YU22703A - Postupak za izolovanje farmaceutski primenljivog dinatrijumetidronata - Google Patents
Postupak za izolovanje farmaceutski primenljivog dinatrijumetidronataInfo
- Publication number
- YU22703A YU22703A YU22703A YUP22703A YU22703A YU 22703 A YU22703 A YU 22703A YU 22703 A YU22703 A YU 22703A YU P22703 A YUP22703 A YU P22703A YU 22703 A YU22703 A YU 22703A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- etidronate disodium
- liquid
- exploitable
- isolating
- pharmaceutically
- Prior art date
Links
- GWBBVOVXJZATQQ-UHFFFAOYSA-L etidronate disodium Chemical compound [Na+].[Na+].OP(=O)([O-])C(O)(C)P(O)([O-])=O GWBBVOVXJZATQQ-UHFFFAOYSA-L 0.000 title abstract 5
- 229940083571 etidronate disodium Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000006185 dispersion Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000012074 organic phase Substances 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Pronalazak se odnosi na postupak za izolovanje dinatrijumetidronata, pri čemu se a) tečnost-tečnost disperzija sastavljena iz - jedne vodeno-organske i - jedne vodene faze koja sadrži dinatrijumetidronat postavi na temperaturu od 0В°C do 30В°C i intenzivno meša, b) zatim se iz tečno-tečno disperzije istaloži krupnozrna frakcija, c) u drugom produženom koraku iz organske faze istaloži frakcija finog zrna, kao i novi oblik čvrstog tela ninatrijumetidronata, koji može da se dobije ovim postupkom. Pripremljen je postupak za dobijanje dinatrijumetidronata sa veličinom zrna u području od 0,2 do 1,0 mm, sa dobrom sposobnošću sipanja, odnosno visokom nasipnom gustinom i sa tim vezano visokom farmaceutskom primenljivošću.[The invention relates to a method for isolating etidronate disodium. According to said method, a liquid-liquid dispersion consisting of an aqueous-organic phase and an aqueous phase containing the etidronate disodium salt is set to a temperature of between 0 В°C and 30 В°C and is intensively mixed; a coarse-grained fraction is subsequently precipitated out of the liquid-liquid dispersion and in a second, delayed step, a fine-grained fraction is precipitated out of the organic phase. The invention also relates to a novel solid form of etidronate disodium that can be obtained using this method. The invention provides a method for producing etidronate disodium with a particle size in the region of 0.2 to 1.0 mm, good flowability and a high bulk density, coupled with properties that can be pharmaceutically exploited to advantage.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10049735A DE10049735A1 (de) | 2000-09-28 | 2000-09-28 | Verfahren zur Isolierung von pharmazeutisch verwertbarem Etidronat-Dinatrium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU22703A true YU22703A (sh) | 2006-08-17 |
Family
ID=7659017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU22703A YU22703A (sh) | 2000-09-28 | 2001-09-28 | Postupak za izolovanje farmaceutski primenljivog dinatrijumetidronata |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6974885B2 (sh) |
| EP (1) | EP1320535B1 (sh) |
| JP (1) | JP3759927B2 (sh) |
| KR (1) | KR100562822B1 (sh) |
| CN (1) | CN1244586C (sh) |
| AT (1) | ATE273314T1 (sh) |
| AU (2) | AU2344902A (sh) |
| BG (1) | BG107668A (sh) |
| BR (1) | BR0114281A (sh) |
| CA (1) | CA2434790C (sh) |
| CZ (1) | CZ2003880A3 (sh) |
| DE (2) | DE10049735A1 (sh) |
| DK (1) | DK1320535T3 (sh) |
| EA (1) | EA004688B1 (sh) |
| EE (1) | EE200300122A (sh) |
| ES (1) | ES2227308T3 (sh) |
| HK (1) | HK1061859A1 (sh) |
| HR (1) | HRP20030335B1 (sh) |
| HU (1) | HUP0301226A3 (sh) |
| IL (2) | IL155081A0 (sh) |
| MX (1) | MXPA03002666A (sh) |
| NO (1) | NO20031399L (sh) |
| NZ (1) | NZ525142A (sh) |
| PL (1) | PL361060A1 (sh) |
| PT (1) | PT1320535E (sh) |
| SK (1) | SK3912003A3 (sh) |
| UA (1) | UA73612C2 (sh) |
| WO (1) | WO2002026751A1 (sh) |
| YU (1) | YU22703A (sh) |
| ZA (1) | ZA200303212B (sh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2940105C (en) * | 2014-02-27 | 2022-07-05 | Unilever Plc | Water soluble laundry capsule comprising reduced levels of fines in hedp |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL124638C (sh) * | 1961-07-03 | |||
| US3855284A (en) * | 1963-11-02 | 1974-12-17 | Henkel & Cie Gmbh | Process for the manufacture of phosphonic acids and phosphonates having at least two phosphorus atoms |
| DE1261850B (de) * | 1965-03-30 | 1968-02-29 | Procter & Gamble | Verfahren zur Herstellung von AEthan-1-hydroxy-1,1-diphosphonsaeure |
| NL149701C (nl) * | 1965-12-08 | 1981-05-15 | Procter & Gamble | Werkwijze voor het bereiden van een tegen tandsteen werkzaam tandverzorgingsmiddel, dat als werkzaam bestanddeel een fosfonzuurderivaat bevat, alsmede gevormd tandverzorgingsmiddel. |
| US3497313A (en) * | 1966-12-29 | 1970-02-24 | Procter & Gamble | Carbonyldiphosphonates |
| US3527795A (en) * | 1967-11-20 | 1970-09-08 | Monsanto Co | Process for preparing water-soluble salts of organic phosphorus acids |
| NL175882C (nl) * | 1977-03-28 | Procter & Gamble | Farmaceutisch preparaat, dat een verbinding met ontstekingtegengaande werking bevat. | |
| GB2095694B (en) * | 1981-03-31 | 1984-08-01 | Hollaway E R Ltd | Tooth cleaning compositions |
| US4504463A (en) * | 1982-06-10 | 1985-03-12 | Mallinckrodt, Inc. | Process for making a lyophilized product for use in skeletal imaging |
| US6143923A (en) * | 1996-10-02 | 2000-11-07 | Lonza Inc. | Process for manufacturing 1-hydroxyalkylidene-1,1-diphosphonic acid (HADP) |
-
2000
- 2000-09-28 DE DE10049735A patent/DE10049735A1/de not_active Withdrawn
-
2001
- 2001-09-28 YU YU22703A patent/YU22703A/sh unknown
- 2001-09-28 EP EP01985659A patent/EP1320535B1/de not_active Expired - Lifetime
- 2001-09-28 PL PL01361060A patent/PL361060A1/xx unknown
- 2001-09-28 CA CA002434790A patent/CA2434790C/en not_active Expired - Fee Related
- 2001-09-28 NZ NZ525142A patent/NZ525142A/en unknown
- 2001-09-28 CZ CZ2003880A patent/CZ2003880A3/cs unknown
- 2001-09-28 HU HU0301226A patent/HUP0301226A3/hu unknown
- 2001-09-28 BR BR0114281-0A patent/BR0114281A/pt not_active IP Right Cessation
- 2001-09-28 KR KR1020037004495A patent/KR100562822B1/ko not_active IP Right Cessation
- 2001-09-28 AU AU2344902A patent/AU2344902A/xx active Pending
- 2001-09-28 CN CNB018165478A patent/CN1244586C/zh not_active Expired - Fee Related
- 2001-09-28 EA EA200300396A patent/EA004688B1/ru not_active IP Right Cessation
- 2001-09-28 WO PCT/DE2001/003766 patent/WO2002026751A1/de active IP Right Grant
- 2001-09-28 IL IL15508101A patent/IL155081A0/xx active IP Right Grant
- 2001-09-28 JP JP2002531135A patent/JP3759927B2/ja not_active Expired - Fee Related
- 2001-09-28 UA UA2003043905A patent/UA73612C2/uk unknown
- 2001-09-28 EE EEP200300122A patent/EE200300122A/xx unknown
- 2001-09-28 DE DE50103250T patent/DE50103250D1/de not_active Expired - Fee Related
- 2001-09-28 AT AT01985659T patent/ATE273314T1/de not_active IP Right Cessation
- 2001-09-28 DK DK01985659T patent/DK1320535T3/da active
- 2001-09-28 AU AU2002223449A patent/AU2002223449B2/en not_active Ceased
- 2001-09-28 PT PT01985659T patent/PT1320535E/pt unknown
- 2001-09-28 MX MXPA03002666A patent/MXPA03002666A/es active IP Right Grant
- 2001-09-28 ES ES01985659T patent/ES2227308T3/es not_active Expired - Lifetime
- 2001-09-28 US US10/381,535 patent/US6974885B2/en not_active Expired - Fee Related
- 2001-09-28 SK SK391-2003A patent/SK3912003A3/sk not_active Application Discontinuation
-
2003
- 2003-03-25 BG BG107668A patent/BG107668A/bg unknown
- 2003-03-25 IL IL155081A patent/IL155081A/en not_active IP Right Cessation
- 2003-03-27 NO NO20031399A patent/NO20031399L/no not_active Application Discontinuation
- 2003-04-24 ZA ZA200303212A patent/ZA200303212B/en unknown
- 2003-04-28 HR HR20030335A patent/HRP20030335B1/xx not_active IP Right Cessation
-
2004
- 2004-07-06 HK HK04104884A patent/HK1061859A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AUPP355798A0 (en) | Process for the production of ultrafine powders | |
| MXPA03007053A (es) | Suspension de cemento de muy baja densidad. | |
| WO2002013786A3 (en) | Method of forming microparticles | |
| SE0000454D0 (sv) | Iron powder and method for the preparaton thereof | |
| AU2002223558A1 (en) | Method for producing polymer coated pigment particles by precipitation | |
| AU2002365069A1 (en) | High quality colloidal nanocrystals and methods of preparation of the same in non-coordinating solvents | |
| PL346244A1 (en) | Method for producing aqueous dispersions of (co)polymers, dispersions obtained using said method, redispersible powders which can be obtained from said dispersions and use thereof | |
| BR0206164A (pt) | Partìculas cristalinas de oxalato de escitalopram, método para a produção de partìculas cristalinas de oxalato de escitalopram, e, forma de dosagem unitária sólida | |
| CA2430318A1 (en) | Powder formulation and method for producing the same | |
| CA2138125A1 (en) | Process for Making Compact Detergent Compositions | |
| MY121489A (en) | Process for producing rare earth metal-based permanent magnet having corrosion-resistant film | |
| WO2003031466A3 (en) | Angiotensin peptide-carrier conjugates and uses thereof | |
| EP1859787A3 (de) | Aufstreuverfahren zur Herstellung von Pulverformulierungen | |
| AU2680000A (en) | Cementitious compositions | |
| HK1037622A1 (en) | Particle-forming compositions containing fused pyrrolocarbrazoles | |
| YU22703A (sh) | Postupak za izolovanje farmaceutski primenljivog dinatrijumetidronata | |
| NO924938L (no) | Fremgangsmaate for fremstilling av kobberpulver | |
| DK1135108T3 (da) | Fremgangsmåde til fremstilling af agglomerater med kerne-skal struktur | |
| AU2002321293A1 (en) | Process for the preparation of methionine | |
| MY139687A (en) | Ceramics particle | |
| MY128492A (en) | Blowing agent powder and process for producing the same | |
| DE60102485D1 (de) | Herstellung von aluminium-silizium-legierungen | |
| TW200517504A (en) | Producing method of sintered ore, producing method of material for sintered ore, agglomerated particle and sintered ore | |
| MY135453A (en) | Recycled ceramic slurry, recycled ceramic powder, ceramic electronic part, and fabricating methods therefor | |
| EP1118404A4 (en) | ALLOY POWDER, SINTERED ALLOY PELLETS AND METHOD FOR THE PRODUCTION THEREOF |