YU48197A - Vinyl-pyrolidinic cefalosporines with base supstituents production thereof, intermedieries used therein, pharma-ceutical preparations containing final products and application thereof in production of medicaments - Google Patents
Vinyl-pyrolidinic cefalosporines with base supstituents production thereof, intermedieries used therein, pharma-ceutical preparations containing final products and application thereof in production of medicamentsInfo
- Publication number
- YU48197A YU48197A YU48197A YU48197A YU48197A YU 48197 A YU48197 A YU 48197A YU 48197 A YU48197 A YU 48197A YU 48197 A YU48197 A YU 48197A YU 48197 A YU48197 A YU 48197A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- production
- hydrogen
- formula
- hydroxy
- supstituents
- Prior art date
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na derivate cefalosporina opšte formule u kojoj X je CH ili N, R1 je vodonik ili ciklopentil, R2 je grupa formule R3 je vodonik, alkalnometalni jon ili tercijarna amonijum-grupa, R4 je vodonik, grupa koja štiti amino-grupu, pirolidin-2-ilmetil, azetidin-3-ilmetil, iminometil, 1-karbamimidoil, R5 je vodonik, dialkilkarbamoil, ω-hidroksialkil, ω-aminoalkil, piridinium-1-ilmetil, 1-hidroksi-3-aminometil-propil ili (hidroksi)-(pirolidin-2-il)metil, R6 je vodonik, trifluorometili li hidroksi, i R7 je alkil, ω-hidroksi-alkil, cikloalkil, 3-pirolidinil, 3-azetidinil, iminometil ili 1-karbamimidoil, kao i na njihove lako hidrolizuuće estre, farmaceutski prihvatljive soli pomenutih jedinjenja i hidrate jedinjenja formule I i njihove estre i soli; pronalazak se dalje odnosi na dobivanje jedinjenja formule I, njihiovu primenu kao farmaceutski aktivnih supstanci, naročito za lečenje i profilaksu infekcionih oboljenja, i na farmaceutske preparate koji sadrže jedinjenje formule I za lečenje i profilaksu infekcionih oboljenja.The present invention relates to cephalosporin derivatives of general formula wherein X is CH or N, R 1 is hydrogen or cyclopentyl, R 2 is a group of formula R 3 is hydrogen, an alkali metal ion or a tertiary ammonium group, R 4 is hydrogen, a group protecting an amino group, Pyrrolidin-2-ylmethyl, azetidin-3-ylmethyl, iminomethyl, 1-carbamimidoyl, R5 is hydrogen, dialkylcarbamoyl, ω-hydroxyalkyl, ω-aminoalkyl, pyridinium-1-ylmethyl, 1-hydroxy-3-aminomethyl-propyl or (hydroxy ) - ((pyrrolidin-2-yl) methyl, R6 is hydrogen, trifluoromethyl or hydroxy, and R7 is alkyl, ω-hydroxy-alkyl, cycloalkyl, 3-pyrrolidinyl, 3-azetidinyl, iminomethyl or 1-carbamimidoyl, and to their easily hydrolyzable esters, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and their esters and salts; the invention further relates to the preparation of compounds of formula I, their use as pharmaceutically active substances, in particular for the treatment and prophylaxis of infectious diseases, and to pharmaceutical compositions containing a compound of formula I for the treatment and prophylaxis of infectious diseases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96120472 | 1996-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU48197A true YU48197A (en) | 2000-10-30 |
Family
ID=8223516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU48197A YU48197A (en) | 1996-12-19 | 1997-12-10 | Vinyl-pyrolidinic cefalosporines with base supstituents production thereof, intermedieries used therein, pharma-ceutical preparations containing final products and application thereof in production of medicaments |
Country Status (11)
| Country | Link |
|---|---|
| AR (1) | AR009669A1 (en) |
| BR (1) | BRPI9705650B8 (en) |
| CO (1) | CO4930271A1 (en) |
| HR (1) | HRP970691A2 (en) |
| ID (1) | ID19269A (en) |
| PE (1) | PE47399A1 (en) |
| PL (1) | PL323854A1 (en) |
| TR (1) | TR199701643A2 (en) |
| UY (1) | UY24814A1 (en) |
| YU (1) | YU48197A (en) |
| ZA (1) | ZA9711214B (en) |
-
1997
- 1997-12-10 YU YU48197A patent/YU48197A/en unknown
- 1997-12-12 PE PE1997001116A patent/PE47399A1/en not_active Application Discontinuation
- 1997-12-12 ZA ZA9711214A patent/ZA9711214B/en unknown
- 1997-12-17 HR HR96120472.4A patent/HRP970691A2/en not_active Application Discontinuation
- 1997-12-17 CO CO97073566A patent/CO4930271A1/en unknown
- 1997-12-17 ID IDP973903A patent/ID19269A/en unknown
- 1997-12-17 BR BRPI9705650 patent/BRPI9705650B8/en unknown
- 1997-12-17 UY UY24814A patent/UY24814A1/en not_active Application Discontinuation
- 1997-12-18 AR ARP970105959A patent/AR009669A1/en active IP Right Grant
- 1997-12-18 TR TR97/01643A patent/TR199701643A2/en unknown
- 1997-12-18 PL PL97323854A patent/PL323854A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE47399A1 (en) | 1999-05-14 |
| CO4930271A1 (en) | 2000-06-27 |
| TR199701643A3 (en) | 1998-07-21 |
| AR009669A1 (en) | 2000-04-26 |
| HRP970691A2 (en) | 1998-10-31 |
| TR199701643A2 (en) | 1998-07-21 |
| ZA9711214B (en) | 1998-06-19 |
| BRPI9705650B1 (en) | 2011-06-28 |
| MX9710004A (en) | 1998-09-30 |
| ID19269A (en) | 1998-06-28 |
| BRPI9705650A (en) | 1999-05-25 |
| UY24814A1 (en) | 2000-12-29 |
| BRPI9705650B8 (en) | 2021-07-06 |
| PL323854A1 (en) | 1998-06-22 |
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