ZA852799B - Organic amine phosphonic acid complexes for the treatment of calcific tumors - Google Patents

Organic amine phosphonic acid complexes for the treatment of calcific tumors

Info

Publication number
ZA852799B
ZA852799B ZA852799A ZA852799A ZA852799B ZA 852799 B ZA852799 B ZA 852799B ZA 852799 A ZA852799 A ZA 852799A ZA 852799 A ZA852799 A ZA 852799A ZA 852799 B ZA852799 B ZA 852799B
Authority
ZA
South Africa
Prior art keywords
treatment
phosphonic acid
organic amine
acid complexes
calcific tumors
Prior art date
Application number
ZA852799A
Other languages
English (en)
Inventor
Jaime Simon
Wynn A Volkert
David A Wilson
David E Troutner
William F Geockeler
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of ZA852799B publication Critical patent/ZA852799B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA852799A 1984-06-04 1985-04-15 Organic amine phosphonic acid complexes for the treatment of calcific tumors ZA852799B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61698584A 1984-06-04 1984-06-04

Publications (1)

Publication Number Publication Date
ZA852799B true ZA852799B (en) 1986-12-30

Family

ID=24471820

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA852799A ZA852799B (en) 1984-06-04 1985-04-15 Organic amine phosphonic acid complexes for the treatment of calcific tumors

Country Status (10)

Country Link
EP (1) EP0164843B1 (fr)
JP (2) JPH0655681B2 (fr)
AU (1) AU563671B2 (fr)
CA (1) CA1243603A (fr)
DE (2) DE164843T1 (fr)
HK (1) HK146895A (fr)
IL (1) IL74902A (fr)
NL (1) NL980021I2 (fr)
NZ (1) NZ211808A (fr)
ZA (1) ZA852799B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515767A (en) * 1983-06-20 1985-05-07 The Dow Chemical Company Radioactive metals complexed with phosphonate derivatives of dicyclopentadienebis(methylamine)
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
EP0225409A1 (fr) * 1985-12-02 1987-06-16 The Dow Chemical Company Complexes d'acide organoaminophosphonique pour le traitement de tumeurs calciques
US4853209A (en) * 1987-05-18 1989-08-01 The Dow Chemical Company Bone marrow suppressing agents
NZ222304A (en) * 1987-05-18 1990-10-26 Dow Chemical Co Suppression of bone marrow using samarium-153, gadolinium-159 or holmium-166 complexes
US4882142A (en) * 1988-12-19 1989-11-21 The Dow Chemical Company Bone marrow suppressing agents
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents
WO1991016075A1 (fr) * 1990-04-20 1991-10-31 Australian Nuclear Science & Technology Organisation Techniques de traitement de la moelle osseuse
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
US5219556A (en) * 1990-07-09 1993-06-15 Mallinckrodt Medical, Inc. Stabilized therapeutic radiopharmaceutical complexes
EP1191948A2 (fr) 1999-06-11 2002-04-03 Neorx Corporation Complexe a forte dose de radionucleides destine a la suppression de la moelle osseuse
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
DE19953636A1 (de) * 1999-11-09 2001-05-23 Karlsruhe Forschzent Radioaktive Materialien

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2543349C2 (de) * 1975-09-29 1984-05-10 Henkel KGaA, 4000 Düsseldorf Preaparate zur herstellung von99m technetium-radiagnostica
CA1078731A (fr) * 1976-12-16 1980-06-03 Charles E. Frosst And Co. Kit de radiographie des os, utilisant le triethylene tetramine hexa (acide methylenephosphonique)
US4504463A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
US4508704A (en) * 1984-02-27 1985-04-02 The Dow Chemical Company Radioactive metals complexed with phosphonate derivatives of bicycloheptane bis(alkylamines)

Also Published As

Publication number Publication date
AU563671B2 (en) 1987-07-16
NL980021I1 (nl) 1998-09-01
EP0164843A3 (en) 1987-09-23
HK146895A (en) 1995-09-22
JPH0655681B2 (ja) 1994-07-27
JPH0448799B2 (fr) 1992-08-07
EP0164843B1 (fr) 1991-06-19
NL980021I2 (nl) 1999-02-01
JPS62132892A (ja) 1987-06-16
IL74902A (en) 1990-12-23
IL74902A0 (en) 1985-07-31
DE3583257D1 (de) 1991-07-25
EP0164843A2 (fr) 1985-12-18
DE164843T1 (de) 1989-12-07
CA1243603A (fr) 1988-10-25
NZ211808A (en) 1989-01-06
AU4122985A (en) 1985-12-12
JPS6122029A (ja) 1986-01-30

Similar Documents

Publication Publication Date Title
GB2207672B (en) Sulphonamidothienylcarboxyic acid compounds
PT82062A (en) Process for preparing pyridinylimidazolidinone compounds
HK146895A (en) Organic amine phosphonic acid complexes for the treatment of calcific tumors
GR862276B (en) Improved process for tetrafluorobenzoic acid
DE3266534D1 (en) Boron containing polyphosphonates for the treatment of calcific tumors
ZA867530B (en) Composition for the treatment of acne
HUT40452A (en) Process for preparing tumor inhibiting (1-benzyl-ethylene-diamine)-platinum(ii) complexes
AU584918B2 (en) Aminocarboxylic acid complexes for the treatment of calcific tumors
DE3164166D1 (en) Process for the oxidation of organic phosphorus compounds
ZA854161B (en) Aminohydroxypropoxy substituted aryl compounds
PH21391A (en) Fungicidal composition based ona phosphorous acid derivative
EP0419998A3 (en) Use of alkylphosphonic acid derivatives for the treatment of psoriasis
KR880700667A (ko) 정신병 치료제로서의 2,3-디히드로-1h-페날렌-2-아미노화합물
ZA856921B (en) Aminocarboxylic acid complexes for the treatment of calcific tumors
HUT40795A (en) Process for preparing fluoro-alkane compounds
YU158586A (en) Process for obtaining carbapenem compounds
EP0180933A3 (en) Process for preparing oxygen-containing organic compounds
GB2171096B (en) Process for preparing pyrone-3-carboxamide compounds
GB2118942B (en) 7b-acylamido-3-cephem-4-carboxylic acid compounds of the formula
EP0165006A3 (en) Processes for preparing substituted halomethyl-s-triazines
IT1188201B (it) Procedimento per produrre composti aromatici c6+
DE3662394D1 (en) Process for producing chlorophenylhydrazine compounds
DE3269425D1 (en) Process for the treatment of organic amine compositions
DE3661531D1 (en) Process for preparing unsaturated organic compounds
SU1175496A1 (ru) "kohtakthый излучateль для дeциmetpoboй tepaпии"