ZA200207973B - Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain. - Google Patents
Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain. Download PDFInfo
- Publication number
- ZA200207973B ZA200207973B ZA200207973A ZA200207973A ZA200207973B ZA 200207973 B ZA200207973 B ZA 200207973B ZA 200207973 A ZA200207973 A ZA 200207973A ZA 200207973 A ZA200207973 A ZA 200207973A ZA 200207973 B ZA200207973 B ZA 200207973B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- methyl
- quinolinyl
- compound according
- diethyl
- Prior art date
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- 208000002193 Pain Diseases 0.000 title claims description 13
- 230000036407 pain Effects 0.000 title claims description 11
- YUPPDBUZMGCMLI-UHFFFAOYSA-N 2-methyl-n-piperidin-4-ylidene-3-quinolin-2-ylbenzamide Chemical class C1=CC=C(C=2N=C3C=CC=CC3=CC=2)C(C)=C1C(=O)N=C1CCNCC1 YUPPDBUZMGCMLI-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 78
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- -1 NO» Chemical group 0.000 claims description 21
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- 230000002829 reductive effect Effects 0.000 claims description 10
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- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 6
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 6
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
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- 229910052763 palladium Inorganic materials 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
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- NLALNTAILOSYIU-UHFFFAOYSA-N n,n-diethyl-4-[quinolin-8-yl-[1-(thiophen-2-ylmethyl)piperidin-4-ylidene]methyl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C2=NC=CC=C2C=CC=1)=C1CCN(CC=2SC=CC=2)CC1 NLALNTAILOSYIU-UHFFFAOYSA-N 0.000 claims 1
- JNCPIWUGOPOEPV-UHFFFAOYSA-N n,n-diethyl-4-[quinolin-8-yl-[1-(thiophen-3-ylmethyl)piperidin-4-ylidene]methyl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C2=NC=CC=C2C=CC=1)=C1CCN(CC2=CSC=C2)CC1 JNCPIWUGOPOEPV-UHFFFAOYSA-N 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0001208A SE0001208D0 (sv) | 2000-04-04 | 2000-04-04 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200207973B true ZA200207973B (en) | 2004-01-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200207973A ZA200207973B (en) | 2000-04-04 | 2002-10-03 | Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6753335B2 (de) |
| EP (1) | EP1286986B1 (de) |
| JP (1) | JP2003529598A (de) |
| KR (1) | KR100755153B1 (de) |
| CN (1) | CN1182134C (de) |
| AR (1) | AR029823A1 (de) |
| AT (1) | ATE289603T1 (de) |
| AU (2) | AU4498201A (de) |
| BR (1) | BR0109817A (de) |
| CA (1) | CA2403600A1 (de) |
| CZ (1) | CZ20023288A3 (de) |
| DE (1) | DE60109032T2 (de) |
| EE (1) | EE200200577A (de) |
| ES (1) | ES2236203T3 (de) |
| HK (1) | HK1051692A1 (de) |
| HU (1) | HUP0300402A3 (de) |
| IL (1) | IL151891A0 (de) |
| IS (1) | IS6574A (de) |
| MX (1) | MXPA02009759A (de) |
| NO (1) | NO323466B1 (de) |
| NZ (1) | NZ522143A (de) |
| PL (1) | PL357770A1 (de) |
| PT (1) | PT1286986E (de) |
| RU (1) | RU2002125506A (de) |
| SE (1) | SE0001208D0 (de) |
| SK (1) | SK285076B6 (de) |
| WO (1) | WO2001074806A1 (de) |
| ZA (1) | ZA200207973B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| SE0101768D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101765D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101766D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0103313D0 (sv) | 2001-10-03 | 2001-10-03 | Astrazeneca Ab | Novel compounds |
| EP1469850B1 (de) | 2002-01-02 | 2013-01-02 | Versi Group, LLC | Verfahren zur behandlung von sexuellen funktionsstörungen mit delta opioid-rezeptor-agonist-verbindungen |
| SE0301441D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
| US20070099957A1 (en) * | 2003-05-16 | 2007-05-03 | Astra Zeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| ES2456705T3 (es) * | 2003-12-12 | 2014-04-23 | Eli Lilly & Company | Antagonistas de receptores opioides |
| SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0402485D0 (sv) | 2004-10-13 | 2004-10-13 | Astrazeneca Ab | Polymorph of N,N-Diethyl-4-(3-Fluorophenyl-Piperidin-4-Ylidene-Methyl)-Benzamide Hydrochloride salt |
| MY148880A (en) | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| DK1049676T3 (da) | 1997-12-24 | 2006-01-16 | Ortho Mcneil Pharm Inc | 4-[Aryl(piperidin-4-yl)]aminobenzamider, som binder til delta-opioidreceptoren |
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2000
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2003
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Also Published As
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