ZA781608B - Prostaglandin analogs - Google Patents

Prostaglandin analogs

Info

Publication number
ZA781608B
ZA781608B ZA00781608A ZA781608A ZA781608B ZA 781608 B ZA781608 B ZA 781608B ZA 00781608 A ZA00781608 A ZA 00781608A ZA 781608 A ZA781608 A ZA 781608A ZA 781608 B ZA781608 B ZA 781608B
Authority
ZA
South Africa
Prior art keywords
prostaglandin analogs
prostaglandin
analogs
Prior art date
Application number
ZA00781608A
Other languages
English (en)
Inventor
W Morozowich
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA781608B publication Critical patent/ZA781608B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA00781608A 1977-04-18 1978-03-20 Prostaglandin analogs ZA781608B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/788,455 US4100192A (en) 1977-04-18 1977-04-18 Inter-phenylene-PG amides

Publications (1)

Publication Number Publication Date
ZA781608B true ZA781608B (en) 1979-03-28

Family

ID=25144544

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00781608A ZA781608B (en) 1977-04-18 1978-03-20 Prostaglandin analogs

Country Status (10)

Country Link
US (4) US4100192A (fr)
JP (1) JPS53132546A (fr)
BE (1) BE866100A (fr)
CH (1) CH634297A5 (fr)
DE (1) DE2816692A1 (fr)
FR (1) FR2387952A1 (fr)
GB (1) GB1581321A (fr)
NL (1) NL7803369A (fr)
SE (1) SE7804261L (fr)
ZA (1) ZA781608B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198525A (en) * 1979-01-15 1980-04-15 The Upjohn Company 11-Deoxy-3,7-inter-m-phenylene-4,5,6-trinor-3-oxa-PGE compounds
DE3029984C2 (de) * 1980-08-08 1983-12-15 Grünenthal GmbH, 5190 Stolberg 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel
AU770343B2 (en) 1999-09-06 2004-02-19 Fumie Sato Prostaglandin E analogues
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
WO2010102078A1 (fr) 2009-03-04 2010-09-10 Allergan, Inc. Solution ophtalmique améliorée à base de bimatoprost
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846475A (en) * 1971-12-03 1974-11-05 Syntex Inc 10-hydroxy pge{11 {11 and pge {11
US3933897A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGA1 -oxa-phenylene compounds
US3933899A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGE2 -oxa-phenylene compounds
US3933900A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGEo oxa-phenylene compounds
US3933898A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGE1 -oxa phenylene compounds
US3933895A (en) * 1972-10-30 1976-01-20 The Upjohn Company Oxa-phenylene compounds
US3981868A (en) * 1973-05-31 1976-09-21 American Cyanamid Company Derivatives of 9-oxo-13-trans-prostenoic acid amides
FR2239458A1 (en) * 1973-07-31 1975-02-28 Aries Robert Prostaglandin amides - with antilipolytic, gonadotrophic, luteolytic, hypotensive and other activities associated with prostaglandins
US4054604A (en) * 1974-01-10 1977-10-18 American Cyanamid Company Amide derivatives of 9-oxo-13-trans-prostenoic acid
GB1540049A (en) * 1976-08-16 1979-02-07 Upjohn Co 9,11-bridged prostaglandins

Also Published As

Publication number Publication date
FR2387952A1 (fr) 1978-11-17
FR2387952B1 (fr) 1980-06-13
NL7803369A (nl) 1978-10-20
GB1581321A (en) 1980-12-10
US4136115A (en) 1979-01-23
US4138549A (en) 1979-02-06
CH634297A5 (de) 1983-01-31
US4100192A (en) 1978-07-11
BE866100A (fr) 1978-10-18
JPS53132546A (en) 1978-11-18
DE2816692A1 (de) 1978-10-19
SE7804261L (sv) 1978-10-19
US4154926A (en) 1979-05-15

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