YU48336B - PROCEDURE FOR PREPARATION OF 6,7-DICHLORO-1,5-DIHYDROIMADAZO / 2,1-B / HINAZOLINE-2 / 3H / ON - Google Patents

PROCEDURE FOR PREPARATION OF 6,7-DICHLORO-1,5-DIHYDROIMADAZO / 2,1-B / HINAZOLINE-2 / 3H / ON

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Publication number
YU48336B
YU48336B YU53792A YU53792A YU48336B YU 48336 B YU48336 B YU 48336B YU 53792 A YU53792 A YU 53792A YU 53792 A YU53792 A YU 53792A YU 48336 B YU48336 B YU 48336B
Authority
YU
Yugoslavia
Prior art keywords
ether
dihydroimadazo
dichloro
cyanoimino
quinazolin
Prior art date
Application number
YU53792A
Other languages
Serbo-Croatian (sh)
Other versions
YU53792A (en
Inventor
J. Reiter
P. Trinka
P. Tompe
E. Szabo
P. Slegel
P. Brlik
A. Halbauer
I. Sztruhar
M. Kenyeres
F. Gorgenyi
M. Scorgo
S. Zsarnoczai
S. Benko
Original Assignee
Egis Gyogyszegyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU170891A external-priority patent/HU209633B/en
Application filed by Egis Gyogyszegyar filed Critical Egis Gyogyszegyar
Publication of YU53792A publication Critical patent/YU53792A/en
Publication of YU48336B publication Critical patent/YU48336B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

POSTUPAK ZA DOBIJANJE 6,7-DIHLORO-1,5-DIHIDROIMADAZO/2,1-B/HINAZOLIN-2/3H/ON formule: ili njihovih soli uključujući njihove hidrate, naznačen time, što se /2-(cijanoimino)-5,6-di-(hloro)-1,2,3,4-tetra-(hidro)-hinazolin-3-il/acetonitril ili alkil estar /2-(cijanoimino)-5,6-di-(hloro)-1,2,3,4-tetra-(hidro)-hinazolin-3-il/-sirćetne kiseline opšte formule: gde R1 je cijano grupa ili grupa formule: u kojoj R1 predstavlja alkil grupu normalnog ili račvastog lanca koja sadrži 1 do 6 atoma ugljenika, koja po izboru nosi fenil supstituent, podvrgava termičkoj ciklizaciji u kiseloj sredini sa etilen glikol etrom, etilen glikol dimetil etrom, etilen glikoldietil etrom, dietilen glikol dimetil etrom, dietilen glikol dietil etrom, 2-(metoksi)etanolom, 2-(etoksi)-etanolom, N-(metil)-pirolidonom, dimetilformamidom, acetonitrilom i/ili dioksanom i/ili alifatičnom organskom kiselinom koja ima 1 do 4 atoma ugljenika kao rastvaračem. Prijava sadrži još 10 zavisnih zahteva.A process for the preparation of 6,7-Dichloro-1,5-dihydroimadazo / 2,1-B / quinazoline-2 / 3H / ON formulas: or salts thereof, including their hydrates, wherein / 2- (cyanoimino) -5 , 6-di- (chloro) -1,2,3,4-tetra- (hydro) -quinazolin-3-yl / acetonitrile or alkyl ester / 2- (cyanoimino) -5,6-di- (chloro) - 1,2,3,4-Tetra- (hydro) -quinazolin-3-yl] -acetic acid of the general formula: wherein R 1 is a cyano group or formula group: in which R 1 represents an alkyl group of a normal or branched chain containing from 1 to 6 the carbon atom, optionally bearing a phenyl substituent, undergoes thermal cyclization in an acidic environment with ethylene glycol ether, ethylene glycol dimethyl ether, ethylene glycoldiethyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, 2- (methoxy) ethanol, ethoxy) -ethanol, N- (methyl) -pyrrolidone, dimethylformamide, acetonitrile and / or dioxane and / or aliphatic organic acid having 1 to 4 carbon atoms as solvent. The application contains 10 more dependent requests.

YU53792A 1991-05-22 1992-05-21 PROCEDURE FOR PREPARATION OF 6,7-DICHLORO-1,5-DIHYDROIMADAZO / 2,1-B / HINAZOLINE-2 / 3H / ON YU48336B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU170791A HU208681B (en) 1991-05-22 1991-05-22 Process for producing quinazoline derivatives
HU170891A HU209633B (en) 1991-05-22 1991-05-22 New process for producing 6,7-dichloro-1,5-dihydroimidazo/2,1-b/-quinazoline-2/3h/-one

Publications (2)

Publication Number Publication Date
YU53792A YU53792A (en) 1994-11-15
YU48336B true YU48336B (en) 1998-05-15

Family

ID=10955782

Family Applications (1)

Application Number Title Priority Date Filing Date
YU53792A YU48336B (en) 1991-05-22 1992-05-21 PROCEDURE FOR PREPARATION OF 6,7-DICHLORO-1,5-DIHYDROIMADAZO / 2,1-B / HINAZOLINE-2 / 3H / ON

Country Status (2)

Country Link
HU (1) HU208681B (en)
YU (1) YU48336B (en)

Also Published As

Publication number Publication date
HU911707D0 (en) 1991-12-30
YU53792A (en) 1994-11-15
HU208681B (en) 1993-12-28
HUT61003A (en) 1992-11-30

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