ZA200703310B - 20-Cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof - Google Patents

20-Cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof Download PDF

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Publication number
ZA200703310B
ZA200703310B ZA200703310A ZA200703310A ZA200703310B ZA 200703310 B ZA200703310 B ZA 200703310B ZA 200703310 A ZA200703310 A ZA 200703310A ZA 200703310 A ZA200703310 A ZA 200703310A ZA 200703310 B ZA200703310 B ZA 200703310B
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South Africa
Prior art keywords
compound
vitamin
disorder
cyclopropyl
cell
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ZA200703310A
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English (en)
Inventor
Milan R Uskokovic
Penna Guiseppe
Marczak Stanislaw
Adorini Luciano
Colli Enrico
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Bioxell Spa
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Publication date
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Publication of ZA200703310B publication Critical patent/ZA200703310B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
ZA200703310A 2004-09-24 2007-04-23 20-Cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof ZA200703310B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61273204P 2004-09-24 2004-09-24

Publications (1)

Publication Number Publication Date
ZA200703310B true ZA200703310B (en) 2008-06-25

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ID=36119461

Family Applications (1)

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ZA200703310A ZA200703310B (en) 2004-09-24 2007-04-23 20-Cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof

Country Status (9)

Country Link
US (1) US20080318911A1 (https=)
EP (1) EP1797033A4 (https=)
JP (1) JP2008514621A (https=)
CN (1) CN101106985A (https=)
AU (1) AU2005289664A1 (https=)
CA (1) CA2580962A1 (https=)
IL (1) IL182145A0 (https=)
WO (1) WO2006036813A2 (https=)
ZA (1) ZA200703310B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2588453A1 (en) * 2004-12-02 2006-06-08 Abbott Laboratories Use of a compound that activates a vitamin d receptor for reducing intimal hyperplasia, smooth muscle cell proliferation and restenosis in mammals
US7286295B1 (en) 2005-11-30 2007-10-23 Sandia Corporation Microoptical compound lens
WO2009115398A1 (en) * 2008-03-18 2009-09-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Vitamin d compounds for the treatment of biliary diseases
KR101845320B1 (ko) * 2009-05-20 2018-04-04 하이브리제닉스 에스에이 이네칼시톨의 신규한 치료 용도
RU2558362C2 (ru) * 2010-10-25 2015-08-10 Тейдзин Фарма Лимитед Производное 23-ин-витамина d3
WO2012118154A1 (ja) * 2011-03-02 2012-09-07 学校法人日本大学 パーシャルアゴニスト活性を持つ新規ビタミンd受容体モジュレーター
US9370527B2 (en) 2012-12-28 2016-06-21 The Regents Of The University Of Michigan Amelioration of intestinal fibrosis and treatment of Crohn's disease
CN103193695B (zh) * 2013-04-22 2015-08-05 中国药科大学 3-苯基-3-吡咯基戊烷类衍生物及其医药用途
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
CN117487012A (zh) * 2019-08-13 2024-02-02 东北泰克诺亚奇股份有限公司 用于抑制纤维粘连蛋白与lilrb4的结合的抗lilrb4抗体或其衍生物
US11760802B2 (en) 2019-12-19 2023-09-19 Ngm Biopharmaceuticals, Inc. ILT3-binding agents and methods of use thereof
CN113274346A (zh) * 2021-05-25 2021-08-20 满孝勇 一种莫匹罗星软膏的应用
EP4593867A2 (en) 2022-09-30 2025-08-06 Extend Biosciences, Inc. Long-acting parathyroid hormone

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
CA2289209C (en) * 1997-05-16 2006-07-25 Women & Infants Hospital Cyclic ether vitamin d3 compounds, 1.alpha. (oh) 3-epi-vitamin d3 compounds and uses thereof
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
CA2459789A1 (en) * 2001-09-21 2003-04-03 F. Hoffmann-La Roche Ag 3-desoxy-vitamin d3 analog esters
JP2007506780A (ja) * 2003-09-24 2007-03-22 ビオエクセル エスピーエー 膀胱機能障害の治療方法
CA2539708A1 (en) * 2003-09-24 2005-04-07 Bioxell S.P.A. 1,3-diaclyated,26,27-alkyl/haloalkyl vitamin d3 compounds and methods of use thereof
JP2007525533A (ja) * 2004-03-01 2007-09-06 ビオエクセル エスピーエー 間質性膀胱炎の治療方法、並びに関連化合物及び組成物

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Publication number Publication date
AU2005289664A1 (en) 2006-04-06
WO2006036813A2 (en) 2006-04-06
JP2008514621A (ja) 2008-05-08
CA2580962A1 (en) 2006-04-06
WO2006036813A3 (en) 2006-09-14
EP1797033A2 (en) 2007-06-20
IL182145A0 (en) 2007-07-24
EP1797033A4 (en) 2010-04-28
CN101106985A (zh) 2008-01-16
US20080318911A1 (en) 2008-12-25

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