ZA202203685B - Accounting for errors in optical measurements - Google Patents
Accounting for errors in optical measurementsInfo
- Publication number
- ZA202203685B ZA202203685B ZA2022/03685A ZA202203685A ZA202203685B ZA 202203685 B ZA202203685 B ZA 202203685B ZA 2022/03685 A ZA2022/03685 A ZA 2022/03685A ZA 202203685 A ZA202203685 A ZA 202203685A ZA 202203685 B ZA202203685 B ZA 202203685B
- Authority
- ZA
- South Africa
- Prior art keywords
- sample
- sample chamber
- accounting
- errors
- blood sample
- Prior art date
Links
- 238000005259 measurement Methods 0.000 title 1
- 230000003287 optical effect Effects 0.000 title 1
- 239000008280 blood Substances 0.000 abstract 4
- 210000004369 blood Anatomy 0.000 abstract 4
- 238000000386 microscopy Methods 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000000151 deposition Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/492—Determining multiple analytes
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/10—Image acquisition
- G06V10/12—Details of acquisition arrangements; Constructional details thereof
- G06V10/14—Optical characteristics of the device performing the acquisition or on the illumination arrangements
- G06V10/143—Sensing or illuminating at different wavelengths
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/698—Matching; Classification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/016—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/018—Platelets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10064—Fluorescence image
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30101—Blood vessel; Artery; Vein; Vascular
- G06T2207/30104—Vascular flow; Blood flow; Perfusion
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Theoretical Computer Science (AREA)
- Hematology (AREA)
- Multimedia (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Quality & Reliability (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Medical Informatics (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (52), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (24). One or more microscopic images of the sample chamber (52) with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962924229P | 2019-10-22 | 2019-10-22 | |
PCT/IB2020/059924 WO2021079305A1 (en) | 2019-10-22 | 2020-10-22 | Accounting for errors in optical measurements |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA202203685B true ZA202203685B (en) | 2024-02-28 |
Family
ID=73040173
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA2022/03685A ZA202203685B (en) | 2019-10-22 | 2022-03-30 | Accounting for errors in optical measurements |
ZA2022/03983A ZA202203983B (en) | 2019-10-22 | 2022-04-07 | Accounting for errors in optical measurements |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA2022/03983A ZA202203983B (en) | 2019-10-22 | 2022-04-07 | Accounting for errors in optical measurements |
Country Status (11)
Country | Link |
---|---|
US (2) | US20220381672A1 (en) |
EP (2) | EP4049176A1 (en) |
JP (2) | JP2022553147A (en) |
KR (2) | KR20220084167A (en) |
CN (2) | CN114787610A (en) |
AU (2) | AU2020372024A1 (en) |
BR (2) | BR112022007712A2 (en) |
CA (2) | CA3155820A1 (en) |
MX (2) | MX2022004703A (en) |
WO (2) | WO2021079306A1 (en) |
ZA (2) | ZA202203685B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US9522396B2 (en) | 2010-12-29 | 2016-12-20 | S.D. Sight Diagnostics Ltd. | Apparatus and method for automatic detection of pathogens |
BR112014016072B1 (en) | 2011-12-29 | 2021-01-12 | Sight Diagnostics Ltd. | method and system for detecting a plasmodium infection in a blood sample |
EP2999988A4 (en) | 2013-05-23 | 2017-01-11 | S.D. Sight Diagnostics Ltd. | Method and system for imaging a cell sample |
IL227276A0 (en) | 2013-07-01 | 2014-03-06 | Parasight Ltd | A method and system for preparing a monolayer of cells, particularly suitable for diagnosis |
AU2016322966B2 (en) | 2015-09-17 | 2021-10-14 | S.D. Sight Diagnostics Ltd | Methods and apparatus for detecting an entity in a bodily sample |
EP3436864B1 (en) | 2016-03-30 | 2021-04-28 | S.D. Sight Diagnostics Ltd. | Image processing device for identifying blood parasites |
CA3022770A1 (en) | 2016-05-11 | 2017-11-16 | S.D. Sight Diagnostics Ltd | Performing optical measurements on a sample |
EP3455610B1 (en) | 2016-05-11 | 2023-01-04 | S.D. Sight Diagnostics Ltd. | Sample carrier for optical measurements |
EP3669179B1 (en) | 2017-08-17 | 2023-07-19 | Abbott Point Of Care Inc | Systems for performing optical and electrochemical assays |
CA3081669A1 (en) | 2017-11-14 | 2019-05-23 | S.D. Sight Diagnostics Ltd | Sample carrier for optical measurements |
EP4073566A1 (en) | 2019-12-12 | 2022-10-19 | S.D. Sight Diagnostics Ltd. | Artificial generation of color blood smear image |
WO2022009104A2 (en) | 2020-07-07 | 2022-01-13 | S.D. Sight Diagnostics Ltd | Focusing a microscope using fluorescent images |
JP2024531132A (en) * | 2021-08-04 | 2024-08-29 | サマンツリー メディカル エスアー | SYSTEM AND METHOD FOR PROVIDING LIVE SPECIMEN MONITORING INFORMATION IN A PARALLEL IMAGING SYSTEM - Patent application |
WO2023144713A1 (en) | 2022-01-25 | 2023-08-03 | S.D. Sight Diagnostics Ltd | Sample carrier for use with a bodily sample |
GB202218615D0 (en) | 2022-12-12 | 2023-01-25 | S D Sight Diagnostics Ltd | System and method for analyzing bodily samples |
WO2024236537A1 (en) | 2023-05-18 | 2024-11-21 | S.D. Sight Diagnostics Ltd | Apparatus and methods for microscopic analysis of a biological sample |
Family Cites Families (29)
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US5281517A (en) * | 1985-11-04 | 1994-01-25 | Cell Analysis Systems, Inc. | Methods for immunoploidy analysis |
CA1340365C (en) * | 1989-03-16 | 1999-02-02 | Alexander M. Saunders | Method for ascertaining the history of a condition of the body from a single blood sample |
KR100499139B1 (en) * | 2003-01-07 | 2005-07-04 | 삼성전자주식회사 | Method of removing abnormal data and blood constituent analysing system using spectroscopy employing the same |
CN101660992B (en) * | 2009-09-29 | 2011-01-12 | 清华大学 | A method for rapidly detecting the sedimentation velocity of algae cells |
JP2011095182A (en) * | 2009-10-30 | 2011-05-12 | Sysmex Corp | Cell analyzing apparatus and cell analyzing method |
WO2012037524A2 (en) * | 2010-09-16 | 2012-03-22 | The General Hospital Corporation | Red blood cell dynamics for diagnosis |
US9522396B2 (en) | 2010-12-29 | 2016-12-20 | S.D. Sight Diagnostics Ltd. | Apparatus and method for automatic detection of pathogens |
WO2013075100A1 (en) * | 2011-11-17 | 2013-05-23 | Cellscape Corporation | Methods, devices, and kits for obtaining and analyzing cells |
BR112014016072B1 (en) | 2011-12-29 | 2021-01-12 | Sight Diagnostics Ltd. | method and system for detecting a plasmodium infection in a blood sample |
EP3002587B1 (en) * | 2011-12-30 | 2017-06-28 | Abbott Point Of Care, Inc. | Method and apparatus for automated platelet identification within a whole blood sample from microscopy images |
TR201809959T4 (en) * | 2013-03-15 | 2018-08-27 | Iris Int Inc | Method and composition for sample dyeing and processing. |
EP2999988A4 (en) | 2013-05-23 | 2017-01-11 | S.D. Sight Diagnostics Ltd. | Method and system for imaging a cell sample |
IL227276A0 (en) | 2013-07-01 | 2014-03-06 | Parasight Ltd | A method and system for preparing a monolayer of cells, particularly suitable for diagnosis |
EP3039477B1 (en) | 2013-08-26 | 2021-10-20 | S.D. Sight Diagnostics Ltd. | Digital microscopy systems, methods and computer program products |
WO2016030897A1 (en) | 2014-08-27 | 2016-03-03 | S.D. Sight Diagnostics Ltd | System and method for calculating focus variation for a digital microscope |
US20170328924A1 (en) * | 2014-11-26 | 2017-11-16 | Ronald Jones | Automated microscopic cell analysis |
AU2016322966B2 (en) | 2015-09-17 | 2021-10-14 | S.D. Sight Diagnostics Ltd | Methods and apparatus for detecting an entity in a bodily sample |
BE1022771B1 (en) * | 2015-10-14 | 2016-08-31 | Multiplicom Nv | Method and system for determining whether a woman is pregnant based on a blood sample |
EP3436864B1 (en) | 2016-03-30 | 2021-04-28 | S.D. Sight Diagnostics Ltd. | Image processing device for identifying blood parasites |
EP3455610B1 (en) | 2016-05-11 | 2023-01-04 | S.D. Sight Diagnostics Ltd. | Sample carrier for optical measurements |
CA3022770A1 (en) | 2016-05-11 | 2017-11-16 | S.D. Sight Diagnostics Ltd | Performing optical measurements on a sample |
EP3482189A4 (en) * | 2016-07-08 | 2020-08-19 | Medica Corporation | AUTOMATED MICROSCOPIC CELL ANALYSIS |
EP3519828A4 (en) * | 2016-09-29 | 2020-06-03 | Animantis, LLC | Methods and apparatus for assessing immune system activity and therapeutic efficacy |
EP3552148A4 (en) * | 2016-12-06 | 2020-07-08 | Abbott Laboratories | Automated slide assessments and tracking in digital microscopy |
CN109085098A (en) * | 2017-06-14 | 2018-12-25 | 北京精微视觉科技有限公司 | A kind of detection method and detection device of cell settlement progress |
CN109270281A (en) * | 2017-07-18 | 2019-01-25 | 深圳市帝迈生物技术有限公司 | Improve the method and apparatus of leukocyte differential count result accuracy and count results repeatability |
CA3081669A1 (en) | 2017-11-14 | 2019-05-23 | S.D. Sight Diagnostics Ltd | Sample carrier for optical measurements |
CN108008949B (en) * | 2017-11-22 | 2022-06-14 | 昌微系统科技(上海)有限公司 | Display method and display system for sample detection process |
US11911764B2 (en) * | 2018-02-21 | 2024-02-27 | Nexcelom Bioscience Llc | System and method for cell imaging, analysis and measurement |
-
2020
- 2020-10-22 JP JP2022521112A patent/JP2022553147A/en active Pending
- 2020-10-22 KR KR1020227017081A patent/KR20220084167A/en not_active Application Discontinuation
- 2020-10-22 US US17/770,365 patent/US20220381672A1/en active Pending
- 2020-10-22 AU AU2020372024A patent/AU2020372024A1/en active Pending
- 2020-10-22 KR KR1020227017082A patent/KR20220084168A/en not_active Application Discontinuation
- 2020-10-22 US US17/770,339 patent/US20220390372A1/en active Pending
- 2020-10-22 BR BR112022007712A patent/BR112022007712A2/en unknown
- 2020-10-22 EP EP20800325.1A patent/EP4049176A1/en active Pending
- 2020-10-22 JP JP2022521238A patent/JP2022553151A/en active Pending
- 2020-10-22 CA CA3155820A patent/CA3155820A1/en active Pending
- 2020-10-22 MX MX2022004703A patent/MX2022004703A/en unknown
- 2020-10-22 EP EP20800326.9A patent/EP4049170A1/en active Pending
- 2020-10-22 AU AU2020370212A patent/AU2020370212A1/en active Pending
- 2020-10-22 WO PCT/IB2020/059925 patent/WO2021079306A1/en unknown
- 2020-10-22 CN CN202080073583.4A patent/CN114787610A/en active Pending
- 2020-10-22 CA CA3155821A patent/CA3155821A1/en active Pending
- 2020-10-22 CN CN202080073623.5A patent/CN114787611A/en active Pending
- 2020-10-22 BR BR112022007708A patent/BR112022007708A2/en unknown
- 2020-10-22 WO PCT/IB2020/059924 patent/WO2021079305A1/en unknown
- 2020-10-22 MX MX2022004704A patent/MX2022004704A/en unknown
-
2022
- 2022-03-30 ZA ZA2022/03685A patent/ZA202203685B/en unknown
- 2022-04-07 ZA ZA2022/03983A patent/ZA202203983B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021079305A1 (en) | 2021-04-29 |
EP4049170A1 (en) | 2022-08-31 |
BR112022007712A2 (en) | 2022-07-12 |
BR112022007708A2 (en) | 2022-07-12 |
KR20220084167A (en) | 2022-06-21 |
CA3155821A1 (en) | 2021-04-29 |
JP2022553151A (en) | 2022-12-22 |
JP2022553147A (en) | 2022-12-22 |
EP4049176A1 (en) | 2022-08-31 |
AU2020372024A1 (en) | 2022-04-21 |
AU2020370212A1 (en) | 2022-04-28 |
CN114787610A (en) | 2022-07-22 |
US20220390372A1 (en) | 2022-12-08 |
US20220381672A1 (en) | 2022-12-01 |
KR20220084168A (en) | 2022-06-21 |
CA3155820A1 (en) | 2021-04-29 |
ZA202203983B (en) | 2024-01-31 |
WO2021079306A1 (en) | 2021-04-29 |
CN114787611A (en) | 2022-07-22 |
MX2022004704A (en) | 2022-05-11 |
MX2022004703A (en) | 2022-05-11 |
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