ZA200308642B - 4-(Phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders. - Google Patents
4-(Phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders. Download PDFInfo
- Publication number
- ZA200308642B ZA200308642B ZA200308642A ZA200308642A ZA200308642B ZA 200308642 B ZA200308642 B ZA 200308642B ZA 200308642 A ZA200308642 A ZA 200308642A ZA 200308642 A ZA200308642 A ZA 200308642A ZA 200308642 B ZA200308642 B ZA 200308642B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenyl
- fluoro
- piperidin
- amino
- diisopropyl
- Prior art date
Links
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- 208000019901 Anxiety disease Diseases 0.000 title claims description 8
- 230000036506 anxiety Effects 0.000 title claims description 8
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- 208000027753 pain disease Diseases 0.000 title claims description 3
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- 238000002600 positron emission tomography Methods 0.000 description 1
- 208000028173 post-traumatic stress disease Diseases 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101773A SE0101773D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200308642B true ZA200308642B (en) | 2005-02-07 |
Family
ID=20284176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200308642A ZA200308642B (en) | 2001-05-18 | 2003-11-05 | 4-(Phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7008952B2 (https=) |
| EP (1) | EP1395557A1 (https=) |
| JP (1) | JP2005508291A (https=) |
| KR (1) | KR20040000472A (https=) |
| CN (1) | CN1527818A (https=) |
| AR (1) | AR036231A1 (https=) |
| BG (1) | BG108334A (https=) |
| BR (1) | BR0209665A (https=) |
| CA (1) | CA2446516A1 (https=) |
| CO (1) | CO5540320A2 (https=) |
| CZ (1) | CZ20033093A3 (https=) |
| EE (1) | EE200300526A (https=) |
| HU (1) | HUP0401610A2 (https=) |
| IL (1) | IL158700A0 (https=) |
| IS (1) | IS7033A (https=) |
| MX (1) | MXPA03010444A (https=) |
| NO (1) | NO20035119D0 (https=) |
| PL (1) | PL367246A1 (https=) |
| RU (1) | RU2003131963A (https=) |
| SE (1) | SE0101773D0 (https=) |
| SK (1) | SK13992003A3 (https=) |
| WO (1) | WO2002094785A1 (https=) |
| ZA (1) | ZA200308642B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101921279A (zh) | 2003-10-01 | 2010-12-22 | 阿得罗公司 | 螺环杂环衍生物及其应用方法 |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| CN113979997A (zh) * | 2021-11-12 | 2022-01-28 | 中国科学院昆明植物研究所 | N,n-(4-哌啶基、芳基)-3-氨基苯酚类衍生物及其药物组合物和其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091096A (en) | 1976-03-19 | 1978-05-23 | Eli Lilly And Company | Dinitroanilines for the control of phytopathogens |
| EG12406A (en) | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| US4252812A (en) | 1977-05-23 | 1981-02-24 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| SE441448B (sv) | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
| DE3200304A1 (de) | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| EP0181793B1 (fr) | 1984-10-16 | 1988-07-27 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique |
| YU150489A (sh) | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| KR940003491B1 (ko) | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
| US5854245A (en) | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| SE9604786D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| WO1999033806A1 (en) | 1997-12-24 | 1999-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor |
| EP1512683B1 (en) | 1998-03-10 | 2011-08-31 | Research Triangle Institute | Novel opiate compounds, methods of making and methods of use |
| SE9904675D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| EP1263758A2 (en) * | 2000-03-03 | 2002-12-11 | Ortho-McNeil Pharmaceutical, Inc. | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-05-18 SE SE0101773A patent/SE0101773D0/xx unknown
-
2002
- 2002-05-16 CA CA002446516A patent/CA2446516A1/en not_active Abandoned
- 2002-05-16 CN CNA028141687A patent/CN1527818A/zh active Pending
- 2002-05-16 RU RU2003131963/04A patent/RU2003131963A/ru not_active Application Discontinuation
- 2002-05-16 SK SK1399-2003A patent/SK13992003A3/sk unknown
- 2002-05-16 WO PCT/SE2002/000957 patent/WO2002094785A1/en not_active Ceased
- 2002-05-16 PL PL02367246A patent/PL367246A1/xx not_active Application Discontinuation
- 2002-05-16 HU HU0401610A patent/HUP0401610A2/hu unknown
- 2002-05-16 EP EP02733713A patent/EP1395557A1/en not_active Withdrawn
- 2002-05-16 EE EEP200300526A patent/EE200300526A/xx unknown
- 2002-05-16 IL IL15870002A patent/IL158700A0/xx unknown
- 2002-05-16 MX MXPA03010444A patent/MXPA03010444A/es unknown
- 2002-05-16 BR BR0209665-0A patent/BR0209665A/pt not_active Application Discontinuation
- 2002-05-16 KR KR10-2003-7014951A patent/KR20040000472A/ko not_active Withdrawn
- 2002-05-16 JP JP2002591458A patent/JP2005508291A/ja active Pending
- 2002-05-16 US US10/477,636 patent/US7008952B2/en not_active Expired - Fee Related
- 2002-05-16 CZ CZ20033093A patent/CZ20033093A3/cs unknown
- 2002-05-16 AR ARP020101818A patent/AR036231A1/es not_active Application Discontinuation
-
2003
- 2003-11-05 ZA ZA200308642A patent/ZA200308642B/en unknown
- 2003-11-07 BG BG108334A patent/BG108334A/bg unknown
- 2003-11-12 CO CO03100170A patent/CO5540320A2/es not_active Application Discontinuation
- 2003-11-13 IS IS7033A patent/IS7033A/is unknown
- 2003-11-17 NO NO20035119A patent/NO20035119D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EE200300526A (et) | 2004-02-16 |
| CN1527818A (zh) | 2004-09-08 |
| CO5540320A2 (es) | 2005-07-29 |
| IL158700A0 (en) | 2004-05-12 |
| CZ20033093A3 (cs) | 2004-07-14 |
| RU2003131963A (ru) | 2005-05-10 |
| SE0101773D0 (sv) | 2001-05-18 |
| US20040142966A1 (en) | 2004-07-22 |
| EP1395557A1 (en) | 2004-03-10 |
| IS7033A (is) | 2003-11-13 |
| CA2446516A1 (en) | 2002-11-28 |
| MXPA03010444A (es) | 2004-03-09 |
| BR0209665A (pt) | 2004-04-20 |
| JP2005508291A (ja) | 2005-03-31 |
| WO2002094785A1 (en) | 2002-11-28 |
| KR20040000472A (ko) | 2004-01-03 |
| US7008952B2 (en) | 2006-03-07 |
| SK13992003A3 (sk) | 2004-04-06 |
| AR036231A1 (es) | 2004-08-25 |
| BG108334A (bg) | 2004-12-30 |
| HUP0401610A2 (hu) | 2004-12-28 |
| NO20035119D0 (no) | 2003-11-17 |
| PL367246A1 (en) | 2005-02-21 |
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