YU70804A - Controlled release oxycodone compositions - Google Patents

Controlled release oxycodone compositions

Info

Publication number
YU70804A
YU70804A YU70804A YU70804A YU70804A YU 70804 A YU70804 A YU 70804A YU 70804 A YU70804 A YU 70804A YU 70804 A YU70804 A YU 70804A YU 70804 A YU70804 A YU 70804A
Authority
YU
Yugoslavia
Prior art keywords
mass
controlled release
hours
oxycodone
released
Prior art date
Application number
YU70804A
Other languages
Serbo-Croatian (sh)
Inventor
Benjamin Oshlack
Mark Chasin
John Joseph Minogue
Robert Francis Kaiko
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of YU70804A publication Critical patent/YU70804A/en
Publication of RS50053B publication Critical patent/RS50053B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Abstract

Invention relates to a solid form of dosage with controlled release to apply orally, containing analgetically efficient quantity of oxycodone or some of the salts thereof in a matrix case, where the speed of solution release form in vitro measured in so called USP Paddle method at 100 -1 in 900 ml water solution of buffer stop (pH between 1,6 and 7,2) at 37°C between 12,5 and 42,5 % (mass) oxycodone released upon one hour, between 25 and 55 % (mass) oxydocone released upon 2 hours, between 45 and 75% (mass) oxycodone released upon 4 hours, and between 55 and 85 % (mass) oxycodone released upon 6 hours, where the release speed in vitro is actually independent of pH when pH is between 1,6 and 7,2. That form of dosage is achieved in the form of a pill. The invention herewith relates to the procedure for preparation of such an orally form of controlled release.
YUP-708/04A 1992-11-25 1993-05-21 OXYCODONOUS CONTROLLED DISPOSALS RS50053B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21014692A 1992-11-25 1992-11-25

Publications (2)

Publication Number Publication Date
YU70804A true YU70804A (en) 2005-11-28
RS50053B RS50053B (en) 2008-11-28

Family

ID=47559778

Family Applications (3)

Application Number Title Priority Date Filing Date
YU20050408A YU20050408A (en) 1992-11-25 1993-05-21 Controlled release oxycodone compositions
YU20050409A YU20050409A (en) 1992-11-25 1993-05-21 Controlled release oxycodone compositions
YU20050410A YU20050410A (en) 1992-11-25 1993-05-21 Controlled release oxycodone compositions

Family Applications Before (3)

Application Number Title Priority Date Filing Date
YU20050408A YU20050408A (en) 1992-11-25 1993-05-21 Controlled release oxycodone compositions
YU20050409A YU20050409A (en) 1992-11-25 1993-05-21 Controlled release oxycodone compositions
YU20050410A YU20050410A (en) 1992-11-25 1993-05-21 Controlled release oxycodone compositions

Country Status (2)

Country Link
RS (1) RS50053B (en)
YU (3) YU20050408A (en)

Also Published As

Publication number Publication date
YU20050409A (en) 2006-05-25
YU20050408A (en) 2006-05-25
YU20050410A (en) 2006-05-25
RS50053B (en) 2008-11-28

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