ZA201302265B - Substituted 2-oxo-and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators - Google Patents
Substituted 2-oxo-and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulatorsInfo
- Publication number
- ZA201302265B ZA201302265B ZA2013/02265A ZA201302265A ZA201302265B ZA 201302265 B ZA201302265 B ZA 201302265B ZA 2013/02265 A ZA2013/02265 A ZA 2013/02265A ZA 201302265 A ZA201302265 A ZA 201302265A ZA 201302265 B ZA201302265 B ZA 201302265B
- Authority
- ZA
- South Africa
- Prior art keywords
- kcnq2
- thioxo
- dihydroquinoline
- carboxamides
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10008920 | 2010-08-27 | ||
| PCT/EP2011/004280 WO2012025239A1 (en) | 2010-08-27 | 2011-08-26 | Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201302265B true ZA201302265B (en) | 2021-05-26 |
Family
ID=43304979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2013/02265A ZA201302265B (en) | 2010-08-27 | 2013-03-26 | Substituted 2-oxo-and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8653102B2 (en) |
| EP (1) | EP2609086B1 (en) |
| JP (1) | JP5837934B2 (en) |
| KR (1) | KR101983979B1 (en) |
| CN (1) | CN103189357B (en) |
| AR (1) | AR082731A1 (en) |
| AU (1) | AU2011295408B2 (en) |
| BR (1) | BR112013004690A2 (en) |
| CA (1) | CA2809287C (en) |
| CL (1) | CL2013000542A1 (en) |
| CO (1) | CO6700825A2 (en) |
| CY (1) | CY1116158T1 (en) |
| DK (1) | DK2609086T3 (en) |
| EC (1) | ECSP13012460A (en) |
| ES (1) | ES2537615T3 (en) |
| HK (1) | HK1185346A1 (en) |
| HR (1) | HRP20150520T1 (en) |
| HU (1) | HUE024870T2 (en) |
| IL (1) | IL223820A (en) |
| MX (1) | MX342459B (en) |
| NZ (1) | NZ608697A (en) |
| PE (1) | PE20140214A1 (en) |
| PL (1) | PL2609086T3 (en) |
| PT (1) | PT2609086E (en) |
| RS (1) | RS54002B1 (en) |
| RU (1) | RU2581362C2 (en) |
| SI (1) | SI2609086T1 (en) |
| TW (1) | TWI552750B (en) |
| WO (1) | WO2012025239A1 (en) |
| ZA (1) | ZA201302265B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2809341A1 (en) * | 2010-08-27 | 2012-03-01 | Gruenenthal Gmbh | Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators |
| WO2014056620A1 (en) * | 2012-10-11 | 2014-04-17 | Grünenthal GmbH | Treatment and/or prophylaxis of tspo mediated diseases and/or disorders |
| WO2017120355A1 (en) * | 2016-01-06 | 2017-07-13 | Teva Pharmaceutical Industries Ltd. | Dihydroquinolines and uses thereof |
| AR110770A1 (en) * | 2017-01-23 | 2019-05-02 | Cadent Therapeutics Inc | POTASSIUM CHANNEL MODULATORS |
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2011
- 2011-08-26 US US13/218,579 patent/US8653102B2/en not_active Expired - Fee Related
- 2011-08-26 PE PE2013000317A patent/PE20140214A1/en active IP Right Grant
- 2011-08-26 NZ NZ608697A patent/NZ608697A/en not_active IP Right Cessation
- 2011-08-26 ES ES11754836.2T patent/ES2537615T3/en active Active
- 2011-08-26 CA CA2809287A patent/CA2809287C/en not_active Expired - Fee Related
- 2011-08-26 EP EP11754836.2A patent/EP2609086B1/en active Active
- 2011-08-26 DK DK11754836T patent/DK2609086T3/en active
- 2011-08-26 BR BR112013004690A patent/BR112013004690A2/en not_active IP Right Cessation
- 2011-08-26 WO PCT/EP2011/004280 patent/WO2012025239A1/en active Application Filing
- 2011-08-26 AU AU2011295408A patent/AU2011295408B2/en not_active Ceased
- 2011-08-26 RU RU2013113301/04A patent/RU2581362C2/en not_active IP Right Cessation
- 2011-08-26 PL PL11754836T patent/PL2609086T3/en unknown
- 2011-08-26 HU HUE11754836A patent/HUE024870T2/en unknown
- 2011-08-26 CN CN201180041440.6A patent/CN103189357B/en not_active Expired - Fee Related
- 2011-08-26 KR KR1020137007666A patent/KR101983979B1/en active IP Right Grant
- 2011-08-26 PT PT117548362T patent/PT2609086E/en unknown
- 2011-08-26 MX MX2013002119A patent/MX342459B/en active IP Right Grant
- 2011-08-26 SI SI201130428T patent/SI2609086T1/en unknown
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2012
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2013
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