HUT61003A - Process for producing quinazoline derivatives - Google Patents

Process for producing quinazoline derivatives

Info

Publication number
HUT61003A
HUT61003A HU170791A HU170791A HUT61003A HU T61003 A HUT61003 A HU T61003A HU 170791 A HU170791 A HU 170791A HU 170791 A HU170791 A HU 170791A HU T61003 A HUT61003 A HU T61003A
Authority
HU
Hungary
Prior art keywords
esp
acid
iii
reaction
ethylene glycol
Prior art date
Application number
HU170791A
Other languages
Hungarian (hu)
Other versions
HU911707D0 (en
HU208681B (en
Inventor
Peter Trinka
Peter Reiter
Peter Slegel
Peter Toempe
Eva Szabo
Janos Brlik
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU170791A priority Critical patent/HU208681B/en
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of HU911707D0 publication Critical patent/HU911707D0/en
Priority to JP4151259A priority patent/JPH05271200A/en
Priority to YU53792A priority patent/YU48336B/en
Priority to SU925011723A priority patent/RU2042678C1/en
Priority to GB9210908A priority patent/GB2256195B/en
Priority to ES92108656T priority patent/ES2095349T3/en
Priority to AT92108656T priority patent/ATE146789T1/en
Priority to EP92108656A priority patent/EP0514917B1/en
Priority to CS921538A priority patent/CZ281671B6/en
Priority to DE69216143T priority patent/DE69216143T2/en
Publication of HUT61003A publication Critical patent/HUT61003A/en
Priority to US08/156,974 priority patent/US5391737A/en
Publication of HU208681B publication Critical patent/HU208681B/en

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Prepn. of 6,7-dichloro-1,5-dihydro -imidazo(2,1-b)quinazolin-2(3H)-one (I;i.e. aragrelide) or its salt or hydrate, comprises cyclising a tetrahydro-quinazoline deriv. of formula (III) by heating in an acidic medium. R1=CN or COOR2; R2=1-6C alkyl opt. substd. by Ph. Cpds. (III) are also claimed. - Reaction is in one or more inert solvents (esp. ethylene glycol, ethylene glycol-dimethyl ether or-diethyl ether, diethylene glycol-dimethyl ether or-diethyl ether, 2-methoxyethanol, 2-ethoxyethanol, N-methylpyrrolidone, DMF, Mecro and/or dioxan). The acid is a mineral acid (esp.tke) or a 1-4C aliphatic acid (esp. acetic acid). Reaction is of 80-130degC.
HU170791A 1991-05-22 1991-05-22 Process for producing quinazoline derivatives HU208681B (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
HU170791A HU208681B (en) 1991-05-22 1991-05-22 Process for producing quinazoline derivatives
JP4151259A JPH05271200A (en) 1991-05-22 1992-05-20 Production of 6,7-dichloro-1,5-dihydro-imidazo(2,1-b)quinazolin-2(3h)-one
YU53792A YU48336B (en) 1991-05-22 1992-05-21 PROCEDURE FOR PREPARATION OF 6,7-DICHLORO-1,5-DIHYDROIMADAZO / 2,1-B / HINAZOLINE-2 / 3H / ON
SU925011723A RU2042678C1 (en) 1991-05-22 1992-05-21 Method of synthesis of 6,7-dichloro-1,5-dihydroimidazo-[2,1-b]-quinazoline-2-(3h)-one, intermediates for their synthesis and a method of their synthesis
GB9210908A GB2256195B (en) 1991-05-22 1992-05-21 Process for the preparation of 6,7-dichloro-1,5-dihydroimidazo [2,1-b] quinazolin-2 [3H]-one
ES92108656T ES2095349T3 (en) 1991-05-22 1992-05-22 PROCEDURE AND DERIVATIVES OF 2- (CIANOIMINO) -QUINAZOLINE USEFUL AS INTERMEDIATES FOR THE PREPARATION OF 6,7-DICHLORO-1,5-DI (HYDRO) IMIDAZO (2,1-B) QUINAZOLIN-2 (3H) -ONE AND PROCEDURE FOR THE PREPARATION OF THE DERIVATIVES OF 2- (CIANOIMINO) -QUINAZOLINE.
DE69216143T DE69216143T2 (en) 1991-05-22 1992-05-22 Process and 2- (cyanoimino) quinazlin intermediates for the preparation of 6,7-di (chloro) -1,5-di (hydro) imidazo- [2,1-b] quinazolin-2 [3H] -one as well Process for rendering the 2- (cyanoimino) quinazoline
AT92108656T ATE146789T1 (en) 1991-05-22 1992-05-22 PROCESS AND 2-(CYANOIMINO)-QUINAZLINE INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF 6,7-DI(CHLORO)-1,5-DI(HYDRO)-IMIDAZO-(2,1- B>QUINAZOLINE-2(3H>-ON AS WELL PROCESS FOR PREPARING 2-(CYANOIMINO)QUINAZOLINE
EP92108656A EP0514917B1 (en) 1991-05-22 1992-05-22 Process for and 2-(cyanoimino)-quinazoline derivatives useful as intermediates in the preparation of 6,7-di-(chloro)-1,5-di(hydro)-imidazo-[2,1-b]quinazolin-2[3H]-one and process for preparing the 2-(cyanoimino)-quinazoline derivatives
CS921538A CZ281671B6 (en) 1991-05-22 1992-05-22 PROCESS FOR PREPARING 6,7-DICHLORO-1,5-DIHYDROIMIDAZO/2,1-b/QUINAZOLIN-2-/3H/-ONE AND A STARTING SUBSTANCE FOR MAKING THE SAME
US08/156,974 US5391737A (en) 1991-05-22 1993-11-24 Process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2[3H]-one

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU170791A HU208681B (en) 1991-05-22 1991-05-22 Process for producing quinazoline derivatives

Publications (3)

Publication Number Publication Date
HU911707D0 HU911707D0 (en) 1991-12-30
HUT61003A true HUT61003A (en) 1992-11-30
HU208681B HU208681B (en) 1993-12-28

Family

ID=10955782

Family Applications (1)

Application Number Title Priority Date Filing Date
HU170791A HU208681B (en) 1991-05-22 1991-05-22 Process for producing quinazoline derivatives

Country Status (2)

Country Link
HU (1) HU208681B (en)
YU (1) YU48336B (en)

Also Published As

Publication number Publication date
HU911707D0 (en) 1991-12-30
YU48336B (en) 1998-05-15
YU53792A (en) 1994-11-15
HU208681B (en) 1993-12-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee