YU26399A - Diphenylalkyl-tetrahydropyridines, process for their preparation, and pharmaceutical composition containing them - Google Patents
Diphenylalkyl-tetrahydropyridines, process for their preparation, and pharmaceutical composition containing themInfo
- Publication number
- YU26399A YU26399A YU26399A YU26399A YU26399A YU 26399 A YU26399 A YU 26399A YU 26399 A YU26399 A YU 26399A YU 26399 A YU26399 A YU 26399A YU 26399 A YU26399 A YU 26399A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- preparation
- pharmaceutical composition
- composition containing
- tetrahydropyridines
- diphenylalkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000000508 neurotrophic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Pronalazak se odnosi na jedinjenja formule (I): u kojoj Y predstavlja -CH- ili -N-; R1 predstavlja, halaogen, grupu CF3, (C1-C4) alkil ili (C1-C-4) alkoksil; R2 i R3 svaki predstavlja vodonik ili (C1-C3) alkil; n predstavlja 0 ili 1; Ph1 i Ph2 svaki predstavlja, nezavisno, fenil grupu koja nije supstituisana ili je mono- ili polisupstituisana. Pronalazak se takodje odnosi na postupak za njihovo dobijanje i na farmaceutski preparat koji ih sadrži. Ova jedinjenja imaju neurotrofičnu i neuroprotektorsku aktivnost.The invention relates to compounds of formula (I): wherein Y represents -CH- or -N-; R 1 represents, halogen, a CF 3 group, (C 1 -C 4) alkyl or (C 1 -C 4) alkoxyl; R 2 and R 3 each represent hydrogen or (C 1 -C 3) alkyl; n represents 0 or 1; Ph1 and Ph2 each independently represent a phenyl group which is unsubstituted or mono- or polysubstituted. The invention also relates to a process for their preparation and to a pharmaceutical composition containing them. These compounds have neurotrophic and neuroprotective activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9615336A FR2757161B1 (en) | 1996-12-13 | 1996-12-13 | DIPHENYLALKYL-TETRAHYDROPYRIDINES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU26399A true YU26399A (en) | 2000-03-21 |
| RS49672B RS49672B (en) | 2007-11-15 |
Family
ID=9498642
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6124318A (en) |
| EP (1) | EP0950049B1 (en) |
| JP (1) | JP2001505903A (en) |
| KR (1) | KR100549656B1 (en) |
| CN (1) | CN1144784C (en) |
| AT (1) | ATE207056T1 (en) |
| AU (1) | AU730142B2 (en) |
| BR (1) | BR9713926A (en) |
| CA (1) | CA2274946C (en) |
| CY (1) | CY2282B1 (en) |
| CZ (1) | CZ290242B6 (en) |
| DE (1) | DE69707504T2 (en) |
| DK (1) | DK0950049T3 (en) |
| EE (1) | EE03764B1 (en) |
| ES (1) | ES2167805T3 (en) |
| FR (1) | FR2757161B1 (en) |
| HK (1) | HK1024001A1 (en) |
| HU (1) | HUP0001437A3 (en) |
| IL (2) | IL130001A0 (en) |
| IS (1) | IS2001B (en) |
| NO (1) | NO313282B1 (en) |
| NZ (1) | NZ336032A (en) |
| PL (1) | PL192926B1 (en) |
| PT (1) | PT950049E (en) |
| RS (1) | RS49672B (en) |
| RU (1) | RU2198874C2 (en) |
| SI (1) | SI0950049T1 (en) |
| SK (1) | SK283332B6 (en) |
| TR (1) | TR199901290T2 (en) |
| UA (1) | UA52708C2 (en) |
| WO (1) | WO1998025904A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2763847B1 (en) * | 1997-05-28 | 2003-06-06 | Sanofi Sa | USE OF 4-SUBSTITUTED TETRAHYDROPYRIDINES FOR MANUFACTURING TGF-BETA-1 MEDICAMENTS |
| WO2001078709A2 (en) * | 2000-04-12 | 2001-10-25 | Minerva Biotechnologies Corporation | Treatment of neurodegenerative disease |
| US6699866B2 (en) | 2001-04-17 | 2004-03-02 | Sepracor Inc. | Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof |
| CA2551946A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Immediate, controlled and sustained release formulations of galantamine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1321701A (en) * | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
| BE775611A (en) * | 1970-11-24 | 1972-03-16 | Synthelabo | DERIVATIVES OF (DIPHENYL-3,3 PROPYL-1) -1 PIPERIDINE, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING IT |
| FR2650505B1 (en) * | 1989-08-07 | 1994-06-03 | Midy Spa | USE OF TRIFLUOROMETHYLPHENYLTETRAHYDROPYRIDINES FOR THE PREPARATION OF MEDICINES FOR COMBATING INTESTINAL MOTORITY DISORDERS |
| US5266573A (en) * | 1989-08-07 | 1993-11-30 | Elf Sanofi | Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders |
| FR2662355B1 (en) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | USE OF 1- [2- (2-NAPHTYL) ETHYL] -4- (3-TRIFLUOROMETHYLPHENYL) -1,2,3,6-TETRAHYDROPYRIDINE FOR THE PREPARATION OF MEDICINES FOR THE TREATMENT OF BRAIN AND NEURAL DISORDERS. |
| US5512584A (en) * | 1991-04-16 | 1996-04-30 | Basf Aktiengesellschaft | 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof |
| HU211019B (en) * | 1991-12-02 | 1995-09-28 | Richter Gedeon Vegyeszet | Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds |
| DK148392D0 (en) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocyclic Compounds |
-
1996
- 1996-12-13 FR FR9615336A patent/FR2757161B1/en not_active Expired - Fee Related
-
1997
- 1997-12-11 US US09/331,005 patent/US6124318A/en not_active Expired - Fee Related
- 1997-12-12 KR KR1019997005202A patent/KR100549656B1/en not_active IP Right Cessation
- 1997-12-12 NZ NZ336032A patent/NZ336032A/en unknown
- 1997-12-12 CN CNB971805830A patent/CN1144784C/en not_active Expired - Fee Related
- 1997-12-12 RU RU99115082/04A patent/RU2198874C2/en not_active IP Right Cessation
- 1997-12-12 ES ES97951326T patent/ES2167805T3/en not_active Expired - Lifetime
- 1997-12-12 PL PL334073A patent/PL192926B1/en not_active IP Right Cessation
- 1997-12-12 UA UA99063287A patent/UA52708C2/en unknown
- 1997-12-12 RS YUP-263/99A patent/RS49672B/en unknown
- 1997-12-12 CZ CZ19992110A patent/CZ290242B6/en not_active IP Right Cessation
- 1997-12-12 CA CA002274946A patent/CA2274946C/en not_active Expired - Fee Related
- 1997-12-12 DE DE69707504T patent/DE69707504T2/en not_active Expired - Fee Related
- 1997-12-12 SK SK787-99A patent/SK283332B6/en unknown
- 1997-12-12 DK DK97951326T patent/DK0950049T3/en active
- 1997-12-12 HU HU0001437A patent/HUP0001437A3/en unknown
- 1997-12-12 AU AU54895/98A patent/AU730142B2/en not_active Ceased
- 1997-12-12 PT PT97951326T patent/PT950049E/en unknown
- 1997-12-12 WO PCT/FR1997/002289 patent/WO1998025904A1/en not_active Application Discontinuation
- 1997-12-12 AT AT97951326T patent/ATE207056T1/en not_active IP Right Cessation
- 1997-12-12 TR TR1999/01290T patent/TR199901290T2/en unknown
- 1997-12-12 JP JP52632398A patent/JP2001505903A/en not_active Ceased
- 1997-12-12 EE EEP199900238A patent/EE03764B1/en not_active IP Right Cessation
- 1997-12-12 BR BR9713926A patent/BR9713926A/en not_active Application Discontinuation
- 1997-12-12 EP EP97951326A patent/EP0950049B1/en not_active Expired - Lifetime
- 1997-12-12 SI SI9730241T patent/SI0950049T1/en unknown
- 1997-12-12 IL IL13000197A patent/IL130001A0/en active IP Right Grant
-
1999
- 1999-05-18 IL IL130001A patent/IL130001A/en not_active IP Right Cessation
- 1999-06-10 IS IS5074A patent/IS2001B/en unknown
- 1999-06-11 NO NO19992870A patent/NO313282B1/en unknown
-
2000
- 2000-05-31 HK HK00103246A patent/HK1024001A1/en not_active IP Right Cessation
-
2002
- 2002-05-15 CY CY0200036A patent/CY2282B1/en unknown
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