YU78695A - Derivates of piperazin, medecines containing two compounds, their application and procedures for the preparation thereof - Google Patents

Derivates of piperazin, medecines containing two compounds, their application and procedures for the preparation thereof

Info

Publication number
YU78695A
YU78695A YU78695A YU78695A YU78695A YU 78695 A YU78695 A YU 78695A YU 78695 A YU78695 A YU 78695A YU 78695 A YU78695 A YU 78695A YU 78695 A YU78695 A YU 78695A
Authority
YU
Yugoslavia
Prior art keywords
compounds
preparation
medecines
derivates
piperazin
Prior art date
Application number
YU78695A
Other languages
Serbo-Croatian (sh)
Inventor
Helmut Pieper
Volkhard Austel
Frank Himmelsbach
Gunter Linz
Brian Guth
Johannes Weisenbergen
Original Assignee
Dr. Karl Thomae Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Karl Thomae Gmbh. filed Critical Dr. Karl Thomae Gmbh.
Publication of YU78695A publication Critical patent/YU78695A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Ovaj pronalazak se odnosi na derivate piperazina, opšte formule u kojoj su Ra do Rc, Y1 do Y3 i E definisani kao u zahtevu 1, njihove tautomere, njihove stereoizomere, uključujući njihove smeše i njihove soli, naročito na njihove fiziološki podnošljive soli sa neorganskim ili organskim kiselinama ili bazama, koji ispoljavaju dragocena farmakološka svojstva, prvenstveno inhibirajuće antiagregaciono delovanje, na lekove koji sadrže ova jedinjenja, na njihovu primenu i postupke za njihovo pripremanje.The present invention relates to piperazine derivatives of the general formula wherein Ra to Rc, Y1 to Y3 and E are defined as in claim 1, their tautomers, their stereoisomers, including mixtures thereof and salts thereof, in particular their physiologically tolerable salts with inorganic or organic acids or bases, which exhibit valuable pharmacological properties, primarily inhibiting anti-aggregation activity, to drugs containing these compounds, to their use and to methods for their preparation.

YU78695A 1994-12-23 1995-12-21 Derivates of piperazin, medecines containing two compounds, their application and procedures for the preparation thereof YU78695A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19944446301 DE4446301A1 (en) 1994-12-23 1994-12-23 New 1-heterocyclyl-piperazine derivs.
DE19526678A DE19526678A1 (en) 1994-12-23 1995-07-21 New heterocyclic substd. piperazine derivs.
DE1995133639 DE19533639A1 (en) 1994-12-23 1995-09-12 Piperazine derivatives, pharmaceutical compositions containing them, their use and processes for their preparation

Publications (1)

Publication Number Publication Date
YU78695A true YU78695A (en) 1998-09-18

Family

ID=6536919

Family Applications (1)

Application Number Title Priority Date Filing Date
YU78695A YU78695A (en) 1994-12-23 1995-12-21 Derivates of piperazin, medecines containing two compounds, their application and procedures for the preparation thereof

Country Status (5)

Country Link
KR (1) KR987000970A (en)
CO (1) CO4700299A1 (en)
DE (3) DE4446301A1 (en)
PE (1) PE63996A1 (en)
YU (1) YU78695A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069143A (en) * 1994-12-20 2000-05-30 Smithkline Beecham Corporation Fibrinogen receptor antagonists
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
US5990107A (en) * 1996-06-28 1999-11-23 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
WO1998000134A1 (en) * 1996-06-28 1998-01-08 Merck & Co., Inc. Fibrinogen receptor antagonists
US5932582A (en) * 1996-06-28 1999-08-03 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
US5945545A (en) * 1996-12-13 1999-08-31 Merck & Co., Inc. Fibrinogen receptor antagonists
AU7675798A (en) 1998-04-09 1999-11-01 Meiji Seika Kaisha Ltd. Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof

Also Published As

Publication number Publication date
PE63996A1 (en) 1997-01-24
DE19526678A1 (en) 1997-01-23
DE19533639A1 (en) 1997-03-13
DE4446301A1 (en) 1996-06-27
CO4700299A1 (en) 1998-12-29
KR987000970A (en) 1998-04-30

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