ZA838826B - Sulfonate prodrugs of corticosteroids - Google Patents

Sulfonate prodrugs of corticosteroids

Info

Publication number
ZA838826B
ZA838826B ZA838826A ZA838826A ZA838826B ZA 838826 B ZA838826 B ZA 838826B ZA 838826 A ZA838826 A ZA 838826A ZA 838826 A ZA838826 A ZA 838826A ZA 838826 B ZA838826 B ZA 838826B
Authority
ZA
South Africa
Prior art keywords
corticosteroids
sulfonate prodrugs
prodrugs
sulfonate
Prior art date
Application number
ZA838826A
Other languages
English (en)
Inventor
Dale Anderson Bradley
Robert Allen Conradi
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA838826B publication Critical patent/ZA838826B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA838826A 1983-01-21 1983-11-25 Sulfonate prodrugs of corticosteroids ZA838826B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/459,742 US4472392A (en) 1983-01-21 1983-01-21 Sulfonate containing ester prodrugs of corticosteroids

Publications (1)

Publication Number Publication Date
ZA838826B true ZA838826B (en) 1984-07-25

Family

ID=23825979

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA838826A ZA838826B (en) 1983-01-21 1983-11-25 Sulfonate prodrugs of corticosteroids

Country Status (8)

Country Link
US (1) US4472392A (ja)
EP (1) EP0120557B1 (ja)
JP (1) JPS59137500A (ja)
CA (1) CA1199908A (ja)
DE (1) DE3478605D1 (ja)
HK (1) HK43993A (ja)
MX (1) MX9203197A (ja)
ZA (1) ZA838826B (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
US5446177A (en) * 1984-12-28 1995-08-29 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
DE3877361T2 (de) * 1987-07-16 1993-05-13 Upjohn Co Aminosalze von alkan-1,n-dicarbonsaeure-mono-(2-sulfato-aethyl)amiden.
WO1994015947A1 (en) * 1993-01-08 1994-07-21 Astra Aktiebolag Novel colon- or ileum-specific steroid derivatives
US5420120A (en) * 1993-12-17 1995-05-30 Alcon Laboratories, Inc. Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
WO2004017904A2 (en) * 2002-08-23 2004-03-04 The Mclean Hospital Corporation Corticosteroid conjugates and uses thereof
US7825147B2 (en) * 2003-08-29 2010-11-02 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-IV
US20070259874A1 (en) * 2003-11-26 2007-11-08 Palle Venkata P Phosphodiesterase Inhibitors
EP1934219A1 (en) 2005-09-16 2008-06-25 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
CA2626628A1 (en) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type iv inhibitors
RU2008119323A (ru) 2005-10-19 2009-11-27 Рэнбакси Лабораториз Лимитед (In) Фармацевтические композиции мускаринового рецептора
EP2066661A2 (en) * 2006-09-22 2009-06-10 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
MX2009003100A (es) * 2006-09-22 2009-05-11 Ranbaxy Lab Ltd Inhibidores de fosfodiesterasa tipo iv.
SG175603A1 (en) * 2006-10-12 2011-11-28 Bellus Health International Ltd Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
US20080207659A1 (en) * 2007-02-15 2008-08-28 Asit Kumar Chakraborti Inhibitors of phosphodiesterase type 4
US20110130403A1 (en) * 2007-03-14 2011-06-02 Ranbaxy Laboratories Limited Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
CA2680625C (en) 2007-03-14 2016-02-23 Ranbaxy Laboratories Limited Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
EP2249921B1 (en) * 2008-02-25 2020-06-17 Eyegate Pharmaceuticals, Inc. Enhanced delivery of dexamethasone phosphate to ocular tissues through iontophoresis
EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
WO2022037704A1 (zh) * 2020-08-21 2022-02-24 诺茗(北京)生物医药有限公司 一种水溶性抗肿瘤前药及其药物组合物和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
US3171846A (en) * 1962-07-10 1965-03-02 Erba Carlo Spa Prednisolone-21-double esters
NL124139C (ja) * 1964-11-04
FR6590M (ja) * 1967-10-31 1968-12-30
US3609712A (en) * 1969-01-15 1971-09-28 Ibm Insulated gate field effect transistor memory array
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
DK404879A (da) * 1978-10-04 1980-04-05 Schering Ag Kortikoid-21-sulfopropionater og deres salte fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende disse forbindelser
DE2848423A1 (de) * 1978-11-08 1980-05-29 Merck Patent Gmbh Hydrocortisonester, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DE3478605D1 (en) 1989-07-13
JPH0226639B2 (ja) 1990-06-12
EP0120557A2 (en) 1984-10-03
HK43993A (en) 1993-05-14
CA1199908A (en) 1986-01-28
US4472392A (en) 1984-09-18
EP0120557B1 (en) 1989-06-07
JPS59137500A (ja) 1984-08-07
EP0120557A3 (en) 1985-02-06
MX9203197A (es) 1992-09-01

Similar Documents

Publication Publication Date Title
ZA838826B (en) Sulfonate prodrugs of corticosteroids
GB8314985D0 (en) Drive-belts of trapezoidal cross-section
GB8408815D0 (en) Derivatives of azet-2-ones
GB8415139D0 (en) Modification of polyolycolic structural elements
ZA841455B (en) Sulfonate containing ester prodrugs of corticosteroids
HUT35000A (en) Process for prodiction of grf-analoges
GB8327533D0 (en) Manufacture of slates
GB2115234B (en) Attachment of trunking
GB2129426B (en) Compounds of thiatriazines
GB8304857D0 (en) Manufacture of nitrophenetoles
DE3360020D1 (en) Fungicide-active derivatives of benzhydrole
GB8428946D0 (en) Positioning of plugs
GB8410287D0 (en) Reducing section of elongated components
IL72271A0 (en) Manufacture of 2-isopropyl-4-methyl-6-hydroxypyrimidine
GB8312327D0 (en) Manufacture of tetra-alkoxy-silanes
ZA832380B (en) Sanitere en/of onmatige voering
HUT36680A (en) Sinergizated herbicid preparatives consisting of tiolcarbamates
AU87691S (en) Set of bedlinen
AU87534S (en) Set of bedlinen
AU87690S (en) Set of bedlinen
AU87689S (en) Set of bedlinen
AU87535S (en) Set of bedlinen
AU87869S (en) Set of bedlinen
AU87870S (en) Set of bedlinen
AU87199S (en) Set of bedlinen