WO2026050737A1 - Procédé de traitement de neurofibromes cutanés (nfc) - Google Patents

Procédé de traitement de neurofibromes cutanés (nfc)

Info

Publication number
WO2026050737A1
WO2026050737A1 PCT/US2025/044347 US2025044347W WO2026050737A1 WO 2026050737 A1 WO2026050737 A1 WO 2026050737A1 US 2025044347 W US2025044347 W US 2025044347W WO 2026050737 A1 WO2026050737 A1 WO 2026050737A1
Authority
WO
WIPO (PCT)
Prior art keywords
subject
vector
cnf
ohsvl
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/044347
Other languages
English (en)
Inventor
Renyuan Bai
Verena STAEDTKE
Carlos Romo
Jaishri BLAKELEY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of WO2026050737A1 publication Critical patent/WO2026050737A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/763—Herpes virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente divulgation concerne une méthode de traitement de neurofibromes cutanés (NFC) chez des patients atteints de neurofibromatose de type 1 (NF1) à l'aide de talimogène laherparepvec (T-VEC), un vecteur de virus herpès simplex oncolytique 1 (oHSV1), à titre d'exemple illustratif. La méthode comprend l'administration à un sujet d'une quantité efficace de T-VEC, typiquement par injection intratumorale. La T-VEC est génétiquement modifiée pour améliorer la sélectivité tumorale et stimuler des réponses immunitaires antitumorales. Le traitement implique une dose initiale suivie de doses ultérieures à des intervalles spécifiés. Le procédé peut comprendre des administrations répétées et une combinaison avec des thérapies supplémentaires pour traiter NFc ou NF1. Cette approche offre une alternative potentielle non invasive aux traitements actuels des NFc chez les patients atteints de NF1.
PCT/US2025/044347 2024-08-29 2025-08-29 Procédé de traitement de neurofibromes cutanés (nfc) Pending WO2026050737A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463688787P 2024-08-29 2024-08-29
US63/688,787 2024-08-29

Publications (1)

Publication Number Publication Date
WO2026050737A1 true WO2026050737A1 (fr) 2026-03-05

Family

ID=98931112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/044347 Pending WO2026050737A1 (fr) 2024-08-29 2025-08-29 Procédé de traitement de neurofibromes cutanés (nfc)

Country Status (1)

Country Link
WO (1) WO2026050737A1 (fr)

Similar Documents

Publication Publication Date Title
Becker et al. Efficacy of epidural perineural injections with autologous conditioned serum for lumbar radicular compression: an investigator-initiated, prospective, double-blind, reference-controlled study
TWI643614B (zh) 低頻率格拉替雷（ｇｌａｔｉｒａｍｅｒ）醋酸鹽之治療
ES2811124T3 (es) Uso de reslizumab para tratar el asma eosinofílica moderada a grave
CN107206073A (zh) 通过施用il‑4r拮抗剂用于治疗伴随鼻息肉的慢性鼻窦炎的方法
JP2013100313A (ja) Ｔａｃｉ融合分子を使用する自己免疫疾患を治療するための方法
ES2733602T3 (es) Métodos para incrementar el volumen espiratorio forzado en pacientes asmáticos que usan benralizumab
US7507703B2 (en) Method of cancer screening; method of cancer treatment; and method of diabetes treatment
Saberi et al. Ondansetron or promethazine: which one is better for the treatment of acute peripheral vertigo?
Masoumi et al. Dexmedetomidine versus midazolam-fentanyl in procedural analgesia sedation for reduction of anterior shoulder dislocation: a randomized clinical trial
Hurlbert et al. A prospective randomized double-blind controlled trial to evaluate the efficacy of an analgesic epidural paste following lumbar decompressive surgery
JP7732784B2 (ja) ワクチンを使用して癌または皮膚病変を治療するための方法および組成物
Pavelka et al. Efficacy and tolerability of injectable collagen-containing products in comparison to trimecaine in patients with acute lumbar spine pain (Study FUTURE-MD-Back Pain).
Sadatsune et al. Effect of preoperative gabapentin on pain intensity and development of chronic pain after carpal tunnel syndrome surgical treatment in women: randomized, double-blind, placebo-controlled study
Fathallah‐Shaykh et al. Response of primary leptomeningeal melanoma to intrathecal recombinant interleukin‐2: A case report
Gutzmer et al. Practical clinical guide on the use of talimogene laherparepvec monotherapy in patients with unresectable melanoma in Europe
Rauf et al. CTNI-42. PHASE I STUDY OF RUXOLITINIB WITH RADIATION AND TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GRADE III GLIOMAS AND GLIOBLASTOMA
Dharmasaroja Early flare-ups of myasthenia gravis after thoracoscopic thymectomy in a patient recently receiving BNT162b2 mRNA COVID-19 vaccination
RU2524309C1 (ru) Способ выбора тактики лечения местно-распространенного рака предстательной железы
Poonkuzhali et al. A study on the efficacy of erector spinae plane block with ropivacaine as post-op analgesia for modified radical mastectomy surgery
WO2022061812A1 (fr) Utilisation d'acétate de glatiramère dans la préparation d'inhibiteur et piégeur de toxicité de abêta42
Çapkin et al. Infliximab-induced palmoplantar psoriasis in a patient with ankylosing spondylitis
Pisansky et al. Catheter tip-associated mass with continuous infusion of sufentanil for persistent spinal pain syndrome Type 2: a case report including histopathologic examination and review of the associated basic and clinical research
Khurana et al. Comparison of intrathecal chloroprocaine with bupivacaine in short gynecological procedures: A randomized double-blind study
WO2009138094A1 (fr) Compositions pharmaceutiques
Steglatro New Drug Approvals

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 25861515

Country of ref document: EP

Kind code of ref document: A1