ZA857987B - Indoleacetic acid derivative - Google Patents
Indoleacetic acid derivativeInfo
- Publication number
- ZA857987B ZA857987B ZA857987A ZA857987A ZA857987B ZA 857987 B ZA857987 B ZA 857987B ZA 857987 A ZA857987 A ZA 857987A ZA 857987 A ZA857987 A ZA 857987A ZA 857987 B ZA857987 B ZA 857987B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid derivative
- indoleacetic acid
- indometacin
- acemetacin
- antiinflammatory
- Prior art date
Links
- QOPBEBWGSGFROG-UHFFFAOYSA-N 2-(1h-indol-2-yl)acetic acid Chemical class C1=CC=C2NC(CC(=O)O)=CC2=C1 QOPBEBWGSGFROG-UHFFFAOYSA-N 0.000 title 1
- 229960004892 acemetacin Drugs 0.000 abstract 1
- FSQKKOOTNAMONP-UHFFFAOYSA-N acemetacin Chemical compound CC1=C(CC(=O)OCC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 FSQKKOOTNAMONP-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229960000905 indomethacin Drugs 0.000 abstract 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 1
- -1 perfluoro Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59222452A JPS61100565A (ja) | 1984-10-22 | 1984-10-22 | インド−ル酢酸誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA857987B true ZA857987B (en) | 1987-06-24 |
Family
ID=16782628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA857987A ZA857987B (en) | 1984-10-22 | 1985-10-17 | Indoleacetic acid derivative |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4868201A (forum.php) |
| EP (1) | EP0179428B1 (forum.php) |
| JP (1) | JPS61100565A (forum.php) |
| KR (1) | KR860003218A (forum.php) |
| AT (1) | ATE41867T1 (forum.php) |
| AU (1) | AU576390B2 (forum.php) |
| CA (1) | CA1287625C (forum.php) |
| DE (1) | DE3569196D1 (forum.php) |
| ES (1) | ES8703423A1 (forum.php) |
| ZA (1) | ZA857987B (forum.php) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1224546B (it) * | 1988-09-29 | 1990-10-04 | Polifarma Spa | Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative |
| CA2072360A1 (en) * | 1989-12-26 | 1991-06-27 | Abraham J. Domb | Prodrug anhydride compositions |
| US5222109A (en) * | 1990-12-28 | 1993-06-22 | Ibm Corporation | Endurance management for solid state files |
| US5436265A (en) * | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
| GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| US7113432B2 (en) | 2000-09-14 | 2006-09-26 | Sandisk Corporation | Compressed event counting technique and application to a flash memory system |
| US6345001B1 (en) | 2000-09-14 | 2002-02-05 | Sandisk Corporation | Compressed event counting technique and application to a flash memory system |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3468907A (en) * | 1967-04-10 | 1969-09-23 | Schering Corp | Glyceryl esters of alpha-(1-aroyl-3-indolyl)alkanoic acids |
| US3966956A (en) * | 1972-07-14 | 1976-06-29 | Troponwerke Dinklage & Company | [1-(P-Chlorobenzoyl)-5-methoxy-2-methyl-3-indole]acetoxyacetic acid and salts in treating inflammation |
| US4104278A (en) * | 1972-11-25 | 1978-08-01 | Troponwerke Dinklage & Co. | Process for the production of compounds with antiphlogistic activity |
| DE2740852A1 (de) * | 1977-09-10 | 1979-03-29 | Troponwerke Gmbh & Co Kg | Basische 1-acylindol-3-acetocyessigsaeureester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3206888A1 (de) * | 1982-02-26 | 1983-09-15 | Troponwerke GmbH & Co KG, 5000 Köln | Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indolacetoxyessigsaeure |
-
1984
- 1984-10-22 JP JP59222452A patent/JPS61100565A/ja active Granted
-
1985
- 1985-10-14 AU AU48573/85A patent/AU576390B2/en not_active Ceased
- 1985-10-17 ZA ZA857987A patent/ZA857987B/xx unknown
- 1985-10-17 CA CA000493174A patent/CA1287625C/en not_active Expired - Lifetime
- 1985-10-21 DE DE8585113334T patent/DE3569196D1/de not_active Expired
- 1985-10-21 EP EP85113334A patent/EP0179428B1/en not_active Expired
- 1985-10-21 KR KR1019850007758A patent/KR860003218A/ko not_active Withdrawn
- 1985-10-21 AT AT85113334T patent/ATE41867T1/de not_active IP Right Cessation
- 1985-10-21 ES ES548067A patent/ES8703423A1/es not_active Expired
-
1987
- 1987-04-27 US US07/042,924 patent/US4868201A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE41867T1 (de) | 1989-04-15 |
| EP0179428B1 (en) | 1989-04-05 |
| AU576390B2 (en) | 1988-08-25 |
| CA1287625C (en) | 1991-08-13 |
| KR860003218A (ko) | 1986-05-21 |
| EP0179428A3 (en) | 1986-07-16 |
| JPS61100565A (ja) | 1986-05-19 |
| JPS6313985B2 (forum.php) | 1988-03-29 |
| AU4857385A (en) | 1986-05-01 |
| US4868201A (en) | 1989-09-19 |
| ES8703423A1 (es) | 1987-02-16 |
| ES548067A0 (es) | 1987-02-16 |
| DE3569196D1 (en) | 1989-05-11 |
| EP0179428A2 (en) | 1986-04-30 |
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