MD901C2 - Cycloalkyl-propanamides, manifestimg the anti-inflammatory and immuno-suppressing activity, process for preparation thereof, cyanamide and pharmaceutical composition - Google Patents

Cycloalkyl-propanamides, manifestimg the anti-inflammatory and immuno-suppressing activity, process for preparation thereof, cyanamide and pharmaceutical composition

Info

Publication number
MD901C2
MD901C2 MD94-0372A MD940372A MD901C2 MD 901 C2 MD901 C2 MD 901C2 MD 940372 A MD940372 A MD 940372A MD 901 C2 MD901 C2 MD 901C2
Authority
MD
Moldova
Prior art keywords
propanamides
cycloalkyl
manifestimg
cyanamide
immuno
Prior art date
Application number
MD94-0372A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD901B2 (en
Inventor
Philip Thomas Hambleton
Charles John Robert Hedgecock
David Paul Kay
Elizabeth Anne Kuo
Wilfred Roger Tully
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD901B2 publication Critical patent/MD901B2/en
Publication of MD901C2 publication Critical patent/MD901C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to the organic chemistry, particularly to the new 7- cycloalkyl-propanamides, their tautomeric kinds and salts as well as to the process for obtaining and application thereof. the purpose of the invention consists in obtaining new 7- cycloalkyl-propanamides as well as their salts. The new products of the invention correspond to the general formula:and have some pharmacological properties. Particularly, they manifest antiinflammatory activity, impeding the inflamatory occurrences, caused by the irritating substances on the one hand and reaction of delayed allergy on the other hand.
MD94-0372A 1990-10-30 1994-07-14 Cycloalkyl-propanamides, manifestimg the anti-inflammatory and immuno-suppressing activity, process for preparation thereof, cyanamide and pharmaceutical composition MD901C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909023535A GB9023535D0 (en) 1990-10-30 1990-10-30 Chemical compounds

Publications (2)

Publication Number Publication Date
MD901B2 MD901B2 (en) 1998-01-31
MD901C2 true MD901C2 (en) 1998-09-30

Family

ID=10684539

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0372A MD901C2 (en) 1990-10-30 1994-07-14 Cycloalkyl-propanamides, manifestimg the anti-inflammatory and immuno-suppressing activity, process for preparation thereof, cyanamide and pharmaceutical composition

Country Status (8)

Country Link
KR (1) KR100211480B1 (en)
GB (2) GB9023535D0 (en)
MD (1) MD901C2 (en)
RU (1) RU2073667C1 (en)
TW (1) TW202427B (en)
UA (1) UA26393A (en)
YU (1) YU48688B (en)
ZA (1) ZA918633B (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2546271A1 (en) * 1975-10-16 1977-04-28 Hoechst Ag Fungicides contg. substd. cyano-acetanilide derivs. - esp. as seed dressings against Helminthosporium gramineum of barley
DE2557003A1 (en) * 1975-12-18 1977-06-23 Hoechst Ag Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity
DE2555685A1 (en) * 1975-12-11 1977-06-23 Hoechst Ag Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity
DE2555789A1 (en) * 1975-12-11 1977-07-07 Hoechst Ag Antiinflammatory and analgesic hydroxy-methylene-cyano-acetanilides - prepd. e.g. by reacting cyanoacetanilide derivs. with ortho-esters and hydrolysing
EP0206951A2 (en) * 1985-05-22 1986-12-30 Rhone-Poulenc Chimie Process for the perfluoroalkylation of aromatic derivatives
EP0326107A1 (en) * 1988-01-26 1989-08-02 Bristol-Myers Squibb Company Antiarthritic beta-cycloalkyl-beta-oxopropionitriles

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2546271A1 (en) * 1975-10-16 1977-04-28 Hoechst Ag Fungicides contg. substd. cyano-acetanilide derivs. - esp. as seed dressings against Helminthosporium gramineum of barley
DE2555685A1 (en) * 1975-12-11 1977-06-23 Hoechst Ag Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity
DE2555789A1 (en) * 1975-12-11 1977-07-07 Hoechst Ag Antiinflammatory and analgesic hydroxy-methylene-cyano-acetanilides - prepd. e.g. by reacting cyanoacetanilide derivs. with ortho-esters and hydrolysing
DE2557003A1 (en) * 1975-12-18 1977-06-23 Hoechst Ag Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity
EP0206951A2 (en) * 1985-05-22 1986-12-30 Rhone-Poulenc Chimie Process for the perfluoroalkylation of aromatic derivatives
EP0326107A1 (en) * 1988-01-26 1989-08-02 Bristol-Myers Squibb Company Antiarthritic beta-cycloalkyl-beta-oxopropionitriles

Also Published As

Publication number Publication date
ZA918633B (en) 1992-12-30
YU173191A (en) 1994-04-05
UA26393A (en) 1999-08-30
GB9023535D0 (en) 1990-12-12
YU48688B (en) 1999-07-28
RU2073667C1 (en) 1997-02-20
KR100211480B1 (en) 1999-08-02
TW202427B (en) 1993-03-21
KR920007986A (en) 1992-05-27
MD901B2 (en) 1998-01-31
GB9105516D0 (en) 1991-05-01

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20140714

KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees