ZA202306022B - Application of antibacterial peptide lrgg in preparing antibacterial synergist of fluoroquinolones - Google Patents

Application of antibacterial peptide lrgg in preparing antibacterial synergist of fluoroquinolones

Info

Publication number
ZA202306022B
ZA202306022B ZA2023/06022A ZA202306022A ZA202306022B ZA 202306022 B ZA202306022 B ZA 202306022B ZA 2023/06022 A ZA2023/06022 A ZA 2023/06022A ZA 202306022 A ZA202306022 A ZA 202306022A ZA 202306022 B ZA202306022 B ZA 202306022B
Authority
ZA
South Africa
Prior art keywords
fluoroquinolones
lrgg
antibacterial
pasteurella multocida
application
Prior art date
Application number
ZA2023/06022A
Inventor
Hongxia Ma
Lingcong Kong
Lei Liu
Qi Cui
Handong Yu
Lili Guan
Haipeng Zhang
Chengguang He
Original Assignee
Univ Jilin Agricultural
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jilin Agricultural filed Critical Univ Jilin Agricultural
Publication of ZA202306022B publication Critical patent/ZA202306022B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention discloses an application of an antibacterial peptide LRGG in preparing an antibacterial synergist of fluoroquinolones, and relates to the technical field of biomedicine. The amino acid sequence of the antibacterial peptide LRGG is shown in SEQ ID NO.1. The antibacterial peptide LRGG provided by the invention can be combined with fluoroquinolones to produce synergistic sterilization effect on gram-negative bacteria, such as Escherichia coli, Shigella dysenteriae and Pasteurella multocida. Among them, the combined application of LRGG and fluoroquinolones has the strongest synergistic bactericidal effect on drug-resistant Pasteurella multocida (MIC=32 micrograms per milliliter), which can increase the antibacterial activity of fluoroquinolones against drug-resistant Pasteurella multocida by 512 times (MIC=0.0625 micrograms per milliliter), and significantly improve the therapeutic effect of fluoroquinolones on infection caused by drug-resistant Pasteurella multocida.
ZA2023/06022A 2023-05-17 2023-06-07 Application of antibacterial peptide lrgg in preparing antibacterial synergist of fluoroquinolones ZA202306022B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310556957.3A CN116621939B (en) 2023-05-17 2023-05-17 Application of antibacterial peptide LRGG in preparation of fluoroquinolone antibacterial synergist

Publications (1)

Publication Number Publication Date
ZA202306022B true ZA202306022B (en) 2023-12-20

Family

ID=87596612

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2023/06022A ZA202306022B (en) 2023-05-17 2023-06-07 Application of antibacterial peptide lrgg in preparing antibacterial synergist of fluoroquinolones

Country Status (2)

Country Link
CN (1) CN116621939B (en)
ZA (1) ZA202306022B (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104140458B (en) * 2014-07-07 2016-05-18 河南科技大学 One kind cecropin antimicrobial peptides and application thereof
TW201710282A (en) * 2015-09-04 2017-03-16 佛教慈濟醫療財團法人 Novel antimicrobial peptides derived from phage of Acinetobacter baumannii and use thereof
US11214594B2 (en) * 2016-06-23 2022-01-04 Konkuk University Industrial Cooperation Corp. Antimicrobial peptide having synergistic antibacterial effect with antibiotics on multidrug resistant bacteria, and use thereof
CN108314722B (en) * 2018-04-27 2020-08-11 九江牧威利元科技中心（普通合伙） Antibacterial peptide and application thereof
WO2021173865A2 (en) * 2020-02-25 2021-09-02 Bambu Vault Llc Compounds for detection of viral pathogens
CN113045628B (en) * 2021-03-23 2022-06-14 山东大学 Application of antibacterial peptide or variant thereof in preparation of antibacterial product

Also Published As

Publication number Publication date
CN116621939A (en) 2023-08-22
CN116621939B (en) 2024-01-19

Similar Documents

Publication Publication Date Title
Boparai et al. Mini review on antimicrobial peptides, sources, mechanism and recent applications
US7723468B2 (en) Antimicrobial peptide, compositions, and uses therefor
Brogden et al. Antimicrobial peptides in animals and their role in host defences
KR102499670B1 (en) Romo1-derived antimicrobial peptides containing lysine substitution and variants thereof
US11479587B2 (en) Cationic intrinsically disordered antimicrobial peptides
CN115475232A (en) Antimicrobial peptides and methods of use thereof
Marone et al. Comparative in vitro activity of silver sulfadiazine, alone and in combination with cerium nitrate, against staphylococci and gram-negative bacteria
KR20210007075A (en) Novel antimicrobial peptide derived from antimicrobial peptides isolated from Korean sea cucumber and uses thereof
WO2006006195B1 (en) Antibacterial peptides and analogues thereof
KR20160055343A (en) An anti-microbial peptide Scolopendrasin-7 isolated from the Scolopendra subspinipes mutilans and its synthetic peptide
CA2866520A1 (en) Antibacterial peptides derived from defensins
CN111087460B (en) Broad-spectrum antibacterial peptide and application thereof
KR101444257B1 (en) A new scolopendrasin ii peptide isolated from the scolopendra subsinipes and its synthetic composition
MX2020010071A (en) Antimicrobial, bacteriophage-derived polypeptides and their use against gram-negative bacteria.
ZA202306022B (en) Application of antibacterial peptide lrgg in preparing antibacterial synergist of fluoroquinolones
RU2012143143A (en) PEPTIDE COMPOUNDS SUITABLE FOR USE AS ANTIBACTERIAL PRODUCTS
KR100836596B1 (en) Salt-resistant antimicrobial peptides and antimicrobial composition comprising thereof
ATE285786T1 (en) MAMMAL-DERIVED PEPTIDES FOR THE TREATMENT OF MICROBIAL INFECTIONS
AU2004212179A1 (en) Antimicrobial agents from Streptococcus mitis and Streptococcus oralis
CN114149483B (en) Antibacterial peptide composition and application thereof
US10150795B2 (en) Peptide having antimicrobial activity against pathogens and antimicrobial peptide composition comprising the same
JP2017533177A5 (en)
MX2021012375A (en) Method of treating and preventing bone and joint infections.
US5254537A (en) Composition and treatment with peptide combinations
JP2021522336A (en) Therapeutic use of fibrinogen gamma prime variants