ZA200006173B - Crystalline Efavirenz. - Google Patents

Crystalline Efavirenz.

Info

Publication number
ZA200006173B
ZA200006173B ZA200006173A ZA200006173A ZA200006173B ZA 200006173 B ZA200006173 B ZA 200006173B ZA 200006173 A ZA200006173 A ZA 200006173A ZA 200006173 A ZA200006173 A ZA 200006173A ZA 200006173 B ZA200006173 B ZA 200006173B
Authority
ZA
South Africa
Prior art keywords
crystalline efavirenz
efavirenz
crystalline
Prior art date
Application number
ZA200006173A
Inventor
Lilian A Radesca
Shelley R Rabel
James R Moore
Michael B Maurin
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22214647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200006173(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of ZA200006173B publication Critical patent/ZA200006173B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
ZA200006173A 1998-06-11 2000-10-31 Crystalline Efavirenz. ZA200006173B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8898198P 1998-06-11 1998-06-11

Publications (1)

Publication Number Publication Date
ZA200006173B true ZA200006173B (en) 2001-10-31

Family

ID=22214647

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200006173A ZA200006173B (en) 1998-06-11 2000-10-31 Crystalline Efavirenz.

Country Status (21)

Country Link
EP (1) EP1086087A1 (en)
JP (1) JP2002517487A (en)
CN (1) CN1307568A (en)
AR (3) AR018670A1 (en)
AU (1) AU758114C (en)
BR (1) BR9911523A (en)
CA (1) CA2333550A1 (en)
EE (1) EE05547B1 (en)
HR (1) HRP990182A2 (en)
HU (1) HUP0103819A3 (en)
IL (1) IL139793A (en)
MY (1) MY126450A (en)
NO (1) NO20006255L (en)
NZ (1) NZ507713A (en)
PL (1) PL198504B1 (en)
SG (3) SG134977A1 (en)
SK (1) SK18182000A3 (en)
TW (1) TWI235152B (en)
UA (1) UA74324C2 (en)
WO (1) WO1999064405A1 (en)
ZA (1) ZA200006173B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
US20060235008A1 (en) 2004-08-19 2006-10-19 Hetero Drugs Limited Novel polymorphs of efavirenz
PE20060587A1 (en) * 2004-09-02 2006-07-09 Bristol Myers Squibb Co SYNTHESIS OF (S) -6-CHLORO-4-CYCLOPROPYLETINYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONA
WO2008108630A1 (en) * 2007-03-02 2008-09-12 Ultimorphix Technologies B.V. Polymorphic forms of efavirenz
WO2009011567A1 (en) * 2007-07-16 2009-01-22 Ultimorphix Technologies B.V. Crystalline forms of efavirenz
SI2303267T1 (en) 2008-02-04 2013-09-30 Pfizer Limited Polymorphic form of a s1, 2, 4c triazolo s4, 3-acpyridine derivative for treating inflammatory diseases
US8383811B2 (en) 2008-12-22 2013-02-26 Hetero Research Foundation Process for preparing efavirenz polymorph
DE102009041443A1 (en) 2009-09-16 2011-03-31 Archimica Gmbh Salts of 6-chloro-4- (cyclopropylethynyl) -1,4-dihydro-4- (trifluoromethyl) -2H-3,1-benzoxazin-2-one and their synthesis, purification and use as precursors of efavirenz
EP2471783A1 (en) 2010-12-23 2012-07-04 Esteve Química, S.A. Novel polymorphic form of efavirenz
CN103508973B (en) * 2012-06-25 2016-04-27 上海迪赛诺药业有限公司 Prepare the method for efavirenz I type crystallization
CN102924398B (en) * 2012-11-22 2015-11-18 安徽贝克生物制药有限公司 For removing the method for the corresponding isomer of efavirenz
AU2013375157B2 (en) * 2013-01-23 2018-07-12 Alienor Farma Increased dosage of Efavirenz for the treatment of cancer
CN105037175B (en) * 2014-07-18 2017-02-22 盐城迪赛诺制药有限公司 Method of improving optical purity of efavirenz intermediate
CN105001101B (en) * 2015-05-28 2017-11-28 乐平市瑞盛制药有限公司 A kind of synthetic method of the trifluoroacetyl aniline hydrate hydrochloride of 4 chlorine 2
CN108947855B (en) * 2018-08-10 2021-10-22 江苏沙星化工有限公司 Synthesis method of efavirenz key intermediate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106507A (en) * 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
WO1995020389A1 (en) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
US5633405A (en) * 1995-05-25 1997-05-27 Merck & Co., Inc. Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one
CA2260922A1 (en) * 1996-07-26 1998-02-05 Du Pont Pharmaceuticals Company A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors
DE69724630T2 (en) * 1996-10-02 2004-07-29 Bristol-Myers Squibb Pharma Co. 4,4-DISUBSTITUTED 1,4-DIHYDRO-2H-3,1-BENZOXAZINE-2-ONE THAT ARE APPLICABLE AS HIV REVERSTRANSCRIPTASE INHIBITORS, INTERMEDIATE PRODUCTS AND METHODS FOR THE PRODUCTION THEREOF
PL197740B1 (en) * 1997-02-05 2008-04-30 Merck & Co Inc Method of crystallising and inhibitor of reverse hiv transcriptase using an antisolvent

Also Published As

Publication number Publication date
AR077469A2 (en) 2011-08-31
JP2002517487A (en) 2002-06-18
CA2333550A1 (en) 1999-12-16
SK18182000A3 (en) 2001-08-06
BR9911523A (en) 2001-09-18
NO20006255L (en) 2001-02-12
AU758114C (en) 2003-10-30
EE05547B1 (en) 2012-06-15
NO20006255D0 (en) 2000-12-08
PL198504B1 (en) 2008-06-30
AU4436499A (en) 1999-12-30
WO1999064405A1 (en) 1999-12-16
SG134977A1 (en) 2007-09-28
EE200000743A (en) 2002-10-15
TWI235152B (en) 2005-07-01
AR018670A1 (en) 2001-11-28
AR077407A2 (en) 2011-08-24
HUP0103819A2 (en) 2002-02-28
EP1086087A1 (en) 2001-03-28
SG111980A1 (en) 2005-06-29
SG111981A1 (en) 2005-06-29
HRP990182A2 (en) 2000-02-29
NZ507713A (en) 2003-08-29
CN1307568A (en) 2001-08-08
MY126450A (en) 2006-10-31
IL139793A0 (en) 2002-02-10
PL345221A1 (en) 2001-12-03
HUP0103819A3 (en) 2003-05-28
UA74324C2 (en) 2005-12-15
AU758114B2 (en) 2003-03-13
IL139793A (en) 2006-10-31

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