ZA200801351B - Sulphonypyrrole hydrochloride salts as histone deacetylases inhibitors - Google Patents
Sulphonypyrrole hydrochloride salts as histone deacetylases inhibitorsInfo
- Publication number
- ZA200801351B ZA200801351B ZA200801351A ZA200801351A ZA200801351B ZA 200801351 B ZA200801351 B ZA 200801351B ZA 200801351 A ZA200801351 A ZA 200801351A ZA 200801351 A ZA200801351 A ZA 200801351A ZA 200801351 B ZA200801351 B ZA 200801351B
- Authority
- ZA
- South Africa
- Prior art keywords
- sulphonypyrrole
- histone deacetylases
- hydrochloride salts
- deacetylases inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05108716 | 2005-09-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200801351B true ZA200801351B (en) | 2009-09-30 |
Family
ID=35810290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200801351A ZA200801351B (en) | 2005-09-21 | 2008-02-08 | Sulphonypyrrole hydrochloride salts as histone deacetylases inhibitors |
Country Status (16)
Country | Link |
---|---|
US (1) | US8188138B2 (ru) |
EP (1) | EP1928826B1 (ru) |
JP (1) | JP5305909B2 (ru) |
KR (1) | KR101314158B1 (ru) |
CN (1) | CN101287706A (ru) |
AR (1) | AR055647A1 (ru) |
AU (1) | AU2006298881A1 (ru) |
BR (1) | BRPI0616040A2 (ru) |
CA (1) | CA2622670A1 (ru) |
EA (1) | EA018698B1 (ru) |
IL (1) | IL189781A0 (ru) |
NO (1) | NO20081796L (ru) |
NZ (1) | NZ566073A (ru) |
TW (1) | TWI382971B (ru) |
WO (1) | WO2007039403A1 (ru) |
ZA (1) | ZA200801351B (ru) |
Families Citing this family (22)
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EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
EP1478358B1 (en) | 2002-02-11 | 2013-07-03 | Bayer HealthCare LLC | Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
CA2526636C (en) | 2003-05-20 | 2012-10-02 | Bayer Pharmaceuticals Corporation | Diaryl ureas for diseases mediated by pdgfr |
KR101130556B1 (ko) * | 2004-03-11 | 2012-03-30 | 4에스체 악티엔게젤샤프트 | Hdac 억제제로서의 설포닐피롤 |
MXPA06012394A (es) | 2004-04-30 | 2007-01-31 | Bayer Pharmaceuticals Corp | Derivados de pirazolilurea sustituidos utiles en el tratamiento de cancer. |
CA2622673C (en) * | 2005-09-21 | 2017-06-27 | Thomas Maier | Sulphonylpyrroles and use thereof as inhibitors of hdac s |
WO2008127659A2 (en) * | 2007-04-13 | 2008-10-23 | University Of Texas Southwestern Medical Center | Combination therapy for cancer |
EP2100882A1 (en) * | 2008-03-12 | 2009-09-16 | 4Sc Ag | (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts |
EP2100878A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Novel method for the production of sulphonylpyrroles as HDAC inhibitors |
EP2330894B8 (en) | 2008-09-03 | 2017-04-19 | BioMarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
DK2680694T3 (en) | 2011-02-28 | 2019-03-25 | Biomarin Pharm Inc | HISTONDEACETYLASE INHIBITORS |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
KR101781922B1 (ko) | 2012-04-10 | 2017-09-26 | 안지 파마슈티컬 코퍼레이션 리미티드 | 히스톤 탈아세틸효소(hdacs) 억제제 |
ES2680224T3 (es) | 2013-03-15 | 2018-09-05 | Biomarin Pharmaceutical Inc. | Inhibidores de HDAC |
RU2657783C2 (ru) | 2013-09-30 | 2018-06-15 | Тайхо Фармасьютикал Ко., Лтд. | Комбинированная терапия с использованием азабициклосоединения для ракового заболевания |
EP3490973B1 (en) | 2016-07-26 | 2021-06-23 | Fresenius Kabi Oncology Ltd | Polymorphic forms of belinostat and processes for preparation thereof |
CA3063111C (en) | 2017-05-16 | 2022-10-11 | Annji Pharmaceutical Co., Ltd. | Histone deacetylases (hdacs) inhibitors |
WO2021121266A1 (zh) * | 2019-12-16 | 2021-06-24 | 广州辑因医疗科技有限公司 | 扩增造血干细胞的小分子化合物及其组合 |
KR20230104109A (ko) | 2020-06-08 | 2023-07-07 | 안지 파마슈티컬 코퍼레이션 리미티드 | 선택적 hdac6 억제제로서 유용한 퀴나졸린 유도체 |
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US4960787A (en) * | 1989-02-06 | 1990-10-02 | Ciba-Geigy Corporation | Certain pyrrolyl-substituted hydroxamic acid derivatives |
JP3342485B2 (ja) | 1991-12-10 | 2002-11-11 | 塩野義製薬株式会社 | 芳香族スルホンアミド系ヒドロキサム酸誘導体 |
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GB9807354D0 (en) * | 1998-04-07 | 1998-06-03 | Glaxo Group Ltd | Antiviral compound |
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NZ529118A (en) * | 2001-05-22 | 2005-10-28 | Pfizer Prod Inc | Crystal forms of azithromycin |
KR20040022238A (ko) | 2001-08-09 | 2004-03-11 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체 화합물 및 그 화합물을 유효성분으로서 함유하는 약제 |
BR0212510A (pt) | 2001-09-14 | 2004-08-24 | Methylgene Inc | Inibidor de histona desacetilase, composto e composição |
US7868204B2 (en) * | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
US6821502B2 (en) * | 2002-06-12 | 2004-11-23 | Chevron U.S.A. Inc. | Method of making aluminum-containing zeolite with IFR structure |
CA2497060C (en) | 2002-08-29 | 2014-05-20 | Temple University - Of The Commonwealth System Of Higher Education | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
GB0226855D0 (en) | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
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EP1709007A1 (en) | 2004-01-22 | 2006-10-11 | Altana Pharma AG | N-4-(6-(heteo)aryl-pyrimidin-4-ylaminophenyl)-benzenesulfonamides as kinase inhibitors |
AR047541A1 (es) * | 2004-02-13 | 2006-01-25 | Sandoz Ag | Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas |
US20050197336A1 (en) | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
KR101130556B1 (ko) * | 2004-03-11 | 2012-03-30 | 4에스체 악티엔게젤샤프트 | Hdac 억제제로서의 설포닐피롤 |
US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
US7351833B2 (en) * | 2004-07-23 | 2008-04-01 | Abbott Laboratories | (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate |
US8436176B2 (en) * | 2004-12-30 | 2013-05-07 | Medicis Pharmaceutical Corporation | Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine |
EP1861365B1 (en) | 2005-03-15 | 2009-07-01 | 4Sc Ag | N-sulphonylpyrroles and their use as histone deacetylase inhibitors |
ATE510821T1 (de) | 2005-04-07 | 2011-06-15 | 4Sc Ag | Sulfonylpyrrole als histondeacetylaseinhibitoren |
UA91546C2 (ru) * | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛЛИЧЕСКАЯ ФОРМА 1-ХЛОР-4-(b-D-ГЛЮКОПИРАНОЗ-1- ИЛ)-2-[4-((S)- ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ЕЕ ПРИМЕНЕНИЕ ПРИ ПРИГОТАВЛЕНИИ ЛЕКАРСТВЕННЫХ СРЕДСТВ |
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JP2008522983A (ja) * | 2005-09-13 | 2008-07-03 | シコール インコーポレイティド | ロクロニウムブロミドの合成方法 |
CA2622673C (en) * | 2005-09-21 | 2017-06-27 | Thomas Maier | Sulphonylpyrroles and use thereof as inhibitors of hdac s |
CN101528212A (zh) * | 2006-09-28 | 2009-09-09 | 默克公司 | Hdac抑制剂和可螯合的金属化合物的药物组合物以及金属-hdac抑制剂螯合物 |
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WO2008143500A1 (en) * | 2007-05-22 | 2008-11-27 | Ultimorphix Technologies B.V. | Tenofovir disoproxil hemi-fumaric acid co-crystal |
TW200944520A (en) * | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
-
2006
- 2006-09-08 EP EP06778423.1A patent/EP1928826B1/en active Active
- 2006-09-08 US US11/992,018 patent/US8188138B2/en not_active Expired - Fee Related
- 2006-09-08 NZ NZ566073A patent/NZ566073A/en not_active IP Right Cessation
- 2006-09-08 AU AU2006298881A patent/AU2006298881A1/en not_active Abandoned
- 2006-09-08 CN CNA2006800345994A patent/CN101287706A/zh active Pending
- 2006-09-08 BR BRPI0616040-9A patent/BRPI0616040A2/pt not_active IP Right Cessation
- 2006-09-08 KR KR1020087008939A patent/KR101314158B1/ko not_active IP Right Cessation
- 2006-09-08 WO PCT/EP2006/066189 patent/WO2007039403A1/en active Application Filing
- 2006-09-08 EA EA200800791A patent/EA018698B1/ru not_active IP Right Cessation
- 2006-09-08 JP JP2008530491A patent/JP5305909B2/ja not_active Expired - Fee Related
- 2006-09-08 CA CA002622670A patent/CA2622670A1/en not_active Abandoned
- 2006-09-21 TW TW095135002A patent/TWI382971B/zh not_active IP Right Cessation
- 2006-09-21 AR ARP060104134A patent/AR055647A1/es not_active Application Discontinuation
-
2008
- 2008-02-08 ZA ZA200801351A patent/ZA200801351B/xx unknown
- 2008-02-26 IL IL189781A patent/IL189781A0/en unknown
- 2008-04-14 NO NO20081796A patent/NO20081796L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20080046730A (ko) | 2008-05-27 |
US20090297473A1 (en) | 2009-12-03 |
EA200800791A1 (ru) | 2009-04-28 |
JP5305909B2 (ja) | 2013-10-02 |
TW200745027A (en) | 2007-12-16 |
JP2009508825A (ja) | 2009-03-05 |
AR055647A1 (es) | 2007-08-29 |
AU2006298881A1 (en) | 2007-04-12 |
KR101314158B1 (ko) | 2013-10-04 |
WO2007039403A1 (en) | 2007-04-12 |
CA2622670A1 (en) | 2007-04-12 |
US8188138B2 (en) | 2012-05-29 |
BRPI0616040A2 (pt) | 2011-06-07 |
CN101287706A (zh) | 2008-10-15 |
EP1928826B1 (en) | 2013-04-24 |
EA018698B1 (ru) | 2013-10-30 |
EP1928826A1 (en) | 2008-06-11 |
TWI382971B (zh) | 2013-01-21 |
IL189781A0 (en) | 2008-08-07 |
NO20081796L (no) | 2008-04-17 |
NZ566073A (en) | 2011-08-26 |
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