ZA200604096B

ZA200604096B - Triazole derivatives as vasopressin antagonists

Triazole derivatives as vasopressin antagonists Download PDF

Info

Publication number: ZA200604096B
Authority: ZA; South Africa
Prior art keywords: triazol; mmol; phenyl; preparation; 400mhz
Prior art date: 2003-12-22

Application number

ZA200604096A

Other languages

English (en)

Inventor

Bryans Justin Stephen

Johnson Patrick Stephen

Roberts Lee Richard

Ryckmans Thomas

Original Assignee

Pfizer

Priority date

2003-12-22

Filing date

2006-05-22

Publication date

2007-11-28

2006-05-22 Application filed by Pfizer filed Critical Pfizer

2007-11-28 Publication of ZA200604096B publication Critical patent/ZA200604096B/en

Links

229940042055 systemic antimycotics triazole derivative Drugs 0.000 title description 4
229940116211 Vasopressin antagonist Drugs 0.000 title description 3
239000003038 vasopressin antagonist Substances 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims description 490
238000002360 preparation method Methods 0.000 claims description 283
-1 COX inhibitor Substances 0.000 claims description 89
125000004433 nitrogen atom Chemical group N* 0.000 claims description 59
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NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 38
206010013935 Dysmenorrhoea Diseases 0.000 claims description 31
229920006395 saturated elastomer Polymers 0.000 claims description 25
239000003814 drug Substances 0.000 claims description 22
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
125000000217 alkyl group Chemical group 0.000 claims description 19
238000011282 treatment Methods 0.000 claims description 18
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125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 16
125000005843 halogen group Chemical group 0.000 claims description 16
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125000000753 cycloalkyl group Chemical group 0.000 claims description 11
208000035475 disorder Diseases 0.000 claims description 10
125000003545 alkoxy group Chemical group 0.000 claims description 8
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