ZA200701043B - Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids - Google Patents

Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids

Info

Publication number
ZA200701043B
ZA200701043B ZA200701043A ZA200701043A ZA200701043B ZA 200701043 B ZA200701043 B ZA 200701043B ZA 200701043 A ZA200701043 A ZA 200701043A ZA 200701043 A ZA200701043 A ZA 200701043A ZA 200701043 B ZA200701043 B ZA 200701043B
Authority
ZA
South Africa
Prior art keywords
glycolipids
compositions
methods
lipid based
based adjuvant
Prior art date
Application number
ZA200701043A
Inventor
Davidsen Jesper
Rosenkrands Ida
Andersen Peter
Original Assignee
Statens Seruminstitut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34982425&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200701043(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Statens Seruminstitut filed Critical Statens Seruminstitut
Publication of ZA200701043B publication Critical patent/ZA200701043B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/118—Chlamydiaceae, e.g. Chlamydia trachomatis or Chlamydia psittaci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to liposome formulations that are physically stable. In particular the present invention relates to steric stabilization of cationic liposomes by incorporating glycolipids into the liposomes. The stabilized liposomes can be used either as an adjuvant for antigenic components or as a drug delivery system. In particular the invention relates to vaccines with adjuvants in aqueous media for immunization, where the final product is stable.
ZA200701043A 2004-07-07 2007-02-05 Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids ZA200701043B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200401070 2004-07-07

Publications (1)

Publication Number Publication Date
ZA200701043B true ZA200701043B (en) 2007-12-27

Family

ID=34982425

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200701043A ZA200701043B (en) 2004-07-07 2007-02-05 Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids

Country Status (16)

Country Link
EP (1) EP1765289B1 (en)
JP (1) JP4987704B2 (en)
KR (1) KR101275837B1 (en)
CN (1) CN1980638B (en)
AT (1) ATE406874T1 (en)
AU (1) AU2005259685B2 (en)
BR (1) BRPI0512757B8 (en)
CA (1) CA2572985C (en)
DE (1) DE602005009535D1 (en)
DK (1) DK1765289T3 (en)
ES (1) ES2315880T3 (en)
PL (1) PL1765289T3 (en)
PT (1) PT1765289E (en)
SI (1) SI1765289T1 (en)
WO (1) WO2006002642A2 (en)
ZA (1) ZA200701043B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2040745T3 (en) * 2006-06-28 2013-03-18 Statens Seruminstitut Expansion of the T cell repertoire to include subdominant epitopes by vaccination with antigens delivered as protein fragments or peptide mixtures
DK2068886T3 (en) 2006-10-03 2013-11-18 Tekmira Pharmaceuticals Corp Lipid-containing preparations
BRPI0811796A2 (en) 2007-06-26 2020-04-28 Statens Serum Institut USE OF A MONOMICOLYL GLYCEROL (MMG) OR SYNTHETIC HOMOLOGISTS OR ANALOGS AND MODIFIED VERSIONS, ADJUVANT OR IMMUNOMODULATOR, HOMOLOGIST OR SYNTHETIC MMG ANALOG OR A MODIFIED VERSION, VACCINE AND APPLICATION SYSTEM
CN102170903B (en) 2008-05-02 2016-04-06 亮点医疗有限公司 For product and the method for immune response stimulating
US9139809B2 (en) * 2009-01-08 2015-09-22 Albert Einstein College Of Medicine Of Yeshiva University Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
JP5854559B2 (en) * 2009-07-06 2016-02-09 ヴァリエーション バイオテクノロジーズ インコーポレイテッド Method for preparing vesicles and preparations produced therefrom
KR101858770B1 (en) * 2010-07-02 2018-05-16 인터벳 인터내셔널 비.브이. Vaccine against ehrlichia canis
DK2729127T3 (en) 2011-07-04 2018-08-06 Statens Seruminstitut METHODS FOR LIPOSOMES PREPARATION
US20140045913A1 (en) * 2011-12-12 2014-02-13 Kyowa Hakko Kirin Co., Ltd. Lipid nano particles comprising combination of cationic lipid
WO2013089151A1 (en) * 2011-12-12 2013-06-20 協和発酵キリン株式会社 Lipid nanoparticles for drug delivery system containing cationic lipids
JP2016175841A (en) * 2013-08-02 2016-10-06 三郎 斎藤 Liposome, and vaccine composition that induces cytotoxic t lymphocyte activity
WO2015042423A2 (en) 2013-09-19 2015-03-26 Zoetis Llc Vaccine
EP3189853A4 (en) * 2014-08-04 2018-07-11 Nitto Denko Corporation Immune-induction-promoting composition including nuclear receptor ligand, and vaccine pharmaceutical composition
KR102085968B1 (en) * 2015-07-20 2020-03-06 조에티스 서비시즈 엘엘씨 Liposomal Auxiliary Compositions
CN114657147B (en) * 2022-01-27 2023-12-01 安徽智飞龙科马生物制药有限公司 Protective agent for biological material and application thereof
CN115068602B (en) * 2022-08-22 2022-11-01 北京华诺泰生物医药科技有限公司 Surface-modified aluminum oxide composite vaccine adjuvant, preparation method and application

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US5108934A (en) * 1983-11-30 1992-04-28 Kabushiki Kaisha Toshiba Quantitative immunoassay utilizing liposomes
JP2714972B2 (en) * 1988-02-02 1998-02-16 千葉製粉株式会社 Modifier for phospholipid aggregates, antiaggregation agent for phospholipid vesicles, fusion inhibitor for phospholipid vesicles, and surface immobilizing agent for phospholipid membranes
JPH03249561A (en) * 1990-02-28 1991-11-07 Toshiba Corp Immunoassay reagent
JPH0482824A (en) * 1990-07-23 1992-03-16 Nippon Oil & Fats Co Ltd Liposome and oil-in-water type emulsion
JPH0616688A (en) * 1992-06-30 1994-01-25 Nippon Oil & Fats Co Ltd Fatty acid sugar ester
JP3884488B2 (en) * 1993-03-10 2007-02-21 千葉製粉株式会社 Oligoglycolipid
JP3329554B2 (en) * 1993-03-10 2002-09-30 千葉製粉株式会社 Dried er
US5885613A (en) * 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
JPH0925287A (en) * 1995-07-13 1997-01-28 Eisai Co Ltd Synthetic lipid
JPH09110722A (en) * 1995-10-20 1997-04-28 Toray Ind Inc Immunoliposome for transducing tumorous cell of antitumor active substance and its preparation
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Also Published As

Publication number Publication date
ATE406874T1 (en) 2008-09-15
JP4987704B2 (en) 2012-07-25
KR101275837B1 (en) 2013-06-18
EP1765289A2 (en) 2007-03-28
EP1765289B1 (en) 2008-09-03
BRPI0512757B1 (en) 2021-04-06
WO2006002642A3 (en) 2006-05-18
BRPI0512757A (en) 2008-04-08
CN1980638A (en) 2007-06-13
KR20070051847A (en) 2007-05-18
PT1765289E (en) 2008-12-05
AU2005259685B2 (en) 2010-04-08
BRPI0512757B8 (en) 2021-05-25
WO2006002642A2 (en) 2006-01-12
SI1765289T1 (en) 2009-02-28
CN1980638B (en) 2011-10-12
DK1765289T3 (en) 2008-12-15
CA2572985C (en) 2014-04-22
ES2315880T3 (en) 2009-04-01
PL1765289T3 (en) 2009-02-27
CA2572985A1 (en) 2006-01-12
AU2005259685A1 (en) 2006-01-12
JP2008505131A (en) 2008-02-21
DE602005009535D1 (en) 2008-10-16

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