ZA200100137B - Method and composition for the treatment of epidermal irritations and infections. - Google Patents
Method and composition for the treatment of epidermal irritations and infections. Download PDFInfo
- Publication number
- ZA200100137B ZA200100137B ZA200100137A ZA200100137A ZA200100137B ZA 200100137 B ZA200100137 B ZA 200100137B ZA 200100137 A ZA200100137 A ZA 200100137A ZA 200100137 A ZA200100137 A ZA 200100137A ZA 200100137 B ZA200100137 B ZA 200100137B
- Authority
- ZA
- South Africa
- Prior art keywords
- zinc
- composition
- stannous fluoride
- gluconate
- amino acid
- Prior art date
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Applications Claiming Priority (1)
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| US8856098P | 1998-06-09 | 1998-06-09 |
Publications (1)
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| ZA200100137B true ZA200100137B (en) | 2001-07-10 |
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|---|---|---|---|
| ZA200100137A ZA200100137B (en) | 1998-06-09 | 2001-01-05 | Method and composition for the treatment of epidermal irritations and infections. |
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|---|---|
| US (2) | US6605289B1 (de) |
| EP (1) | EP1085804B1 (de) |
| JP (1) | JP2002517411A (de) |
| CN (1) | CN1311628A (de) |
| AT (1) | ATE424109T1 (de) |
| AU (1) | AU760870B2 (de) |
| BR (1) | BR9910981A (de) |
| CA (1) | CA2334344C (de) |
| DE (1) | DE69940508D1 (de) |
| EA (1) | EA003463B1 (de) |
| ES (1) | ES2323395T3 (de) |
| IL (1) | IL140095A (de) |
| NZ (1) | NZ509227A (de) |
| TR (1) | TR200003674T2 (de) |
| WO (1) | WO1999063816A1 (de) |
| ZA (1) | ZA200100137B (de) |
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| US20040043047A1 (en) * | 1999-03-26 | 2004-03-04 | Parfums Christian Dior | Cosmetic or dermatological compositions containing at least one substance for increasing the functionality and/or expression of the CD44 membrane receptors of skin cells |
| DE10033717A1 (de) * | 2000-07-12 | 2002-01-24 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitung zur Beseitigung von Sebum |
| US7879365B2 (en) | 2002-02-07 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
| US7563461B2 (en) | 2002-02-07 | 2009-07-21 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
| JP4651944B2 (ja) * | 2002-02-07 | 2011-03-16 | ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 殺精子剤および殺菌剤からの粘膜刺激の予防のための亜鉛塩組成物 |
| US7435429B2 (en) | 2002-02-07 | 2008-10-14 | Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
| AU2003284337B2 (en) * | 2002-10-25 | 2010-04-15 | Precision Dermatology, Inc. | Modulation of zinc levels to improve tissue properties |
| AU2003900064A0 (en) * | 2003-01-09 | 2003-01-23 | Penam Investments Pty. Ltd. | A method of treatment or prophylaxis of viral infection. |
| TWI228051B (en) | 2003-05-19 | 2005-02-21 | Well Being Biochemical Corp | Anti-bacterial, anti-viral, and anti-fungus composition, its preparation and use |
| US20060246148A1 (en) | 2003-07-29 | 2006-11-02 | Well-Being Biochemical Corp. | Anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use |
| CA2532730C (en) | 2003-07-17 | 2013-02-26 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositions containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof |
| EP1576880A1 (de) * | 2004-03-16 | 2005-09-21 | Well-being Biochemical Corp. | Bakterizide, viruzide und fungizide Zusammensetzung, deren Herstellung und Verwendung |
| US20070034118A1 (en) * | 2005-08-12 | 2007-02-15 | Jardine Leslie A | Dosage efficient, storage stable compositions for reducing chromium (VI) in cement |
| GB0715141D0 (en) * | 2007-08-03 | 2007-09-12 | York Pharma Plc | Improving skin barrier function |
| ES2618068T3 (es) * | 2009-03-16 | 2017-06-20 | Visions Marketing Group, Inc. | Composición germicida |
| EP2283805A1 (de) | 2009-07-28 | 2011-02-16 | Sirvis BV | Zusammensetzungen bestehend aus Zink, welches eine Verbindung in der hydrophoben Phase enthält |
| US20130236521A1 (en) * | 2012-03-08 | 2013-09-12 | Herpx Llc | SnF2 APPLICATIONS, METHODS AND RELATED FORMULATIONS |
| BR112015011299A2 (pt) * | 2012-11-20 | 2017-07-11 | Onconox Aps | saquinavir-no para imunomodulação |
| MX369505B (es) * | 2012-12-19 | 2019-11-11 | Colgate Palmolive Co | Complejo de haluro de aminoácido y zinc con cisteína. |
| EP2934438B1 (de) | 2012-12-19 | 2017-02-15 | Colgate-Palmolive Company | Zinkaminosäure-/trimethylglycinhalide |
| JP5968558B2 (ja) | 2012-12-19 | 2016-08-10 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | 亜鉛リジン錯体 |
| CA2892179C (en) | 2012-12-19 | 2020-03-31 | Colgate-Palmolive Company | Composition with zinc amino acid/trimethylglycine halide precursors |
| MX352558B (es) | 2012-12-19 | 2017-11-29 | Colgate Palmolive Co | Composiciones para el cuidado oral que contienen halogenuros de aminoácido de zinc. |
| US9504858B2 (en) | 2012-12-19 | 2016-11-29 | Colgate-Palmolive Company | Zinc amino acid halide complex with cysteine |
| US9675823B2 (en) | 2012-12-19 | 2017-06-13 | Colgate-Palmolive Company | Two component compositions containing zinc amino acid halide complexes and cysteine |
| MX352357B (es) | 2012-12-19 | 2017-11-22 | Colgate Palmolive Co | Productos para el cuidado oral que contienen un complejo de zinc tetrabásico-aminoácido-halogenuro. |
| US9572756B2 (en) | 2012-12-19 | 2017-02-21 | Colgate-Palmolive Company | Teeth whitening methods, visually perceptible signals and compositions therefor |
| US10188112B2 (en) | 2012-12-19 | 2019-01-29 | Colgate-Palmolive Company | Personal cleansing compositions containing zinc amino acid/trimethylglycine halide |
| MX353019B (es) | 2012-12-19 | 2017-12-18 | Colgate Palmolive Co | Enjuagues bucales de haluros de aminoácidos y zinc. |
| RU2628540C2 (ru) | 2012-12-19 | 2017-08-18 | Колгейт-Палмолив Компани | Продукты для ухода за полостью рта, включающие оксид цинка и триметилглицин |
| EP2934441B1 (de) | 2012-12-19 | 2017-04-26 | Colgate-Palmolive Company | Orales gel mit einem zinkaminosäurekomplex |
| BR112015014453B1 (pt) | 2012-12-19 | 2019-06-11 | Colgate-Palmolive Company | Composição para higiene oral, complexo iônico, usos de um haleto de zinco tetrabásico em conjunto com trimetilglicina na forma de sal de adição de ácido e complexo |
| EP2934695B1 (de) | 2012-12-19 | 2016-11-30 | Colgate-Palmolive Company | Schweisshemmende mittel mit protein und antiperspirantsalzen |
| US9498421B2 (en) | 2012-12-19 | 2016-11-22 | Colgate-Palmolive Company | Two component compositions containing tetrabasic zinc-amino acid halide complexes and cysteine |
| US9750670B2 (en) | 2012-12-19 | 2017-09-05 | Colgate-Palmolive Company | Zinc amino acid complex with cysteine |
| EP3380064B1 (de) | 2015-12-30 | 2020-05-06 | Colgate-Palmolive Company | Kosmetische formulierungen |
| MX370240B (es) * | 2015-12-30 | 2019-12-06 | Colgate Palmolive Co | Composiciones para el cuidado personal. |
| CN117618259A (zh) | 2018-03-29 | 2024-03-01 | 宝洁公司 | 用于促进牙龈健康的口腔护理组合物 |
| CN109381357B (zh) * | 2018-12-13 | 2021-09-03 | 广州宝莱生物科技有限公司 | 一种祛痘润肤水蛭冻干粉 |
| WO2021067992A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Methods of use of oral care compositions comprising hops |
| BR112022004332A2 (pt) | 2019-09-30 | 2022-05-31 | Procter & Gamble | Composições dentifrícias para o tratamento de biofilme dental |
| CA3155865A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | TOOTHPASTE COMPOSITIONS FOR TREATING DENTAL BIOFILM |
| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2749213A (en) * | 1952-07-03 | 1956-06-05 | American Home Prod | Stannous fluoro complex salts |
| US3282792A (en) * | 1964-01-09 | 1966-11-01 | Bristol Myers Co | Stabilized stannous fluoride dentifrice compositions |
| US4097590A (en) * | 1975-07-24 | 1978-06-27 | Geraldine Fay Weisz | Methods and compositions for treatment of bacterial and fungus infections of the skin |
| US4138477A (en) * | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
| US4267164A (en) * | 1980-01-31 | 1981-05-12 | Block Drug Company Inc. | Effervescent stannous fluoride tablet |
| AU548560B2 (en) * | 1980-05-20 | 1985-12-19 | Vipont Laboratories Inc. | Benzophenanthridine alkaloids as antimicrobial agents |
| US4406881A (en) * | 1980-05-20 | 1983-09-27 | Vipont Laboratories | Antimicrobial agent |
| US4383990A (en) * | 1980-10-01 | 1983-05-17 | Beecham Group Limited | Antiviral agents, their preparation and use |
| US4469674A (en) * | 1981-09-03 | 1984-09-04 | Richardson-Vicks Inc. | Stable oral compositions containing zinc and fluoride compounds |
| US4415590A (en) * | 1982-04-26 | 1983-11-15 | Betamed Pharmaceuticals, Inc. | Herpes treatment |
| US4419346A (en) * | 1982-08-13 | 1983-12-06 | Nabisco Brands, Inc. | Method and composition to inhibit the growth of Streptococcus mutans by the use of saccharin/fluoride combination |
| US4431631A (en) * | 1983-01-03 | 1984-02-14 | Colgate-Palmolive Company | Aqueous oral solution |
| US4568540A (en) * | 1984-04-18 | 1986-02-04 | Johnson & Johnson | Oral hygiene compositions |
| GB2179536B (en) * | 1984-06-11 | 1988-12-21 | Godfrey Science & Design Inc | Improvement in the flavour of zinc supplements for oral use |
| US4664906A (en) * | 1984-08-30 | 1987-05-12 | Johnson & Johnson Products Inc. | Oral compositions |
| US4684517A (en) * | 1985-02-04 | 1987-08-04 | Colgate-Palmolive Company | Mouthrinse composition containing hydrogen peroxide and fluoride |
| US4765984A (en) * | 1986-01-22 | 1988-08-23 | Colgate-Palmolive Company | Stable single unit dose oral product |
| US4952392A (en) * | 1986-03-17 | 1990-08-28 | Peri-Oral Dental Products, Inc. | Use of periwinkle in oral hygiene |
| US5004597A (en) * | 1987-09-14 | 1991-04-02 | The Procter & Gamble Company | Oral compositions comprising stannous flouride and stannous gluconate |
| US5098716A (en) * | 1990-08-23 | 1992-03-24 | Embro William J | Method and composition for treating diseases having a viral etiology |
| US5094845A (en) * | 1991-03-04 | 1992-03-10 | David G. Vlock | Oral compositions containing zinc gluconate complexes |
| US5416075A (en) | 1993-11-30 | 1995-05-16 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Biospecific emulsions |
| US5708023A (en) * | 1994-03-28 | 1998-01-13 | The Trustees Of Columbia University In The City Of New York | Zinc gluconate gel compositions |
| EP0691124A1 (de) * | 1994-07-07 | 1996-01-10 | Sara Lee/DE N.V. | Mundpflegemittel |
| CN1115620A (zh) * | 1994-07-26 | 1996-01-31 | 袁升彪 | 婴幼儿童饮用水 |
| US5624906A (en) * | 1994-12-08 | 1997-04-29 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds |
| DE69528445D1 (de) | 1994-12-12 | 2002-11-07 | Unilever Nv | Anti-mikrobielles Mittel |
| US5658946A (en) * | 1996-05-29 | 1997-08-19 | The Procter & Gamble Company | Methods for the treatment of herpes virus infections |
| US5908640A (en) * | 1997-07-25 | 1999-06-01 | Embro; William J. | Veterinary compositions for treating epidermal irritations |
-
1999
- 1999-06-09 DE DE69940508T patent/DE69940508D1/de not_active Expired - Lifetime
- 1999-06-09 BR BR9910981-6A patent/BR9910981A/pt not_active Application Discontinuation
- 1999-06-09 ES ES99928533T patent/ES2323395T3/es not_active Expired - Lifetime
- 1999-06-09 AU AU45583/99A patent/AU760870B2/en not_active Ceased
- 1999-06-09 TR TR2000/03674T patent/TR200003674T2/xx unknown
- 1999-06-09 CA CA002334344A patent/CA2334344C/en not_active Expired - Lifetime
- 1999-06-09 JP JP2000552901A patent/JP2002517411A/ja active Pending
- 1999-06-09 EA EA200100015A patent/EA003463B1/ru not_active IP Right Cessation
- 1999-06-09 US US09/701,498 patent/US6605289B1/en not_active Expired - Lifetime
- 1999-06-09 CN CN99809091A patent/CN1311628A/zh active Pending
- 1999-06-09 EP EP99928533A patent/EP1085804B1/de not_active Expired - Lifetime
- 1999-06-09 WO PCT/US1999/013048 patent/WO1999063816A1/en active IP Right Grant
- 1999-06-09 AT AT99928533T patent/ATE424109T1/de not_active IP Right Cessation
- 1999-06-09 NZ NZ509227A patent/NZ509227A/en unknown
- 1999-06-09 IL IL14009599A patent/IL140095A/xx not_active IP Right Cessation
-
2001
- 2001-01-05 ZA ZA200100137A patent/ZA200100137B/en unknown
-
2003
- 2003-03-31 US US10/403,784 patent/US20040042978A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2334344C (en) | 2005-08-16 |
| IL140095A0 (en) | 2002-02-10 |
| WO1999063816A1 (en) | 1999-12-16 |
| EP1085804A4 (de) | 2005-09-28 |
| EA003463B1 (ru) | 2003-06-26 |
| EP1085804B1 (de) | 2009-03-04 |
| TR200003674T2 (tr) | 2001-07-23 |
| DE69940508D1 (de) | 2009-04-16 |
| US20040042978A1 (en) | 2004-03-04 |
| CA2334344A1 (en) | 1999-12-16 |
| CN1311628A (zh) | 2001-09-05 |
| BR9910981A (pt) | 2004-08-03 |
| AU760870B2 (en) | 2003-05-22 |
| US6605289B1 (en) | 2003-08-12 |
| AU4558399A (en) | 1999-12-30 |
| EA200100015A1 (ru) | 2001-06-25 |
| IL140095A (en) | 2005-11-20 |
| EP1085804A1 (de) | 2001-03-28 |
| NZ509227A (en) | 2003-08-29 |
| ES2323395T3 (es) | 2009-07-14 |
| ATE424109T1 (de) | 2009-03-15 |
| JP2002517411A (ja) | 2002-06-18 |
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