ZA200703310B - 20-Cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof - Google Patents

20-Cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof Download PDF

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Publication number
ZA200703310B
ZA200703310B ZA200703310A ZA200703310A ZA200703310B ZA 200703310 B ZA200703310 B ZA 200703310B ZA 200703310 A ZA200703310 A ZA 200703310A ZA 200703310 A ZA200703310 A ZA 200703310A ZA 200703310 B ZA200703310 B ZA 200703310B
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South Africa
Prior art keywords
compound
vitamin
disorder
cyclopropyl
cell
Prior art date
Application number
ZA200703310A
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English (en)
Inventor
Milan R Uskokovic
Penna Guiseppe
Marczak Stanislaw
Adorini Luciano
Colli Enrico
Original Assignee
Bioxell Spa
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Publication date
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Publication of ZA200703310B publication Critical patent/ZA200703310B/en

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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • A61P31/20Antivirals for DNA viruses
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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    • A61P7/06Antianaemics
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
ZA200703310A 2004-09-24 2007-04-23 20-Cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof ZA200703310B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61273204P 2004-09-24 2004-09-24

Publications (1)

Publication Number Publication Date
ZA200703310B true ZA200703310B (en) 2008-06-25

Family

ID=36119461

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200703310A ZA200703310B (en) 2004-09-24 2007-04-23 20-Cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof

Country Status (9)

Country Link
US (1) US20080318911A1 (zh)
EP (1) EP1797033A4 (zh)
JP (1) JP2008514621A (zh)
CN (1) CN101106985A (zh)
AU (1) AU2005289664A1 (zh)
CA (1) CA2580962A1 (zh)
IL (1) IL182145A0 (zh)
WO (1) WO2006036813A2 (zh)
ZA (1) ZA200703310B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1830826A2 (en) * 2004-12-02 2007-09-12 Abbott Laboratories Use of a compound that activates a vitamin d receptor for reducing intimal hyperplasia, smooth muscle cell proliferation and restenosis in mammals
US7286295B1 (en) 2005-11-30 2007-10-23 Sandia Corporation Microoptical compound lens
WO2009115398A1 (en) * 2008-03-18 2009-09-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Vitamin d compounds for the treatment of biliary diseases
CN102448466A (zh) * 2009-05-20 2012-05-09 混合基因股份公司 伊奈骨化醇的新治疗应用
US9006220B2 (en) * 2010-10-25 2015-04-14 Teijin Pharma Limited 23-yne-vitamin D3 derivative
JP5950413B2 (ja) * 2011-03-02 2016-07-13 学校法人日本大学 パーシャルアゴニスト活性を持つ新規ビタミンd受容体モジュレーター
US9370527B2 (en) 2012-12-28 2016-06-21 The Regents Of The University Of Michigan Amelioration of intestinal fibrosis and treatment of Crohn's disease
CN103193695B (zh) * 2013-04-22 2015-08-05 中国药科大学 3-苯基-3-吡咯基戊烷类衍生物及其医药用途
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
MX2022001756A (es) * 2019-08-13 2022-05-18 Tohoku Techno Arch Co Ltd Inhibidor del punto de control inmunitario, agente terapeutico para la enfermedad relacionada con el punto de control inmunitario, inmunosupresor, anticuerpo contra la fibronectina o derivado del mismo, analogo de la fibronectina, kit para detectar la fibronectina o una proteina parcial de la misma, y metodo para detectar la fibronectina o una proteina parcial de la misma.
CA3164642A1 (en) 2019-12-19 2021-06-24 Ngm Biopharmaceuticals, Inc. Ilt3-binding agents and methods of use thereof
CN113274346A (zh) * 2021-05-25 2021-08-20 满孝勇 一种莫匹罗星软膏的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
CA2289209C (en) * 1997-05-16 2006-07-25 Women & Infants Hospital Cyclic ether vitamin d3 compounds, 1.alpha. (oh) 3-epi-vitamin d3 compounds and uses thereof
AU1022999A (en) * 1997-09-08 1999-03-29 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
KR100628586B1 (ko) * 2001-09-21 2006-09-26 에프. 호프만-라 로슈 아게 3-데속시-비타민 디3 유사 에스테르
EP1663250A4 (en) * 2003-09-24 2006-12-20 Bioxell Spa TREATMENT OF MALFUNCTION OF BLADDER
US20080064668A1 (en) * 2003-09-24 2008-03-13 Bioxell S.P.A. 1,3-Diacylated, 26,27-Alkyl/Haloakyl Vitamin D3 Compounds and Methods of Use Thereof
JP2007525533A (ja) * 2004-03-01 2007-09-06 ビオエクセル エスピーエー 間質性膀胱炎の治療方法、並びに関連化合物及び組成物

Also Published As

Publication number Publication date
WO2006036813A2 (en) 2006-04-06
EP1797033A2 (en) 2007-06-20
AU2005289664A1 (en) 2006-04-06
WO2006036813A3 (en) 2006-09-14
US20080318911A1 (en) 2008-12-25
CN101106985A (zh) 2008-01-16
EP1797033A4 (en) 2010-04-28
JP2008514621A (ja) 2008-05-08
CA2580962A1 (en) 2006-04-06
IL182145A0 (en) 2007-07-24

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