ES8200358A1 - PROCEDURE FOR OBTAINING N-2-5- (DIMETHYLAMINE) METHYL-2-FURANIL METHYL THIO-N-METHYL-2-NITRO-1,1-ETHENODIAMINE. (Machine-translation by Google Translate, not legally binding)
- Google Patents
PROCEDURE FOR OBTAINING N-2-5- (DIMETHYLAMINE) METHYL-2-FURANIL METHYL THIO-N-METHYL-2-NITRO-1,1-ETHENODIAMINE. (Machine-translation by Google Translate, not legally binding)
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Inke SA
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Inke SA
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Priority to ES495493ApriorityCriticalpatent/ES495493A0/en
Publication of ES8200358A1publicationCriticalpatent/ES8200358A1/en
Publication of ES495493A0publicationCriticalpatent/ES495493A0/en
PROCEDURE FOR OBTAINING N- (2 - ((((5 - ((DIMETHYLAMINE) METHYL) -2FURANIL) METHYL) THIO) ETHYL) -N'' - METHYL-2-NITRO-1,1-ETHENODIAMINE, OF FORMULA (I). EQUIMOLAR AMOUNTS OF 2 - ((((2-FURANIL) METHYL) THIO) ETHANOAMINE, OF FORMULA (II), AND OF 1,1-BIS (METHYLITHIUM) -2-NITROETHENE, ARE REACTIONED AT A TEMPERATURE OF 0-120C, IN AN AQUEOUS MEDIUM OR IN AN ORGANIC SOLVENT. THE REACTION PRODUCT IS TREATED WITH A AUCOUS SOLUTION OF 40 METHYLAMINE BY WEIGHT, USING A LOWER ALCOHOL AS A SOLVENT, AND AT A TEMPERATURE BETWEEN 0C AND THE REFLUX OF THE SOLVENT. EXCESS OF METHYLAMINE IS ELIMINATED; THE PRODUCT OBTAINED IS WASHED WITH WATER AND REACTED WITH FORMALDEHYDE AND DIMETHYLAMINE. THE FINAL PRODUCT IS PURIFIED BY RECRISTALIZATION IN A SOLVENT. OF APPLICATION IN THE GASTRODUODENAL ULCER AND ALL THE SYNDROMES ACCOMPANIED BY GASTRIC SECRETION. (Machine-translation by Google Translate, not legally binding)
2-nitro aminopyrimidone derivatives, a process for their preparation and their use to prepare 2-aminopyrimidone derivatives which have histamine H2-antagonist activity.
PROCEDURE FOR OBTAINING N-2-5- (DIMETHYLAMINE) METHYL-2-FURANIL METHYL THIO-N-METHYL-2-NITRO-1,1-ETHENODIAMINE. (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of N- (2 - ((5 - ((dimethylamine) methyl) furfuril) tio) ethyl) -n'-methyl -2- nitro-1,1- etenodyamine (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of N- (2- (((5- ((dimethylamino) methyl) -2-furanil) methyl) tio) ethyl) -n'-methyl-2-nitro-1,1-etenodyamine (Machine-translation by Google Translate, not legally binding)
Procedure for the preparation of N- (2 - ((5- (dimethylamino) -metil-2-furanil) methyl) tio) ethyl) -n'-methyl-2-nitro 1,1-etenodyamine (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of N-2- (5- (dimethylaminum) methyl-2-furanil) methyl) tio) ethyl) -n'-methyl-2-nitro-1,1-etenodyamine. (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of N- (2 - ((5- (dimethylamine) methyl) -2-furanil) methyl) tio) ethyl) -n'-methyl-2-nitro-1,1-etenodyamine (Machine-translation by Google Translate, not legally binding)
Procedure for preparation of hydrochloride 1- (2- (5-dimethylaminomethyl-2- (furylmethyl) ethyl) -amino-1-methylamine-2-nitroethylene (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of N-2- (5- (dimethylamino) methyl-2-furanil) methyl tio ethyl-n '- (2-etanol) -2-nitro-1,1-etenodyamine. (Machine-translation by Google Translate, not legally binding)
Procedure for the obtaining of N- (2-oxo-1-pirrolidinil) acetyl piperazines substituted. (Machine-translation by Google Translate, not legally binding)