WO2025012902A1 - Novaluron aqueous stable composition - Google Patents
Novaluron aqueous stable composition Download PDFInfo
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- WO2025012902A1 WO2025012902A1 PCT/IL2024/050673 IL2024050673W WO2025012902A1 WO 2025012902 A1 WO2025012902 A1 WO 2025012902A1 IL 2024050673 W IL2024050673 W IL 2024050673W WO 2025012902 A1 WO2025012902 A1 WO 2025012902A1
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- novaluron
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- weight ratio
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/04—Insecticides
Definitions
- the present invention relates to a stable aqueous composition comprising novaluron, at least two wetting agents, and at least two dispersing agents.
- Novaluron ( ⁇ )-l-[3-chloro-4-(l,l,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6- difluorobenzoyl)urea, is used as insect growth regulators (IGR).
- IGR insect growth regulators
- the most commonly used formulations for solid water insoluble pesticides are suspension concentrates, emulsifiable concentrate and emulsion in water formulations which are liquid formulations and where the pesticide is dissolved in organic carrier.
- Novaluron is solid at ambient temperature, has an extremely low water solubility and very low wettability. As such, it is highly challenging to formulate high amounts of novaluron especially in water-based compositions.
- WO2022/264064 discloses water dispersible solid compositions comprising novaluron and an organo-silicone based surfactant.
- novaluron discloses water dispersible solid compositions comprising novaluron and an organo-silicone based surfactant.
- organo-silicone based surfactant there is still a need for stable, high load, easy to handle and efficient liquid compositions of novaluron.
- the present invention provides a stable high load agrochemical composition comprising of: (a) an amount of novaluron; (b) a system of at least two wetting agents; and (c) a system of at least two dispersing agents.
- the present invention further provides use of at least two wetting agents and at least two dispersing agents for increasing the stability of a liquid composition comprising novaluron.
- the present invention further provides use of the composition as disclosed herein for treating a plant.
- the present invention further provides a method of treating a plant using the composition as disclosed herein.
- the present invention further provides a process for preparing a composition as disclosed herein.
- the term "effective amount” refers to an amount of the novaluron as described herein, which when ingested, contacted with or sensed, is sufficient to achieve a good level of control, i.e. sufficient for controlling harmful insects on crop plants without causing any significant damage to the treated crop plants.
- an "agriculturally acceptable additive” is a compound that is known and accepted in the art for use in the formation of compositions for agricultural or horticultural use.
- plant includes reference to the whole plant, plant organ (e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), plant cells, a locus of the plant, or propagation material thereof.
- plant organ e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.
- plant includes reference to agricultural crops including field crops (soybean, maize, wheat, rice, etc.), vegetable crops (potatoes, cabbages, etc.) and fruits (peach, etc.).
- propagation material is to be understood to denote all the generative parts of the plant such as seeds and spores, vegetative structures such as bulbs, corms, tubers, rhizomes, roots stems, basal shoots, stolons and buds.
- locus includes not only areas where insect may already exist, but also areas where insect has yet to emerge, and also to areas under cultivation.
- treating a plant is to be understood as controlling insecticidal attack or protecting a plant from insecticidal attack or a disease caused by unwanted insect or preventing insecticidal attack or plant disease caused by unwanted insect.
- ha refers to hectare
- Novaluron in water, and in particular high load of novaluron, is challenging.
- Novaluron has an extremely low water solubility and very low wettability.
- Such formulations often face problems such as high viscosity, problems in the milling process, sedimentations, and instability, especially after storage (14 days at 54°C).
- the present invention provides a stable high load agrochemical composition comprising of: (a) an amount of novaluron; (b) a system of at least two wetting agents; and (c) a system of at least two dispersing agents.
- the wetting agents are selected from organo-silicone based surfactants and alkyl polyalkylene glycol ether phosphoric acid ester acid.
- the wetting agent system is a combination of at least one organo-silicone based surfactant and at least one alkyl polyalkylene glycol ether phosphoric acid ester acid.
- the wetting agent system can optionally further include an alcohol ethoxylate.
- the alcohol ethoxylate is a secondary alcohol ethoxylate.
- the organo-silicone based surfactant is an organo-modified tri-siloxane.
- the organo-silicone based surfactant is BreakThru S-240.
- the alkyl polyalkylene glycol ether phosphoric acid ester acid form is selected from Hostaphat® 1306 (Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form), Hostaphat® CC 100 (Cetyl phosphoric acid ester, acid form, mono/diester ⁇ 98 %), SERVOXYL VPDZ 3/100 (tridecyl polyglycol ether (3EO) phosphate), PROTE-PON P-TD-06-Z (alkyl ether phosphoric acid), LUBRHOPHOS LP 700 (phosphate ester with aromatic base), RHODAFAC BG 510 (phosphate ester with aliphatic base), DERMALIX C (alkyl phosphate in aqu.
- Hostaphat® 1306 Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form
- Hostaphat® CC 100 Cetyl phosphoric acid este
- alkyl polyalkylene glycol ether phosphoric acid ester acid form is Hostaphat® 1306.
- the alcohol ethoxylate is selected form Tergitol 15-S-7, Tergitol 15-S-9, Tergitol 15-S-12, and a compound of the following structure:
- the alcohol ethoxylate is Tergitol 15-S-7.
- the dispersing agents are selected from polyelectrolyte comb copolymer, EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
- the dispersing agents system comprises a combination of polyelectrolyte comb copolymer surfactant and at least one other dispersing agent.
- the at least one other dispersing agent is selected from EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
- the polyelectrolyte comb copolymer is the polyelectrolyte disclosed in application publication WO 2017/098325, the entire content of which is incorporated herein by reference.
- the polyelectrolyte comb copolymer comprises a hydrophobic anchoring moiety and at least one hydrophilic charged stabilizing moiety.
- the hydrophilic charged stabilizing moiety comprises at least one charged monomer, preferably anionic monomer having a sulfonate group.
- the molar ratio of the hydrophobic anchoring moiety to the hydrophilic charged stabilizing moiety is 1:2-4.
- the weight ratio of the hydrophobic anchoring moiety to the hydrophilic charged stabilizing moiety is less than 0.6. In some embodiments, at least 60% by weight of the hydrophilic charged stabilizing moiety is charged monomers.
- the polyelectrolyte comb copolymer is PolyAgroA.
- PolyAgro A is a polyelectrolyte-layer forming block copolymer formulation.
- the composition of PolyAgro A is represented in the following Table:
- PolyAgro A is a di-block copolymer, with a total weight of 17000 g/mol, composed of a hydrophobic block (Anchor block- ANCHOR) and a hydrophilic block (Stabilizing block - STAB).
- the stabilizing, hydrophilic, block is made of sodium 2-Acryloylamino-2-methylpropane-l- sulfonate (AMPS) monomers, which are 77% of the overall monomers in the polymer.
- AMPS 2-Acryloylamino-2-methylpropane-l- sulfonate
- the other 23% of the monomers belongs to the anchor, hydrophobic, block which is made of ethyl acrylate monomers.
- the total amount of monomers in the polymer (degree of polymerization, DPn) is 85 monomers.
- Such polymer may be obtained from Rhodia Operations, a corporation of Paris, France, a member of the SOLVAY Group.
- Such polymer may also be prepared as described in application publication No. WO 2017/098325.
- WO 2017/098325 was applied by Rhodia Operations, a member of the SOLVAY Group, and Adama Makhteshim Ltd.
- the polyelectrolyte-layer forming block copolymer used in the formulations of the subject invention may be prepared according to the following procedure. a) Macro CTA
- the EO-PO copolymer is selected from Ethylan NS 500 (Polyalkoxylated butyl ether), Antarox B/848 (Oxirane, methyl-, polymer with oxirane), Ultraic 5000 HM (Ethoxylated and Propoxylated Alcohol), Toximul 8350 (Polyethylene-polypropylene glycol monobutyl ether), Tergitol XD (Ethylene Oxide / Propylene Oxide Block Copolymers), Atlas G-5000-S0-(CQ) (Oxirane, 2-methyl-, polymer with oxirane, monobutyl ether) , Atlas G- 5002L-LQ-(CQ) (oxirane, monobutyl ether), SYNERGEN 848 (block polyoxalkylate) , Ethylan 992 and Ultraric 5000 HM (EU source) (Polyethylene-polypropylene Glycol Monobutyl Ether).
- high-load refers to composition containing an amount of active ingredients greater than 30% w/w based on the total weight of the composition.
- the amount of the novaluron is 35-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-50% w/w, based on the total weight of the composition.
- the amount of the novaluron is 40% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 60% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
- the amount of the novaluron is between about 350 g/L to about 750 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is between about 400 g/L to about 800 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is between about 400 g/L to about 700 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is between about 400 g/L to about 600 g/L, based on the total weight of the composition. The amount of the novaluron may be an intermediate range selected from any of the above indicated ratios.
- the amount of the novaluron is about 780 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 750 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 700 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 650 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 600 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 550 g/L, based on the total weight of the composition.
- the amount of the novaluron is about 500 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 450 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 400 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 350 g/L, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
- the total amount of the wetting agents system is 1.5-10% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is 1.5-7.5% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is 1.5-6% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is about 4.5% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is about 7.5% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
- the total amount of the dispersing agents system is 2-12% w/w, based on the total weight of the composition. In some embodiments, the total amount of the dispersing agents system is 2-10% w/w, based on the total weight of the composition. In some embodiments, the total amount of the dispersing agents system is 2-8% w/w, based on the total weight of the composition. In some embodiments, the total amount of the dispersing agents system is about 5% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
- the amount of the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form is 1-4% w/w, based on the total weight of the composition.
- the amount may be any intermediate or intermediate range selected from the indicated amount.
- the amount of the polyether trisiloxane is 0.5-2% w/w, based on the total weight of the composition.
- the amount may be any intermediate or intermediate range selected from the indicated amount.
- the amount of the polymethyl methacrylate-polyethylene glycol graft copolymer is 1-4% w/w, based on the total weight of the composition.
- the amount may be any intermediate or intermediate range selected from the indicated amount.
- the amount of the Tristyrylphenol Ethoxylate Phosphate Ester acid form is 1-4% w/w, based on the total weight of the composition.
- the amount may be any intermediate or intermediate range selected from the indicated amount.
- the amount of the polyoxyethylene sorbitol ester is 1-4% w/w, based on the total weight of the composition.
- the amount may be any intermediate or intermediate range selected from the indicated amount.
- the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1.6:1. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1.5:1. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1.2:1. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:1.6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:2.5. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:3.33.
- the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:4.2. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:5. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1: 6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:36 to 1:1.6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:33 to 1:1.6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is about 1:9.
- the weight ratio between the wetting agents system and the novaluron in the composition is about 1:12. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is about 1:13. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
- the weight ratio between the wetting agents in the composition is 8:1 to 1:2.
- the weight ratio may be any intermediate range selected from the indicated ratio.
- the weight ratio between the dispersing agents in the composition is 4:1 to 1:4.
- the weight ratio may be any intermediate range selected from the indicated ratios.
- the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:3.75.
- the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:5. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:7.5.
- the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:55 to 1: 8.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:50 to 1: 8.75.
- the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is about 1:30. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is about 1:26. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is about 1:20. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
- the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:2.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:7.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:10. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:12.5.
- the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:15. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:110 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:100 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:60.
- the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:53. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:40.
- the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and the polyether trisiloxane in the composition is 8:1 to 1:2.
- the weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
- the amount of the alcohol ethoxylate is 1-4% w/w, based on the total weight of the composition.
- the amount may be any intermediate or intermediate range selected from the indicated amounts.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1.6:1.
- the weight ratio may be an intermediate range selected from any of the indicated ratio.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:1.25.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:1.875.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:2.5.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:3.125.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:3.75. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:27.5 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:25 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:8. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:10. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:12. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
- the weight ratio between the dispersing agents in the composition is 4:1 to 1:4.
- the weight ratio between the polyelectrolyte comb co-polymer and the additional dispersing agent in the composition is 4:1 to 1:4.
- the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio between polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:5.
- the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:55 to 1: 8.75.
- the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:50 to 1: 8.75. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is about 1:30. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is about 1:26. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is about 1:20.
- the weight ratio may be any intermediate or intermediate range selected from the indicated ratios. The weight ratio may be an intermediate range selected from any of the indicated ratios.
- the composition is a high load, SC composition.
- the stabilizer(s) is Magnesium Aluminium Silicate (smectite clay) selected from Van Gel B.
- the preservative(s) is selected from Proxel GXL, Nipacide BIT AS 20, Amebact B 20, Biotrend CMT1.5, Rocima BT 25 microbicide, Wancide 520XL.
- the adjuvant is dissolved in an organic solvent.
- the organic solvent is an oil.
- the amount of the adjuvant is 30-50% w/w based on the total weight of the adjuvant EC composition.
- the adjuvant EC formulation further comprises an emulsifier.
- the emulsifier is selected from Benzenesulfonic acid, mono-Cll-13- branched alkyl derivatives, calcium salts selected from NINATE® 401-ND.
- the emulsifier is Dioctyl Sodium Sulfosuccinate selected from Emcol 4500, Lankropol KO2, Geropon CYA/75, DOSS 75E.
- the adjuvant EC formulation comprises an oil.
- the oil is soybean oil selected from Methyl soyate, Steposol ME.
- the present invention provides an SE composition.
- the SE composition is a mixture of an SC novaluron composition and an EC novaluron composition.
- the novaluron is partly dispersed in the water, and partly dissolved in the oil phase.
- the SE composition is a mixture of the SC novaluron composition and the EC adjuvant mixture.
- the novaluron is partly dispersed in the water, and partly dissolved in the EC adjuvant mixture.
- the amount of the novaluron that is dispersed in the water in the SE formulation is between 25-60% based on the weight of the composition.
- the amount of the novaluron that is dissolved in the EC mixture of the SE formulation is between 1-10% based on the weight of the composition.
- the present invention provides an SE composition
- an SE composition comprising: a) Novaluron in amount of about 35-50% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition, c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition, and d) an adjuvant in amount of about 4-7% w/w based on the total weight of the composition.
- the present invention provides an SE composition
- an SE composition comprising: a) Novaluron in amount of about 35% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.4% w/w based on the total weight of the composition; c) a system of at least two dispersing agents in amount of about 5% w/w based on the total weight of the composition; and d) an adjuvant in amount of about 4% w/w based on the total weight of the composition.
- the present invention provides use of at least two wetting agents and at least two dispersing agents for increasing the stability of a liquid composition comprising novaluron.
- the wetting agents are selected from organo-silicone based surfactants and alkyl polyalkylene glycol ether phosphoric acid ester acid.
- the wetting agent system is a combination of at least one organo-silicone based surfactant and at least one alkyl polyalkylene glycol ether phosphoric acid ester acid.
- the wetting agent system can optionally further include an alcohol ethoxylate.
- the alcohol ethoxylate is a secondary alcohol ethoxylate.
- the organo-silicone based surfactant is an organo-modified tri-siloxane.
- the organo-silicone based surfactant is BreakThru S-240.
- the alkyl polyalkylene glycol ether phosphoric acid ester acid form is selected from Hostaphat® 1306 (Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form), Hostaphat® CC 100 (Cetyl phosphoric acid ester, acid form, mono/diester ⁇ 98 %), SERVOXYL VPDZ 3/100 (tridecyl polyglycol ether (3EO) phosphate), PROTE-PON P-TD-06-Z (alkyl ether phosphoric acid), LUBRHOPHOS LP 700 (phosphate ester with aromatic base), RHODAFAC BG 510 (phosphate ester with aliphatic base), DERMALIX C (alkyl phosphate in aqu.
- SANDOCLEAN SKBB alkyl phosphate esters
- PROTE-PON TD-09-K30 alkyl ether potassium phosphate
- PAE 147 phosphated alcohol ethoxylate
- LIBRAPHOS AD sodium salt of Libraphos EP 120
- NIKKOL DDP-2 alkyl ether phosphate; free acid form
- MARLOPHOR NP7-ACID nonylphenol polyethyleneglycol ether phosphoric acid partial ester
- MARLOWET 5301 coconut polyethylene glycol ether phosphoric acid partial ester
- ATLAS G-2203 potassium salt of phosphoric acid ester
- FOSFODET 1214 N/16 ethoxylated fatty alcohol phosphate ester
- the alkyl polyalkylene glycol ether phosphoric acid ester acid form is Hostaphat® 1306.
- the alcohol ethoxylate is selected form Tergitol 15-S-7, Tergitol 15-S-9, Tergitol 15-S-12, and a compound of the following structure:
- the alcohol ethoxylate is Tergitol 15-S-7.
- the dispersing agents are selected from polyelectrolyte comb copolymer, EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
- the dispersing agents system comprises a combination of polyelectrolyte comb copolymer surfactant and at least one other dispersing agent.
- the at least one other dispersing agent is selected from EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
- the polyelectrolyte comb copolymer is the polyelectrolyte disclosed in application publication WO 2017/098325, the entire content of which is incorporated herein by reference.
- the polyelectrolyte comb copolymer comprises a hydrophobic anchoring moiety and at least one hydrophilic charged stabilizing moiety.
- the hydrophilic charged stabilizing moiety comprises at least one charged monomer, preferably anionic monomer having a sulfonate group.
- the molar ratio of the hydrophobic anchoring moiety to the hydrophilic charged stabilizing moiety is 1:2-4.
- the weight ratio of the hydrophobic anchoring moiety to the hydrophilic charged stabilizing moiety is less than 0.6.
- the polyelectrolyte comb copolymer is PolyAgroA.
- the EO-PO copolymer is selected from Ethylan NS 500 (Polyalkoxylated butyl ether), Antarox B/848 (Oxirane, methyl-, polymer with oxirane), Ultraic 5000 HM (Ethoxylated and Propoxylated Alcohol), Toximul 8350 (Polyethylene-polypropylene glycol monobutyl ether), Tergitol XD (Ethylene Oxide / Propylene Oxide Block Copolymers), Atlas G-5000-S0-(CQ) (Oxirane, 2-methyl-, polymer with oxirane, monobutyl ether) , Atlas G- 5002L-LQ-(CQ) (oxirane, monobutyl ether), SYNERGEN 848 (block polyoxalkylate) , Ethylan 992 and Ultraric 5000 HM (EU source) (Polyethylene-polypropylene Glycol Monobutyl Ether).
- the polymethyl methacrylate-polyethylene glycol graft copolymer is selected from Atlox 4913, STEP-FLOW 3000, STEP-FLOW 4000 and Tersperse 2500.
- the Tristyrylphenol Ethoxylate Phosphate Ester, acid form is selected from Soprophor 3D33, Soprophor FL, Surfom 1322 SC, Agnique PE TSP 16T, and Dispersogen TP 160T.
- the polyoxyethylene sorbitol ester is selected from Tween 20, Hostacerin L 20, Hostacerin L 20 SG Vita, Alkamuls T 20, Emulsogen 4156, Alkest TW 20.
- the dispersant and the wetter are the same. In some embodiments, the dispersant and the wetter are different.
- the composition is high-load.
- high-load refers to composition containing an amount of active ingredients greater than 30% w/w based on the total weight of the composition.
- the amount of the novaluron is 5-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 10-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 15-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 20-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 25-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 30-60% w/w, based on the total weight of the composition.
- the amount of the novaluron is 35-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-50% w/w, based on the total weight of the composition.
- the amount of the novaluron is 40% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 60% w/w, based on the total weight of the composition.
- the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:2.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:7.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:10. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:12.5.
- the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:15. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:110 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:100 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:60.
- the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:53. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:40.
- the amount of the alcohol ethoxylate is 1-4% w/w, based on the total weight of
- T1 the composition.
- the amount may be any intermediate or intermediate range selected from the indicated amounts.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1.6:1.
- the weight ratio may be an intermediate range selected from any of the indicated ratio.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:1.25.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:1.875.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:2.5.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:3.125.
- the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:3.75. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:27.5 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:25 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:8. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:10. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:12. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
- the weight ratio between the polyelectrolyte comb co-polymer and the additional dispersing agent in the composition is 4:1 to 1:4.
- the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:55 to 1: 8.75.
- the composition is a high load, SC composition.
- the density of the SC composition is between 1-1.5 g/ml.
- the density may be an intermediate range selected from the indicated range.
- the density of the SE composition is between 1-1.5 g/ml.
- the density may be an intermediate range selected from the indicated range.
- the density of the SC composition is about 1.3 g/ml.
- the density of the SE composition is about 1.3 g/ml.
- the density of the SC composition is about 1.2 g/ml.
- the density of the SE composition is about 1.2 g/ml.
- the composition further comprises at least one agriculturally acceptable additive.
- agriculturally acceptable additives include, but are not limited to, carrier(s), anti-foaming agent(s), anti-freezing agent(s), stabilizer(s), preservative(s), thickener(s), and any combination thereof.
- the composition further comprises adjuvant(s).
- the adjuvant is a penetrant.
- the adjuvant enhances penetration of the active ingredient.
- the adjuvant is a spreader.
- the adjuvant improves the dispersion of the active ingredient on the leaf.
- agriculturally acceptable additive is a compound that is known and accepted in the art for use in the formation of liquid compositions for agricultural or horticultural use.
- the carrier is water.
- the anti-foaming agent(s) is selected from Silcolapse 432, SAG 1572.
- the anti- freezing agent(s) is selected from Propylene glycol, Glycerine.
- the stabilizer(s) is Magnesium Aluminium Silicate (smectite clay) selected from Van Gel B.
- the preservative(s) is selected from Proxel GXL, Nipacide BIT AS 20, Amebact B 20, Biotrend CMT1.5, Rocima BT 25 microbicide, Wancide 520XL.
- the thickener(s) is polysaccharide(s) selected from Xanthan gum, Kelzan, Kelzan Advanced Performance, AG RH 23, Kelzan AP-AS, Kelzan HP, Rheozan, Rhodopol 23, Rhodopol 50 MC, Rhodopol MD 50, Rhodopol G, Rhodicare D, XCD Biopolymer, AG-RHO POL 23/W.
- the thickener(s) is Carboxy Methyl Cellulose, Cabosil, Bentone MA, Bentone LT.
- the adjuvant(s) is organo-silicone based surfactants selected from Silwet® L77, Silwet 806, BREAK-THRU® S 240, BREAK-THRU® S 233.
- the adjuvant(s) is Alkamuls AP, Synergen SOC, Methyl soyate, Steposol ME.
- the amount of the additives is 8-15% w/w, based on the total weight of the composition.
- the amount of the adjuvant is 4-20% w/w, based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 10% w/w, based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 5% w/w, based on the total weight of the composition.
- the present invention provides a suspension concentrate composition
- a suspension concentrate composition comprising: a) Novaluron in amount of about 35-60% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition; and c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition.
- the present invention provides a suspension concentrate composition
- a suspension concentrate composition comprising: a) Novaluron in amount of about 35-50% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition; and c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition.
- the present invention provides a water dispersible composition
- a water dispersible composition comprising: a) novaluron in amount of about 58% w/w based on the total weight of the composition, b) Tergitol 15-S-7 in amount of about 1.5% w/w based on the total weight of the composition, c) Hostaphat® 1306 in amount of about 2% w/w based on the total weight of the composition, d) BreakThru S-240 in amount of about 1% w/w based on the total weight of the composition, e) Ethylan NS 500 in amount of 3% w/w based on the total weight of the composition, and f) PolyAgroA in amount of about 2% w/w based on the total weight of the composition.
- the suspension concentrate is physically stable.
- physical stability of the suspension refers to a state when the novaluron particles are dispersed and/or dissolved and do not float on the water surface.
- the physical stability is assessed after storage for 14 days at 54°C.
- the viscosity of the composition is less than 3000 cps. In some embodiments, the viscosity of the composition is less than 2500 cps. In some embodiments, the viscosity of the composition is less than 2000 cps. In some embodiments, the viscosity of the composition is less than 1500 cps. In some embodiments, the viscosity of the composition is less than 1000 cps. In some embodiments, the viscosity of the composition is less than 800 cps. In some embodiments, the viscosity of the composition is less than 700 cps. In some embodiments, the viscosity of the composition is less than 600 cps. In some embodiments, he viscosity of the composition is less than 500 cps. The viscosity may be an intermediate range selected from any the indicated values.
- the adjuvant(s) was added "as is" to the SC compositions and the amount of the adjuvant(s) is 1-20% w/w. In some embodiments, the amount of the adjuvant is 5%-10% w/w, based on the total weight of the composition.
- the SC composition comprises an adjuvant EC composition.
- the adjuvant is dissolved in an organic solvent.
- the organic solvent is an oil.
- the adjuvant EC formulation further comprises an emulsifier.
- the emulsifier is selected from Benzenesulfonic acid, mono-Cll-13- branched alkyl derivatives, calcium salts selected from NINATE® 401-ND.
- the emulsifier is Dioctyl Sodium Sulfosuccinate selected from Emcol 4500, Lankropol KO2, Geropon CYA/75, DOSS 75E.
- the present invention provides an SE composition.
- the SE composition is a mixture of an SC novaluron composition and an EC novaluron composition.
- the novaluron is partly dispersed in the water, and partly dissolved in the oil phase.
- the SE composition is a mixture of the SC novaluron composition and the EC adjuvant mixture.
- the novaluron is partly dispersed in the water, and partly dissolved in the EC adjuvant mixture.
- the amount of the novaluron that is dissolved in the EC mixture of the SE formulation is between 1-10% based on the weight of the composition.
- the present invention provides an SE composition
- an SE composition comprising: a) Novaluron in amount of about 35-50% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition, c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition, and d) an adjuvant in amount of about 4-7% w/w based on the total weight of the composition.
- the present invention provides an SE composition
- an SE composition comprising: e) Novaluron in amount of about 35% w/w based on the total weight of the composition, f) a system of at least 2 wetting agents in amount of about 1.4% w/w based on the total weight of the composition; g) a system of at least two dispersing agents in amount of about 5% w/w based on the total weight of the composition; and h) an adjuvant in amount of about 4% w/w based on the total weight of the composition.
- the present invention provides use of the composition as described herein for treating a plant.
- the plant is a pesticide sensitive crop.
- the pesticide sensitive crop is cucumber.
- the pesticide sensitive crop is lettuce.
- the pesticide sensitive crop is pepper.
- the pesticide sensitive crop is cabbage.
- the pesticide sensitive crop is cucurbit.
- the pesticide sensitive crop is wine grapes.
- the pesticide sensitive crop is cotton.
- the pesticide sensitive crop is corn.
- the pesticide sensitive crop is soybean.
- the composition is obtained using one of the processes of preparation described herein.
- the present invention provides a method for treating a plant comprising (1) obtaining the composition as described herein and (2) contacting the plant with an effective amount of the composition.
- the present invention also provides a method for controlling unwanted insects comprising applying an effective amount of the herein described composition to a plant, or an area infested with the unwanted insects so as to thereby control the unwanted insects.
- the composition is applied at a rate from about 100 ppm to about 1000 ppm of novaluron. In some embodiments, the composition is applied at a rate from about 100 ppm to about 500 ppm of novaluron. In some embodiments, the composition is applied at a rate from about 200 ppm to about 400 ppm of novaluron. In some embodiments, the composition is applied at a rate of about 200 ppm of novaluron. In some embodiments, the composition is applied at a rate of about 200-500 ppm of novaluron.
- the composition is applied at a rate from about 40 gr/ha to about 180 g/ha of novaluron.
- the composition is applied at a rate from about 50 gr/ha to about 150 g/ha of novaluron.
- the pesticide sensitive crop is cucumber. In some embodiments, the pesticide sensitive crop is lettuce. In some embodiments, the pesticide sensitive crop is pepper. In some embodiments, the pesticide sensitive crop is cabbage. In some embodiments, the pesticide sensitive crop is cucurbit. In some embodiments, the pesticide sensitive crop is wine grapes. In some embodiments, the pesticide sensitive crop is cotton. In some embodiments, the pesticide sensitive crop is corn. In some embodiments, the pesticide sensitive crop is soybean.
- the composition when the pesticide sensitive crop is cucumber, the composition is applied at a rate from about 40 gr/ha to about 180 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is cucumber, the suspension is applied at a rate from about 40 gr/ha to about 150 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is cucumber, the suspension is applied at a rate from about 50 gr/ha to about 115 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is cotton, the composition is applied at a rate from about 10 gr/ha to about 105gr/ha of novaluron.
- the composition when the pesticide sensitive crop is corn, the composition is applied at a rate from about 10 gr/ha to about 87.6 gr/ha of novaluron. In some embodiments, when the pesticide sensitive crop is soybean, the composition is applied at a rate from about 35 gr/ha to about 87.6 gr/ha of novaluron.
- the composition when the pesticide sensitive crop is lettuce, the composition is applied at a rate from about 50 gr/ha to about 180g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is lettuce, the composition is applied at a rate from about 50 gr/ha to about 150g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is lettuce, the composition is applied at a rate from about 65 gr/ha to about 115 g/ha of novaluron.
- the composition when the pesticide sensitive crop is pepper, the composition is applied at a rate from about 40 gr/ha to about 180 g/ha of novaluron In some embodiments, when the pesticide sensitive crop is pepper, the composition is applied at a rate from about 40 gr/ha to about 150 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is pepper, the composition is applied at a rate from about 50 gr/ha to about 115 g/ha of novaluron.
- the composition when the pesticide sensitive crop is cabbage, the composition is applied at a rate from about 50 gr/ha to about 200 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is cabbage, the composition is applied at a rate from about 65 gr/ha to about 115 g/ha of novaluron.
- the composition when the pesticide sensitive crop is cucurbit, the composition is applied at a rate from about 40 gr/ha to about 150 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is cucurbit, the composition is applied at a rate from about 50 gr/ha to about 115 g/ha of novaluron.
- the composition when the pesticide sensitive crop is wine grapes, the composition is applied at a rate from about 40 gr/ha to about 130g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is wine grapes, the composition is applied at a rate from about 50 gr/ha to about lOOg/ha of novaluron.
- the composition is applied once during a growing season.
- the composition is applied at least one time during a growing season.
- the composition is applied two or more times during a growing season.
- the composition is applied to soil. In some embodiments, the combination or composition is applied to foliage.
- the composition is applied at a rate from about 100 ppm to about 1000 ppm of novaluron. In some embodiments, the composition is applied at a rate from about 100 ppm to about 500 ppm of novaluron. In some embodiments, the composition is applied at a rate from about 200 ppm to about 400 ppm of novaluron. In some embodiments, the composition is applied at a rate of about 200 ppm of novaluron. In some embodiments, the composition is applied at a rate of about 200-500 ppm of novaluron.
- the composition is applied to soil. In some embodiments, the composition is applied to foliage.
- compositions, uses and methods described herein are particularly effective for controlling insects of, inter alia, the orders Lepidoptera, Coleoptera, Homoptera, Heteroptera, Diptera, Thysanoptera, Orthoptera, Anoplura, Siphonaptera, Mallophaga, Thysanura, Isoptera, Psocoptera and Hymenoptera, as well as representatives of the order Acarina of the families Ixodidae Argasidae, Tetranychidae and Dermanyssidae leaf rollers.
- compositions, uses and methods described herein are also effective in controlling flies, e.g. Musca domestica, termites, cockroaches and mosquito larvae.
- compositions, uses and methods described herein are also suitable for controlling plantdestructive feeding insects in ornamentals and crops of useful plants, especially in cotton (e. g. against Spodoptera littoralis and Heliothis virescens) and in fruit and vegetables (e. g.
- compositions disclosed herein may be applied to control and/or prevent a variety of insect in the presence of plant.
- the plant is a crop. In some embodiments, plant is a pesticide sensitive crop. In some embodiments, the crop is a soft crop such as vegetable and fruits.
- the methods of the present invention may be used on any crop plants, including but not limited to monocotyledons such as sugar cane cereals, rice, maize (corn), and/or; or dicotyledon crop such as beets (such as sugar beet or fodder beet); fruits (such as pomes, stone fruits, or soft fruits, for example apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, or blackberries); leguminous plants (such as beans, lentils, peas, or soybeans); oil plants (such as rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, or groundnuts); cucumber plants (such as marrows, cucumbers or melons); fiber plants (such as cotton, flax, hemp, or jute); citrus fruits (such as Winegrapes, oranges, lemons, grapefruit, or mandarins); vegetables (such as spinach, lettuce, cabbages, carrots, tomatoes, potatoes, cucurbits, or
- the plants are monocotyledonous plants, more preferably, cereals.
- the cereal crop is wheat.
- the cereal crop is triticale.
- the cereal crop is rye.
- the cereal crop is oat.
- the cereal crop is barley.
- the crop plants are rice plants.
- the crop plants are sugar cane plants.
- the crop plants are corn plants.
- compositions, uses and methods described herein are further effective for controlling ectoparasites such as Lucilia sericata, in domestic animals and productive livestock, e. g. by treating animals' skin, cowsheds, barns, stables etc., and pastures.
- ectoparasites such as Lucilia sericata
- the present invention provides a process for preparing the composition described herein, the process comprising mixing wetting agents, dispersing agents, novaluron and water.
- the process comprises optionally adjusting the pH of the composition.
- the pH of the composition in between 5-8.
- the pH is adjusted using concentrated NaOH solution and/or concentrated HCI solution.
- the process comprises: (1) mixing the wetting agents, the dispersing agents, additives and water, and (2) adding novaluron.
- novaluron is added gradually.
- the mixture is milled.
- the milling process is wet milling.
- the milling process obtains particle size D90 between 2 to 10 micrometers, preferably between 4 to 7 micrometers.
- the process includes high shear.
- the process comprises mixing the SC composition as described herein with an adjuvant formulated "as is”.
- the process comprises mixing the SC composition as described herein with an adjuvant formulated as an EC as described herein.
- the process for preparing the EC formulation comprises mixing the adjuvant with a solvent and at least one emulsifier.
- Example 2 Novaluron 56.1%+ Tergitol 15-S-7+Ethylan NS 500
- Example 3 Novaluron 56.1%+ Tergitol 15-S-7+Ethylan NS 500+PolyAgroA
- Example 4 Novaluron 57.9%+Tergitol 15-S-7+ Ethylan NS 500+ PolyAgroA+ BreakThru S-240.
- Example 5 Novaluron 57.9%+Tergitol 15-S-7+ Ethylan NS 500+ PolyAgroA+ Hostaphat 1306.
- Example 6 Novaluron 57.9%+ Tergitol 15-S-7+Hostapaht 1306+BreakThru S-240+Ethylan NS 500+PolyAgroA
- Example 7 Novaluron 57.9%+Tergitol 15-S-7+Hostaphat 1306+BreakThru S-240+PolyAgroA.
- Example 8 Novaluron 57.9%+Tergitol 15-S-7+Hostaphat 1306+BreakThru S-240+Ethylan NS 500.
- Formulation with PolyAgroA is better than the formulation without PolyAgroA (example 8).
- PolyAgroA reduces the viscosity and is advantageous in terms of entrance into the water.
- Example 9 Novaluron 57.9%+Tergitol 15-S-7+Hostaphat 1306+BreakThru S-240+Ethylan NS
- Example 10 Novaluron 57.9%+Hostapaht 1306+BreakThru S-240+Ethylan NS 500+PolyAgroA
- Example 11 Novaluron 57.9%+ Tergitol 15-S-7+Hostapaht 1306+BreakThru S-240+Atlox 4913+PolyAgroA
- Example 12 Novaluron 57.9%+ Tergitol 15-S-7+Hostapaht 1306+BreakThru S- 240+Soprophor 3D33+PolyAgroA
- Example 13 Novaluron 57.9%+Tergitol 15-S-7+Hostapaht 1306+BreakThru S-240+Tween 20+PolyAgroA
- Example 17 Example 18:
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Abstract
The present invention is directed to a stable liquid agrochemical composition comprising novaluron and use thereof.
Description
NOVALURON AQUEOUS STABLE COMPOSITION
Throughout this application various publications are referenced. The disclosures of these documents in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains.
TECHNICAL FIELD
The present invention relates to a stable aqueous composition comprising novaluron, at least two wetting agents, and at least two dispersing agents.
BACKGROUND
Novaluron, (±)-l-[3-chloro-4-(l,l,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6- difluorobenzoyl)urea, is used as insect growth regulators (IGR). The most commonly used formulations for solid water insoluble pesticides are suspension concentrates, emulsifiable concentrate and emulsion in water formulations which are liquid formulations and where the pesticide is dissolved in organic carrier.
Novaluron is solid at ambient temperature, has an extremely low water solubility and very low wettability. As such, it is highly challenging to formulate high amounts of novaluron especially in water-based compositions.
WO2022/264064 discloses water dispersible solid compositions comprising novaluron and an organo-silicone based surfactant. However, there is still a need for stable, high load, easy to handle and efficient liquid compositions of novaluron.
SUMMARY
The present invention provides a stable high load agrochemical composition comprising of: (a) an amount of novaluron; (b) a system of at least two wetting agents; and (c) a system of at least two dispersing agents.
The present invention further provides use of at least two wetting agents and at least two dispersing agents for increasing the stability of a liquid composition comprising novaluron.
The present invention further provides use of the composition as disclosed herein for treating a plant.
The present invention further provides a method of treating a plant using the composition as disclosed herein.
The present invention further provides a process for preparing a composition as disclosed herein.
DETAILED DESCRIPTION OF THE INVENTION
Definitions
Prior to setting forth the present subject matter in detail, it may be helpful to provide definitions of certain terms to be used herein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in the art to which this subject matter belongs.
As used herein, the term "effective amount" refers to an amount of the novaluron as described herein, which when ingested, contacted with or sensed, is sufficient to achieve a good level of control, i.e. sufficient for controlling harmful insects on crop plants without causing any significant damage to the treated crop plants.
As used herein, an "agriculturally acceptable additive" is a compound that is known and accepted in the art for use in the formation of compositions for agricultural or horticultural use.
As used herein, the term "plant" includes reference to the whole plant, plant organ (e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), plant cells, a locus of the plant, or propagation material thereof.
As used herein, the term "plant" includes reference to agricultural crops including field crops (soybean, maize, wheat, rice, etc.), vegetable crops (potatoes, cabbages, etc.) and fruits (peach, etc.).
As used herein, the term "propagation material" is to be understood to denote all the generative parts of the plant such as seeds and spores, vegetative structures such as bulbs, corms, tubers, rhizomes, roots stems, basal shoots, stolons and buds.
As used herein, the term "locus" includes not only areas where insect may already exist, but also areas where insect has yet to emerge, and also to areas under cultivation.
As used herein, the term "treating a plant" is to be understood as controlling insecticidal attack or protecting a plant from insecticidal attack or a disease caused by unwanted insect or preventing insecticidal attack or plant disease caused by unwanted insect.
As described herein, the term "wetter" and "wetting agent" are interchangeable.
As used herein, the term "ha" refers to hectare.
The term "a" or "an" as used herein includes the singular and the plural, unless specifically stated otherwise. Therefore, the terms "a," "an" or "at least one" can be used interchangeably in this application.
Throughout the application, descriptions of various embodiments use the term "comprising"; however, it will be understood by one of skill in the art, that in some specific instances, an embodiment can alternatively be described using the language "consisting essentially of" or "consisting of."
The term "about" as used herein specifically includes ±10% from the indicated values in the range. In addition, the endpoints of all ranges directed to the same component or property herein are inclusive of the endpoints, are independently combinable, and include all intermediate points and ranges. It is understood that where a parameter range is provided, all integers within that range, and tenths thereof, are also provided by the invention. For example, "10-50%" includes 10%, 10.1%, 10.2%, etc. up to 50%.
Formulating novaluron in water, and in particular high load of novaluron, is challenging. Novaluron has an extremely low water solubility and very low wettability. Such formulations often face problems such as high viscosity, problems in the milling process, sedimentations, and instability, especially after storage (14 days at 54°C).
It was found that novaluron can be formulated in a stable liquid composition comprising a system of at least two wetting agents, and a system of at least two dispersing agents.
Compositions:
According to one aspect, the present invention provides a stable high load agrochemical composition comprising of: (a) an amount of novaluron; (b) a system of at least two wetting agents; and (c) a system of at least two dispersing agents.
According to some embodiments, the wetting agents are selected from organo-silicone based surfactants and alkyl polyalkylene glycol ether phosphoric acid ester acid.
According to some embodiments, the wetting agent system is a combination of at least one organo-silicone based surfactant and at least one alkyl polyalkylene glycol ether phosphoric acid ester acid.
The wetting agent system can optionally further include an alcohol ethoxylate. In some embodiments, the alcohol ethoxylate is a secondary alcohol ethoxylate.
In some embodiment, the organo-silicone based surfactant is an organo-modified tri-siloxane.
In some embodiments, the organo-silicone based surfactants are selected from Silwet® L77, Silwet 806, BREAK-THRU® S 240, BREAK-THRU® S 233, the compound 3-(8- methoxyoctoxy)propyl-methyl-bis(trimethylsilyloxy)silane and a compound of the following s ,truc .ture: .
ein n=l-4, y=3-10, z=0-5, and R is an alkyl having 1-4 carbon atoms or H or OH.
In some specific embodiments, the organo-silicone based surfactant is BreakThru S-240.
In some other embodiments, the alkyl polyalkylene glycol ether phosphoric acid ester acid form is selected from Hostaphat® 1306 (Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form), Hostaphat® CC 100 (Cetyl phosphoric acid ester, acid form, mono/diester ~ 98 %), SERVOXYL VPDZ 3/100 (tridecyl polyglycol ether (3EO) phosphate), PROTE-PON P-TD-06-Z (alkyl ether phosphoric acid), LUBRHOPHOS LP 700 (phosphate ester with aromatic base), RHODAFAC BG 510 (phosphate ester with aliphatic base), DERMALIX C (alkyl phosphate in aqu. /organic medium), SANDOCLEAN SKBB (alkyl phosphate esters), PROTE-PON TD-09-K30 (alkyl ether potassium phosphate), PAE 147 (phosphated alcohol ethoxylate), LIBRAPHOS AD (sodium salt of Libraphos EP 120), NIKKOL DDP-2 (di POE (2) alkyl ether phosphate; free acid form), MARLOPHOR NP7-ACID (nonylphenol polyethyleneglycol ether phosphoric acid partial ester), MARLOWET 5301 (coconut polyethylene glycol ether phosphoric acid partial ester), ATLAS G-2203 (potassium salt of phosphoric acid ester), FOSFODET 1214 N/16 (ethoxylated fatty alcohol phosphate ester).
In some embodiments, the alkyl polyalkylene glycol ether phosphoric acid ester acid form is Hostaphat® 1306.
In some other embodiments, the alcohol ethoxylate is selected form Tergitol 15-S-7, Tergitol 15-S-9, Tergitol 15-S-12, and a compound of the following structure:
, wherein m+n=15 and x is number of repeating ethoxylate (EO) units.
In some embodiments, the alcohol ethoxylate is Tergitol 15-S-7.
In some embodiments, the dispersing agents are selected from polyelectrolyte comb copolymer, EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
In some other embodiments, the dispersing agents system comprises a combination of polyelectrolyte comb copolymer surfactant and at least one other dispersing agent.
In some embodiments, the at least one other dispersing agent is selected from EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
In some embodiments, the polyelectrolyte comb copolymer is the polyelectrolyte disclosed in application publication WO 2017/098325, the entire content of which is incorporated herein by reference.
In some embodiments, the polyelectrolyte comb copolymer comprises a hydrophobic anchoring moiety and at least one hydrophilic charged stabilizing moiety.
In some embodiments, the hydrophilic charged stabilizing moiety comprises at least one charged monomer, preferably anionic monomer having a sulfonate group.
In some embodiments, the molar ratio of the hydrophobic anchoring moiety to the hydrophilic charged stabilizing moiety is 1:2-4.
In some embodiments, the weight ratio of the hydrophobic anchoring moiety to the hydrophilic charged stabilizing moiety is less than 0.6.
In some embodiments, at least 60% by weight of the hydrophilic charged stabilizing moiety is charged monomers.
In some embodiments, the polyelectrolyte comb copolymer is PolyAgroA.
PolyAgro A is a polyelectrolyte-layer forming block copolymer formulation. The composition of PolyAgro A is represented in the following Table:
PolyAgro A is a di-block copolymer, with a total weight of 17000 g/mol, composed of a hydrophobic block (Anchor block- ANCHOR) and a hydrophilic block (Stabilizing block - STAB). The stabilizing, hydrophilic, block is made of sodium 2-Acryloylamino-2-methylpropane-l- sulfonate (AMPS) monomers, which are 77% of the overall monomers in the polymer. The other 23% of the monomers belongs to the anchor, hydrophobic, block which is made of ethyl acrylate monomers. The total amount of monomers in the polymer (degree of polymerization, DPn) is 85 monomers.
Such polymer may be obtained from Rhodia Operations, a corporation of Paris, France, a member of the SOLVAY Group.
Such polymer may also be prepared as described in application publication No. WO 2017/098325. WO 2017/098325 was applied by Rhodia Operations, a member of the SOLVAY Group, and Adama Makhteshim Ltd.
As described in WO 2017/098325, the polyelectrolyte-layer forming block copolymer used in the formulations of the subject invention may be prepared according to the following procedure. a) Macro CTA
Into a 2L double jacketed reactor equipped with mechanical agitator and reflux condenser was added 11.26 g of O-ethyl-S-(l-methoxycarbonylethyl)xanthate
(CH3CH(CO2CH3))S(C=S)OEt), 264.08g of Ethanol, and 356.32g of De-ionized water and 1400g of AMPS(Na) solution (50% active) and 1.52g of 4,4'-Azobis(4-cyanopentanoic acid). The reactor contents were heated to 70°C under agitation and nitrogen. The reaction mixture was aged at 70°C for a further hour whereupon it was cooled to ambient temperature and discharged. The measured solids content was 37.6% (115°C, 60 mins). GPC Mais : Mn=16300 Mw=2600 I P=1.6. b) Chain extension
Into a 5L double jacketed reactor equipped with mechanical agitator and reflux condenser was added 2127g of macro CTA solution (see a) and 330g of de-ionized water. The reactor contents were heated to 70°C under agitation and a nitrogen stream. Once 70°C was reached, 106.67g of ethyl acrylate (EA) was added over 2H00 and a 37.37g of a solution of 10 wt% of 4,4'-Azobis(4-cyanopentanoic acid) was concomitantly added over 2h30. After the end of the introduction of the initiator solution, the reaction solution was further aged for one hour. Thereafter a shot of 44.85g of a 10 wt% solution of 4,4'-Azobis(4-cyanopentanoic acid) was added and the mixture aged at 70°C for a further hour whereupon it was cooled to ambient temperature and discharged. The measured solids content was 40.0% (115°C, 60 mins).
Ethanol was removed from the polymer solution using a rotary evaporator. Water was back added to achieve a polymer solution with a final solids content of 40.4%.
2600g of polymer solution was placed in a 5L double jacketed reactor equipped with mechanical agitator and reflux condenser. The pH of the solution was increased to 8,5 using a 50% solution of NaOH. The mixture was heated to 70°C with stirring whereupon 48.4 of a 30% solution of hydrogen peroxide was added in 1 hour. At the end of the additions, the solution was aged for a further 3h00 whereupon it was cooled and discharged. The residuals monomers were measure by HPLC and GC (AMPS = 22ppm, EA = 2ppm). The measured solids content was 37.5%.
In some other embodiments, the EO-PO copolymer is selected from Ethylan NS 500 (Polyalkoxylated butyl ether), Antarox B/848 (Oxirane, methyl-, polymer with oxirane), Ultraic 5000 HM (Ethoxylated and Propoxylated Alcohol), Toximul 8350 (Polyethylene-polypropylene glycol monobutyl ether), Tergitol XD (Ethylene Oxide / Propylene Oxide Block Copolymers), Atlas G-5000-S0-(CQ) (Oxirane, 2-methyl-, polymer with oxirane, monobutyl ether) , Atlas G- 5002L-LQ-(CQ) (oxirane, monobutyl ether), SYNERGEN 848 (block polyoxalkylate) , Ethylan 992 and Ultraric 5000 HM (EU source) (Polyethylene-polypropylene Glycol Monobutyl Ether).
In some other embodiments, the polymethyl methacrylate-polyethylene glycol graft copolymer is selected from Atlox 4913, STEP-FLOW 3000, STEP-FLOW 4000 and Tersperse 2500.
In some embodiments, the Tristyrylphenol Ethoxylate Phosphate Ester, acid form is selected from Soprophor 3D33, Soprophor FL, Surfom 1322 SC, Agnique PE TSP 16T, and Dispersogen TP 160T.
In some embodiments, the polyoxyethylene sorbitol ester is selected from Tween 20, Hostacerin L 20, Hostacerin L 20 SG Vita, Alkamuls T 20, Emulsogen 4156, Alkest TW 20.
In some embodiments, the dispersant and the wetter are the same.
In some embodiments, the dispersant and the wetter are different.
In some embodiments, the composition is high-load.
In some embodiments, high-load refers to composition containing an amount of active ingredients greater than 30% w/w based on the total weight of the composition.
In some embodiments, the amount of the novaluron is 5-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 10-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 15-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 20-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 25-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 30-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40% w/w, based on the total weight of the composition. In some embodiments, the amount
of the novaluron is 50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 60% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
In some embodiments, the amount of the novaluron is between about 350 g/L to about 750 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is between about 400 g/L to about 800 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is between about 400 g/L to about 700 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is between about 400 g/L to about 600 g/L, based on the total weight of the composition. The amount of the novaluron may be an intermediate range selected from any of the above indicated ratios. In some embodiments, the amount of the novaluron is about 780 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 750 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 700 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 650 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 600 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 550 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 500 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 450 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 400 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 350 g/L, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
In some embodiments, the total amount of the wetting agents system is 1.5-10% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is 1.5-7.5% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is 1.5-6% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is about 4.5% w/w, based on the total weight of the composition. In some
embodiments, the total amount of the wetting agents system is about 7.5% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
In some embodiments, the total amount of the dispersing agents system is 2-12% w/w, based on the total weight of the composition. In some embodiments, the total amount of the dispersing agents system is 2-10% w/w, based on the total weight of the composition. In some embodiments, the total amount of the dispersing agents system is 2-8% w/w, based on the total weight of the composition. In some embodiments, the total amount of the dispersing agents system is about 5% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
In some embodiments, the amount of the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the polyether trisiloxane is 0.5-2% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the EO-PO copolymer is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the polymethyl methacrylate-polyethylene glycol graft copolymer is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the polyelectrolyte comb co-polymer is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the Tristyrylphenol Ethoxylate Phosphate Ester acid form is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the polyoxyethylene sorbitol ester is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1.6:1. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1.5:1. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1.2:1. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:1.6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:2.5. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:3.33. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:4.2. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:5. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1: 6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:36 to 1:1.6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:33 to 1:1.6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is about 1:9. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is about 1:12. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is about 1:13. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, the weight ratio between the wetting agents in the composition is 8:1 to 1:2. The weight ratio may be any intermediate range selected from the indicated ratio.
In some embodiments, the weight ratio between the dispersing agents in the composition is 4:1 to 1:4. The weight ratio may be any intermediate range selected from the indicated ratios.
In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether
phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:5. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:55 to 1: 8.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:50 to 1: 8.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is about 1:30. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is about 1:26. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is about 1:20. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:2.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:7.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:10. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:12.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:15. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:110 to
1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:100 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:60. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:53. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:40.
In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and the polyether trisiloxane in the composition is 8:1 to 1:2. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, when the wetting agents system further comprises an alcohol ethoxylate, the amount of the alcohol ethoxylate is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1.6:1. The weight ratio may be an intermediate range selected from any of the indicated ratio. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:1.25. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:1.875. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:2.5. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:3.125. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:3.75. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:27.5 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:25 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:8. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:10. In some embodiments, the weight ratio between the dispersing agents system and the
novaluron in the composition is 1:12. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, the weight ratio between the dispersing agents in the composition is 4:1 to 1:4.
In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and the additional dispersing agent in the composition is 4:1 to 1:4.
In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio between polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:5. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:55 to 1: 8.75. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:50 to 1: 8.75. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is about 1:30. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is about 1:26. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is about 1:20. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios. The weight ratio may be an intermediate range selected from any of the indicated ratios.
In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio between the
additional dispersing agent and novaluron in the composition is 1:60 to 1:5. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:55 to 1: 8.75. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:50 to 1: 8.75. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is about 1:30. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is about 1:26. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is about 1:20. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is about 1:16. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is about 1:13. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, the composition is a suspension concentrate (SC). In some embodiments, the composition is an aqueous suspension. In some embodiments, the composition is a suspoemulsion (SE). In some embodiments, novaluron is dispersed in an aqueous carrier. In some embodiments, novaluron is partly dispersed in an aqueous carrier and partly dissolved in an organic carrier.
In some embodiments, the composition is a high load, SC composition.
In some embodiments, the composition is a high load, SE composition.
In some embodiments, the density of the SC composition is between 1-1.5 g/ml. The density may be an intermediate range selected from the indicated range.
In some embodiments, the density of the SE composition is between 1-1.5 g/ml. The density may be an intermediate range selected from the indicated range.
In some embodiments, the density of the SC composition is about 1.3 g/ml.
In some embodiments, the density of the SE composition is about 1.3 g/ml.
In some embodiments, the density of the SC composition is about 1.2 g/ml.
In some embodiments, the density of the SE composition is about 1.2 g/ml.
In some embodiments, the composition further comprises at least one agriculturally acceptable additive. Agriculturally acceptable additives include, but are not limited to, carrier(s), anti-foaming agent(s), anti-freezing agent(s), stabilizer(s), preservative(s), thickener(s), and any combination thereof.
In some embodiments, the composition further comprises adjuvant(s). In some embodiment, the adjuvant is a penetrant. In some embodiment, the adjuvant enhances penetration of the active ingredient. In some embodiments, the adjuvant is a spreader. In some embodiment, the adjuvant improves the dispersion of the active ingredient on the leaf.
In some embodiments, agriculturally acceptable additive is a compound that is known and accepted in the art for use in the formation of liquid compositions for agricultural or horticultural use.
In some embodiments, the carrier is water.
In some embodiments, the anti-foaming agent(s) is selected from Silcolapse 432, SAG 1572.
In some embodiments, the anti- freezing agent(s) is selected from Propylene glycol, Glycerine.
In some embodiments, the stabilizer(s) is Magnesium Aluminium Silicate (smectite clay) selected from Van Gel B.
In some embodiments, the preservative(s) is selected from Proxel GXL, Nipacide BIT AS 20, Amebact B 20, Biotrend CMT1.5, Rocima BT 25 microbicide, Wancide 520XL.
In some embodiments, the thickener(s) is polysaccharide(s) selected from Xanthan gum, Kelzan, Kelzan Advanced Performance, AG RH 23, Kelzan AP-AS, Kelzan HP, Rheozan, Rhodopol 23, Rhodopol 50 MC, Rhodopol MD 50, Rhodopol G, Rhodicare D, XCD Biopolymer, AG-RHO POL 23/W.
In some embodiments, the thickener(s) is Carboxy Methyl Cellulose, Cabosil, Bentone MA, Bentone LT.
In some embodiments, the adjuvant(s) is organo-silicone based surfactants selected from Silwet® L77, Silwet 806, BREAK-THRU® S 240, BREAK-THRU® S 233.
In some embodiments, the adjuvant(s) is Alkamuls AP, Synergen SOC, Methyl soyate, Steposol ME.
In some embodiments, the amount of the additives is 8-15% w/w, based on the total weight of the composition.
In some embodiments, the amount of the adjuvant is 4-20% w/w, based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 10% w/w, based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 5% w/w, based on the total weight of the composition.
In some embodiments, the present invention provides a suspension concentrate composition comprising: a) Novaluron in amount of about 35-60% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition; and c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition.
In some embodiments, the present invention provides a suspension concentrate composition comprising: a) Novaluron in amount of about 35-50% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition; c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition; and d) an adjuvant in an amount of about 4-20% w/w, based on the total weight of the composition.
In some embodiments, the present invention provides a water dispersible composition comprising: a) novaluron in amount of about 58% w/w based on the total weight of the composition,
b) Tergitol 15-S-7 in amount of about 1.5% w/w based on the total weight of the composition, c) Hostaphat® 1306 in amount of about 2% w/w based on the total weight of the composition, d) BreakThru S-240 in amount of about 1% w/w based on the total weight of the composition, e) Ethylan NS 500 in amount of 3% w/w based on the total weight of the composition, and f) PolyAgroA in amount of about 2% w/w based on the total weight of the composition.
In some embodiments, the suspension concentrate is physically stable.
In some embodiments, physical stability of the suspension refers to a state when the novaluron particles are dispersed and/or dissolved and do not float on the water surface.
In some embodiments, the physical stability is assessed after storage for 14 days at 54°C.
In some embodiments, the viscosity of the composition is less than 3000 cps. In some embodiments, the viscosity of the composition is less than 2500 cps. In some embodiments, the viscosity of the composition is less than 2000 cps. In some embodiments, the viscosity of the composition is less than 1500 cps. In some embodiments, the viscosity of the composition is less than 1000 cps. In some embodiments, the viscosity of the composition is less than 800 cps. In some embodiments, the viscosity of the composition is less than 700 cps. In some embodiments, the viscosity of the composition is less than 600 cps. In some embodiments, he viscosity of the composition is less than 500 cps. The viscosity may be an intermediate range selected from any the indicated values.
In some embodiments, the adjuvant(s) was added "as is" to the SC compositions and the amount of the adjuvant(s) is 1-20% w/w. In some embodiments, the amount of the adjuvant is 5%-10% w/w, based on the total weight of the composition.
In some embodiments, the adjuvant is separately formulated as an emulsified concentrate (EC).
In some embodiments, the SC composition comprises an adjuvant EC composition.
In some embodiments, the adjuvant is dissolved in an organic solvent.
In some embodiments, the organic solvent is an oil.
In some embodiments, the amount of the adjuvant is 30-50% w/w based on the total weight of the adjuvant EC composition.
In some embodiments, the adjuvant EC formulation further comprises an emulsifier.
In some embodiments, the emulsifier is selected from Benzenesulfonic acid, mono-Cll-13- branched alkyl derivatives, calcium salts selected from NINATE® 401-ND.
In some embodiments, the emulsifier is Dioctyl Sodium Sulfosuccinate selected from Emcol 4500, Lankropol KO2, Geropon CYA/75, DOSS 75E.
In some embodiments, the adjuvant EC formulation comprises an oil.
In some embodiments, the oil is soybean oil selected from Methyl soyate, Steposol ME.
In some embodiments, the present invention provides an SE composition.
In some embodiments the SE composition is a mixture of an SC novaluron composition and an EC novaluron composition. In some embodiments, the novaluron is partly dispersed in the water, and partly dissolved in the oil phase.
In some embodiments the SE composition is a mixture of the SC novaluron composition and the EC adjuvant mixture. In some embodiments, the novaluron is partly dispersed in the water, and partly dissolved in the EC adjuvant mixture.
In some embodiments, the amount of the novaluron that is dispersed in the water in the SE formulation is between 25-60% based on the weight of the composition.
In some embodiments, the amount of the novaluron that is dissolved in the EC mixture of the SE formulation is between 1-10% based on the weight of the composition.
In some embodiments, the present invention provides an SE composition comprising: a) Novaluron in amount of about 35-50% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition, c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition, and d) an adjuvant in amount of about 4-7% w/w based on the total weight of the composition.
In some embodiments, the present invention provides an SE composition comprising: a) Novaluron in amount of about 35% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.4% w/w based on the total weight of the composition; c) a system of at least two dispersing agents in amount of about 5% w/w based on the total weight of the composition; and d) an adjuvant in amount of about 4% w/w based on the total weight of the composition.
Use of stabilizing system:
In another aspect, the present invention provides use of at least two wetting agents and at least two dispersing agents for increasing the stability of a liquid composition comprising novaluron.
According to some embodiments, the wetting agents are selected from organo-silicone based surfactants and alkyl polyalkylene glycol ether phosphoric acid ester acid.
According to some embodiments, the wetting agent system is a combination of at least one organo-silicone based surfactant and at least one alkyl polyalkylene glycol ether phosphoric acid ester acid.
The wetting agent system can optionally further include an alcohol ethoxylate. In some embodiments, the alcohol ethoxylate is a secondary alcohol ethoxylate.
In some embodiment, the organo-silicone based surfactant is an organo-modified tri-siloxane.
In some embodiments, the organo-silicone based surfactants are selected from Silwet® L77, Silwet 806, BREAK-THRU® S 240, BREAK-THRU® S 233, the compound 3-(8- methoxyoctoxy)propyl-methyl-bis(trimethylsilyloxy)silane and a compound of the following s ,truc .ture: .
ein n=l-4, y=3-10, z=0-5, and R is an alkyl having 1-4 carbon atoms or H or OH.
In some specific embodiments, the organo-silicone based surfactant is BreakThru S-240.
In some other embodiments, the alkyl polyalkylene glycol ether phosphoric acid ester acid form is selected from Hostaphat® 1306 (Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form), Hostaphat® CC 100 (Cetyl phosphoric acid ester, acid form, mono/diester ~ 98 %), SERVOXYL VPDZ 3/100 (tridecyl polyglycol ether (3EO) phosphate), PROTE-PON P-TD-06-Z (alkyl ether phosphoric acid), LUBRHOPHOS LP 700 (phosphate ester with aromatic base), RHODAFAC BG 510 (phosphate ester with aliphatic base), DERMALIX C (alkyl phosphate in aqu. /organic medium), SANDOCLEAN SKBB (alkyl phosphate esters), PROTE-PON TD-09-K30 (alkyl ether potassium phosphate), PAE 147 (phosphated alcohol ethoxylate), LIBRAPHOS AD (sodium salt of Libraphos EP 120), NIKKOL DDP-2 (di POE (2) alkyl ether phosphate; free acid form), MARLOPHOR NP7-ACID (nonylphenol polyethyleneglycol ether phosphoric acid partial ester), MARLOWET 5301 (coconut polyethylene glycol ether phosphoric acid partial ester), ATLAS G-2203 (potassium salt of phosphoric acid ester), FOSFODET 1214 N/16 (ethoxylated fatty alcohol phosphate ester).
In some embodiments, the alkyl polyalkylene glycol ether phosphoric acid ester acid form is Hostaphat® 1306.
In some other embodiments, the alcohol ethoxylate is selected form Tergitol 15-S-7, Tergitol 15-S-9, Tergitol 15-S-12, and a compound of the following structure:
, wherein m+n=15 and x is number of repeating ethoxylate (EO) units.
In some embodiments, the alcohol ethoxylate is Tergitol 15-S-7.
In some embodiments, the dispersing agents are selected from polyelectrolyte comb copolymer, EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
In some other embodiments, the dispersing agents system comprises a combination of polyelectrolyte comb copolymer surfactant and at least one other dispersing agent.
In some embodiments, the at least one other dispersing agent is selected from EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
In some embodiments, the polyelectrolyte comb copolymer is the polyelectrolyte disclosed in application publication WO 2017/098325, the entire content of which is incorporated herein by reference.
In some embodiments, the polyelectrolyte comb copolymer comprises a hydrophobic anchoring moiety and at least one hydrophilic charged stabilizing moiety.
In some embodiments, the hydrophilic charged stabilizing moiety comprises at least one charged monomer, preferably anionic monomer having a sulfonate group.
In some embodiments, the molar ratio of the hydrophobic anchoring moiety to the hydrophilic charged stabilizing moiety is 1:2-4.
In some embodiments, the weight ratio of the hydrophobic anchoring moiety to the hydrophilic charged stabilizing moiety is less than 0.6.
In some embodiments, the polyelectrolyte comb copolymer is PolyAgroA.
In some other embodiments, the EO-PO copolymer is selected from Ethylan NS 500 (Polyalkoxylated butyl ether), Antarox B/848 (Oxirane, methyl-, polymer with oxirane), Ultraic 5000 HM (Ethoxylated and Propoxylated Alcohol), Toximul 8350 (Polyethylene-polypropylene glycol monobutyl ether), Tergitol XD (Ethylene Oxide / Propylene Oxide Block Copolymers), Atlas G-5000-S0-(CQ) (Oxirane, 2-methyl-, polymer with oxirane, monobutyl ether) , Atlas G- 5002L-LQ-(CQ) (oxirane, monobutyl ether), SYNERGEN 848 (block polyoxalkylate) , Ethylan 992 and Ultraric 5000 HM (EU source) (Polyethylene-polypropylene Glycol Monobutyl Ether).
In some other embodiments, the polymethyl methacrylate-polyethylene glycol graft copolymer is selected from Atlox 4913, STEP-FLOW 3000, STEP-FLOW 4000 and Tersperse 2500.
In some embodiments, the Tristyrylphenol Ethoxylate Phosphate Ester, acid form is selected from Soprophor 3D33, Soprophor FL, Surfom 1322 SC, Agnique PE TSP 16T, and Dispersogen TP 160T.
In some embodiments, the polyoxyethylene sorbitol ester is selected from Tween 20, Hostacerin L 20, Hostacerin L 20 SG Vita, Alkamuls T 20, Emulsogen 4156, Alkest TW 20.
In some embodiments, the dispersant and the wetter are the same.
In some embodiments, the dispersant and the wetter are different.
In some embodiments, the composition is high-load.
In some embodiments, high-load refers to composition containing an amount of active ingredients greater than 30% w/w based on the total weight of the composition.
In some embodiments, the amount of the novaluron is 5-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 10-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 15-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 20-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 25-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 30-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 35-50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-60% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40-50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 40% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 50% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 55% w/w, based on the total weight of the composition. In some embodiments, the amount of the novaluron is 60% w/w, based on the total weight of the composition.
In some embodiments, the amount of the novaluron is between about 350 g/L to about 750 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is between about 400 g/L to about 800 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is between about 400 g/L to about 700 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is between about 400 g/L to about 600 g/L, based on the total weight of the composition. The amount of the novaluron may be an intermediate range selected from
any of the above indicated ratios. In some embodiments, the amount of the novaluron is about 780 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 750 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 700 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 650 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 600 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 550 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 500 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 450 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 400 g/L, based on the total weight of the composition. In some embodiments, the amount of the novaluron is about 350 g/L, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
In some embodiments, the total amount of the wetting agents system is 1.5-10% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is 1.5-7.5% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is 1.5-6% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is about 4.5% w/w, based on the total weight of the composition. In some embodiments, the total amount of the wetting agents system is about 7.5% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
In some embodiments, the total amount of the dispersing agents system is 2-12% w/w, based on the total weight of the composition. In some embodiments, the total amount of the dispersing agents system is 2-10% w/w, based on the total weight of the composition. In some embodiments, the total amount of the dispersing agents system is 2-8% w/w, based on the total weight of the composition. In some embodiments, the total amount of the dispersing agents system is about 5% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
In some embodiments, the amount of the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form is 1-4% w/w, based on the total weight of the composition.
The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the polyether trisiloxane is 0.5-2% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the EO-PO copolymer is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the polymethyl methacrylate-polyethylene glycol graft copolymer is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the polyelectrolyte comb co-polymer is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the Tristyrylphenol Ethoxylate Phosphate Ester acid form is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the amount of the polyoxyethylene sorbitol ester is 1-4% w/w, based on the total weight of the composition. The amount may be any intermediate or intermediate range selected from the indicated amount.
In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1.6:1. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1.5:1. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1.2:1. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:1.6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:2.5. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:3.33. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is
1:40 to 1:4.2. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1:5. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:40 to 1: 6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:36 to 1:1.6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is 1:33 to 1:1.6. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is about 1:9. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is about 1:12. In some embodiments, the weight ratio between the wetting agents system and the novaluron in the composition is about 1:13. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, the weight ratio between the two wetting agents in the composition is 8:1 to 1:2. The weight ratio may be an intermediate range selected from the indicated ratios.
In some embodiments, the weight ratio between the two dispersing agents in the composition is 4:1 to 1:4. The weight ratio may be an intermediate range selected from the indicated ratios.
In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:5. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:55 to 1: 8.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether
phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is 1:50 to 1: 8.75. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is about 1:30. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is about 1:26. In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and novaluron in the composition is about 1:20. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:2.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:7.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:10. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:12.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:15. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:120 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:110 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is 1:100 to 1:17.5. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:60. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:53. In some embodiments, the weight ratio between the polyether trisiloxane and novaluron in the composition is about 1:40.
In some embodiments, the weight ratio between the Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form and the polyether trisiloxane in the composition is 8:1 to 1:2. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, when the wetting agents system further comprises an alcohol ethoxylate, the amount of the alcohol ethoxylate is 1-4% w/w, based on the total weight of
T1
the composition. The amount may be any intermediate or intermediate range selected from the indicated amounts.
In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1.6:1. The weight ratio may be an intermediate range selected from any of the indicated ratio. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:1.25. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:1.875. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:2.5. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:3.125. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:3.75. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:30 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:27.5 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:25 to 1:4.375. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:8. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:10. In some embodiments, the weight ratio between the dispersing agents system and the novaluron in the composition is 1:12. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, the weight ratio between the dispersing agents in the composition is 4:1 to 1:4.
In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and the additional dispersing agent in the composition is 4:1 to 1:4.
In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio between polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:5. In
some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:55 to 1: 8.75. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is 1:50 to 1: 8.75. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is about 1:30. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is about 1:26. In some embodiments, the weight ratio between the polyelectrolyte comb co-polymer and novaluron in the composition is about 1:20. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios. The weight ratio may be an intermediate range selected from any of the indicated ratios.
In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:5. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:55 to 1: 8.75. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is 1:50 to 1: 8.75. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is about 1:30. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is about 1:26. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is about 1:20. In some embodiments, the weight ratio between the additional dispersing agent and novaluron in the composition is about 1:16. In some embodiments, the
weight ratio between the additional dispersing agent and novaluron in the composition is about 1:13. The weight ratio may be any intermediate or intermediate range selected from the indicated ratios.
In some embodiments, the composition is a suspension concentrate (SC). In some embodiments, the composition is an aqueous suspension. In some embodiments, the composition is a suspoemulsion (SE). In some emboodiments, novaluron is dispersed in an aqueous carrier. In some embodiments, novaluron is partly dispersed in an aqueous carrier and partly dissolved in an organic carrier.
In some embodiments, the composition is a high load, SC composition.
In some embodiments, the composition is a high load, SE composition.
In some embodiments, the density of the SC composition is between 1-1.5 g/ml. The density may be an intermediate range selected from the indicated range.
In some embodiments, the density of the SE composition is between 1-1.5 g/ml. The density may be an intermediate range selected from the indicated range.
In some embodiments, the density of the SC composition is about 1.3 g/ml.
In some embodiments, the density of the SE composition is about 1.3 g/ml.
In some embodiments, the density of the SC composition is about 1.2 g/ml.
In some embodiments, the density of the SE composition is about 1.2 g/ml.
In some embodiments, the composition further comprises at least one agriculturally acceptable additive. Agriculturally acceptable additives include, but are not limited to, carrier(s), anti-foaming agent(s), anti-freezing agent(s), stabilizer(s), preservative(s), thickener(s), and any combination thereof.
In some embodiments, the composition further comprises adjuvant(s). In some embodiment, the adjuvant is a penetrant. In some embodiment, the adjuvant enhances penetration of the active ingredient. In some embodiments, the adjuvant is a spreader. In some embodiment, the adjuvant improves the dispersion of the active ingredient on the leaf.
In some embodiments, agriculturally acceptable additive is a compound that is known and accepted in the art for use in the formation of liquid compositions for agricultural or horticultural use.
In some embodiments, the carrier is water.
In some embodiments, the anti-foaming agent(s) is selected from Silcolapse 432, SAG 1572.
In some embodiments, the anti- freezing agent(s) is selected from Propylene glycol, Glycerine.
In some embodiments, the stabilizer(s) is Magnesium Aluminium Silicate (smectite clay) selected from Van Gel B.
In some embodiments, the preservative(s) is selected from Proxel GXL, Nipacide BIT AS 20, Amebact B 20, Biotrend CMT1.5, Rocima BT 25 microbicide, Wancide 520XL.
In some embodiments, the thickener(s) is polysaccharide(s) selected from Xanthan gum, Kelzan, Kelzan Advanced Performance, AG RH 23, Kelzan AP-AS, Kelzan HP, Rheozan, Rhodopol 23, Rhodopol 50 MC, Rhodopol MD 50, Rhodopol G, Rhodicare D, XCD Biopolymer, AG-RHO POL 23/W.
In some embodiments, the thickener(s) is Carboxy Methyl Cellulose, Cabosil, Bentone MA, Bentone LT.
In some embodiments, the adjuvant(s) is organo-silicone based surfactants selected from Silwet® L77, Silwet 806, BREAK-THRU® S 240, BREAK-THRU® S 233.
In some embodiments, the adjuvant(s) is Alkamuls AP, Synergen SOC, Methyl soyate, Steposol ME.
In some embodiments, the amount of the additives is 8-15% w/w, based on the total weight of the composition.
In some embodiments, the amount of the adjuvant is 4-20% w/w, based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 10% w/w, based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 5% w/w, based on the total weight of the composition.
In some embodiments, the present invention provides a suspension concentrate composition comprising: a) Novaluron in amount of about 35-60% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition; and c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition.
In some embodiments, the present invention provides a suspension concentrate composition comprising: a) Novaluron in amount of about 35-50% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition; and c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition.
In some embodiments, the present invention provides a water dispersible composition comprising: a) novaluron in amount of about 58% w/w based on the total weight of the composition, b) Tergitol 15-S-7 in amount of about 1.5% w/w based on the total weight of the composition, c) Hostaphat® 1306 in amount of about 2% w/w based on the total weight of the composition, d) BreakThru S-240 in amount of about 1% w/w based on the total weight of the composition, e) Ethylan NS 500 in amount of 3% w/w based on the total weight of the composition, and f) PolyAgroA in amount of about 2% w/w based on the total weight of the composition.
In some embodiments, the suspension concentrate is physically stable.
In some embodiments, physical stability of the suspension refers to a state when the novaluron particles are dispersed and/or dissolved and do not float on the water surface.
In some embodiments, the physical stability is assessed after storage for 14 days at 54°C.
In some embodiments, the viscosity of the composition is less than 3000 cps. In some embodiments, the viscosity of the composition is less than 2500 cps. In some embodiments, the viscosity of the composition is less than 2000 cps. In some embodiments, the viscosity of the composition is less than 1500 cps. In some embodiments, the viscosity of the composition is less than 1000 cps. In some embodiments, the viscosity of the composition is less than 800 cps. In some embodiments, the viscosity of the composition is less than 700 cps. In some embodiments, the viscosity of the composition is less than 600 cps. In some embodiments, he viscosity of the composition is less than 500 cps. The viscosity may be an intermediate range selected from any the indicated values.
In some embodiments, the adjuvant(s) was added "as is" to the SC compositions and the amount of the adjuvant(s) is 1-20% w/w. In some embodiments, the amount of the adjuvant is 5%-10% w/w, based on the total weight of the composition.
In some embodiments, the adjuvant is separately formulated as an emulsified concentrate (EC).
In some embodiments, the SC composition comprises an adjuvant EC composition.
In some embodiments, the adjuvant is dissolved in an organic solvent.
In some embodiments, the organic solvent is an oil.
In some embodiments, the amount of the adjuvant is 30-50% w/w based on the total weight of the adjuvant EC composition.
In some embodiments, the adjuvant EC formulation further comprises an emulsifier.
In some embodiments, the emulsifier is selected from Benzenesulfonic acid, mono-Cll-13- branched alkyl derivatives, calcium salts selected from NINATE® 401-ND.
In some embodiments, the emulsifier is Dioctyl Sodium Sulfosuccinate selected from Emcol 4500, Lankropol KO2, Geropon CYA/75, DOSS 75E.
In some embodiments, the adjuvant EC formulation comprises an oil.
In some embodiments, the oil is soybean oil selected from Methyl soyate, Steposol ME.
In some embodiments, the present invention provides an SE composition.
In some embodiments the SE composition is a mixture of an SC novaluron composition and an EC novaluron composition. In some embodiments, the novaluron is partly dispersed in the water, and partly dissolved in the oil phase.
In some embodiments the SE composition is a mixture of the SC novaluron composition and the EC adjuvant mixture. In some embodiments, the novaluron is partly dispersed in the water, and partly dissolved in the EC adjuvant mixture.
In some embodiments, the amount of the novaluron that is dispersed in the water in the SE formulation is between 25-60% based on the weight of the composition.
In some embodiments, the amount of the novaluron that is dissolved in the EC mixture of the SE formulation is between 1-10% based on the weight of the composition.
In some embodiments, the present invention provides an SE composition comprising: a) Novaluron in amount of about 35-50% w/w based on the total weight of the composition, b) a system of at least 2 wetting agents in amount of about 1.5-6% w/w based on the total weight of the composition, c) a system of at least two dispersing agents in amount of about 2-8% w/w based on the total weight of the composition, and d) an adjuvant in amount of about 4-7% w/w based on the total weight of the composition.
In some embodiments, the present invention provides an SE composition comprising: e) Novaluron in amount of about 35% w/w based on the total weight of the composition, f) a system of at least 2 wetting agents in amount of about 1.4% w/w based on the total weight of the composition; g) a system of at least two dispersing agents in amount of about 5% w/w based on the total weight of the composition; and h) an adjuvant in amount of about 4% w/w based on the total weight of the composition.
Uses:
In another aspect, the present invention provides use of the composition as described herein for treating a plant.
In some embodiments, the plant is a pesticide sensitive crop.
In some embodiments, the pesticide sensitive crop is cucumber. In some embodiments, the pesticide sensitive crop is lettuce. In some embodiments, the pesticide sensitive crop is pepper. In some embodiments, the pesticide sensitive crop is cabbage. In some embodiments, the pesticide sensitive crop is cucurbit. In some embodiments, the pesticide sensitive crop is wine grapes. In some embodiments, the pesticide sensitive crop is cotton. In some embodiments, the pesticide sensitive crop is corn. In some embodiments, the pesticide sensitive crop is soybean.
In some embodiments, the composition is obtained using one of the processes of preparation described herein.
In another aspect, the present invention provides a method for treating a plant comprising (1) obtaining the composition as described herein and (2) contacting the plant with an effective amount of the composition.
The present invention also provides a method for controlling unwanted insects comprising applying an effective amount of the herein described composition to a plant, or an area infested with the unwanted insects so as to thereby control the unwanted insects.
In some embodiments, the composition is applied at a rate from about 100 ppm to about 1000 ppm of novaluron. In some embodiments, the composition is applied at a rate from about 100 ppm to about 500 ppm of novaluron. In some embodiments, the composition is applied at a rate from about 200 ppm to about 400 ppm of novaluron. In some embodiments, the composition is applied at a rate of about 200 ppm of novaluron. In some embodiments, the composition is applied at a rate of about 200-500 ppm of novaluron.
In some embodiments, the composition is applied at a rate from about 40 gr/ha to about 180 g/ha of novaluron.
In some embodiments, the composition is applied at a rate from about 50 gr/ha to about 150 g/ha of novaluron.
In some embodiments, the pesticide sensitive crop is cucumber. In some embodiments, the pesticide sensitive crop is lettuce. In some embodiments, the pesticide sensitive crop is pepper. In some embodiments, the pesticide sensitive crop is cabbage. In some embodiments, the pesticide sensitive crop is cucurbit. In some embodiments, the pesticide sensitive crop is wine grapes. In some embodiments, the pesticide sensitive crop is cotton. In some
embodiments, the pesticide sensitive crop is corn. In some embodiments, the pesticide sensitive crop is soybean.
In some embodiments, when the pesticide sensitive crop is cucumber, the composition is applied at a rate from about 40 gr/ha to about 180 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is cucumber, the suspension is applied at a rate from about 40 gr/ha to about 150 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is cucumber, the suspension is applied at a rate from about 50 gr/ha to about 115 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is cotton, the composition is applied at a rate from about 10 gr/ha to about 105gr/ha of novaluron. In some embodiments, when the pesticide sensitive crop is corn, the composition is applied at a rate from about 10 gr/ha to about 87.6 gr/ha of novaluron. In some embodiments, when the pesticide sensitive crop is soybean, the composition is applied at a rate from about 35 gr/ha to about 87.6 gr/ha of novaluron.
In some embodiments, when the pesticide sensitive crop is lettuce, the composition is applied at a rate from about 50 gr/ha to about 180g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is lettuce, the composition is applied at a rate from about 50 gr/ha to about 150g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is lettuce, the composition is applied at a rate from about 65 gr/ha to about 115 g/ha of novaluron.
In some embodiments, when the pesticide sensitive crop is pepper, the composition is applied at a rate from about 40 gr/ha to about 180 g/ha of novaluron In some embodiments, when the pesticide sensitive crop is pepper, the composition is applied at a rate from about 40 gr/ha to about 150 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is pepper, the composition is applied at a rate from about 50 gr/ha to about 115 g/ha of novaluron.
In some embodiments, when the pesticide sensitive crop is cabbage, the composition is applied at a rate from about 50 gr/ha to about 200 g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is cabbage, the composition is applied at a rate from about 65 gr/ha to about 115 g/ha of novaluron.
In some embodiments, when the pesticide sensitive crop is cucurbit, the composition is applied at a rate from about 40 gr/ha to about 150 g/ha of novaluron. In some embodiments,
when the pesticide sensitive crop is cucurbit, the composition is applied at a rate from about 50 gr/ha to about 115 g/ha of novaluron.
In some embodiments, when the pesticide sensitive crop is wine grapes, the composition is applied at a rate from about 40 gr/ha to about 130g/ha of novaluron. In some embodiments, when the pesticide sensitive crop is wine grapes, the composition is applied at a rate from about 50 gr/ha to about lOOg/ha of novaluron.
In some embodiments, the composition is applied once during a growing season.
In some embodiments, the composition is applied at least one time during a growing season.
In some embodiments, the composition is applied two or more times during a growing season.
In some embodiments, the composition is applied to soil. In some embodiments, the combination or composition is applied to foliage.
In some embodiments, the composition is applied at a rate from about 100 ppm to about 1000 ppm of novaluron. In some embodiments, the composition is applied at a rate from about 100 ppm to about 500 ppm of novaluron. In some embodiments, the composition is applied at a rate from about 200 ppm to about 400 ppm of novaluron. In some embodiments, the composition is applied at a rate of about 200 ppm of novaluron. In some embodiments, the composition is applied at a rate of about 200-500 ppm of novaluron.
In some embodiments, the composition is applied to soil. In some embodiments, the composition is applied to foliage.
The compositions, uses and methods described herein are particularly effective for controlling insects of, inter alia, the orders Lepidoptera, Coleoptera, Homoptera, Heteroptera, Diptera, Thysanoptera, Orthoptera, Anoplura, Siphonaptera, Mallophaga, Thysanura, Isoptera, Psocoptera and Hymenoptera, as well as representatives of the order Acarina of the families Ixodidae Argasidae, Tetranychidae and Dermanyssidae leaf rollers.
The compositions, uses and methods described herein are also effective in controlling flies, e.g. Musca domestica, termites, cockroaches and mosquito larvae.
The compositions, uses and methods described herein are also suitable for controlling plantdestructive feeding insects in ornamentals and crops of useful plants, especially in cotton (e. g. against Spodoptera littoralis and Heliothis virescens) and in fruit and vegetables (e. g.
against Laspeyresia pomonella, Cydia pomonella, Lithocolletis blancardella, Stigmella malella, 4doxophyes orana, Psylla piri, Cryptophlebia leucotreta, phyllocnistis citrella, Cydia molesta, Anarsia lineatella, Leptinotarsa decemlineata and Epilachna varivestis), as well as for controlling several species of mites, e. g., oleivora.
The compositions disclosed herein may be applied to control and/or prevent a variety of insect in the presence of plant.
In some embodiments, the plant is a crop. In some embodiments, plant is a pesticide sensitive crop. In some embodiments, the crop is a soft crop such as vegetable and fruits.
The methods of the present invention may be used on any crop plants, including but not limited to monocotyledons such as sugar cane cereals, rice, maize (corn), and/or; or dicotyledon crop such as beets (such as sugar beet or fodder beet); fruits (such as pomes, stone fruits, or soft fruits, for example apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, or blackberries); leguminous plants (such as beans, lentils, peas, or soybeans); oil plants (such as rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, or groundnuts); cucumber plants (such as marrows, cucumbers or melons); fiber plants (such as cotton, flax, hemp, or jute); citrus fruits (such as Winegrapes, oranges, lemons, grapefruit, or mandarins); vegetables (such as spinach, lettuce, cabbages, carrots, tomatoes, potatoes, cucurbits, or paprika); lauraceae (such as avocados, cinnamon, or camphor); tobacco; nuts; coffee; tea; vines; hops; durian; bananas; natural rubber plants; and ornamentals (such as flowers, shrubs, broad-leaved trees, or evergreens, for example conifers).
In some embodiments, the plants are monocotyledonous plants, more preferably, cereals. In a specific embodiment, the cereal crop is wheat. In another specific embodiment, the cereal crop is triticale. In another specific embodiment, the cereal crop is rye. In another specific embodiment, the cereal crop is oat. In a further embodiment, the cereal crop is barley. In another embodiment, the crop plants are rice plants. In still another embodiment, the crop plants are sugar cane plants. In yet another embodiment, the crop plants are corn plants.
The compositions, uses and methods described herein are further effective for controlling ectoparasites such as Lucilia sericata, in domestic animals and productive livestock, e. g. by treating animals' skin, cowsheds, barns, stables etc., and pastures.
Process of preparation:
In another aspect, the present invention provides a process for preparing the composition described herein, the process comprising mixing wetting agents, dispersing agents, novaluron and water.
In some embodiments, the process comprises optionally adjusting the pH of the composition.
In some embodiments the pH of the composition in between 5-8.
In some embodiments, the pH is adjusted using concentrated NaOH solution and/or concentrated HCI solution.
In some embodiments, the process comprises: (1) mixing the wetting agents, the dispersing agents, additives and water, and (2) adding novaluron.
In some embodiments, novaluron is added gradually.
In some embodiments, the mixture is milled. The milling process is wet milling.
In some embodiments, the milling process obtains particle size D90 between 2 to 10 micrometers, preferably between 4 to 7 micrometers.
In some embodiments, the process includes high shear.
In some embodiments, the process comprises mixing the SC composition as described herein with an adjuvant formulated "as is".
In some embodiments, the process comprises mixing the SC composition as described herein with an adjuvant formulated as an EC as described herein.
In some embodiments, the process for preparing the EC formulation comprises mixing the adjuvant with a solvent and at least one emulsifier.
EXAMPLES
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Atlox 4913, half of the Silcolapse 432, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring.
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Ethylan NS 500, half of the Silcolapse 432, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring.
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Ethylan NS 500, half of the Silcolapse 432, PolyAgroA, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring.
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, BreakThru S-240, Ethylan NS 500, half of the Silcolapse 432, PolyAgroA, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring.
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Hostaphat 1306, Ethylan NS 500, half of the Silcolapse 432, PolyAgroA, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring.
Example 6: Novaluron 57.9%+ Tergitol 15-S-7+Hostapaht 1306+BreakThru S-240+Ethylan NS 500+PolyAgroA
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Hostaphat 1306, BreakThru S-240, Ethylan NS 500, half of the Silcolapse 432, PolyAgroA, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring, and optionally leaving 5% gap in the water addition for next step.
9. Optionally add 5% adjuvant by applying high shear.
A chemically stable formulation was obtained, as shown in the next table:
Stability tests for example 6 (Novaluron 57.9%+ Tergitol 15-S-7+Hostapaht 1306+BreakThru
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Hostaphat 1306, half of the Silcolapse 432, PolyAgroA, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring, and optionally leaving 5% gap in the water addition for next step.
9. Optionally add 5% adjuvant by applying high shear.
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Hostaphat 1306, BreakThru S-240, Ethylan NS 500, half of the Silcolapse 432, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring.
Formulation with PolyAgroA (example 6) is better than the formulation without PolyAgroA (example 8). PolyAgroA reduces the viscosity and is advantageous in terms of entrance into the water.
Example 9: Novaluron 57.9%+Tergitol 15-S-7+Hostaphat 1306+BreakThru S-240+Ethylan NS
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Ethylan NS 500, half of the Silcolapse 432, Atlox 4913, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring.
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Hostaphat 1306, BreakThru S-240, Ethylan NS 500, PolyAgroA, half of the Silcolapse 432, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring.
Example 11: Novaluron 57.9%+ Tergitol 15-S-7+Hostapaht 1306+BreakThru S-240+Atlox 4913+PolyAgroA
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Hostaphat 1306, BreakThru S-240, Atlox 4913, half of the Silcolapse 432, PolyAgroA, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring, and optionally leaving 5% gap in the water addition for next step.
9. Optionally add 5% adjuvant by applying high shear.
Example 12: Novaluron 57.9%+ Tergitol 15-S-7+Hostapaht 1306+BreakThru S- 240+Soprophor 3D33+PolyAgroA
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Hostaphat 1306, BreakThru S-240, Soprophor 3D33, half of the Silcolapse 432, PolyAgroA, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring.
Example 13: Novaluron 57.9%+Tergitol 15-S-7+Hostapaht 1306+BreakThru S-240+Tween 20+PolyAgroA
Production process:
1. Add Van Gel B to the water and apply high shear.
2. Add Tergitol 15-S-7, Hostaphat 1306, BreakThru S-240, Tween 20, half of the Silcolapse 432, PolyAgroA, Propylene glycol and apply high shear.
3. Add gradually Novaluron while stirring.
4. Apply high shear
5. Mill the mixture until particle size is less than 5 micrometers. (D90<5 micrometer).
6. Calculate the milling factor.
7. Adjust pH if needed (to pH 6~7) with concentrated NaOH solution/HCI solution.
8. Close the formulation by adding Silcolapse 432, Xanthan gum 2% solution, Proxel GXL and the remaining water while stirring, and optionally leaving 5% gap in the water addition for next step.
9. Optionally add 5% adjuvant by applying high shear.
* All values are % w/w ** optional
Examples of adjuvant EC formulations:
Example of SC formulation comprising adjuvant EC:
Example 22:
Stage 1: SC preparation (68%)
2. Mill the mixture to get the desired particle size distribution (D90<5 micrometer).
3. pH adjustment (with NaOH solution)
Stage 2: EC preparation (10%)
Stage 3: Final (22%)
1. Add the oil phase (10%) to the milled mixture from stage 1.
Example 23: evaluation of novaluron formulations mixed with adjuvants against larvae of S. frugiperda.
Insects
Field strain of S. frugiperda was collected in June 2021 from corn fields near Negba (located in the northern Negev desert, near the city of Ashkelon) and was reared on mixture of cornpolenta and premixed diet (Ward's Stonefly Heliothis Diet, USA) under standard rearing conditions of 27°C, 55% RH and 14 h photoperiod.
Insecticides
The standard Rimon (novaluron) 100 EC compared to Rimon Supra 100 SC and to other formulations comprising adjuvant as follows:
Bioassays:
Leaves of corn dipped in aqueous concentrations of a formulation or in water as control. After 15 seconds of dipping, the corn leaves then allowed to air dry for 2 h. Afterwards, S. frugiperda larvae (third instars, 8-10 mm), reared in a controlled growth room (27 ± 2°C and 50% RH with a photoperiod of 14:10 h light: dark) placed inside Petri dishes on treated corn leaves; in
addition, filter papers also added to the dishes (to avoid too much moisture). The experiments done on 10 larvae for each concentration and repeated at least three times, on separate.
Mortality of the larvae in comparison with the control determined five days after exposure to the formulations, and larval weight gain (LWG) determined on day five.
Claims
1. A stable liquid agrochemical composition comprising of:
(a) novaluron;
(b) a system of at least two wetting agents; and
(c) a system of at least two dispersing agents.
2. The composition of claim 1, wherein the wetting agents are selected from organo-silicone based surfactants and alkyl polyalkylene glycol ether phosphoric acid.
4. The composition of claim 3, wherein the organo-silicone based surfactant is BreakThru S-240.
5. The composition of claim 2, wherein the alkyl polyalkylene glycol ether phosphoric acid ester acid form is selected from Hostaphat® 1306 (Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form), Hostaphat® CC 100 (Cetyl phosphoric acid ester, acid form, mono/diester ~ 98 % ), SERVOXYL VPDZ 3/100 (tridecyl polyglycol ether (3EO) phosphate), PROTE-PON P-TD-06-Z (alkyl ether phosphoric acid), LUBRHOPHOS LP 700 (phosphate ester with aromatic base), RHODAFAC BG 510 (phosphate ester with aliphatic base), DERMALIX C (alkyl phosphate in aqu. /organic medium), SANDOCLEAN SKBB (alkyl phosphate esters), PROTE-PON TD-09-K30 (alkyl ether potassium phosphate), PAE 147 (phosphated alcohol ethoxylate), LIBRAPHOS AD (sodium salt of Libraphos EP 120), NIKKOL DDP-2 (di POE (2) alkyl ether phosphate; free acid form), MARLOPHOR NP7-ACID (nonylphenol polyethyleneglycol ether phosphoric acid partial ester), MARLOWET 5301 (coconut polyethylene glycol ether phosphoric acid partial ester), ATLAS G-
2203 (potassium salt of phosphoric acid ester), FOSFODET 1214 N/16 (ethoxylated fatty alcohol phosphate ester).
6. The composition of claim 5, wherein the alkyl polyalkylene glycol ether phosphoric acid ester acid form is Hostaphat® 1306.
7. The composition of claim 2, wherein the wetting agent system further comprises an alcohol ethoxylate.
8. The composition of claim 7, wherein the alcohol ethoxylate is selected form
, wherein m+n=15 and x is number of repeating ethoxylate (EO) units.
9. The composition of claim 8, wherein the alcohol ethoxylate is Tergitol 15-S-7.
10. The composition of claim 1 or 2, wherein the system of dispersing agents comprises a polyelectrolyte comb copolymer.
11. The composition of claim 10, wherein the polyelectrolyte comb copolymer is PolyAgroA.
12. The composition of claim 10 or 11, further comprises a dispersing agent selected from EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
13. The composition of claim 12, wherein the EO-PO copolymer is selected from Ethylan NS 500 (Polyalkoxylated butyl ether), Antarox B/848 (Oxirane, methyl-, polymer with oxirane), Ultraic 5000 HM (Ethoxylated and Propoxylated Alcohol), Toximul 8350 (Polyethylene-polypropylene glycol monobutyl ether), Tergitol XD (Ethylene Oxide / Propylene Oxide Block Copolymers), Atlas G-5000-S0-(CQ) (Oxirane, 2-methyl-, polymer with oxirane, monobutyl ether) , Atlas G-5002L-LQ-(CQ) (oxirane, monobutyl ether), SYNERGEN 848 (block polyoxalkylate) , Ethylan 992 and Ultraric 5000 HM (EU source) (Polyethylenepolypropylene Glycol Monobutyl Ether).
14. The composition of claim 12, wherein the polymethyl methacrylatepolyethylene glycol graft copolymer is selected from Atlox 4913, STEP-FLOW 3000 and STEPFLOW 4000.
15. The composition of claim 12, wherein the Tristyrylphenol Ethoxylate Phosphate Ester, acid form is selected from Soprophor 3D33, Soprophor FL, Surfom 1322 SC, Agnique PE TSP 16T, and Dispersogen TP 160T.
16. The composition of claim 12, wherein the polyoxyethylene sorbitol ester is selected from Tween 20, Hostacerin L 20, Hostacerin L 20 SG Vita, Alkamuls T 20, Emulsogen 4156, Alkest TW 20.
17. The composition of any one of claims 1-16, wherein the composition further comprises at least one agriculturally acceptable additive.
18. The composition of claim 17, wherein the at least one additive is selected from a carrier, an anti-foam agent, an anti-freeze agent, a stabilizer, a preservative, a thickener, an adjuvant, or a combination thereof.
19. The composition of claim 18, wherein the carrier is an aqueous carrier.
20. The composition of claim 19, wherein the composition is a suspension concentrate (SC) or a suspoemlusion (SE).
21. The composition of any one of claims 1-20, wherein the amount of the novaluron is 35-60% w/w, based on the total weight of the composition.
22. The composition of any one of claims 1-21, wherein the amount of the wetting agents system is between 1.5-10% w/w, based on the total weight of the composition.
23. The composition of any one of claims 1-22, wherein the amount of the dispersing agents system is between 2-12% w/w, based on the total weight of the composition.
24. The composition of any one of claims 1-23, wherein the pH of the composition is between 6-8.
25. Use of at least two wetting agents and at least two dispersing agents for increasing the stability of a liquid composition comprising novaluron.
26. The use of claim 25, wherein the amount of the novaluron is 35-60% w/w, based on the total weight of the composition.
27. The use of claim 25 or 26, wherein the wetting agents are selected from organo-silicone based surfactants and alkyl polyalkylene glycol ether phosphoric acid ester acid.
28. The use of claim 27, wherein the organo-silicone based surfactants are selected from Silwet® L77, Silwet 806, BREAK-THRU® S 240, and BREAK-THRU® S 233.
29. The use of claim 28, wherein the organo-silicone based surfactant is BreakThru S-240.
30. The use of claim 27, wherein the alkyl polyalkylene glycol ether phosphoric acid ester acid form is selected from Hostaphat® 1306 (Alkyl polyethylene glycol ether phosphoric acid mono / diester (50/50), acid form), Hostaphat® CC 100 (Cetyl phosphoric acid ester, acid form, mono/diester ~ 98 % ), SERVOXYL VPDZ 3/100 (tridecyl polyglycol ether (3EO) phosphate), PROTE-PON P-TD-06-Z (alkyl ether phosphoric acid), LUBRHOPHOS LP 700 (phosphate ester with aromatic base), RHODAFAC BG 510 (phosphate ester with aliphatic base), DERMALIX C (alkyl phosphate in aqu. /organic medium), SANDOCLEAN SKBB (alkyl phosphate esters), PROTE-PON TD-09-K30 (alkyl ether potassium phosphate), PAE 147 (phosphated alcohol ethoxylate), LIBRAPHOS AD (sodium salt of Libraphos EP 120), NIKKOL DDP-2 (di POE (2) alkyl ether phosphate; free acid form), MARLOPHOR NP7-ACID (nonylphenol polyethyleneglycol ether phosphoric acid partial ester), MARLOWET 5301 (coconut polyethylene glycol ether phosphoric acid partial ester), ATLAS G-2203 (potassium salt of phosphoric acid ester), FOSFODET 1214 N/16 (ethoxylated fatty alcohol phosphate ester).
31. The use of claim 30, wherein the alkyl polyalkylene glycol ether phosphoric acid ester acid form is Hostaphat® 1306.
32. The use of claim 27, further comprising an alcohol ethoxylate.
33. The use of claim 32, wherein the alcohol ethoxylate is selected form Tergitol 15-S-7, Tergitol 15-S-9 and Tergitol 15-S-12.
34. The use of claim 33, wherein the alcohol ethoxylate is Tergitol 15-S-7.
35. The use of claim 25 or 26, wherein the dispersing agents comprises an polyelectrolyte comb copolymer.
36. The use of claim 35, wherein the polyelectrolyte comb copolymer is PolyAgroA.
37. The use of claim 35 or 36, further comprises a dispersing agent selected from EO-PO copolymer, polymethyl methacrylate-polyethylene glycol graft copolymer, Tristyrylphenol Ethoxylate Phosphate Ester, acid form and polyoxyethylene sorbitol ester.
38. The composition of claim 37, wherein the EO-PO copolymer is selected from Ethylan NS 500 (Polyalkoxylated butyl ether), Antarox B/848 (Oxirane, methyl-, polymer with oxirane), Ultraic 5000 HM (Ethoxylated and Propoxylated Alcohol), Toximul 8350 (Polyethylene-polypropylene glycol monobutyl ether), Tergitol XD (Ethylene Oxide / Propylene Oxide Block Copolymers), Atlas G-5000-S0-(CQ) (Oxirane, 2-methyl-, polymer with oxirane, monobutyl ether) , Atlas G-5002L-LQ-(CQ) (oxirane, monobutyl ether), SYNERGEN 848 (block polyoxalkylate) , Ethylan 992 and Ultraric 5000 HM (EU source) (Polyethylenepolypropylene Glycol Monobutyl Ether).
39. The composition of claim 37, wherein the polymethyl methacrylatepolyethylene glycol graft copolymer is selected from Atlox 4913, STEP-FLOW 3000 and STEPFLOW 4000.
40. The composition of claim 37, wherein the Tristyrylphenol Ethoxylate Phosphate Ester, acid form is selected from Soprophor 3D33, Soprophor FL, Surfom 1322 SC, Agnique PE TSP 16T, and Dispersogen TP 160T.
41. The composition of claim 37, wherein the polyoxyethylene sorbitol ester is selected from Tween 20, Hostacerin L 20, Hostacerin L 20 SG Vita, Alkamuls T 20, Emulsogen 4156, Alkest TW 20.
42. The use of any one of claims 25-41, wherein the liquid composition is an aqueous composition.
43. The use of claim 42, wherein the aqueous composition is a suspension concentrate (SC) or suspoemusion (SE).
44. The use of any one of claims 20-33, wherein the amount of the wetting agents system is between 1.5-10% w/w, based on the total weight of the composition.
45. The use of any one of claims 20-34, wherein the amount of the dispersing agents system is between 2-12% w/w, based on the total weight of the composition.
46. Use of the composition of any one of claims 1-24 for treating a plant.
47. A method for treating a plant comprising (1) obtaining the composition of any one of claims 1-24, and (2) contacting the plant with an effective amount of the composition.
48. A process for preparing the composition of any one of claims 1-24, the process comprising mixing wetting agents, dispersing agents, novaluron and water.
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