ZA200501061B - Combination of VEGF receptor tyrosine kinase inhibitors for treatment of cancer - Google Patents
Combination of VEGF receptor tyrosine kinase inhibitors for treatment of cancer Download PDFInfo
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- ZA200501061B ZA200501061B ZA200501061A ZA200501061A ZA200501061B ZA 200501061 B ZA200501061 B ZA 200501061B ZA 200501061 A ZA200501061 A ZA 200501061A ZA 200501061 A ZA200501061 A ZA 200501061A ZA 200501061 B ZA200501061 B ZA 200501061B
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| GBGB0218526.2A GB0218526D0 (en) | 2002-08-09 | 2002-08-09 | Combination therapy |
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| NZ (1) | NZ537754A (https=) |
| WO (1) | WO2004014426A1 (https=) |
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| CZ301689B6 (cs) | 1999-11-05 | 2010-05-26 | Astrazeneca Ab | Derivát chinazolinu a farmaceutický prostredek, který ho obsahuje |
| GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| ES2267748T3 (es) | 2000-04-07 | 2007-03-16 | Astrazeneca Ab | Compuestos de quinazolina. |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| JP4608215B2 (ja) | 2002-02-01 | 2011-01-12 | アストラゼネカ アクチボラグ | キナゾリン化合物 |
| GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
| RU2350618C2 (ru) | 2002-11-04 | 2009-03-27 | Астразенека Аб | ПРОИЗВОДНЫЕ ХИНАЗОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Src ТИРОЗИНКИНАЗЫ |
| PT1592423E (pt) * | 2003-02-13 | 2011-06-16 | Astrazeneca Ab | Terapia de combinação de zd6474 com 5-fu e/ou cpt-11 |
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| KR20070072543A (ko) * | 2004-09-27 | 2007-07-04 | 아스트라제네카 아베 | Ｚｄ6474 및 이마티닙을 포함하는 병합법 |
| GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
| RU2007134908A (ru) * | 2005-04-14 | 2009-05-20 | Вайет (Us) | Применение ингибитора активности киназы рецептора эпидермального фактора роста для лечения пациентов, невосприимчивых к гефитинибу |
| US20080219977A1 (en) * | 2005-07-27 | 2008-09-11 | Isaiah Josh Fidler | Combinations Comprising Gemcitabine and Tyrosine Kinase Inhibitors for the Treatment of Pancreatic Cancer |
| GB0519879D0 (en) | 2005-09-30 | 2005-11-09 | Astrazeneca Ab | Chemical process |
| CA2833706C (en) | 2005-11-11 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| WO2007071958A2 (en) * | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Combination of zd6474 and pemetrexed |
| US20070258976A1 (en) * | 2006-05-04 | 2007-11-08 | Ward Keith W | Combination Therapy for Diseases Involving Angiogenesis |
| AU2007299080B2 (en) * | 2006-09-18 | 2013-04-18 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
| EP2066353B1 (en) * | 2006-09-29 | 2013-01-02 | AstraZeneca AB | Combination of zd6474 and bevacizumab for cancer therapy |
| PL2451445T3 (pl) | 2009-07-06 | 2019-09-30 | Boehringer Ingelheim International Gmbh | Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| GB201516905D0 (en) * | 2015-09-24 | 2015-11-11 | Stratified Medical Ltd | Treatment of Neurodegenerative diseases |
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| GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| ATE369894T1 (de) * | 2000-11-22 | 2007-09-15 | Novartis Pharma Gmbh | Kombination enthaltend ein mittel zur verminderung von vegf-aktivität und ein mittel zur verminderung von egf-aktivität |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| DE60311788T2 (de) * | 2002-04-16 | 2007-11-22 | Astrazeneca Ab | Kombinationstherapie zur behandlung von krebs |
| KR20050056190A (ko) * | 2002-08-09 | 2005-06-14 | 아스트라제네카 아베 | 암의 치료에서의 방사선 요법과 함께 혈관 내피 성장 인자수용체의 억제제인 ｚｄ6474의 병행 치료 |
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| GB0223854D0 (en) * | 2002-10-12 | 2002-11-20 | Astrazeneca Ab | Therapeutic treatment |
| PT1592423E (pt) * | 2003-02-13 | 2011-06-16 | Astrazeneca Ab | Terapia de combinação de zd6474 com 5-fu e/ou cpt-11 |
| GB0316127D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| EP1648465B1 (en) * | 2003-07-10 | 2010-08-25 | AstraZeneca AB | Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
| GB0412074D0 (en) * | 2004-05-29 | 2004-06-30 | Astrazeneca Ab | Combination product |
| KR20070072543A (ko) * | 2004-09-27 | 2007-07-04 | 아스트라제네카 아베 | Ｚｄ6474 및 이마티닙을 포함하는 병합법 |
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| WO2007071958A2 (en) * | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Combination of zd6474 and pemetrexed |
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- 2003-08-05 BR BR0313117-3A patent/BR0313117A/pt not_active IP Right Cessation
- 2003-08-05 EP EP03784248A patent/EP1534338A1/en not_active Withdrawn
- 2003-08-05 JP JP2004527018A patent/JP2006500346A/ja active Pending
- 2003-08-05 US US10/523,838 patent/US20050245549A1/en not_active Abandoned
- 2003-08-05 MX MXPA05001457A patent/MXPA05001457A/es active IP Right Grant
- 2003-08-05 CA CA002495489A patent/CA2495489A1/en not_active Abandoned
-
2005
- 2005-01-31 NO NO20050528A patent/NO20050528L/no not_active Application Discontinuation
- 2005-02-01 IL IL16662505A patent/IL166625A0/xx unknown
- 2005-02-04 ZA ZA200501061A patent/ZA200501061B/en unknown
-
2009
- 2009-07-13 US US12/501,593 patent/US20100130493A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050245549A1 (en) | 2005-11-03 |
| AU2003252976A1 (en) | 2004-02-25 |
| CN100556456C (zh) | 2009-11-04 |
| IL166625A0 (en) | 2006-01-15 |
| WO2004014426A1 (en) | 2004-02-19 |
| CA2495489A1 (en) | 2004-02-19 |
| US20100130493A1 (en) | 2010-05-27 |
| NZ537754A (en) | 2008-02-29 |
| JP2006500346A (ja) | 2006-01-05 |
| NO20050528L (no) | 2005-05-03 |
| MXPA05001457A (es) | 2005-06-06 |
| EP1534338A1 (en) | 2005-06-01 |
| CN1674938A (zh) | 2005-09-28 |
| GB0218526D0 (en) | 2002-09-18 |
| BR0313117A (pt) | 2005-07-05 |
| KR20050059060A (ko) | 2005-06-17 |
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