YU102403A - Postupci za dizajniranje leka, baziranog na strukturi, za identifikovanje inhibitora d-ala-d-ala ligaze, kao antibakterijskih lekova - Google Patents
Postupci za dizajniranje leka, baziranog na strukturi, za identifikovanje inhibitora d-ala-d-ala ligaze, kao antibakterijskih lekovaInfo
- Publication number
- YU102403A YU102403A YU102403A YUP102403A YU102403A YU 102403 A YU102403 A YU 102403A YU 102403 A YU102403 A YU 102403A YU P102403 A YUP102403 A YU P102403A YU 102403 A YU102403 A YU 102403A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- ala
- enzyme
- identifying
- drug design
- based drug
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Pronalazak se zasniva na otkriću da odredjeni mali molekuli mogu da se vežu za mesto vezivanja ATF-a u D-Ala-D-Ala ligazi, čak i u odsustvu supstrata enzima, i da mogu da dovedu do konformacione promene u strukturi enzima, slično promeni koja se dešava nakon vezivanja ATF-a i supstrata za enzim. Bez namere da se oslonac potraži u nekoj teoriji, veruje se da su ovakve konformacione promene potrebne, bilo za aktivaciju, bilo za inhibiciju enzima. Podatak dobijen iz ovog otkrića, omogućio je identifikaciju ključnih interakcija u aktivnom mestu enzima, kao i dizajn i podešavanje inhibitora.[The invention is based on the discovery that certain small molecules can bind to the ATP binding site of D-Ala-D-Ala ligase, even in the absence of the enzyme's substrate, and can cause a conformational change in the enzyme structure similar to that which occurs upon binding of ATP and substrate to the enzyme. Without wishing to be bound by any theory, it is believed that such a conformational change is required for either activation or inhibition of the enzyme. The information obtained from this discovery has enabled identification of key interactions in the active site of the enzyme, as well as the design and opimization of inhibitors.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30167601P | 2001-06-28 | 2001-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU102403A true YU102403A (sh) | 2006-08-17 |
Family
ID=23164377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU102403A YU102403A (sh) | 2001-06-28 | 2002-06-28 | Postupci za dizajniranje leka, baziranog na strukturi, za identifikovanje inhibitora d-ala-d-ala ligaze, kao antibakterijskih lekova |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20030119061A1 (sh) |
| EP (1) | EP1412516A4 (sh) |
| CN (1) | CN1268765C (sh) |
| BG (1) | BG108549A (sh) |
| BR (1) | BR0211312A (sh) |
| CA (1) | CA2451837A1 (sh) |
| CZ (1) | CZ200441A3 (sh) |
| EA (1) | EA007612B1 (sh) |
| EE (1) | EE200400044A (sh) |
| HU (1) | HUP0600158A2 (sh) |
| IL (1) | IL159539A0 (sh) |
| MX (1) | MXPA04000157A (sh) |
| PL (1) | PL367484A1 (sh) |
| SK (1) | SK282004A3 (sh) |
| WO (1) | WO2003002063A2 (sh) |
| YU (1) | YU102403A (sh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329060B2 (en) * | 2008-10-22 | 2012-12-11 | General Electric Company | Blue-green and green phosphors for lighting applications |
| WO2016050199A1 (zh) * | 2014-09-30 | 2016-04-07 | 三峡大学 | 一种鸟氨酸脱羧酶的药物设计口袋及其应用 |
| CN108504647B (zh) * | 2018-03-09 | 2021-11-05 | 中山大学 | 一种dna促旋酶的药物结合口袋及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6251620B1 (en) * | 1995-08-30 | 2001-06-26 | Ariad Pharmaceuticals, Inc. | Three dimensional structure of a ZAP tyrosine protein kinase fragment and modeling methods |
| US6037117A (en) * | 1997-01-31 | 2000-03-14 | Smithkline Beecham Corporation | Methods using the Staphylococcus aureus glycyl tRNA synthetase crystalline structure |
| US6183121B1 (en) * | 1997-08-14 | 2001-02-06 | Vertex Pharmaceuticals Inc. | Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets |
-
2002
- 2002-06-28 WO PCT/US2002/020465 patent/WO2003002063A2/en not_active Application Discontinuation
- 2002-06-28 YU YU102403A patent/YU102403A/sh unknown
- 2002-06-28 EE EEP200400044A patent/EE200400044A/xx unknown
- 2002-06-28 CN CNB028152700A patent/CN1268765C/zh not_active Expired - Fee Related
- 2002-06-28 HU HU0600158A patent/HUP0600158A2/hu unknown
- 2002-06-28 SK SK28-2004A patent/SK282004A3/sk not_active Application Discontinuation
- 2002-06-28 CZ CZ200441A patent/CZ200441A3/cs unknown
- 2002-06-28 CA CA002451837A patent/CA2451837A1/en not_active Abandoned
- 2002-06-28 PL PL02367484A patent/PL367484A1/xx not_active Application Discontinuation
- 2002-06-28 US US10/186,886 patent/US20030119061A1/en not_active Abandoned
- 2002-06-28 MX MXPA04000157A patent/MXPA04000157A/es unknown
- 2002-06-28 EA EA200400093A patent/EA007612B1/ru unknown
- 2002-06-28 IL IL15953902A patent/IL159539A0/xx unknown
- 2002-06-28 BR BR0211312-0A patent/BR0211312A/pt not_active IP Right Cessation
- 2002-06-28 EP EP02749688A patent/EP1412516A4/en not_active Withdrawn
-
2004
- 2004-01-28 BG BG108549A patent/BG108549A/bg unknown
-
2006
- 2006-08-01 US US11/461,678 patent/US20070207512A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0600158A2 (en) | 2006-05-29 |
| PL367484A1 (en) | 2005-02-21 |
| EA007612B1 (ru) | 2006-12-29 |
| US20030119061A1 (en) | 2003-06-26 |
| CA2451837A1 (en) | 2003-01-09 |
| SK282004A3 (sk) | 2005-06-02 |
| US20070207512A1 (en) | 2007-09-06 |
| EA200400093A1 (ru) | 2005-06-30 |
| CZ200441A3 (cs) | 2004-08-18 |
| MXPA04000157A (es) | 2005-06-06 |
| EP1412516A4 (en) | 2004-09-08 |
| BG108549A (bg) | 2005-02-28 |
| CN1539020A (zh) | 2004-10-20 |
| EP1412516A2 (en) | 2004-04-28 |
| EE200400044A (et) | 2004-10-15 |
| IL159539A0 (en) | 2004-06-01 |
| WO2003002063A2 (en) | 2003-01-09 |
| CN1268765C (zh) | 2006-08-09 |
| WO2003002063A3 (en) | 2003-02-20 |
| BR0211312A (pt) | 2004-07-13 |
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| YU102403A (sh) | Postupci za dizajniranje leka, baziranog na strukturi, za identifikovanje inhibitora d-ala-d-ala ligaze, kao antibakterijskih lekova | |
| ITTO20010813A0 (it) | Procedimento per il trasferimento di messaggi tramite udp, relativo sistema e prodotto informatico. |