YU48688B - New 3-cycloalkil-propanamides their tautomeric form, their salts, process for their preparation - Google Patents

New 3-cycloalkil-propanamides their tautomeric form, their salts, process for their preparation

Info

Publication number
YU48688B
YU48688B YU173191A YU173191A YU48688B YU 48688 B YU48688 B YU 48688B YU 173191 A YU173191 A YU 173191A YU 173191 A YU173191 A YU 173191A YU 48688 B YU48688 B YU 48688B
Authority
YU
Yugoslavia
Prior art keywords
carbon atoms
radical
represent
propanamides
new
Prior art date
Application number
YU173191A
Other languages
Serbo-Croatian (sh)
Other versions
YU173191A (en
Inventor
Philip Thomas Hambleton
Charles John Robert Hedgecock
David Paul Kay
Elizabeth Anne Kuo
Wilfred Roger Tully
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Priority to SI9111731A priority Critical patent/SI9111731B/en
Priority to HR920979A priority patent/HRP920979B1/en
Publication of YU173191A publication Critical patent/YU173191A/en
Publication of YU48688B publication Critical patent/YU48688B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Novi 3-cikloalkil propanamidi prema opštoj formuli I: u kojoj R1 predstavlja cikloalkil grupu koja obuhvata 3-6 atoma ugljenika, R2 predstavlja atom vodonika, alkil radikal koji obuhvata 1-3 atoma ugljenika, R3,R4,R5,R6 i R7 identični ili različiti, predstavljaju atom vodonika, atom halogena, alkil radikal normalan ili račvast koji obuhvata 1-6 atoma ugljenika, alkoksi radikal normalan ili račvast koji obuhvata 1-6 atoma ugljenika, alkiltio radikal koji obuhvata 1-6 atoma ugljenika, radikal -(CH2)m-CF3, -O-(CH2)m-CF3, -S-(CH2)m-CF3 u kojima m predstavlja broj između 0 i 3, radikal gde n predstavlja broj između 1 i 3, Hal1 i Hal2 identični ili različiti i Hal i Hal3 predstavljaju atom halogena, ili R3,R4,R5,R6 i R7 identični ili različiti predstavljaju grupu nitro, azido, nitril ili -CO-R' gde R' predstavlja radikal hidroksi, alkil ili alkoksi koji obuhvata 1-3 atoma ugljenika ili R4i R5 grade zajedno grupu -O-CH2-O-; njihovi tautomerni oblici kao i njihove adicione soli sa mineralnim ili organskim bazama. - Prijava sadrži još 2 nezavisna i 4 zavisna zahteva.New 3-cycloalkyl propanamides according to general formula I: in which R 1 represents a cycloalkyl group comprising 3-6 carbon atoms, R 2 represents a hydrogen atom, an alkyl radical comprising 1-3 carbon atoms, R 3, R 4, R 5, R 6 and R 7 are identical or different, represent a hydrogen atom, a halogen atom, an alkyl radical normal or branched comprising 1-6 carbon atoms, an alkoxy radical normal or branched comprising 1-6 carbon atoms, an alkylthio radical comprising 1-6 carbon atoms, the radical - (CH2) m-CF3, -O- (CH2) m-CF3, -S- (CH2) m-CF3 in which m represents a number between 0 and 3, a radical wherein n represents a number between 1 and 3, Hal1 and Hal2 identical or different and Hal and Hal3 represent a halogen atom, or R3, R4, R5, R6 and R7 identical or different represent a group of nitro, azido, nitrile or -CO-R 'where R' represents a hydroxy, alkyl or alkoxy radical comprising 1-3 carbon atoms or R4 and R5 together form a group -O-CH2-O-; their tautomeric forms as well as their addition salts with mineral or organic bases. - The application contains 2 more independent and 4 dependent requests.

YU173191A 1990-10-30 1991-10-30 New 3-cycloalkil-propanamides their tautomeric form, their salts, process for their preparation YU48688B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9111731A SI9111731B (en) 1990-10-30 1991-10-30 Novel 3-cycloalkyl-propanamides, their tautomeric forms, their salts, processes for their preparation, use as medicaments and preparations containing them
HR920979A HRP920979B1 (en) 1990-10-30 1992-10-02 Novel 3-cycloalkylpropanamides,their tautomers and salts, process for their preparation, their use as medicaments and compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909023535A GB9023535D0 (en) 1990-10-30 1990-10-30 Chemical compounds
GB919105516A GB9105516D0 (en) 1990-10-30 1991-03-15 Chemical compounds

Publications (2)

Publication Number Publication Date
YU173191A YU173191A (en) 1994-04-05
YU48688B true YU48688B (en) 1999-07-28

Family

ID=10684539

Family Applications (1)

Application Number Title Priority Date Filing Date
YU173191A YU48688B (en) 1990-10-30 1991-10-30 New 3-cycloalkil-propanamides their tautomeric form, their salts, process for their preparation

Country Status (8)

Country Link
KR (1) KR100211480B1 (en)
GB (2) GB9023535D0 (en)
MD (1) MD901C2 (en)
RU (1) RU2073667C1 (en)
TW (1) TW202427B (en)
UA (1) UA26393A (en)
YU (1) YU48688B (en)
ZA (1) ZA918633B (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2546271A1 (en) * 1975-10-16 1977-04-28 Hoechst Ag Fungicides contg. substd. cyano-acetanilide derivs. - esp. as seed dressings against Helminthosporium gramineum of barley
DE2555789A1 (en) * 1975-12-11 1977-07-07 Hoechst Ag Antiinflammatory and analgesic hydroxy-methylene-cyano-acetanilides - prepd. e.g. by reacting cyanoacetanilide derivs. with ortho-esters and hydrolysing
DE2557003A1 (en) * 1975-12-18 1977-06-23 Hoechst Ag Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity
DE2555685A1 (en) * 1975-12-11 1977-06-23 Hoechst Ag Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity
DE3669709D1 (en) * 1985-05-22 1990-04-26 Rhone Poulenc Chimie METHOD FOR PERFLUORALCYLATING AROMATIC DERIVATIVES.
US4888357A (en) * 1988-01-26 1989-12-19 Bristol-Myers Company Antiarthritic β-cycloalkyl-β-oxopropionitriles

Also Published As

Publication number Publication date
GB9105516D0 (en) 1991-05-01
GB9023535D0 (en) 1990-12-12
MD901B2 (en) 1998-01-31
ZA918633B (en) 1992-12-30
RU2073667C1 (en) 1997-02-20
YU173191A (en) 1994-04-05
KR920007986A (en) 1992-05-27
MD901C2 (en) 1998-09-30
KR100211480B1 (en) 1999-08-02
TW202427B (en) 1993-03-21
UA26393A (en) 1999-08-30

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