ZA77787B - New derivatives of 3-quinoline carboxylic acid,process for preparing them and pharmaceutical compositions - Google Patents

New derivatives of 3-quinoline carboxylic acid,process for preparing them and pharmaceutical compositions

Info

Publication number
ZA77787B
ZA77787B ZA00770787A ZA77787A ZA77787B ZA 77787 B ZA77787 B ZA 77787B ZA 00770787 A ZA00770787 A ZA 00770787A ZA 77787 A ZA77787 A ZA 77787A ZA 77787 B ZA77787 B ZA 77787B
Authority
ZA
South Africa
Prior art keywords
preparing
carboxylic acid
pharmaceutical compositions
quinoline carboxylic
new derivatives
Prior art date
Application number
ZA00770787A
Other languages
English (en)
Inventor
R Deraedt
O Martret
A Allais
F Clemence
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of ZA77787B publication Critical patent/ZA77787B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
ZA00770787A 1976-02-11 1977-02-10 New derivatives of 3-quinoline carboxylic acid,process for preparing them and pharmaceutical compositions ZA77787B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7603754A FR2340735A1 (fr) 1976-02-11 1976-02-11 Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament

Publications (1)

Publication Number Publication Date
ZA77787B true ZA77787B (en) 1978-03-29

Family

ID=9168994

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00770787A ZA77787B (en) 1976-02-11 1977-02-10 New derivatives of 3-quinoline carboxylic acid,process for preparing them and pharmaceutical compositions

Country Status (19)

Country Link
US (1) US4107310A (fr)
JP (1) JPS52116479A (fr)
AU (1) AU508345B2 (fr)
BE (1) BE851306A (fr)
CA (1) CA1089464A (fr)
CH (1) CH620437A5 (fr)
DD (1) DD129552A5 (fr)
DE (1) DE2705446A1 (fr)
DK (1) DK150512C (fr)
ES (1) ES455804A1 (fr)
FR (1) FR2340735A1 (fr)
GB (1) GB1572482A (fr)
IE (1) IE44879B1 (fr)
IL (1) IL51413A (fr)
LU (1) LU76742A1 (fr)
NL (1) NL7701398A (fr)
SE (1) SE441528B (fr)
SU (1) SU867299A3 (fr)
ZA (1) ZA77787B (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190659A (en) * 1973-08-27 1980-02-26 Sandoz, Inc. Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
US4187309A (en) * 1977-06-20 1980-02-05 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4281131A (en) 1977-06-20 1981-07-28 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4273930A (en) * 1977-06-20 1981-06-16 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acid esters
US4221797A (en) * 1978-08-14 1980-09-09 Sandoz, Inc. Dihydroquinoline-one derivatives
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2482596A1 (fr) * 1980-05-19 1981-11-20 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament
US4266050A (en) * 1980-07-02 1981-05-05 American Home Products Corporation 1,2-Dihydro-4-hydroxy-2-imino-N-substituted-3-quinolinecarboxamide derivatives
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
HU190796B (en) * 1981-06-12 1986-11-28 Roussel Uclaf,Fr Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives
FR2507602A1 (fr) * 1981-06-12 1982-12-17 Roussel Uclaf Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2523130A1 (fr) * 1982-03-15 1983-09-16 Roussel Uclaf Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2509728A1 (fr) * 1981-07-17 1983-01-21 Roussel Uclaf Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR2537139B2 (fr) * 1982-03-15 1985-09-20 Roussel Uclaf Nouveau derive de la n-dihydrothiazolyl 3-quinoleine carboxamide, procede de preparation, application a titre de medicament et compositions le renfermant
FR2530633A1 (fr) * 1982-06-03 1984-01-27 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant
FR2551437B2 (fr) * 1982-06-03 1985-10-25 Roussel Uclaf Nouveaux derives de l'acide 4-oh 3-quinoleine carboxylique substitues en 2, nouveau procede de preparation, leur application comme medicament et les compositions les renfermant et produits necessaires a leur preparation
FR2532939A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
FR2537140B1 (fr) * 1982-12-07 1986-07-18 Roussel Uclaf Nouveaux derives de la 4-hydroxy-3-quinoleine carboxamide, leur sels, procede de preparation, application a titre de medicaments, et compositions les renfermant
SE452170B (sv) * 1983-10-03 1987-11-16 Boliden Ab Forfarande for utvinning av metall ur koppar och/eller edelmetall innehallande material som innehaller antimon och vismut
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) * 1984-07-09 1986-07-22 Ciba-Geigy Corporation Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
JPH0358559A (ja) * 1989-07-26 1991-03-13 Sekisui Chem Co Ltd 電話システム
US5175151A (en) * 1990-09-07 1992-12-29 Schering Corporation Antiviral compounds and antihypertensive compounds
DE69128481T2 (de) * 1990-09-07 1998-04-09 Schering Corp Antivirale und antihypertensive verbindungen
US5179093A (en) * 1991-05-10 1993-01-12 Schering Corporation Quinoline-diones
DE4138820A1 (de) * 1991-11-26 1993-05-27 Basf Ag Chinolin-3-carbonsaeureamide, deren herstellung und verwendung
SE9201076L (sv) * 1992-04-06 1993-10-07 Shimon Slavin Användningen av gamla läkemedel för behandling av diabetes
SE9400810D0 (sv) * 1994-03-10 1994-03-10 Pharmacia Ab New use of Quinoline-3-carboxamide compounds
SE9400809D0 (sv) * 1994-03-10 1994-03-10 Pharmacia Ab New use of quinoline-3-carboxamide compounds
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
SE0400235D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
US8314124B2 (en) * 2004-02-06 2012-11-20 Active Biotech Ab Crystalline salts of quinoline compounds and methods for preparing them
RU2525115C2 (ru) * 2004-06-24 2014-08-10 Вертекс Фармасьютикалз Инкорпорейтед Способ модуляции транспортеров атф-связывающей кассеты
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN101006076B (zh) 2004-06-24 2010-09-29 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
WO2006087830A1 (fr) * 2005-02-18 2006-08-24 Kanebo, Ltd. Structure de textile tisse sous forme de bande et son procede de fabrication
NZ567088A (en) * 2005-10-19 2012-06-29 Teva Pharma Crystals of laquinimod sodium, and process for the manufacture thereof
JP2009521468A (ja) * 2005-12-24 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｂｃ輸送体の調節因子としてのキノリン−４−オン誘導体
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
KR101495327B1 (ko) * 2006-06-12 2015-02-24 테바 파마슈티컬 인더스트리즈 리미티드 안정한 라퀴니모드 제제
US20080221161A1 (en) * 2007-02-09 2008-09-11 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
WO2009082471A1 (fr) * 2007-12-20 2009-07-02 Teva Pharmaceutical Industries, Ltd. Préparations de laquinimod stables
WO2010028015A2 (fr) * 2008-09-03 2010-03-11 Auspex Pharmaceuticals, Inc Modulateurs 2-oxo-1,2-dihydro-quinoléines de la fonction immunitaire
PT2408750E (pt) 2009-03-20 2015-10-15 Vertex Pharma Processo para a produção de modeladores do regulador de condutância transmembranar da fibrose cística
MX2012001333A (es) * 2009-07-30 2012-06-01 Teva Pharma Tratamiento de la enfermedad de crohn con la laquinimod.
EP3064206B1 (fr) * 2009-08-10 2019-03-20 Active Biotech AB Traitement de la maladie de huntington utilisant du laquinimod
AU2011223697B2 (en) * 2010-03-03 2016-07-14 Teva Pharmaceutical Industries Ltd. Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
NZ602512A (en) * 2010-03-03 2014-07-25 Teva Pharma Treatment of lupus arthritis using laquinimod
EA201290837A1 (ru) * 2010-03-03 2013-05-30 Тева Фармасьютикал Индастриз Лтд. Лечение волчаночного нефрита с применением лаквинимода
CN102267984B (zh) * 2010-06-04 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 4-羟基喹啉-3-酰胺衍生物及其制备方法和用途
BR112013007850A2 (pt) 2010-10-14 2016-06-07 Immunahr Ab 1,2-diidro-4-hidróxi-2-oxo-quinolina-3-carboxanilidas como ativadores de ahr
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
EP2537517A1 (fr) * 2011-06-22 2012-12-26 Active Biotech AB 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide enrichie au deuterium
BR112014008731A2 (pt) 2011-10-12 2017-04-25 Teva Pharma tratamento de esclerose múltipla com combinação de laquinimode e fingolimode
JP2015505564A (ja) 2012-02-03 2015-02-23 テバ ファーマシューティカル インダストリーズ リミティド 第一選択の抗ＴＮＥα療法に失敗したクローン病患者を治療するためのラキニモドの使用
EP2819670A1 (fr) 2012-02-27 2015-01-07 Vertex Pharmaceuticals Incorporated Composition pharmaceutique et son administration
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
MX2015005632A (es) 2012-11-07 2016-02-05 Teva Pharma Sales de amina de laquinimod.
SG11201505952WA (en) 2013-01-31 2015-08-28 Vertex Pharma Quinoline and quinazoline amides as modulators of sodium channels
NZ630427A (en) 2013-03-14 2017-06-30 Teva Pharma Crystals of laquinimod sodium and improved process for the manufacture thereof
EP3137092A4 (fr) 2014-04-29 2017-10-11 Teva Pharmaceutical Industries Ltd. Laquinimod pour le traitement de patients atteints de sclérose en plaques récurrente rémittente (sep-rr) chez ayant un degré d'incapacité élevé
RU2749213C2 (ru) 2014-10-07 2021-06-07 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL289475A (fr) * 1962-03-01
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
DE2705446C2 (fr) 1989-10-12
NL7701398A (nl) 1977-08-15
ES455804A1 (es) 1978-01-16
IE44879L (en) 1977-08-11
SE7700804L (sv) 1977-08-12
LU76742A1 (fr) 1977-08-19
US4107310A (en) 1978-08-15
JPS623152B2 (fr) 1987-01-23
CA1089464A (fr) 1980-11-11
GB1572482A (en) 1980-07-30
CH620437A5 (fr) 1980-11-28
DE2705446A1 (de) 1977-08-18
DK150512C (da) 1987-11-16
IE44879B1 (en) 1982-05-05
DK150512B (da) 1987-03-16
DD129552A5 (de) 1978-01-25
AU508345B2 (en) 1980-03-20
IL51413A0 (en) 1977-04-29
BE851306A (fr) 1977-08-10
FR2340735A1 (fr) 1977-09-09
SE441528B (sv) 1985-10-14
JPS52116479A (en) 1977-09-29
IL51413A (en) 1980-09-16
DK56077A (da) 1977-08-12
SU867299A3 (ru) 1981-09-23
AU2221877A (en) 1978-08-17
FR2340735B1 (fr) 1978-11-03

Similar Documents

Publication Publication Date Title
ZA77787B (en) New derivatives of 3-quinoline carboxylic acid,process for preparing them and pharmaceutical compositions
EG12067A (en) Process for preparing of benzoic acids,and their derivatives
YU174375A (en) Process for preparing (4-trifluoromethyl-phenoxy)-phenoxypropionic acid and derivatives thereof
IL47820A0 (en) New derivatives of 3-quinoline carboxylic acid,process for preparing them and pharmaceutical compositions
GB1516747A (en) Substituted propanol-(2)derivatives and their nicotinic acid esters and process for their preparation and their use
JPS5236637A (en) Phenoxy alkyl carboxylic acid derivatives *process for preparing the same and pharmaceutical containing the same having lipidddepleting activity
HU174980B (hu) Sposob poluchenija proizvodnykh fenoksi-alkil-karbonovykh kislot
DE2861461D1 (en) Derivatives of aminobenzoic acids, process for their preparation and pharmaceutical compositions containing them.
HU179598B (en) Process for preparing cef-3-em-4-carboxylic acid derivatives
HU174848B (hu) Sposob poluchenija novykh proizvodnykh 15,15-ehtilendioksi-prostanovoj kisloty
CS194774B2 (en) Process for preparing derivatives of 1,4-dihydropyridine suitable especially as antihypertensive and antianginar medicament
HU172966B (hu) Sposob poluchenija proizvodnykh 17-aril-18,19,20-triol-prost-16-inovoj kisloty
GB1554310A (en) Process for the preparation of 5-oxo-hexanoic acid and derivatives thereof
IL51690A (en) 5-substituted-2-hydroxy-cyclopentane carboxylic or propionic acid lactones,process of preparation and pharmaceutical compositions
HU173305B (hu) Sposob poluchenija novykh proizvodnykh penam-karbonovojj-kisloty i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
JPS527934A (en) Novel propionic acid derivatives and process for preparation thereof
ZA755688B (en) Basically substituted 3-sulfamoylbenzoic acid derivatives and process for their preparation
JPS51141845A (en) Cyclopentanee11heptanoic acid derivatives and process for manufacture thereof
HU172484B (hu) Sposob poluchenija 2-alkoksikarbonilamino-5/6/-fenil-sul'foniloksi-benzimidazolov s antgel'minticheskoj aktivnost'ju
GB1487166A (en) Process for preparing p-isobutyl-phenylacetic acid derivatives
IL54070A0 (en) 17 -acetylene derivatives of androst-4-ene, process for preparing them and pharmaceutical compositions
HU171688B (hu) Sposob poluchenija novykh proizvodnykh penam-3-karbonovojj kisloty i farmacevticheskiky kompozicijj soderzhahhikh ikh aktivnymi agentami
ZA755310B (en) Process for the preparation of 9,11,15-trihydroxy-13, 14-dehydro-prostaglandins and new prost-5-en-13-ynoic acid derivatives
HU171836B (hu) Sposob poluchenija proizvodnykh tiazolo/5,4-f/khinolin-8-karbonovoj kisloty
IL49442A (en) (3-carboxy-2-methyl-5-indolyloxy)alkanoic acid derivatives,process for their preparation and pharmaceutical compositions comprising them