ZA83409B - R-and s-isomers of 6-chloro-7,8-dihydroxy-1-(4-hydroxy-phenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine - Google Patents

R-and s-isomers of 6-chloro-7,8-dihydroxy-1-(4-hydroxy-phenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine

Info

Publication number
ZA83409B
ZA83409B ZA83409A ZA83409A ZA83409B ZA 83409 B ZA83409 B ZA 83409B ZA 83409 A ZA83409 A ZA 83409A ZA 83409 A ZA83409 A ZA 83409A ZA 83409 B ZA83409 B ZA 83409B
Authority
ZA
South Africa
Prior art keywords
benzazepine
tetrahydro
dihydroxy
isomers
chloro
Prior art date
Application number
ZA83409A
Other languages
English (en)
Inventor
Dennis Marvin Ackerman
Carl Kaiser
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of ZA83409B publication Critical patent/ZA83409B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ZA83409A 1982-02-24 1983-01-21 R-and s-isomers of 6-chloro-7,8-dihydroxy-1-(4-hydroxy-phenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine ZA83409B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35181582A 1982-02-24 1982-02-24

Publications (1)

Publication Number Publication Date
ZA83409B true ZA83409B (en) 1983-10-26

Family

ID=23382525

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA83409A ZA83409B (en) 1982-02-24 1983-01-21 R-and s-isomers of 6-chloro-7,8-dihydroxy-1-(4-hydroxy-phenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine

Country Status (6)

Country Link
EP (1) EP0087319A1 (xx)
JP (1) JPS58157767A (xx)
AU (1) AU1068283A (xx)
IL (1) IL67749A (xx)
NZ (1) NZ203064A (xx)
ZA (1) ZA83409B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514394A (en) * 1983-05-25 1985-04-30 Smithkline Beckman Corporation Anti-hypertensive use of 1-(4'-branched alkylsulfonylphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines
US4600714A (en) * 1984-04-26 1986-07-15 Smithkline Beckman Corporation Fenoldopam 4',8-bis-hydrogen sulfate and dopaminergic use thereof
US4707483A (en) * 1985-12-20 1987-11-17 Smithkline Beckman Corporation 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
CN103172565A (zh) * 2011-12-22 2013-06-26 四川科伦药物研究有限公司 一种手性菲诺多泮的拆分方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197297A (en) * 1976-11-17 1980-04-08 Smithkline Corporation 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
US4328153A (en) * 1980-07-17 1982-05-04 Smith Kline Corporation Dopaminergic benzazepines

Also Published As

Publication number Publication date
IL67749A0 (en) 1983-05-15
NZ203064A (en) 1985-05-31
AU1068283A (en) 1983-09-01
JPS58157767A (ja) 1983-09-19
IL67749A (en) 1986-09-30
EP0087319A1 (en) 1983-08-31

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