ZA202100390B - Fusion constructs and methods of using thereof - Google Patents

Fusion constructs and methods of using thereof

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Publication number
ZA202100390B
ZA202100390B ZA2021/00390A ZA202100390A ZA202100390B ZA 202100390 B ZA202100390 B ZA 202100390B ZA 2021/00390 A ZA2021/00390 A ZA 2021/00390A ZA 202100390 A ZA202100390 A ZA 202100390A ZA 202100390 B ZA202100390 B ZA 202100390B
Authority
ZA
South Africa
Prior art keywords
methods
fragment
variant
fusion constructs
composition
Prior art date
Application number
ZA2021/00390A
Other languages
English (en)
Inventor
Sabzevari Helen
Metenou Simon
Chen Changhung
R Shah Rutul
Original Assignee
Precigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Precigen Inc filed Critical Precigen Inc
Publication of ZA202100390B publication Critical patent/ZA202100390B/en

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K—PEPTIDES
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    • C07K14/70503—Immunoglobulin superfamily
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
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  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA2021/00390A 2018-07-09 2021-01-19 Fusion constructs and methods of using thereof ZA202100390B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862695623P 2018-07-09 2018-07-09
US201862695627P 2018-07-09 2018-07-09
US201962863710P 2019-06-19 2019-06-19
US201962864367P 2019-06-20 2019-06-20
US201962866420P 2019-06-25 2019-06-25
PCT/US2019/041085 WO2020014285A2 (en) 2018-07-09 2019-07-09 Fusion constructs and methods of using thereof

Publications (1)

Publication Number Publication Date
ZA202100390B true ZA202100390B (en) 2023-10-25

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Application Number Title Priority Date Filing Date
ZA2021/00390A ZA202100390B (en) 2018-07-09 2021-01-19 Fusion constructs and methods of using thereof
ZA2023/00423A ZA202300423B (en) 2018-07-09 2023-01-10 Fusion constructs and methods of using thereof

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ZA2023/00423A ZA202300423B (en) 2018-07-09 2023-01-10 Fusion constructs and methods of using thereof

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US (2) US11535669B2 (https=)
EP (1) EP3820496A4 (https=)
JP (2) JP7617839B2 (https=)
KR (1) KR20210042909A (https=)
CN (2) CN112672753B (https=)
AU (1) AU2019301070B2 (https=)
CA (1) CA3105750A1 (https=)
IL (1) IL279965A (https=)
SG (1) SG11202100208VA (https=)
WO (1) WO2020014285A2 (https=)
ZA (2) ZA202100390B (https=)

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