ZA200800394B - Solid pharmaceutical composition comprising 1-(4-chloro anilino)-4(4-pyridylmethyl)phthalazine and a ph modifier - Google Patents

Solid pharmaceutical composition comprising 1-(4-chloro anilino)-4(4-pyridylmethyl)phthalazine and a ph modifier

Info

Publication number
ZA200800394B
ZA200800394B ZA200800394A ZA200800394A ZA200800394B ZA 200800394 B ZA200800394 B ZA 200800394B ZA 200800394 A ZA200800394 A ZA 200800394A ZA 200800394 A ZA200800394 A ZA 200800394A ZA 200800394 B ZA200800394 B ZA 200800394B
Authority
ZA
South Africa
Prior art keywords
phthalazine
pyridylmethyl
modifier
pharmaceutical composition
solid pharmaceutical
Prior art date
Application number
ZA200800394A
Other languages
English (en)
Inventor
Becker Dieter
Loggia Nicoletta
Lueckel Barbara
Kramer Andrea
Siepe Stefanie
Ries Angelika
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA200800394B publication Critical patent/ZA200800394B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200800394A 2005-08-22 2008-01-14 Solid pharmaceutical composition comprising 1-(4-chloro anilino)-4(4-pyridylmethyl)phthalazine and a ph modifier ZA200800394B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0517205.1A GB0517205D0 (en) 2005-08-22 2005-08-22 Organic compounds

Publications (1)

Publication Number Publication Date
ZA200800394B true ZA200800394B (en) 2009-08-26

Family

ID=35098110

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200800394A ZA200800394B (en) 2005-08-22 2008-01-14 Solid pharmaceutical composition comprising 1-(4-chloro anilino)-4(4-pyridylmethyl)phthalazine and a ph modifier

Country Status (24)

Country Link
US (1) US20100280035A1 (zh)
EP (1) EP1919459A1 (zh)
JP (1) JP2009504795A (zh)
KR (1) KR20080037680A (zh)
CN (1) CN101287452A (zh)
AR (1) AR055610A1 (zh)
AU (1) AU2006284133A1 (zh)
BR (1) BRPI0615014A2 (zh)
CA (1) CA2619396A1 (zh)
CR (1) CR9713A (zh)
CU (1) CU20080025A7 (zh)
EC (1) ECSP088202A (zh)
GB (1) GB0517205D0 (zh)
GT (1) GT200600379A (zh)
IL (1) IL188921A0 (zh)
MX (1) MX2008002493A (zh)
NO (1) NO20081440L (zh)
PA (1) PA8691901A1 (zh)
PE (1) PE20070421A1 (zh)
RU (1) RU2008110740A (zh)
TW (1) TW200738284A (zh)
UY (1) UY29757A1 (zh)
WO (1) WO2007022944A1 (zh)
ZA (1) ZA200800394B (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1958616A1 (en) * 2007-02-13 2008-08-20 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical formulations of 1-[4-chloroanilino]-4-[4-pyridylmethyl] phthalazine or salts thereof
JP4864024B2 (ja) * 2008-02-15 2012-01-25 エスエス製薬株式会社 時限放出製剤
FR2930147B1 (fr) * 2008-04-18 2013-02-08 Flamel Tech Sa Forme orale solide dotee d'un double profil de liberation
US20120251588A1 (en) * 2011-03-30 2012-10-04 Miyuki Fukasawa Coating Composition, Solid Preparation Coated Therewith, and Method for Preparing Solid Preparation
US20120301541A1 (en) * 2011-05-24 2012-11-29 Haronsky Elina Compressed core for pharmaceutical composition
CA2778748A1 (en) * 2011-06-01 2012-12-01 Nitto Denko Corporation Particulate preparation and method for producing the same
FR2985177B1 (fr) * 2012-01-02 2016-04-01 Oreal Composition cosmetique solide aqueuse comprenant de l'alkylcellulose, au moins deux huiles non volatiles et au moins deux agents tensioactifs
EA036269B1 (ru) 2014-12-18 2020-10-21 Принсипиа Биофарма Инк. Лечение пузырчатки
US20190231784A1 (en) 2016-06-29 2019-08-01 Principia Biopharma Inc. Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
CN113559074B (zh) * 2020-06-28 2023-04-21 海创药业股份有限公司 一种喹啉类化合物缓释片及其制备方法
US20230364063A1 (en) * 2020-07-02 2023-11-16 Artham Therapeutics Inc. Oral pharmaceutical composition and method for producing same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
WO2005051350A2 (en) * 2003-10-28 2005-06-09 Torrent Pharmaceuticals Limited Water dispersible tablet

Also Published As

Publication number Publication date
MX2008002493A (es) 2008-04-03
JP2009504795A (ja) 2009-02-05
ECSP088202A (es) 2008-03-26
TW200738284A (en) 2007-10-16
CU20080025A7 (es) 2010-03-25
UY29757A1 (es) 2007-03-30
BRPI0615014A2 (pt) 2011-05-03
CN101287452A (zh) 2008-10-15
EP1919459A1 (en) 2008-05-14
AR055610A1 (es) 2007-08-29
CA2619396A1 (en) 2007-03-01
PE20070421A1 (es) 2007-04-25
AU2006284133A1 (en) 2007-03-01
IL188921A0 (en) 2008-08-07
KR20080037680A (ko) 2008-04-30
GB0517205D0 (en) 2005-09-28
WO2007022944A1 (en) 2007-03-01
GT200600379A (es) 2007-03-28
CR9713A (es) 2008-04-16
US20100280035A1 (en) 2010-11-04
NO20081440L (no) 2008-03-19
RU2008110740A (ru) 2009-09-27
PA8691901A1 (es) 2009-05-15

Similar Documents

Publication Publication Date Title
ZA200800394B (en) Solid pharmaceutical composition comprising 1-(4-chloro anilino)-4(4-pyridylmethyl)phthalazine and a ph modifier
EP1934934A4 (en) SYSTEMS AND METHODS FOR BLOCK TRANSACTIONS BASED ON INDICATIONS OF INTEREST (IOI)
EP1747522A4 (en) METHODS AND SYSTEMS FOR ENSURING GUARANTEED COMMERCIAL TRANSACTIONS
IS2959B (is) Indasól, bensótríasól og N-hliðstæður þar af sem p38 kínasahindrar
IL176233A0 (en) Organophosphorous indazole derivatives and use thereof as protein kinase inhibitors
EP1932840A4 (en) HETEROCYCLIC NITROGEN COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF
EP1875427A4 (en) SYSTEM AND METHOD FOR MANAGING TRADE BETWEEN TWO UNIT-ASSOCIATED UNITS
EP1883041A4 (en) MEMORY CARD AND CARD ADAPTER
ZA200801441B (en) p38MAP kinase inhibitors and methods for using the same
GB0505970D0 (en) Culture medium containing kinase inhibitor, and uses thereof
ZA200709269B (en) Protein kinase inhibitors
IL187685A0 (en) Aminoquinoline and aminoquinazoline kinase modulators
HK1105415A1 (en) Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
EP2047367A4 (en) MEMORY SYSTEM AND MEMORY CHIP
EP1886284A4 (en) DATA STRUCTURE AND ARCHITECTURE FOR PROCESSING TRANSACTION DATA
ZA200802362B (en) Bio-conversion system for banking and merchant markets
IL187692A0 (en) Alkylquinoline and alkylquinazoline kinase modulators
EP1952379A4 (en) SYSTEMS AND METHODS FOR RENDERING BUILDING SPACES
PL1896422T3 (pl) Inhibitory kinazy tyrozynowej
EP1759466A4 (en) DATA PROCESSING WITH MULTIPLE PROFIT
EP1951252A4 (en) INHIBITORS OF TYROSINE KINASES
EP1893194A4 (en) IMPROVED PROTEIN KINASE HEMMER ON INDOLINON BASE
EP1878223A4 (en) METHOD AND SYSTEMS FOR DEVICE-INDEPENDENT MEDIA TRANSACTIONS
GB0511957D0 (en) Financial transaction method and system
GB0517177D0 (en) Trading system