ZA202403104B - Pharmaceutical formulation comprising tacrolimus, method for the preparation thereof and use - Google Patents

Pharmaceutical formulation comprising tacrolimus, method for the preparation thereof and use

Info

Publication number
ZA202403104B
ZA202403104B ZA2024/03104A ZA202403104A ZA202403104B ZA 202403104 B ZA202403104 B ZA 202403104B ZA 2024/03104 A ZA2024/03104 A ZA 2024/03104A ZA 202403104 A ZA202403104 A ZA 202403104A ZA 202403104 B ZA202403104 B ZA 202403104B
Authority
ZA
South Africa
Prior art keywords
tacrolimus
preparation
pharmaceutical formulation
microparticles
relates
Prior art date
Application number
ZA2024/03104A
Other languages
English (en)
Inventor
Evangelos Karavas
Efthymios Koutris
Lida Kalantzi
Sotiria Chaitidou
Nikos Lemonakis
Anna Papadaki
Vincent Brieudes
Artemis Kalezi
Athanasios Katsenis
Katerina Kotti
Original Assignee
Pharmathen Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GR20210100639A external-priority patent/GR1010308B/el
Priority claimed from GB2116138.5A external-priority patent/GB2612779A/en
Application filed by Pharmathen Sa filed Critical Pharmathen Sa
Publication of ZA202403104B publication Critical patent/ZA202403104B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA2024/03104A 2021-09-27 2024-04-22 Pharmaceutical formulation comprising tacrolimus, method for the preparation thereof and use ZA202403104B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GR20210100639A GR1010308B (el) 2021-09-27 2021-09-27 Φαρμακευτικο σκευασμα που περιλαμβανει τακρολιμους, μεθοδος για την παρασκευη και χρηση αυτου
GB2116138.5A GB2612779A (en) 2021-11-10 2021-11-10 Pharmaceutical formulation comprising Tacrolimus, method for the preparation thereof and use
PCT/EP2022/025445 WO2023046321A1 (en) 2021-09-27 2022-09-27 Pharmaceutical formulation comprising tacrolimus, method for the preparation thereof and use

Publications (1)

Publication Number Publication Date
ZA202403104B true ZA202403104B (en) 2025-01-29

Family

ID=83902713

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2024/03104A ZA202403104B (en) 2021-09-27 2024-04-22 Pharmaceutical formulation comprising tacrolimus, method for the preparation thereof and use

Country Status (10)

Country Link
US (1) US20250319028A1 (https=)
EP (1) EP4440550A1 (https=)
JP (1) JP2024536879A (https=)
KR (1) KR20240060874A (https=)
AU (1) AU2022351126A1 (https=)
CA (1) CA3233139A1 (https=)
CO (1) CO2024005380A2 (https=)
MX (1) MX2024003886A (https=)
WO (1) WO2023046321A1 (https=)
ZA (1) ZA202403104B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120000593B (zh) * 2024-12-27 2026-03-20 广东药科大学 一种他克莫司微晶及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006002365A2 (en) 2004-06-24 2006-01-05 Angiotech International Ag Microparticles with high loadings of a bioactive agent
MX2007011494A (es) 2005-03-17 2007-12-06 Elan Pharma Int Ltd Composiciones inyectables de compuestos inmunosupresores nanoparticulados.
WO2017173534A1 (en) * 2016-04-05 2017-10-12 The Hospital For Sick Children System for delivery of fk506 for enhancing nerve regeneration

Also Published As

Publication number Publication date
CO2024005380A2 (es) 2024-05-30
MX2024003886A (es) 2024-07-10
WO2023046321A1 (en) 2023-03-30
WO2023046321A8 (en) 2024-05-30
AU2022351126A1 (en) 2024-05-09
EP4440550A1 (en) 2024-10-09
CA3233139A1 (en) 2023-03-30
KR20240060874A (ko) 2024-05-08
JP2024536879A (ja) 2024-10-08
US20250319028A1 (en) 2025-10-16

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