F2 in which R represents a sugar combination of the composition Roa-dF-Rod or Roa-Rod-Rod, where Roa represents rhodosamine, dF represents deoxyfucose and Rod represents rhodinose, and the physiologically acceptable acid addition salts thereof. 1. Claims for the contracting State AT A process for the preparation of compounds of the Formula I see diagramm : EP0186807,P11,F1 in which R represents a sugar combination of the composition Roa-dF-Rod or Roa-Rod-Rod, where Roa represents rhodosamine, dF represents deoxyfucose and Rod represents rhodinose, and the physiologically acceptable acid addition salts thereof, which comprises fermentation of the microorganism Streptomyces purpurascens DSM 2658 in a customary manner under aerobic conditions, in the presence of a nutrient medium, addition of a chemical inhibitor after a particular fermentation time, and isolation, from the culture liquid and the mycelium, of the compounds which have been formed, using organic solvents followed by chromatography in a customary manner.
ZA859607A 1984-12-18 1985-12-17 Anthracycline derivatives,a microbiological process for their preparation,and their use as medicaments ZA859607B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843446052 DE3446052A1 (en) 1984-12-18 1984-12-18 ANTHRACYCLINE DERIVATIVES, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
ZA859607B true ZA859607B (en) 1986-08-27

Family

ID=6253030

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA859607A ZA859607B (en) 1984-12-18 1985-12-17 Anthracycline derivatives,a microbiological process for their preparation,and their use as medicaments

Country Status (16)

Country Link
EP (1) EP0186807B1 (en)
JP (1) JPS61145145A (en)
AT (1) ATE45582T1 (en)
AU (1) AU585918B2 (en)
DE (2) DE3446052A1 (en)
DK (1) DK587185A (en)
ES (1) ES8704506A1 (en)
FI (1) FI80723C (en)
GR (1) GR853020B (en)
HU (1) HU197596B (en)
MX (1) MX7626E (en)
NO (1) NO164038C (en)
NZ (1) NZ214561A (en)
PH (1) PH24107A (en)
PT (1) PT81692B (en)
ZA (1) ZA859607B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3446052A1 (en) * 1984-12-18 1986-07-17 Hoechst Ag, 6230 Frankfurt ANTHRACYCLINE DERIVATIVES, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE3920062A1 (en) * 1989-06-20 1991-01-10 Hoechst Ag NEW ANTHRACYCLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
CN116064288B (en) * 2022-08-30 2024-04-09 内蒙古农业大学 Streptomyces roseoformis HC7-22 for plant iron-removing and growth-promoting and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US436630A (en) * 1890-09-16 Truss-pad
GB2048245B (en) * 1979-04-27 1983-03-16 Erba Farmitalia Biosynthetic antracyline glycoside
JPS5874694A (en) * 1981-10-29 1983-05-06 Sanraku Inc Anthracycline derivative
DE3446052A1 (en) * 1984-12-18 1986-07-17 Hoechst Ag, 6230 Frankfurt ANTHRACYCLINE DERIVATIVES, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
ES549951A0 (en) 1987-04-01
EP0186807A2 (en) 1986-07-09
PT81692A (en) 1986-01-01
ATE45582T1 (en) 1989-09-15
NO164038B (en) 1990-05-14
FI80723C (en) 1990-07-10
HUT43641A (en) 1987-11-30
GR853020B (en) 1986-04-15
FI854978A0 (en) 1985-12-16
MX7626E (en) 1990-03-29
JPS61145145A (en) 1986-07-02
HU197596B (en) 1989-04-28
AU585918B2 (en) 1989-06-29
NO854909L (en) 1986-06-19
DE3446052A1 (en) 1986-07-17
NZ214561A (en) 1989-08-29
NO164038C (en) 1990-08-22
PT81692B (en) 1988-04-21
DK587185D0 (en) 1985-12-17
DK587185A (en) 1986-06-19
EP0186807B1 (en) 1989-08-16
FI854978A (en) 1986-06-19
ES8704506A1 (en) 1987-04-01
DE3572359D1 (en) 1989-09-21
PH24107A (en) 1990-03-05
AU5136285A (en) 1986-07-17
EP0186807A3 (en) 1986-11-20
FI80723B (en) 1990-03-30

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