YU87401A - Derivatives of 4'-demycarosyl-8a-aza-8a-homotylosin - Google Patents

Derivatives of 4'-demycarosyl-8a-aza-8a-homotylosin

Info

Publication number
YU87401A
YU87401A YU87401A YUP87401A YU87401A YU 87401 A YU87401 A YU 87401A YU 87401 A YU87401 A YU 87401A YU P87401 A YUP87401 A YU P87401A YU 87401 A YU87401 A YU 87401A
Authority
YU
Yugoslavia
Prior art keywords
derivatives
homotylosin
aza
demycarosyl
acyl
Prior art date
Application number
YU87401A
Other languages
Serbo-Croatian (sh)
Inventor
Nevenka Lopotar
Amalija Narandja
Stjepan Mutak
Original Assignee
Pliva
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva filed Critical Pliva
Publication of YU87401A publication Critical patent/YU87401A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Pronalazak se odnosi na derivate 4'-dimikarozil-8a-aza-8a-homotilozina formule I u kojoj R predstavlja CHO, CH(OCH3)2 ili CH2N[CH2(C6H5)]2, R1 predstavlja H ili C1-C3 acil, R2 predstavlja OR6 i R6 predstavlja H ili C1-C3 acil, R3 predstavlja H ili R2 i R3 zajedno predstavljaju = O, R4 predstavlja OH, R5 predstavlja H ili R4 i R5 zajedno predstavljaju = O, i na postupak za njihiovo dobijanje. Novi derivati pokazuju antibakterijsko dejstvo i takodje se mogu koristiti kao intermedijeri za dobijanje novih 17-točlanih azalidnih antibiotika.The invention relates to 4'-dimicarosyl-8a-aza-8a-homotylosin derivatives of formula I in which R represents CHO, CH (OCH3) 2 or CH2N [CH2 (C6H5)] 2, R1 represents H or C1-C3 acyl, R2 represents OR6 and R6 represents H or C1-C3 acyl, R3 represents H or R2 and R3 together represent = O, R4 represents OH, R5 represents H or R4 and R5 together represent = O, and to a process for their preparation. The new derivatives show antibacterial activity and can also be used as intermediates to obtain new 17-point azalide antibiotics.

YU87401A 1999-06-11 2000-06-06 Derivatives of 4'-demycarosyl-8a-aza-8a-homotylosin YU87401A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR990192A HRP990192A2 (en) 1999-06-11 1999-06-11 4'-DEMICAROZYL-8a-AZA-8a-HOMOTHILOSINE DERIVATIVES

Publications (1)

Publication Number Publication Date
YU87401A true YU87401A (en) 2004-07-15

Family

ID=10946940

Family Applications (1)

Application Number Title Priority Date Filing Date
YU87401A YU87401A (en) 1999-06-11 2000-06-06 Derivatives of 4'-demycarosyl-8a-aza-8a-homotylosin

Country Status (13)

Country Link
EP (1) EP1189914A1 (en)
JP (1) JP2003502338A (en)
AU (1) AU767543B2 (en)
CA (1) CA2375812A1 (en)
CZ (1) CZ20014362A3 (en)
EA (1) EA200200026A1 (en)
HR (1) HRP990192A2 (en)
HU (1) HUP0201610A3 (en)
NO (1) NO322424B1 (en)
SK (1) SK17572001A3 (en)
UA (1) UA66930C2 (en)
WO (1) WO2000077016A1 (en)
YU (1) YU87401A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
MXPA05009430A (en) * 2003-03-05 2006-04-07 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using the same.
JPWO2005019238A1 (en) 2003-08-22 2006-10-19 明治製菓株式会社 Novel azalides and azalactam derivatives and their production
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU45033B (en) * 1987-04-14 1991-06-30 Pliva Zagreb Process for preparing 10,11,12,13-tetrahydro derivative
YU149889A (en) * 1989-07-26 1991-02-28 Pliva Zagreb Process for preparing biologically active derivatives of tylozine
CZ211798A3 (en) * 1997-07-16 1999-02-17 Pliva, Farmaceutska, Kemijska, Prehrambena I Kozmetička Industrije, Dioničko Društvo Linear 8a-secoazalides and process for preparing thereof

Also Published As

Publication number Publication date
AU5558300A (en) 2001-01-02
EP1189914A1 (en) 2002-03-27
NO322424B1 (en) 2006-10-02
HRP990192A2 (en) 2001-04-30
HUP0201610A3 (en) 2003-03-28
CA2375812A1 (en) 2000-12-21
CZ20014362A3 (en) 2002-04-17
EA200200026A1 (en) 2002-06-27
HUP0201610A2 (en) 2002-10-28
UA66930C2 (en) 2004-06-15
WO2000077016A1 (en) 2000-12-21
NO20016030D0 (en) 2001-12-10
JP2003502338A (en) 2003-01-21
NO20016030L (en) 2002-01-30
AU767543B2 (en) 2003-11-13
SK17572001A3 (en) 2002-04-04

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