ZA200701999B - Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6h)-YL]-N-(2-hydroxyethyl)-4-methyl-benzamide - Google Patents

Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6h)-YL]-N-(2-hydroxyethyl)-4-methyl-benzamide

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Publication number
ZA200701999B
ZA200701999B ZA200701999A ZA200701999A ZA200701999B ZA 200701999 B ZA200701999 B ZA 200701999B ZA 200701999 A ZA200701999 A ZA 200701999A ZA 200701999 A ZA200701999 A ZA 200701999A ZA 200701999 B ZA200701999 B ZA 200701999B
Authority
ZA
South Africa
Prior art keywords
oxopyrimidin
difluorobenzyl
benzamide
oxy
hydroxyethyl
Prior art date
Application number
ZA200701999A
Other languages
English (en)
Inventor
Jon G Selbo
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of ZA200701999B publication Critical patent/ZA200701999B/xx

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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ZA200701999A 2004-10-13 2007-03-07 Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6h)-YL]-N-(2-hydroxyethyl)-4-methyl-benzamide ZA200701999B (en)

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US61846604P 2004-10-13 2004-10-13

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ZA200701999B true ZA200701999B (en) 2008-10-29

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ZA200701999A ZA200701999B (en) 2004-10-13 2007-03-07 Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6h)-YL]-N-(2-hydroxyethyl)-4-methyl-benzamide

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US (2) US8324230B2 (xx)
EP (2) EP1802589B1 (xx)
JP (1) JP4937129B2 (xx)
KR (1) KR100872675B1 (xx)
CN (1) CN101039921A (xx)
AR (1) AR051384A1 (xx)
AU (1) AU2005293290A1 (xx)
BR (1) BRPI0516001A (xx)
CA (1) CA2584246C (xx)
ES (1) ES2463681T3 (xx)
IL (1) IL181815A0 (xx)
MX (1) MX2007004514A (xx)
NO (1) NO20072445L (xx)
TW (1) TWI303633B (xx)
WO (1) WO2006040649A1 (xx)
ZA (1) ZA200701999B (xx)

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FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
PE20120003A1 (es) * 2009-01-30 2012-02-12 Glaxosmithkline Llc Hidrocloruro de n-{(1s)-2-amino-1-[(3-fluorofenil)metil)etil}-5-cloro-4-(4-cloro-1-metil-1h-pirazol-5-il)-2-tiofenocarboxamida cristalino
HUE029371T2 (en) 2009-11-27 2017-02-28 Genzyme Corp GENZ 112638 For treatment of Gaucher or Fabry disease in combination therapy
SG10201600077RA (en) 2011-01-11 2016-02-26 Glaxosmithkline Llc Combination
KR101252711B1 (ko) * 2011-03-31 2013-04-09 김두철 가구용 경첩
MX2015000830A (es) 2012-07-18 2015-10-26 Sunshine Lake Pharma Co Ltd Derivados heterociclicos nitrogenosos y su aplicacion en farmacos.
ES2663806T3 (es) 2013-12-19 2018-04-17 unshine Lake Pharma Co., Ltd. Derivados heterocíclicos nitrogenados y su aplicación en el tratamiento de la fibrosis tisular

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JPS61205261A (ja) 1985-03-08 1986-09-11 Sagami Chem Res Center ６―置換―５―フルオロウラシル誘導体
AU7798994A (en) 1993-10-20 1995-05-08 Upjohn Company, The Pyrimidinones as antiarthritic and anti-inflammatories
AU735901C (en) 1996-12-05 2004-02-12 Amgen, Inc. Substituted pyrimidinone and pyridone compounds and methods of use
JP2002517486A (ja) * 1998-06-12 2002-06-18 バーテックス ファーマシューティカルズ インコーポレイテッド ｐ３８のインヒビター
WO2001029010A1 (en) * 1999-10-21 2001-04-26 Merck & Co., Inc. Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment
EP1553949B1 (en) 2002-08-13 2007-04-18 Warner-Lambert Company LLC Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
US7183287B2 (en) * 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones
US20070167621A1 (en) 2003-04-03 2007-07-19 Pharmacia Corporation Substituted pyrimidinones

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KR100872675B1 (ko) 2008-12-10
US20080269264A1 (en) 2008-10-30
EP1802589B1 (en) 2014-04-09
CA2584246C (en) 2011-08-09
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JP2008515963A (ja) 2008-05-15
MX2007004514A (es) 2007-05-09
IL181815A0 (en) 2007-07-04
AR051384A1 (es) 2007-01-10
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US8324230B2 (en) 2012-12-04
CA2584246A1 (en) 2006-04-20
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US8933088B2 (en) 2015-01-13
AU2005293290A1 (en) 2006-04-20
EP2708531A1 (en) 2014-03-19
US20130158053A1 (en) 2013-06-20
BRPI0516001A (pt) 2008-08-19
JP4937129B2 (ja) 2012-05-23
CN101039921A (zh) 2007-09-19

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