YU45634B - PROCESS FOR THE PREPARATION OF 1- / 2- / 5-DIMETHYLAMINOMETHYL-2- (FURYLMETHYLTHIOL) -ETHYL / -AMINO-1-METHYLAMINO-2-NITROETHYLENE HYDROCHLORIDE - Google Patents

PROCESS FOR THE PREPARATION OF 1- / 2- / 5-DIMETHYLAMINOMETHYL-2- (FURYLMETHYLTHIOL) -ETHYL / -AMINO-1-METHYLAMINO-2-NITROETHYLENE HYDROCHLORIDE

Info

Publication number
YU45634B
YU45634B YU122484A YU122484A YU45634B YU 45634 B YU45634 B YU 45634B YU 122484 A YU122484 A YU 122484A YU 122484 A YU122484 A YU 122484A YU 45634 B YU45634 B YU 45634B
Authority
YU
Yugoslavia
Prior art keywords
nitroethylene
methylamino
dimethylaminomethyl
hydrochloride
ethyl
Prior art date
Application number
YU122484A
Other languages
Serbo-Croatian (sh)
Other versions
YU122484A (en
Inventor
E. Kasztreiner
O. Fuchs
A. Lazar
N. Makk
T. Lang
B. Stefko
T. Balogh
T. Somogyi
J. Engler
J. Kosary
J. Borvendeg
E. Hudiesler
A. Szabo
P. Matyus
B. Vitalis
L. Toldy
Original Assignee
Richter Gedeon Vegyeszeti Gyar R.T.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU251583A external-priority patent/HU193497B/en
Priority claimed from HU251483A external-priority patent/HU193496B/en
Application filed by Richter Gedeon Vegyeszeti Gyar R.T. filed Critical Richter Gedeon Vegyeszeti Gyar R.T.
Publication of YU122484A publication Critical patent/YU122484A/xx
Publication of YU45634B publication Critical patent/YU45634B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Abstract

POSTUPAK ZA DOBIJANJE HIDROHLORIDA 1-/2-/5-DIMETILAMINOMETIL-2-(FURILMETILTIO)-ETIL /-AMINO-1-METILAMINO-2-NITROETILENA, formule (I): i, ako se želi, za transformisanje ovog jedinjenja u bazu formule (I), naznačen time, što obuhvata reakciju monohidrohlorida 2-/(2-aminoetil)-tiometil/-5-dimetil-aminoetilfurana formule (II): sa 1-metiltio-1-metilamino-2-nitroetilenom formule (III). po izboru u prisustvu vode na temperaturi izmedju 20 i 90 C.A PROCESS FOR THE PREPARATION OF 1- / 2- / 5-DIMETHYLAMINOMETHYL-2- (FURYLMETHYLTHIO) -ETHYL / 1-AMINO-1-METHYLAMINO-2-NITROETHYLENE HYDROCHLORIDE, of formula (I): and, if desired, for transforming this compound into a base of formula (I), comprising reacting 2 - [(2-aminoethyl) -thiomethyl] -5-dimethyl-aminoethylfuran monohydrochloride of formula (II): with 1-methylthio-1-methylamino-2-nitroethylene of formula (III) . optionally in the presence of water at a temperature between 20 and 90 C.

YU122484A 1983-07-15 1984-07-13 PROCESS FOR THE PREPARATION OF 1- / 2- / 5-DIMETHYLAMINOMETHYL-2- (FURYLMETHYLTHIOL) -ETHYL / -AMINO-1-METHYLAMINO-2-NITROETHYLENE HYDROCHLORIDE YU45634B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU251583A HU193497B (en) 1983-07-15 1983-07-15 Process for preparing sanitidine hydrogen halogenides
HU251483A HU193496B (en) 1983-07-15 1983-07-15 Process for production of basic tioether and it salts i

Publications (2)

Publication Number Publication Date
YU122484A YU122484A (en) 1986-10-31
YU45634B true YU45634B (en) 1992-07-20

Family

ID=26317525

Family Applications (1)

Application Number Title Priority Date Filing Date
YU122484A YU45634B (en) 1983-07-15 1984-07-13 PROCESS FOR THE PREPARATION OF 1- / 2- / 5-DIMETHYLAMINOMETHYL-2- (FURYLMETHYLTHIOL) -ETHYL / -AMINO-1-METHYLAMINO-2-NITROETHYLENE HYDROCHLORIDE

Country Status (13)

Country Link
KR (1) KR910007966B1 (en)
AR (1) AR242029A1 (en)
AT (1) AT389873B (en)
CA (1) CA1279328C (en)
CS (1) CS248717B2 (en)
DK (1) DK162525C (en)
ES (1) ES534363A0 (en)
FI (1) FI88157C (en)
MX (1) MX159694A (en)
NO (1) NO842904L (en)
SE (1) SE457082B (en)
SU (1) SU1384197A3 (en)
YU (1) YU45634B (en)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
KR840002007B1 (en) * 1980-01-08 1984-10-27 그랙소 그룹 리밋티드 Process for the preparation of a furan derivative
NO811501L (en) * 1980-05-13 1981-11-16 Crc Ricerca Chim PROCEDURE FOR THE PREPARATION OF ETHENDIAMINE DERIVATIVES, AND INTERMEDIATES FOR THESE
ES8200358A1 (en) * 1980-09-30 1981-11-01 Inke Sa PROCEDURE FOR OBTAINING N-2-5- (DIMETHYLAMINE) METHYL-2-FURANIL METHYL THIO-N-METHYL-2-NITRO-1,1-ETHENODIAMINE. (Machine-translation by Google Translate, not legally binding)
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
ES8200101A1 (en) * 1980-12-03 1981-10-16 Inke Sa Procedure for the obtaining of N- (2- (((5- ((dimethylamino) methyl) -2-furanil) methyl) tio) ethyl) -n'-methyl-2-nitro-1,1-etenodyamine (Machine-translation by Google Translate, not legally binding)
ES497737A0 (en) * 1980-12-13 1981-11-16 Parellada Llauger Miguel PROCEDURE FOR OBTAINING N- (2 - ((5 - ((DIMETHYLAMI-NO) METHYL) FURFURIL) THIO) ETHYL) -N'- METHYL -2- NITRO-1,1- ETHENO- DIAMINE
JPS57134476A (en) * 1980-12-30 1982-08-19 Glaxo Group Ltd Manufacture of furan derivatives
PT74235B (en) * 1980-12-30 1984-01-04 Glaxo Group Ltd Process for the preparation of a furan derivative
PT74459B (en) * 1981-02-20 1984-10-09 Glaxo Group Ltd Process for the preparation of a furan derivative
ES8300325A1 (en) * 1981-05-02 1982-11-01 Especialidades Farmaco Terape Procedure for the obtaining of a compound derived from the furfurilico alcohol. (Machine-translation by Google Translate, not legally binding)
AR229878A1 (en) * 1981-05-07 1983-12-30 Glaxo Group Ltd PROCEDURE FOR PREPARING RANITIDINE
ES502940A0 (en) * 1981-06-10 1982-11-01 Lafarquim PROCEDURE FOR OBTAINING DERIVATIVES OF FURIL METHYL MERCAPTAN AND ITS SALTS OF PHARMACOLOGICAL INTEREST
ES8301226A1 (en) * 1981-11-20 1982-11-16 Especialidades Latinas Medic U Procedure for obtaining N- (2-5-dimethylamine, methyl-2-furanyl-methyl-thio-ethyl-n'-methyl-s-nitro-etano-diamine. (Machine-translation by Google Translate, not legally binding)
ES8300327A1 (en) * 1982-01-13 1982-11-01 Barisintex Sa Procedure for the obtaining of derivatives of aminoalkilfuranos. (Machine-translation by Google Translate, not legally binding)
ES511830A0 (en) * 1982-04-30 1983-02-01 Inke Sa PROCEDURE FOR OBTAINING N-2- (5- (DIMETILANMINO) METHYL-2-FURANIL) METHYL) THIO) ETHYL) -N'-METHYL-2-NITRO-1,1-ETHENO-DIAMINE.
ES512315A0 (en) * 1982-05-19 1983-02-01 Tabah Papo Marcelo PROCEDURE FOR THE OBTAINING OF A NEW FURANIC DERIVATIVE OF THERAPEUTIC INTEREST.

Also Published As

Publication number Publication date
KR850001187A (en) 1985-03-16
FI88157B (en) 1992-12-31
MX159694A (en) 1989-08-07
DK345284A (en) 1985-01-16
YU122484A (en) 1986-10-31
CS248717B2 (en) 1987-02-12
SE457082B (en) 1988-11-28
DK345284D0 (en) 1984-07-13
FI842822A (en) 1985-01-16
SE8403717L (en) 1985-01-16
ES8602732A1 (en) 1985-12-01
FI842822A0 (en) 1984-07-13
ES534363A0 (en) 1985-12-01
DK162525B (en) 1991-11-11
SE8403717D0 (en) 1984-07-13
AR242029A1 (en) 1993-02-26
SU1384197A3 (en) 1988-03-23
KR910007966B1 (en) 1991-10-04
ATA227284A (en) 1989-07-15
NO842904L (en) 1985-01-16
AT389873B (en) 1990-02-12
FI88157C (en) 1993-04-13
DK162525C (en) 1992-03-30
CA1279328C (en) 1991-01-22

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