YU78600A - Poboljšani postupak dobijanja adukta schiff-ove baze amina sa 0-hidroksi aldehidima i na njima baziranih formulacija materijala - Google Patents
Poboljšani postupak dobijanja adukta schiff-ove baze amina sa 0-hidroksi aldehidima i na njima baziranih formulacija materijalaInfo
- Publication number
- YU78600A YU78600A YU78600A YU78600A YU78600A YU 78600 A YU78600 A YU 78600A YU 78600 A YU78600 A YU 78600A YU 78600 A YU78600 A YU 78600A YU 78600 A YU78600 A YU 78600A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- condensation
- weight
- improved process
- aldehyde
- final product
- Prior art date
Links
- 239000002262 Schiff base Substances 0.000 title abstract 2
- 150000004753 Schiff bases Chemical class 0.000 title abstract 2
- 150000001299 aldehydes Chemical class 0.000 title abstract 2
- 150000001412 amines Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000005494 condensation Effects 0.000 abstract 5
- 238000009833 condensation Methods 0.000 abstract 5
- 239000012467 final product Substances 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- IXWOUPGDGMCKGT-UHFFFAOYSA-N 2,3-dihydroxybenzaldehyde Chemical compound OC1=CC=CC(C=O)=C1O IXWOUPGDGMCKGT-UHFFFAOYSA-N 0.000 abstract 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000006482 condensation reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000376 reactant Substances 0.000 abstract 2
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical compound OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 abstract 2
- DGXAGETVRDOQFP-UHFFFAOYSA-N 2,6-dihydroxybenzaldehyde Chemical compound OC1=CC=CC(O)=C1C=O DGXAGETVRDOQFP-UHFFFAOYSA-N 0.000 abstract 1
- OFQBYHLLIJGMNP-UHFFFAOYSA-N 3-ethoxy-2-hydroxybenzaldehyde Chemical compound CCOC1=CC=CC(C=O)=C1O OFQBYHLLIJGMNP-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 229960003581 pyridoxal Drugs 0.000 abstract 1
- 235000008164 pyridoxal Nutrition 0.000 abstract 1
- 239000011674 pyridoxal Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Opisan je poboljsani postpak za dobijanje krajnjih proizvoda adukta kondenzovanja Schiff-ove baze cije su komponente protein, koji ima blagotvorno dejstvo na zivotinje, i aromatski o-hidroksi aldehid, a sastoji se u dovodjenju u kontakt gore navedenih komponenata u vodenoj sredini pri pH od 7,0 ili vise da bi se dobila reakciona smesa, pod uslovima koji su efikasni da se navedena reakcija kondenzovanja sustinski dovede do kraja uklanjanjem od oko 97,0% do oko 99,9% mas%, pozeljno od oko 98,0% do oko 99,0 mas% vode vec prisutne ili nastale tokom navedene reakcije kondenzovanja, konzistentnim za odrzavanje integriteta reagensa kondenzovanja i krajnjeg proizvoda, adukta, i da se osigura brzina konverzije u navedeni krajnji proizvod, adukt kondenzovanja, tj., sa rezultujucim prinosom navedenog krajnjeg proizvoda, adukta kondenzovanja, jednakim ili vecim od oko 98,5 mas%, pozeljno jednakim ili vecim od oko 99,5 mas%, bazirano na masi reaktanata. Pozeljni aromatski o-hidroksi aldehidi su o-vanilin; salicilaldehid; 2,3-dihidroksibenzaldehid; 2,6-dihidroksibenzaldehid;2-hidroksi-3-etoksibenzaldehid; ili piridoksal. Mogu se koristiti proteini iz veoma sirokog opsega. Poboljasni postupak obezbedjuje prinose preko 90% i sustinski kvantitativnu konverziju aldehida i proteina u adukt kondenzovanja.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9071498P | 1998-06-26 | 1998-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU78600A true YU78600A (sh) | 2002-11-15 |
Family
ID=22223965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU78600A YU78600A (sh) | 1998-06-26 | 1999-06-02 | Poboljšani postupak dobijanja adukta schiff-ove baze amina sa 0-hidroksi aldehidima i na njima baziranih formulacija materijala |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20030125528A1 (sh) |
| EP (1) | EP1087989A1 (sh) |
| JP (1) | JP2002519356A (sh) |
| KR (1) | KR20010083070A (sh) |
| CN (1) | CN1305490A (sh) |
| AP (1) | AP9901593A0 (sh) |
| AU (1) | AU3842499A (sh) |
| BR (1) | BR9912203A (sh) |
| CA (1) | CA2331388A1 (sh) |
| CZ (1) | CZ20004806A3 (sh) |
| GT (1) | GT199900097A (sh) |
| HU (1) | HUP0102693A3 (sh) |
| ID (1) | ID27131A (sh) |
| IL (1) | IL139585A0 (sh) |
| MA (1) | MA24885A1 (sh) |
| PA (1) | PA8476501A1 (sh) |
| PL (1) | PL345264A1 (sh) |
| RU (1) | RU2201936C2 (sh) |
| TN (1) | TNSN99133A1 (sh) |
| TR (1) | TR200003732T2 (sh) |
| UY (1) | UY25579A1 (sh) |
| WO (1) | WO2000000507A1 (sh) |
| YU (1) | YU78600A (sh) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1136080A3 (en) * | 2000-03-14 | 2002-06-05 | Pfizer Products Inc. | Use of o-vanillin and o-vanillin/trolox combinations |
| US20050142217A1 (en) * | 2000-04-26 | 2005-06-30 | Adams Michael A. | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype |
| US6432077B1 (en) * | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
| US20070219131A1 (en) * | 2004-04-15 | 2007-09-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
| KR101150242B1 (ko) | 2004-10-27 | 2012-06-13 | 유니버시티 오브 덴버 | 부신피질 자극 호르몬 유사체 및 관련 방법 |
| ITMO20060222A1 (it) * | 2006-07-10 | 2008-01-11 | Alfio Bertolini | Pacchetto di medicazione antiemorragico |
| EP2155643B1 (en) | 2007-06-08 | 2016-08-10 | MannKind Corporation | Ire-1a inhibitors |
| CN101861142A (zh) * | 2007-11-22 | 2010-10-13 | 诺沃-诺迪斯克保健股份有限公司 | 含醛化合物对液体配制因子VII(a)多肽的稳定化 |
| US20100105627A1 (en) * | 2008-09-17 | 2010-04-29 | Paul Salama | Pharmaceutical compositions and related methods of delivery |
| PL2680696T3 (pl) * | 2010-12-03 | 2015-10-30 | Dow Agrosciences Llc | Sposób wytwarzania enamin |
| CN104262600B (zh) * | 2014-09-09 | 2016-01-06 | 天津大学 | 同一侧基上含有西弗碱和巯基的双重敏感型两亲性共聚物及其制备方法与应用 |
| WO2016057754A1 (en) * | 2014-10-10 | 2016-04-14 | The University Of Kansas | Antibiotic activity of iron sequestring polymers |
| MA41462A (fr) | 2015-02-03 | 2021-05-12 | Chiasma Inc | Méthode de traitement de maladies |
| WO2017180714A1 (en) * | 2016-04-12 | 2017-10-19 | University Of Kansas | ANTIFUNGAL ACTIVITY OF lRON SEQUESTERING POLYMERS |
| CN106008566A (zh) * | 2016-06-27 | 2016-10-12 | 金子烁 | 5-氯水杨醛缩丙氨酸席夫碱锌配合物及其制备方法 |
| RU2729391C2 (ru) * | 2018-12-28 | 2020-08-06 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Моноклональное антитело, способное нейтрализовать биологическую активность интерферона бета-1а человека |
| CN110332260B (zh) * | 2019-08-12 | 2021-09-24 | 湖北康晨安宝矿业设备有限责任公司 | 一种前桥行驻一体制动器 |
| CN112194574B (zh) * | 2020-10-13 | 2022-03-29 | 天津大学 | 一种邻香草醛球形晶体的制备方法 |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
| CN113105359A (zh) * | 2021-03-05 | 2021-07-13 | 天津大学 | 一种席夫碱化合物及其制备方法 |
| CN115053909B (zh) * | 2022-06-22 | 2024-04-19 | 湖南工业大学 | 一种生物基绿色复合抗菌剂及其制备方法和应用 |
| CN116173314B (zh) * | 2023-01-17 | 2024-04-16 | 成都美益博雅材料科技有限公司 | 复合材料及其制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8703718D0 (en) * | 1987-02-18 | 1987-03-25 | Dalgety Uk Ltd | Colour production |
| EP0434765B1 (en) * | 1988-09-30 | 1995-11-08 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having schiff base linkages |
| US5198422A (en) * | 1992-06-11 | 1993-03-30 | Smithkline Beecham Corporation | Stabilized somatotropin for parenteral administration |
-
1999
- 1999-06-02 PL PL99345264A patent/PL345264A1/xx not_active Application Discontinuation
- 1999-06-02 KR KR1020007014840A patent/KR20010083070A/ko active IP Right Grant
- 1999-06-02 JP JP2000557268A patent/JP2002519356A/ja active Pending
- 1999-06-02 CA CA002331388A patent/CA2331388A1/en not_active Abandoned
- 1999-06-02 YU YU78600A patent/YU78600A/sh unknown
- 1999-06-02 AU AU38424/99A patent/AU3842499A/en not_active Abandoned
- 1999-06-02 WO PCT/IB1999/000993 patent/WO2000000507A1/en not_active Application Discontinuation
- 1999-06-02 ID IDW20002725A patent/ID27131A/id unknown
- 1999-06-02 HU HU0102693A patent/HUP0102693A3/hu unknown
- 1999-06-02 CZ CZ20004806A patent/CZ20004806A3/cs unknown
- 1999-06-02 TR TR2000/03732T patent/TR200003732T2/xx unknown
- 1999-06-02 IL IL13958599A patent/IL139585A0/xx unknown
- 1999-06-02 BR BR9912203-0A patent/BR9912203A/pt not_active IP Right Cessation
- 1999-06-02 RU RU2000133344/04A patent/RU2201936C2/ru not_active IP Right Cessation
- 1999-06-02 CN CN99807518A patent/CN1305490A/zh active Pending
- 1999-06-02 EP EP99921066A patent/EP1087989A1/en not_active Withdrawn
- 1999-06-22 UY UY25579A patent/UY25579A1/es not_active Application Discontinuation
- 1999-06-23 TN TNTNSN99133A patent/TNSN99133A1/fr unknown
- 1999-06-23 MA MA25643A patent/MA24885A1/fr unknown
- 1999-06-24 AP APAP/P/1999/001593A patent/AP9901593A0/en unknown
- 1999-06-24 GT GT199900097A patent/GT199900097A/es unknown
- 1999-06-25 PA PA19998476501A patent/PA8476501A1/es unknown
-
2002
- 2002-09-27 US US10/256,482 patent/US20030125528A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TNSN99133A1 (fr) | 2005-11-10 |
| HUP0102693A2 (hu) | 2001-11-28 |
| RU2201936C2 (ru) | 2003-04-10 |
| GT199900097A (es) | 2000-12-15 |
| PL345264A1 (en) | 2001-12-03 |
| AP9901593A0 (en) | 1999-06-30 |
| CN1305490A (zh) | 2001-07-25 |
| WO2000000507A1 (en) | 2000-01-06 |
| ID27131A (id) | 2001-03-01 |
| TR200003732T2 (tr) | 2001-06-21 |
| MA24885A1 (fr) | 1999-12-31 |
| CZ20004806A3 (cs) | 2001-08-15 |
| CA2331388A1 (en) | 2000-01-06 |
| KR20010083070A (ko) | 2001-08-31 |
| JP2002519356A (ja) | 2002-07-02 |
| BR9912203A (pt) | 2001-04-10 |
| PA8476501A1 (es) | 2001-12-14 |
| IL139585A0 (en) | 2002-02-10 |
| HUP0102693A3 (en) | 2002-12-28 |
| EP1087989A1 (en) | 2001-04-04 |
| UY25579A1 (es) | 2000-02-23 |
| US20030125528A1 (en) | 2003-07-03 |
| AU3842499A (en) | 2000-01-17 |
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