WO2019239358A1 - Agricultural composition - Google Patents
Agricultural composition Download PDFInfo
- Publication number
- WO2019239358A1 WO2019239358A1 PCT/IB2019/054929 IB2019054929W WO2019239358A1 WO 2019239358 A1 WO2019239358 A1 WO 2019239358A1 IB 2019054929 W IB2019054929 W IB 2019054929W WO 2019239358 A1 WO2019239358 A1 WO 2019239358A1
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- WIPO (PCT)
- Prior art keywords
- composition
- fluensulfone
- effective amount
- fipronil
- azoxystrobin
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
Definitions
- the present subject matter relates to mixtures and compositions comprising fluensulfone, fipronil and azoxystrobin, as well as preparation and uses thereof.
- Crop protection is critical from early stages of crop development. Preventing pests and diseases at the root of the crop during root development leads to increased crop health and yield.
- Y oung roots are most sensitive and there is a need to develop multi-functional mixtures with broad spectrum activity against pests and diseases which affect the crop during the crop’s early developmental stages.
- Roots are highly affected by nematodes, insects and pathogens at the locus of the plant.
- Fluensulfone (5-chloro-2-(3,4,4-trif!uorobut-3-en-l-ylsulfonyl)-l,3-thiazole) is a nematocide which has a significantly reduced environmental impact with low toxicity to non-target insects and mammals. Fluensulfone's mode of action is distinct from currently available nematicides and therefore presents a promising new chemical entity for crop protection.
- Insecticide and fungicide are also required for improving root development.
- the present invention provides a stable composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the present invention provides a stable composition for controlling nematode, enhancing plant development, regulating plant growth, preventing plant and/or soil disease, and/or controlling plant and/or soil disease, wherein the composition comprising (i) an effective amount of fluensulfone (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the present invention further provides a stable composition
- a stable composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, (iv) an aqueous carrier, and (v) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the present invention provides a stable composition
- a stable composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, (iv) an aqueous carrier, (v) an organic carrier, and (vi) at least one physically stabilizing additive, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the present invention provides a stable composition
- a stable composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, (iv) an aqueous carrier, (v) an organic carrier, and (vi) a physically stabilizing system, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the present invention also provides the use of polyvinylpyrrolidone for stabilizing a composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention also provides the use of a combination of polyvinylpyrrolidone and polyalkylene oxide block copolymer for stabilizing a composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the present invention provides a method for controlling nematode, enhancing plant development, regulating plant growth, preventing plant and/or soil disease, and/or controlling plant and/or soil disease, wherein the method comprises applying an effective amount of any one of the mixtures or compositions disclosed herein to the plant, a locus of the plant or propagation material of the plant so as to thereby control nematode, enhance development of the plant, regulate the growth of the plant, prevent plant and/or soil disease, and/or control plant and/or soil disease.
- the present invention provides a method for controlling nematode, enhancing plant development, regulating plant growth, preventing plant and/or soil disease, and/or controlling plant and/or soil disease, wherein the method comprises applying (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin to the plant, a locus of the plant or propagation material of the plant so as to thereby control nematode, enhance development of the plant, regulate the growth of the plant, prevent plant and/or soil disease, and/or control plant and/or soil disease.
- the invention provides a process for preparing the stable composition described herein, wherein the process comprises the steps of: (1) milling a dispersion of fipronil and azoxystrobin in water, (2) dissolving fluensulfone in an organic carrier to obtain a solution, (3) preparing an emulsion from the solution obtained in step (2), and (4) preparing suspoemulsion composition from the dispersion obtained from step (1) and the emulsion obtained from step (3).
- the term“broad spectrum” is used to describe efficiency against a wide range of diseases and infections of the plant, the locus thereof or propagation material thereof.
- the term“stable” when used in connection with physical stabilization or when used in connection with a composition means that no significant crystallization and/or thickening was observed after at least 2 weeks of storage at a temperature of at least 50°C.
- the term“stable” when used in connection with suspoemulsion means no crystallization and/or thickening was observed after at least 2 weeks of storage at a temperature of at least 50°C.
- Stability is assessed according to CIPAC test protocols. Physical stability of the composition is tested using CIPAC methodologies MT 36.3- Emulsion (5%) 342 ppm water (2 h) test; MT l85-Wet Sieve Test; MT 148.1- Pourability; MT 39.3-Storage Stability 0°C; and MT l84-Suspensibility.
- CIPAC test is standard in the relevant industry for assessing before and after storage stability. Stability can be assessed under normal storage conditions which is after two years storage at room temperature. Stability can also be assessed under accelerated storage conditions which is after 2 weeks storage at 54°C or equivalent or after 8 weeks at 40°C or after 12 weeks at 35°C.
- the term“effective” when used to describe a method for controlling of undesired pest, such as nematodes, means that the method provides a good level of control of the undesired pest without significantly interfering with the normal growth and development of the crop.
- the term "effective amount" when used in connection with an active component refers to an amount of the active component that, when ingested, contacted with or sensed, is sufficient to achieve a good level of control or activity.
- the term“effective amount” when used in connection with a non-active component, i.e. additive, such as polymer and organic carrier, refers to an amount of the additive that is sufficient to improve the stability of the composition.
- agriculturally acceptable carrier means carrier which are known and accepted in the art for the formation of compositions for agricultural or horticultural use.
- adjuvant is broadly defined as any substance that itself is not an active ingredient but which enhances or is intended to enhance the effectiveness of the pesticide with which it is used.
- Adjuvants may be understood to include, but are not limited to, spreading agents, penetrants, compatibility agents, and drift retardants.
- agriculturally acceptable inert additives is defined as any substance that itself is not an active ingredient but is added to the composition such as thickening agent, sticking agents, surfactants, anti-oxidation agent, anti-foaming agents and thickeners.
- tank mix means that two or more chemical pesticides or compositions are mixed in the spray tank at the time of spray application.
- ready mix means a composition that may be applied to plants directly after dilution.
- the composition comprises the combination of the active ingredients.
- plant includes reference to the whole plant, plant organ (e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), and propagation material or plant cells.
- plant organ e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.
- plant includes reference to agricultural crops including field crops (soybean, maize, wheat, rice, etc.), vegetable crops (potatoes, cabbages, etc.), fruits (peach, etc.), semi-perennial crops (sugarcane) and perennial crops (coffee and guava)
- propagation material is to be understood to denote all the generative parts of the plant such as seeds and spores, vegetative structures such as bulbs, corms, tubers, rhizomes, roots stems, basal shoots, stolons and buds.
- locus includes not only areas where the pest may already be developed, but also areas where pest have yet to emerge, and also to areas under cultivation.
- mixture or“combination” refers, but is not limited to, a combination in any physical form, e.g., blend, solution, suspension, dispersion, emulsion, alloy, or the like.
- enhancing crop plants means improving one or more of plant quality, plant vigor, nutrient uptake, root system, tolerance to stress factors, and/or yield in a plant to which the mixture or composition described herein has been applied as compared to a control plant grown under the same conditions except to which the mixture or composition described herein has not been applied.
- enhancing roots system means the roots system is improved qualitatively or quantitatively in plant to which the mixture or composition described herein has been applied as compared to the roots systems in a control plant grown under the same conditions except to which the mixture or composition described herein has not been applied.
- Enhanced roots systems include but are not limited to improved visual appearance and composition of the roots system (i.e., improved color, density, and uniformity), increased root growth, a more developed root system, stronger and healthier roots, improved plant stand, and increased roots system weight.
- improving plant quality means that one or more traits are improved qualitatively or quantitatively in a plant to which the mixture or composition described herein has been applied as compared to the same trait in a control plant grown under the same conditions except to which the mixture or composition described herein has not been applied.
- traits include but are not limited to improved visual appearance and composition of the plant (i.e.. improved color, density, uniformity, compactness), reduced ethylene (reduced production and/or inhibition of reception), improved visual appearance and composition of harvested material (i.e.. seeds, fruits, leaves, vegetables, shoot/stem/cane),), improved carbohydrate content (i.e..
- plant growth regulation or “regulating plant growth” includes restricting vertical stem growth, promoting root growth, stunting, increasing stem diameter and stem-wall thickness, and the like.
- mixture or“combination” refers, but is not limited to, a combination in any physical form, e.g., blend, solution, alloy, or the like.
- plants refers to any and all physical parts of a plant, including but not limited to seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage, and fruits.
- surfactant means an agriculturally acceptable material which imparts emulsifiability, stability, spreading, wetting, dispersibility or other surface modifying properties.
- suitable surfactants include non-ionic, anionic, cationic and ampholytic surfactants.
- 0.1% to 50% includes 0.1 %, 0.2 %, 0.3 %, 0.4 % etc. up to 50 %.
- Fluensulfone, fipronil and azoxystrobin have been studied and used for many years. For many crops, there is a need for a combination of different pesticides for improving root development and efficiency of rooting.
- the present invention provides a stable composition comprising fluensulfone, fipronil and azoxystrobin.
- composition of the present invention is unexpectedly more efficient in controlling nematode.
- the composition is also unexpectedly more efficient in regulating plant growth and enhancing plant development, including, for example, enhancing root development.
- the composition is ready to use after dilution.
- composition of the present invention provides a number of advantages over tank mixes comprising fluensulfone, fipronil and azoxystrobin. These advantages include, but are not limited to, simplicity of use, stability, reduced amount of solvents and increased effectiveness.
- the present invention provides a stable, broad spectrum composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of an insecticide, and (iii) an effective amount of a fungicide.
- the present invention provides a broad spectrum, stable, ready to dilute composition comprising: (i) fluensulfone, (ii) fipronil and (iii) azoxystrobin.
- the fungicide is a strobilurin fungicide.
- the insecticide is a phenypyrazole insecticide.
- the strobilurin fungicide is azoxystrobin.
- the phenylpyrazole insecticide is fipronil.
- the present invention provides a stable composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention provides a stable, broad spectrum composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention provides a stable, broad spectrum composition for use on sugar cane, wherein the composition comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention provides a stable, broad spectrum composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, and (iv) an agriculturally acceptable carrier.
- the present invention provides a stable composition
- a stable composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, (iv) at least one physically stabilizing additive, (v) an aqueous carrier, and (vi) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the present invention provides a stable composition
- a stable composition comprising (i) an effective amount of fluensulfone (ii) an effective amount of fipronil (iii) an effective amount of azoxystrobin, (iv) a physically stabilizing system, (v) an aqueous carrier, and (vi) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the present invention further provides a stable, broad spectrum composition
- a stable, broad spectrum composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, (iv) an aqueous carrier, and (v) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and fluensulfone in dissolved in the organic carrier.
- the present invention further provides a stable suspoemulsion composition
- a stable suspoemulsion composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, (iv) an aqueous carrier, and (v) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the present invention provides a stable, broad spectrum composition for controlling pests wherein the composition comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention provides a broad spectrum, stable, ready to dilute composition comprising: (i) fluensulfone, (ii) fipronil and (iii) azoxystrobin.
- the present invention provides a broad spectrum, stable, ready to dilute composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention provides a broad spectrum, stable, ready to dilute composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention provides a broad spectrum, stable, ready to dilute composition for use on sugar cane, wherein the composition comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention provides a broad spectrum, stable, ready to dilute composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, and (iv) an agriculturally acceptable carrier.
- the present invention provides a broad spectrum, stable, ready to dilute composition
- a broad spectrum, stable, ready to dilute composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, (iv) at least one physically stabilizing additive, (v) an aqueous carrier, and (vi) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the present invention provides a broad spectrum, stable, ready to dilute composition
- a broad spectrum, stable, ready to dilute composition comprising (i) an effective amount of fluensulfone (ii) an effective amount of fipronil (iii) an effective amount of azoxystrobin, (iv) a physically stabilizing system, (v) an aqueous carrier, and (vi) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the present invention provides a broad spectrum, stable, ready to dilute composition
- a broad spectrum, stable, ready to dilute composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, (iv) an aqueous carrier, and (v) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and fluensulfone in dissolved in the organic carrier.
- the present invention provides a broad spectrum, stable, ready to dilute composition
- a broad spectrum, stable, ready to dilute composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, (iii) an effective amount of azoxystrobin, (iv) an aqueous carrier, and (v) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the present invention provides a broad spectrum, stable, ready to dilute composition for controlling pests wherein the composition comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the pests are nematode. In some embodiments, the pests are insects. In some embodiments, the pests are fungi. In some embodiments, the pests are nematodes, insects and fungi.
- the present invention provides a stable composition for controlling nematodes wherein the composition comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention also provides a stable, broad spectrum composition for enhancing crop plant, wherein the composition comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention also provides a stable, broad spectrum composition for enhancing plant development, wherein the composition comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the composition enhances root development. In some embodiments, the composition enhances the root system of the plant. In some embodiments, the composition enhances plant quality. In some embodiments, the composition enhances plant vigor. In some embodiments, the composition enhances plant yield. In some embodiments, the composition prevents root damage. In some embodiments, the composition improves rooting.
- the present invention provides a stable, broad spectrum composition for regulating plant growth, wherein the composition comprises (i) an effective amount of fluensulfone (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the composition is a ready mix composition. In some embodiments, the composition is a ready to dilute composition.
- the present invention provides a stable, ready mix, broad spectrum composition for, enhancing nematode controlling, enhancing root systems, enhancing crop plants development and vigor and improving plant potential yield by preventing root damage and improving rooting, wherein the composition comprises (i) an effective amount of fluensulfone (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the present invention provides a stable, ready mix composition comprising (i) an effective amount of fluensulfone (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the present invention provides a stable, ready mix composition
- a stable, ready mix composition comprising (i) an effective amount of fluensulfone (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin, wherein the azoxystrobin and fipronil are suspended in the aqueous carrier and fluensulfone is dissolved in the organic carrier.
- the present invention provides a stable, ready mix composition
- a stable, ready mix composition comprising (i) an effective amount of fluensulfone (ii) an effective amount of fipronil (iii) an effective amount of azoxystrobin, (iv) at least one physically stabilizing additive, (v) an aqueous carrier and (vi) an organic carrier, wherein the azoxystrobin and fipronil are suspended in the aqueous carrier and fluensulfone is dissolved in the organic carrier.
- the present invention provides a stable, ready mix composition
- a stable, ready mix composition comprising (i) an effective amount of fluensulfone (ii) an effective amount of fipronil (iii) an effective amount of azoxystrobin, (iv) a physically stabilizing system, (v) an aqueous carrier, and (vi) an organic carrier, wherein the azoxystrobin and fipronil are suspended in the aqueous carrier and fluensulfone is dissolved in the organic carrier.
- the present invention provides a stable, ready mix, broad spectrum composition for, enhancing root systems, enhancing crop plants development and vigor and improving plant potential yield by preventing root damage and improving rooting, wherein the composition comprises (i) an effective amount of fluensulfone (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the total amount of fluensulfone, fipronil and azoxystrobin in the composition is greater than 200 grams per liter. In some embodiments, the total amount of fluensulfone, fipronil and azoxystrobin in the composition is greater than 300 grams per liter. In some embodiments, the total amount of fluensulfone, fipronil and azoxystrobin in the composition is from 200 grams per liter to 500 grams per liter.
- the fluensulfone is at least 30% by weight of the organic carrier
- the fluensulfone is at least 40% by weight of the organic carrier.
- the fluensulfone is at least 50% by weight of the organic carrier.
- the composition comprises a stable ratio of ingredients.
- the composition comprises an aqueous carrier.
- the fipronil is suspended in the aqueous carrier.
- the azoxystrobin is suspended in the aqueous carrier.
- the composition comprises an organic carrier.
- the fluensulfone is dissolved in the organic carrier.
- the composition is a suspoemulsion. In some embodiment, the composition is a suspoemulsion comprising an organic carrier. In some embodiments, in the suspoemulsion, the fluensulfone is dissolved in the organic carrier.
- the composition is a suspoemulsion composition
- a suspoemulsion composition comprising an aqueous carrier and an organic carrier, wherein the fipronil and the azoxystrobin are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the fluensulfone is at least 30% by weight of the organic carrier.
- the fluensulfone is at least 40% by weight of the organic carrier.
- the fluensulfone is at least 50% by weight of the organic carrier.
- the organic carrier is an amide. In some embodiments, the organic carrier is a fatty acid amide.
- the fatty acid amide is selected from the group consisting of alkylamines of C6 - Cl 8 carboxylic acids and alkanolamines of C6 - Cl 8 carboxylic acids.
- the organic carrier is a fatty acid amide derivative.
- the fatty acid amide derivative is selected from a group consisting of alkylamines and alkanolamines with C6 - C18 carboxylic acids.
- the fatty acid amide is an N,N-dialkyl fatty acid amide derivative. In some embodiments, the N,N-dialkyl fatty acid amide derivative is dimethylamide of C10 fatty acid. In some embodiments, the fatty acid amide is an N,N-dialkyl fatty acid amide. In some embodiments, the fatty acid amide is N,N-dimethyl-decanamide.
- the organic carrier is Genagen® 4296.
- Genagen® 4296 is a dimethylamide based on naturally derived fatty acids from Clariant.
- the organic carrier is an amide solvent.
- amide solvent is an N,N-dialkyl fatty acid amide derivative.
- the amide solvent is N,N-dimethyl-decanamide.
- the solvent is Genagen ® 4296. Genagen® 4296 is a dimethylamide based on naturally derived fatty acids from Clariant.
- the composition comprises at least one physically stabilizing additive. In some embodiments, the composition comprises a physically stabilizing system.
- the physically stabilizing system is a combination of polyvinylpyrrolidone and polyalkylene oxide block copolymer.
- the physically stabilizing additive is polyvinylpyrrolidone. In some embodiments, the stabilizing additive is a polyalkylene oxide block copolymer. In some embodiments, the physically stabilizing additives are polyvinylpyrrolidone and a polyalkylene oxide block copolymer. In some embodiments, the polyalkylene oxide block copolymer is di block copolymer.
- the polyalkylene oxide block copolymer is tri block copolymer.
- Polyalkylene oxide refers to polyethylene oxide, polypropylene oxide, polybutylene oxide and combination thereof.
- the polyalkylene oxide block copolymer is alkylated.
- the polyalkylene oxide block copolymer is di-alkylated.
- the polyalkylene oxide block copolymer is Poloxamer.
- the tri block copolymer is polyethylene oxide /polypropylene oxide/polyethylene oxide.
- the physically stabilizing system is a combination of polyvinylpyrrolidone and a polyalkylene oxide block copolymer.
- the polyalkylene oxide block copolymer is Synperonic PE/F 68.
- the polyvinylpyrrolidone is PVP K-30.
- the composition comprises at least one agriculturally acceptable carrier.
- the composition further comprises one or more components including, but not limited to, solvents, solubilizers, and surfactants.
- the composition requires a lower amount of solvents than known tank mixes.
- the composition comprises fluensulfone in an amount ranging from about 1 % to 60% by weight based on the total weight of the composition, preferably about 5% to 40% by weight based on the weight of the total composition, preferably from about 5% to 30% by weight based on the total weight of the composition, more preferably from about 10% to 20% by weight based on the total weight of the composition, and most preferably from about 14% to 18 % by weight based on the total weight of the composition based on the total weight of the composition.
- the composition comprises fluensulfone in an amount of about 15% by weight based on the total weight of the composition.
- the composition comprises fluensulfone in an amount of about 16% by weight based on the total weight of the composition.
- the composition comprises fipronil in an amount ranging from about 1 % to 50% by weight based on the total weight of the composition, preferably from about 1 % to 40% by weight based on the total weight of the composition, preferably from about 3% to 20% by weight based on the total weight of the composition, more preferably from about 4% to 8% by weight based on the total weight of the composition, more preferably from about 5% to 7% by weight based on the total weight of the composition.
- the composition comprises fipronil in an amount of about 6 /o by weight based on the total weight of the composition.
- the composition comprises fipronil in an amount of about 6.4% by weight based on the total weight of the composition.
- the composition comprises azoxystrobin in an amount ranging from about 0.1% to 50% by weight based on the total weight of the composition, preferably from about 0.1% to 20% by weight based on the total weight of the composition, preferably from about 0.5% to 10% by weight based on the total weight of the composition, preferably from about 1% to 5% by weight based on the total weight of the composition, preferably from about 1.5% to 3% by weight based on the total weight of the composition.
- the composition comprises azoxystrobin in an amount of about
- the composition comprises azoxystrobin in an amount of about
- the composition comprises azoxystrobin in an amount of 1.86 % by weight based on the total weight of the composition.
- the composition comprises a stable weight ratio of ingredients.
- the weight ratio of fluensulfone to fipronil in the composition is about 5: 1, preferably is about 3: 1, more preferably is about 2.5: 1.
- the weight ratio of fluensulfone to fipronil is from about 5 : 1 to about 1 : 1.
- the composition comprises a stable weight ratio of ingredients.
- the weight ratio of fluensulfone to azoxystrobin in the composition is about 20: 1, preferably is about 10: 1, more preferably is about 8.5: 1.
- the weight ratio of fluensulfone to azoxystrobin in the composition is from about 20: 1 to about 1.5: 1.
- the composition comprises a stable weight ratio of ingredients.
- the weight ratio of fipronil to azoxystrobin in the composition is about 7: 1, preferably is about 5: 1, more preferably is about 3.4: 1.
- the weight ratio of fipronil to azoxystrobin in the composition is from about 8: 1 to about 1 : 1.
- the composition comprises a stable weight ratio of ingredients.
- the weight ratio of fluensulfone to fipronil to azoxystrobin is about 8.5:3.4: 1 .
- the composition comprises a stable weight ratio of ingredients.
- the weight ratio of fluensulfone to the combination of fipronil and azoxystrobin is from about 4: 1 to about 1 : 1.
- the composition is liquid.
- the composition comprises fluensulfone in an amount ranging from about 10 to 600 g/1, preferably about 50 to 400 g/1, preferably from about 50 to 300 g/1, more preferably from about 100 to 200 g/1, and most preferably from about 140 to 180 g/1. In some embodiments, the composition comprises fluensulfone in an amount of about 150 g/1. In some embodiments, the composition comprises fluensulfone in an amount of about l60g/l.
- the composition comprises fipronil in an amount ranging from about 10 to 500 g/l, preferably from about 10 to 400 g/l, preferably from about 30 to 200 g/l, more preferably from about 40 to 80 g/l, more preferably from about 50 to 70 g/l. In some embodiments, the composition comprises fipronil in an amount of about 60 g/l. In some embodiments, the composition comprises fipronil in an amount of about 64 g/l.
- the composition comprises azoxystrobin in an amount ranging from about 1 to 500 g/l, preferably from about 1 to 200 g/l, preferably from about 5 to 100 g/l, preferably from about 10 to 50 g/l, preferably from about 15 to 30 g/l. In some embodiments, the composition comprises azoxystrobin in an amount of about 18 g/l. In some embodiments, the composition comprises azoxystrobin in an amount of 19 g/l.
- the composition comprises fluensulfone in an amount ranging from about 130 g to about 300 g, preferably in amount of about 160 g.
- the composition comprises fluensulfone in an amount ranging from about 100 g to about 300 g.
- the composition comprises fipronil in an amount ranging from about 40 g to about 80 g, preferably in amount of about 64 g.
- the composition comprises azoxystrobin in an amount ranging from about 10 g to about 30 g, preferably in amount of about 19 g.
- the composition comprises (i) 160 g of fluensulfone, (ii) 64 g of fipronil, and (iii) 19 g of azoxystrobin.
- the composition comprises fluensulfone in an amount ranging from about 130 g/l to about 300 g/l, preferably in amount of about 160 g/l.
- the composition comprises fipronil in an amount ranging from about 40 g/l to about 80 g/l, preferably in amount of about 64 g/l.
- the composition comprises azoxystrobin in an amount ranging from about 10 g/l to about 30 g/l, preferably in amount of about 19 g/l.
- the present invention provides a composition comprising: a) from 100 to 300 g/l of fluensulfone; b) from 40 to 80 g/l of fipronil; and d) from 10 to 30 g/l of azoxystrobin; wherein the total amount of fluensulfone, fipronil and azoxstrobin is greater than 200 g/L.
- the present invention provides a stable, broad spectrum composition comprising (i) 160 g/l of fluensulfone, (ii) 64 g/l of fipronil and (iii) 19 g/l of azoxystrobin.
- the present invention provides a stable, broad spectrum composition for use on sugar cane, wherein the composition comprises (i) 160 g/l of fluensulfone, (ii) 64 g/l of fipronil and (iii) 19 g/l of azoxystrobin.
- the amount of physically stabilizing additive in the composition ranges from about 1 % to about 5 % by weight based on the total weight of the composition
- the amount of polyvinylpyrrolidone in the composition ranges from about 1% to about 5% by weight based on the total weight of the composition.
- the amount of polyvinylpyrrolidone in the composition is about 1.4% by weight based on the total weight of the composition.
- the amount of polyalkylene oxide block copolymer in the composition ranges from about 1% to about 5% by weight based on the total weight of the composition.
- the amount of polyalkylene oxide block copolymer in the composition is about 2.8 % by weight based on the total weight of the composition.
- the total amount of physically stabilizing system in the composition ranges from about 2% to about 10% by weight based on the total weight of the composition, more preferably is about 4.2% by weight based on the total weight of the composition.
- the composition comprises additional at least one solvent.
- the total amount of organic carrier in the composition ranges from about 5 to about 50% by weight based on the total weight of the composition, preferably from about to about 20% by weight based on the total weight of the composition, more preferably about 15% by weight based on the total weight of the composition
- the total amount of aqueous carrier in the composition ranges from about 10 to about 70% by weight based on the total weight of the composition, preferably from about 20 to about 60% by weight based on the total weight of the composition, more preferably about 50 % by weight based on the total weight of the composition.
- the composition comprises one or more additional surfactants, which can include but are not limited to alkali metal, alkaline earth metal and ammonium salts of aromatic sulfonic acids, such as ligninsoulfonic acid, phenolsulfonic acid, naphthalene sulfonic acid, dibutylnaphthalene-sulfonic acid, and fatty acids, alkylsulfonates, alkyl aryl sulfonates, alkyl sulfates, lauryl ether sulfates, fatty alcohol sulfates, and sulfated hexa-, hepta-, and octa- decanolates, sulfated fatty alcohol glycol ethers, furthermore condensates of naphthalene or of naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octylphenyl ether, ethoxy
- composition is packaged within a single vessel and is ready to use directly after dilution.
- the present invention provides a stable composition
- a stable composition comprising (i) 160 g/l of fluensulfone (ii) 64 g/l of fipronil (iii) 19 g/l of azoxystrobin, (iv) 15 g/l of polyvinylpyrrolidone and (v) 30 g/l polyalkylene oxide block copolymer, wherein the azoxystrobin and fipronil are suspended in the aqueous carrier and fluensulfone in soluble in the organic carrier.
- the present invention provides a stable composition
- a stable composition comprising (i) 160 g/l of fluensulfone, (ii) 65 g/l of fipronil, (iii) 19 g/l of azoxystrobin, (iv) 15 g/l of PVP K-30, (v) 30 g/l Synperonic PE/F 68, (vi) an aqueous carrier, and (vii) an organic carrier, wherein the azoxystrobin and the fipronil are suspended in the aqueous carrier and the fluensulfone is dissolved in the organic carrier.
- the organic carrier is an amide.
- the organic carrier is a fatty acid amide.
- the fatty acid amide is selected from the group consisting of alkylamines of C6 - Cl 8 carboxylic acids and alkanolamines of C6 - Cl 8 carboxylic acids.
- the organic carrier is a fatty acid amide derivative.
- the fatty acid amide derivative is selected from a group consisting of alkylamines and alkanolamines with C6 - C18 carboxylic acids.
- the fatty acid amide is an N,N-dialkyl fatty acid amide derivative. In some embodiments, the N,N-dialkyl fatty acid amide derivative is dimethylamide of C10 fatty acid. In some embodiments, the fatty acid amide is an N,N-dialkyl fatty acid amide. In some embodiments, the fatty acid amide is N,N-dimethyl-decanamide.
- the organic carrier is Genagen® 4296.
- Genagen® 4296 is a dimethylamide based on naturally derived fatty acids from Clariant.
- the organic carrier is an amide solvent.
- amide solvent is an N,N-dialkyl fatty acid amide derivative.
- the amide solvent is N,N-dimethyl-decanamide.
- the solvent is Genagen ® 4296. Genagen® 4296 is a dimethylamide based on naturally derived fatty acids from Clariant.
- the present composition may further comprise one or more additional agriculturally acceptable inert additives, as known in the art, including but not limited to solid diluents, liquid diluents, wetting agents, adhesives, thickening agents, anti-foaming agent, preservative, wetting agent, anti-oxidation agent, binders, fertilizers, or anti-freeze agents.
- additional crop protection agents known in the art, for example pesticides, safeners, agents for controlling phytopathogenic fungi or bacteria, and the like.
- Anti-foaming agents can include but are not limited to nonionic aqueous emulsion of polydimethylsiloxane .
- Thickeners can include but are not limited to xanthan gum.
- Anti -oxidation agents can include but are not limited to butyl hydroxytoluene.
- the present composition may further comprise additional agriculturally adjuvant.
- the composition comprises sodium dioctyl sulphosuccinate. In some embodiments the amount of sodium dioctyl sulphosuccinate in the composition is 0.1 % to 1 % by weight based on the total weight of the composition. In some embodiments the amount of sodium dioctyl sulphosuccinate in the composition is 0.46 % by weight based on the total weight of the composition.
- the composition comprises polydimethylsiloxanes. In some embodiments, the amount of polydimethylsiloxanes in the composition is 0.1% to 1% by weight based on the total weight of the composition. In some embodiments, the amount of polydimethylsiloxanes in the composition is 0.56 % by weight based on the total weight of the composition.
- the composition comprises butyl hydroxytoluene. In some embodiments, the amount of butyl hydroxytoluene in the composition is 0.01% to 0.5% by weight based on the total weight of the composition. In some embodiments, the amount of butyl hydroxytoluene in the composition is 0.19% by weight based on the total weight of the composition.
- the composition comprises epoxidized soya-bean oil. In some embodiments, the amount of epoxidized soya-bean oil in the composition is 0.01 % to 0.5% by weight based on the total weight of the composition. In some embodiments, the amount of epoxidized soya-bean oil in the composition is 0.19% by weight based on the total weight of the composition.
- the composition comprises N,N-dimethyl-decanamide. In some embodiments, the amount of N,N-dimethyl-decanamide in the composition is from 1% to 30% by weight based on the total weight of the composition. In some embodiments, the amount of N,N-dimethyl-decanamide in the composition is from 10% to 20% by weight based on the total weight of the composition. In some embodiments, the amount of N,N- dimethyl-decanamide in the composition is from 13% to 16% by weight based on the total weight of the composition. In some embodiments, the amount of N,N-dimethyl- decanamide in the composition is 14.4% by weight based on the total weight of the composition.
- the composition comprises butyl block copolymer. In some embodiments, the amount of butyl block copolymer in the composition is 1% to 5% by weight based on the total weight of the composition. In some embodiments, the amount of butyl block copolymer in the composition is 2.8% by weight based on the total weight of the composition.
- the composition comprises xanthan gum. In some embodiments, the amount of xanthan gum in the composition is 0.01% to 0.5% by weight based on the total weight of the composition. In some embodiments, the amount of xanthan gum in the composition is 0.15% by weight based on the total weight of the composition.
- the composition comprises (benzyloxy)methanol. In some embodiments, the amount of (benzyloxy)methanol in the composition is 0.01% by weight based on the total weight of the composition. In some embodiments, the composition comprises l,2-benzisothiazolin-3-one/sodium hydroxide. In some embodiments, the amount of l,2-benzisothiazolin-3 -one/sodium hydroxide in the composition is 0.01% by weight based on the total weight of the composition.
- the composition comprise water.
- the water is soft water.
- the amount of water in the composition is 30% to 80% by weight based on the total weight of the composition. In some embodiments, the amount of water in the composition is 45% to 60% by weight based on the total weight of the composition. In some embodiments, the amount of water in the composition is about 54% by weight based on the total weight of the composition.
- the present invention also provides a stable, composition comprising:
- azoxystrobin and the fipronil are suspended in water and the fluensulfone is dissolved in the organic carrier.
- the present invention also provides a stable composition comprising:
- the present invention also provides a stable composition comprising: (i) an effective amount of fluensulfone,
- the present invention also provides a stable, broad spectrum composition comprising:
- the present invention also provides a stable, broad spectrum composition comprising:
- the present invention also provides a stable, composition comprising:
- the present invention also provides a stable, broad spectrum composition comprising:
- the present invention also provides a stable, composition comprising:
- azoxystrobin and the fipronil are suspended in water and the fluensulfone is dissolved in the organic carrier.
- the present invention also provides a stable, broad spectrum composition comprising:
- the present invention also provides a stable, broad spectrum composition comprising:
- azoxystrobin and the fipronil are suspended in water and the fluensulfone is dissolved in the organic carrier and wherein the amount of fluensulfone in the organic carrier is at least 40% by weight of the organic carrier.
- the present invention also provides a stable, broad spectrum composition comprising:
- the amount of fluensulfone in the organic carrier is at least 30% by weight of the organic carrier.
- the present invention also provides a stable, broad spectrum composition comprising:
- azoxystrobin and the fipronil are suspended in water and the fluensulfone is dissolved in the organic carrier and wherein the amount of fluensulfone in the organic carrier is at least 30% by weight of the organic carrier.
- the present invention also provides a stable, broad spectrum composition comprising:
- the amount of fluensulfone in the organic carrier is at least 50% by weight of the organic carrier.
- the present invention also provides a stable, broad spectrum composition comprising:
- azoxystrobin and the fipronil are suspended in water and the fluensulfone is dissolved in the organic carrier and wherein the amount of fluensulfone in the organic carrier is at least 50% by weight of the organic carrier.
- the organic carrier is an amide.
- the organic carrier is a fatty acid amide.
- the fatty acid amide is selected from the group consisting of alkylamines of C6 - Cl 8 carboxylic acids and alkanolamines of C6 - Cl 8 carboxylic acids.
- the organic carrier is a fatty acid amide derivative.
- the fatty acid amide derivative is selected from a group consisting of alkylamines and alkanolamines with C6 - C18 carboxylic acids.
- the fatty acid amide is an N,N-dialkyl fatty acid amide derivative. In some embodiments, the N,N-dialkyl fatty acid amide derivative is dimethylamide of C10 fatty acid. In some embodiments, the fatty acid amide is an N,N-dialkyl fatty acid amide. In some embodiments, the fatty acid amide is N,N-dimethyl-decanamide.
- the organic carrier is Genagen® 4296.
- Genagen® 4296 is a dimethylamide based on naturally derived fatty acids from Clariant.
- the organic carrier is an amide solvent.
- amide solvent is an N,N-dialkyl fatty acid amide derivative.
- the amide solvent is N,N-dimethyl-decanamide.
- the solvent is Genagen ® 4296. Genagen® 4296 is a dimethylamide based on naturally derived fatty acids from Clariant.
- the present invention also provides a stable, broad spectrum composition comprising:
- the present invention also provides a stable, broad spectrum composition comprising:
- the present invention also provides a stable, broad spectrum composition comprising:
- the weight ratio of fluensulfone to fipronil to azoxystrobin is about 8.5:3.4: 1 .
- the present invention also provides a stable, broad spectrum composition comprising:
- the present invention also provides a stable, broad spectrum composition comprising:
- the composition comprises one or more additional active ingredient (s). In some embodiments, the composition comprises one or more additional non-active ingredient(s).
- the polyvinylpyrrolidone is absorbed to the fipronil particle and reduces solubility of fipronil in the organic carrier.
- the organic carrier may also be stabilized and be covered by polyalkylene oxide block copolymer.
- the present invention also provides the use of polyvinyl pyrrolidone for stabilizing a composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the present invention also provides the use of polyvinyl pyrrolidone for stabilizing a suspoemulsion composition
- a suspoemulsion composition comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin,
- the present invention also provides the use of combination of polyvinylpyrrolidone and polyalkylene oxide block copolymer for stabilizing a suspoemulsion composition comprising i) an effective amount of fluensulfone (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the present invention provides a pesticidal mixture comprising any one of the compositions disclosed herein.
- the present invention provides a pesticidal mixture for use on sugar cane, wherein the pesticidal mixture comprises any one of the compositions disclosed herein.
- the present invention provides a pesticidal mixture for use on sugar cane, wherein the pesticidal mixture comprises (i) an effective amount of fluensulfone (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the present invention provides a pesticidal mixture comprising (i) 160 g/1 of fluensulfone, (ii) 64 g/1 of fipronil and (iii) 19 g/1 of azoxystrobin.
- the present invention provides a pesticidal mixture for use on sugar cane, wherein the pesticidal mixture comprises (i) 160 g/1 of fluensulfone, (ii) 64 g/1 of fipronil and (iii) 19 g/1 of azoxystrobin.
- the present invention provides an agricultural mixture comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention provides an agricultural mixture comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin, wherein the weight ratio of fluensulfone:fipronil:azoxystrobin is about 8.5:3 4: 1.
- the present invention provides an agricultural mixture comprising (i) fluensulfone, (ii) fipronil, and (iii) azoxystrobin in a weight ratio of about 8.5:3.4: 1.
- the present invention provides an agricultural mixture comprising (i) 160 g/l of fluensulfone, (ii) 64 g/l of fipronil, and (iii) 19 g/l of azoxystrobin.
- the present invention provides an agricultural mixture comprising (i) 160 g of fluensulfone, (ii) 64 g of fipronil, and (iii) 19 g of azoxystrobin.
- the present invention provides an agricultural mixture for use on sugar cane wherein the agricultural mixture comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin.
- the present invention provides an agricultural mixture for use on sugar cane, wherein the agricultural mixture comprises (i) fluensulfone, (ii) fipronil, and (iii) azoxystrobin in a weight ratio of about 8.5: 3.4: 1.
- the present invention provides an agricultural mixture for use on sugar cane, wherein the agricultural mixture comprises (i) 160 g of fluensulfone, (ii) 64 g of fipronil, and (iii) 19 g of azoxystrobin.
- the present invention provides an agricultural mixture for use on sugar cane, wherein the agricultural mixture comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin, and wherein the weight ratio of fluensulfone:fipronil:azoxystrobin is about 8.5:3.4: 1.
- the present invention provides an agricultural mixture for use on sugar cane, wherein the agricultural mixture comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin, and wherein the weight ratio of fluensulfone to fipronil and azoxystrobin is about 4: 1 to 1 : 1.
- the present invention provides an agricultural mixture for use on sugar cane, wherein the agricultural mixture comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin, and wherein the weight ratio of fluensulfone to fipronil and azoxystrobin is about 2: 1.
- the present invention provides an agricultural mixture for use on sugar cane, wherein the agricultural mixture comprises (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin, and wherein the weight ratio of fluensulfone to fipronil and azoxystrobin is about 1.93: 1.
- the present invention provides an agricultural mixture for use on sugar cane, wherein the agricultural mixture comprises (i) 160 g/1 of fluensulfone, (ii) 64 g/1 of fipronil, and (iii) 19 g/1 of azoxystrobin.
- the mixture comprises fluensulfone in an amount ranging from about 130 g to about 300 g, preferably in amount of about 160 g.
- the mixture comprises fluensulfone in an amount ranging from about 100 g to about 300 g.
- the mixture comprises fipronil in an amount ranging from about 40 g to about 80 g, preferably in amount of about 64 g.
- the mixture comprises azoxystrobin in an amount ranging from about 10 g to about 30 g, preferably in amount of about 19 g.
- the mixture comprises (i) 160 g of fluensulfone, (ii) 64 g of fipronil, and (iii) 19 g of azoxystrobin.
- the mixture comprises fluensulfone in an amount ranging from about 130 g/1 to about 300 g/1, preferably in amount of about 160 g/1.
- the mixture comprises fipronil in an amount ranging from about 40 g/1 to about 80 g/1, preferably in amount of about 64 g/1.
- the mixture comprises azoxystrobin in an amount ranging from about 10 g/1 to about 30 g/1, preferably in amount of about 19 g/1. In some embodiments, the mixture comprises azoxystrobin in an amount ranging from 10 g/1 to 30 g/1.
- the present invention provides a mixture comprising: a) from 100 to 300 g of fluensulfone; b) from 40 to 80 g of fipronil; and d) from 10 to 30 g of azoxystrobin; wherein the total amount of fluensulfone, fipronil and azoxstrobin in the mixture is greater than 200 g.
- the present invention provides a mixture comprising: a) from 100 g/l to 300 g/l of fluensulfone; b) from 40 g/l to 80 g/l of fipronil; and d) from 10 g/l to 30 g/l of azoxystrobin; wherein the total amount of fluensulfone, fipronil and azoxstrobin in the mixture is greater than 200 g/l.
- the mixture comprises (i) 160 g/l of fluensulfone, (ii) 64 g/l of fipronil, and (iii) 19 g/l of azoxystrobin.
- the mixture comprises a stable weight ratio of ingredients.
- the weight ratio of fluensulfone to fipronil in the mixture is about 5: 1, preferably is about 3: 1, more preferably is about 2.5: 1.
- weight ratio of fluensulfone to fipronil is from about 5 : 1 to about 1 : 1.
- the mixture comprises a stable weight ratio of ingredients.
- the weight ratio of fluensulfone to azoxystrobin in the mixture is about 20: 1, preferably is about 10: 1, more preferably is about 8.5: 1.
- the weight ratio of fluensulfone to azoxystrobin in the mixture is from about 20: 1 to about 1.5: 1.
- the mixture comprises a stable weight ratio of ingredients.
- the weight ratio of fipronil to azoxystrobin in the mixture is about 7: 1, preferably is about 5: 1, more preferably is about 3.4: 1.
- the weight ratio of fipronil to azoxystrobin in the mixture is from about 8: 1 to about 1 : 1.
- the mixture comprises a stable weight ratio of ingredients.
- the weight ratio of fluensulfone to fipronil to azoxystrobin in the mixture is about 8.5:3.4: 1.
- the mixture comprises an effective weight ratio of ingredients.
- the weight ratio of fluensulfone to fipronil in the mixture is about 5: 1, preferably is about 3: 1, more preferably is about 2.5 : 1.
- weight ratio of fluensulfone to fipronil in the mixture is from about 5 : 1 to about 1 : 1.
- the mixture comprises an effective weight ratio of ingredients.
- the weight ratio of fluensulfone to azoxystrobin in the mixture is about 20: 1, preferably is about 10: 1, more preferably is about 8.5: 1.
- the weight ratio of fluensulfone to azoxystrobin in the mixture is from about 20: 1 to about 1.5: 1.
- the mixture comprises an effective weight ratio of ingredients.
- the weight ratio of fipronil to azoxystrobin in the mixture is about 7: 1, preferably is about 5: 1, more preferably is about 3.4: 1.
- the weight ratio of fipronil to azoxystrobin in the mixture is from about 8 : 1 to about 1: 1.
- the mixture comprises an effective weight ratio of ingredients.
- the weight ratio of fluensulfone to fipronil to azoxystrobin in the mixture is about 8.5:3.4: 1.
- the mixture comprises an effective weight ratio of ingredients.
- the weight ratio of fluensulfone to the combination of fipronil and azoxystrobin is from about 4: 1 to about 1 : 1.
- effective weight ratio refers to the weight ratio at which efficacy of fluensulfone for controlling nematodes is improved and/or at which plant development is enhanced, wherein enhanced plant development includes, but is not limited to, enhanced root systems and/or shoot of the crop plant and/or plant vigor and/or plant potential yield.
- plant vigor is assessed using the relative vigor index. In some embodiments, plant vigor is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.
- enhancement in root system is measured by root weight.
- root weight is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.
- enhancement in shoot is measured by shoot weight. In some embodiments, shoot weight is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.
- the present invention provides a mixture comprising (i) an amount of fluensulfone, (ii) an amount of fipronil and (iii) an amount of azoxystrobin.
- the amount of fluensulfone, the amount of fipronil and the amount of azoxystrobin when applied together is more effective than when each agent at the same amount is applied alone.
- the amount of fluensulfone in the mixture is less than the pesticidally effective amount of fluensulfone than when fluensulfone is used alone.
- the amount of fipronil in the mixture is less than the pesticidally effective amount of fipronil than when fipronil is used alone.
- the amount of azoxystrobin in the mixture is less than the pesticidally effective amount of azoxystrobin when azoxystrobin is used alone.
- the present invention provides a synergistic mixture comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil and (iii) an effective amount of azoxystrobin.
- the weight ratio of fluensulfone to fipronil to azoxystrobin is about 8.5:3.4: 1.
- the weight ratio of fluensulfone to fipronil in the mixture is about 5: 1, preferably is about 3: 1, more preferably is about 2.5: 1.
- the weight ratio of fluensulfone to azoxystrobin in the mixture is about 20: 1, preferably is about 10: 1, more preferably is about 8.5: 1.
- the weight ratio of fipronil to azoxystrobin in the mixture is about 7: 1, preferably is about 5: 1, more preferably is about 3.4: 1.
- the mixture or synergistic mixture comprises one or more additional active ingredient (s). In some embodiments, the mixture or synergistic mixture comprises one or more additional non-active ingredient(s).
- a synergistic effect exists whenever the action of an active ingredient combination is greater than the sum of the actions of the individual components.
- the mixture is synergistic for enhancing crop plant. In some embodiments, the mixture is synergistic for enhancing plant development. In some embodiments, the mixture is synergistic for enhancing root system. In some embodiments, the mixture is synergistic for improving plant quality. In some embodiments, the mixture is synergistic for regulating plant growth. In some embodiments, the mixture is synergistic for controlling nematodes.
- E represents the expected effect, e.g. percentage of pest control, for the combination of the three active ingredient at defined doses (for example equal to x, y and z respectively)
- X is the effect, e.g. percentage of pest control, observed for compound (I) at a defined dose (equal to x)
- Y is the effect, e.g. percentage of pest control, observed for compound (II) at a defined dose (equal to y)
- Z is the effect, e.g. percentage of pest control, observed for compound (III) at a defined dose (equal to z).
- the mixture comprises an organic carrier.
- the organic carrier is an amide.
- the organic carrier is a fatty acid amide.
- the fatty acid amide is selected from the group consisting of alkylamines of C6 - C18 carboxylic acids and alkanolamines of C6 - Cl 8 carboxylic acids.
- the organic carrier is a fatty acid amide derivative.
- the fatty acid amide derivative is selected from a group consisting of alkylamines and alkanolamines with C6 - C18 carboxylic acids.
- the fatty acid amide is an N,N-dialkyl fatty acid amide derivative. In some embodiments, the N,N-dialkyl fatty acid amide derivative is dimethylamide of C10 fatty acid. In some embodiments, the fatty acid amide is an N,N-dialkyl fatty acid amide. In some embodiments, the fatty acid amide is N,N-dimethyl-decanamide.
- the organic carrier is Genagen® 4296.
- Genagen® 4296 is a dimethylamide based on naturally derived fatty acids from Clariant.
- the organic carrier is an amide solvent.
- amide solvent is an N,N-dialkyl fatty acid amide derivative.
- the amide solvent is N,N-dimethyl-decanamide.
- the solvent is Genagen ® 4296.
- Genagen® 4296 is a dimethylamide based on naturally derived fatty acids from Clariant.
- the mixture comprises at least one physically stabilizing additive. In some embodiments, the mixture comprises a physically stabilizing system.
- the physically stabilizing system is a combination of polyvinylpyrrolidone and polyalkylene oxide block copolymer.
- the physically stabilizing additive is polyvinylpyrrolidone. In some embodiments, the stabilizing additive is a polyalkylene oxide block copolymer. In some embodiments, the physically stabilizing additives are polyvinylpyrrolidone and a polyalkylene oxide block copolymer.
- the polyalkylene oxide block copolymer is di block copolymer.
- the polyalkylene oxide block copolymer is tri block copolymer.
- Polyalkylene oxide refers to polyethylene oxide, polypropylene oxide, polybutylene oxide and combination thereof.
- the polyalkylene oxide block copolymer is alkylated.
- the polyalkylene oxide block copolymer is di-alkylated.
- the polyalkylene oxide block copolymer is Poloxamer.
- the tri block copolymer is polyethylene oxide /polypropylene oxide/polyethylene oxide.
- the physically stabilizing system is a combination of polyvinylpyrrolidone and a polyalkylene oxide block copolymer.
- the polyalkylene oxide block copolymer is Synperonic PE/F 68.
- the polyvinylpyrrolidone is PVP K-30.
- the mixtures described herein may be a tank mix or a diluted form of any one of the compositions described herein.
- the mixture is a tank mix.
- the mixture comprises any one of the compositions described herein wherein the composition is diluted.
- the present invention also contemplates methods of making a mixture comprising (i) fluensulfone, (ii) fipronil, (iii) azoxystrobin, (vi) an organic carrier, and (v) a physically stabilizing additive, wherein the method comprises mixing the fluensulfone, fipronil, azoxystrobin, organic carrier and physically stabilizing additive, in any order, to obtain the mixture.
- the present invention provides a method for controlling nematodes comprising applying an effective amount of the any one of the compositions or the mixtures disclosed herein to one or more plants, the locus thereof or propagation material thereof so as to thereby enhance nematode control.
- the present invention provides a method for enhancing nematode control comprising applying an effective amount of the any one of the compositions or the mixtures disclosed herein to one or more plants, the locus thereof or propagation material thereof so as to thereby enhance nematode control.
- the present invention provides a method for enhancing root systems and/or enhancing crop plants development and/or enhancing crop plants vigor and/or improving plant potential yield comprising applying an effective amount of the any one of the mixtures or compositions disclosed herein to one or more plants, the locus thereof or propagation material thereof.
- the present invention provides a method for enhancing plant development comprising applying an effective amount of the any one of the compositions or the mixtures disclosed herein to one or more plants, the locus thereof or propagation material thereof so as to thereby enhance plant development.
- the present invention provides a method for enhancing root system comprising applying an effective amount of the any one of the compositions or the mixtures disclosed herein to one or more plants, the locus thereof or propagation material thereof so as to thereby enhance the root system.
- the present invention provides a method for enhancing plant vigor comprising applying an effective amount of the any one of the compositions or the mixtures disclosed herein to one or more plants, the locus thereof or propagation material thereof so as to thereby enhance plant vigor.
- the present invention provides a method for improving plant potential yield comprising applying an effective amount of the any one of the compositions or the mixtures disclosed herein to one or more plants, the locus thereof or propagation material thereof so as to thereby improve plant potential yield.
- the present invention provides a method for regulating plant growth comprising applying an effective amount of the any one of the compositions or the mixtures disclosed herein to one or more plants, the locus thereof or propagation material thereof so as to thereby regulate plant growth.
- the present invention provides a method for controlling nematodes comprising applying (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin to one or more plants, the locus thereof or propagation material thereof so as to thereby enhance nematode control.
- the present invention provides a method for enhancing nematode control comprising (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin to one or more plants, the locus thereof or propagation material thereof so as to thereby enhance nematode control.
- the present invention provides a method for enhancing crop plant comprising applying (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin to one or more plants, the locus thereof or propagation material thereof so as to thereby enhance the crop plant.
- the present invention provides a method for enhancing plant development comprising applying (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin to one or more plants, the locus thereof or propagation material thereof so as to thereby enhance plant development.
- enhancing plant development comprises enhancing root system. In some embodiments, enhancing plant development comprises enhancing plant vigor. In some embodiments, enhancing plant development comprises improving plant potential yield. In some embodiment, enhancing plant development comprises enhancing potential yield.
- the method enhances root development. In some embodiments, the method enhances the root system of the plant. In some embodiments, the method enhances plant quality. In some embodiments, the method enhances plant vigor. In some embodiments, the method enhances plant yield. In some embodiments, the method prevents root damage. In some embodiments, the method improves rooting.
- the present invention provides a method for regulating plant growth comprising applying (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin to one or more plants, the locus thereof or propagation material thereof so as to thereby regulate plant growth.
- plant vigor is assessed using the relative vigor index. In some embodiments, plant vigor is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.
- enhancement in root system is measured by root weight.
- root weight is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.
- enhancement in shoot is measured by shoot weight. In some embodiments, shoot weight is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.
- the present invention provides a method for preventing plant and/or soil disease comprising applying an effective amount of the any one of the mixtures or compositions disclosed herein to one or more plants, the locus thereof or propagation material thereof so as to thereby prevent plant and/or soil disease.
- the present invention provides a method for controlling plant and/or soil disease comprising applying an effective amount of the any one of the mixtures or compositions disclosed herein to one or more plants, the locus thereof or propagation material thereof so as to thereby control plant and/or soil disease.
- the present invention provides a method for controlling plant and/or soil disease comprising applying (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin to one or more plants, the locus thereof or propagation material thereof so as to thereby control plant and/or soil disease.
- the present invention provides a method for preventing plant and/or soil disease comprising applying (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin to one or more plants, the locus thereof or propagation material thereof so as to thereby prevent plant and/or soil disease.
- the methods of the present invention refer to any plant and/or soil diseases, including but not limited to Sugarcane weevil (Sphenophorus levis), Lesion nematode (Pratylenchus zeae), Root Knot nematode (Meloidogyne javanica), Black root rot (Thielaviopsis paradoxa), and Heterotermes tenuis and Ceratocystis paradoxa.
- the method is effective on plant and/or root system affected by plant and/or soil diseases, including but not limited to plant and/or soil diseases caused by Sugarcane weevil (Sphenophorus levis), Lesion nematode (Pratylenchus zeae), Root Knot nematode (Meloidogyne javanica), Black root rot (Thielaviopsis paradoxa), and Heterotermes tenuis and Ceratocystis paradoxa.
- Sugarcane weevil Sphenophorus levis
- Lesion nematode Proratylenchus zeae
- Root Knot nematode Malloidogyne javanica
- Black root rot Tinaviopsis paradoxa
- Heterotermes tenuis and Ceratocystis paradoxa Heterotermes tenuis and Ceratocystis paradoxa.
- the method, the mixtures and the compositions disclosed herein is effective on plant and/or root system affected by plant and/or soil diseases caused by Sugarcane weevil (Sphenophorus levis), Lesion nematode (Pratylenchus zeae), Root Knot nematode (Meloidogyne javanica), Heterotermes tenuis and Ceratocystis paradoxa.
- the methods of the present invention refer to any crop plants, including but not limited to monocotyledons such as sugar cane, cereals, rice, maize (com), and/or; or dicotyledon crop such as beets (such as sugar beet or fodder beet); fruits (such as pomes, stone fruits, or soft fruits, for example apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, or blackberries); leguminous plants (such as beans, lentils, peas, or soybeans); oil plants (such as rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, or groundnuts); cucumber plants (such as marrows, cucumbers or melons); fiber plants (such as cotton, flax, hemp, or jute); citrus fruits (such as oranges, lemons, grapefruit, or mandarins); vegetables (such as spinach, lettuce, cabbages, carrots, tomatoes, potatoes, cucurbits, or paprika); laura
- the plants are monocotyledonous plants, more preferably, cereals, in particular wheat or barley.
- the cereal crop is wheat.
- the cereal crop is triticale.
- the cereal crop is rye.
- the cereal crop is oat.
- the cereal crop is barley.
- the crop plants are rice plants.
- the crop plants are sugar cane plants.
- the crop plants are com plants.
- the sugar cane is plant cane.
- the sugar cane is ratoon sugarcane.
- the crop plants are dicotyledonous plants. In one embodiment, the crop plants are oil seed rape plants.
- the fluensulfone is applied at an amount from about 1 g/ha to about 1000 g/ha. In some embodiments, the fluensulfone is applied at an amount from about 100 g/ha to about 700 g/ha. In some embodiments, the fluensulfone is applied at an amount from about 100 g/ha to about 200 g/ha. In some embodiments, the fluensulfone is applied at an amount from about 300 g/ha to about 400 g/ha. In some embodiments, the fluensulfone is applied at an amount from about 600 g/ha to about 700 g/ha. In some embodiments, the fluensulfone is applied at an amount of about 160 g/ha. In some embodiments, the fluensulfone is applied at an amount of about 320 g/ha. In some embodiments, the fluensulfone is applied at an amount of about 640 g/ha.
- the fipronil is applied at an amount from about 1 g/ha to about 500 g/ha. In some embodiments, the fipronil is applied at an amount from about 50 g/ha to about 300 g/ha. In some embodiments, the fipronil is applied at an amount from about 50 g/ha to about 80 g/ha. In some embodiments, the fipronil is applied at an amount from about 100 g/ha to about 150 g/ha. In some embodiments, the fipronil is applied at an amount from about 225 g/ha to about 275 g/ha. In some embodiments, the fipronil is applied at an amount of about 64 g/ha. In some embodiments, the fipronil is applied at an amount of about 128 g/ha. In some embodiments, the fipronil is applied at an amount of about 256 g/ha.
- the azoxystrobin is applied at an amount from about 1 g/ha to about 100 g/ha. In some embodiments, the azoxystrobin is applied at an amount from about 10 g/ha to about 80 g/ha. In some embodiments, the azoxystrobin is applied at an amount from about 15 g/ha to about 25 g/ha. In some embodiments, the azoxystrobin is applied at an amount from about 35 g/ha to about 45 g/ha. In some embodiments, the azoxystrobin is applied at an amount from about 70 g/ha to about 80 g/ha. In some embodiments, the azoxystrobin is applied at an amount of about 19 g/ha. In some embodiments, the azoxystrobin is applied at an amount of about 38 g/ha. In some embodiments, the azoxystrobin is applied at an amount of about 76 g/ha.
- the rate of application of the present composition may vary within wide limits and depends upon the nature of the soil, the method of application, the prevailing climatic conditions, and other factors governed by the method of application and the time of application.
- the composition is generally applied at a rate of about 2 to about 5 L/ha.
- the composition is applied at a rate of about 2.5 to 4 L/ha.
- the composition is applied at a rate of about 3 to 4 L/ha.
- the composition is applied at a rate of about 2.5 L/ha.
- the composition is applied at a rate of about 4 L/ha.
- the composition is applied at a rate of about 3.5 L/ha
- the composition is applied at a rate of about 3 L/ha.
- the composition is applied at a rate of about 1.6 to 2.0 L/ha.
- the volume of mixture for sugarcane is 200 L/ha.
- compositions and/or mixtures disclosed herein are applied before planting.
- compositions and/or mixtures disclosed herein are applied at the time of planting.
- the mixtures and/or compositions described herein are applied as a soil application.
- soil application refers to furrow application.
- the application is by ground spraying.
- the sugarcane is plant cane and the composition or mixture disclosed herein is applied in the planting furrow with ground equipment.
- the sugarcane is ratoon sugarcane and the composition or mixture disclosed herein is applied in the planting line using a tractor sprayer.
- composition or mixture disclosed herein is applied with drop size of 150 a 300 m (micra) VMD.
- composition or mixture disclosed herein is applied with a drop density of 40 drops/cm 2 or higher.
- composition or mixture disclosed herein is applied at a temperature up to 30°C.
- the composition or mixture disclosed herein is applied when the relative humidity of the air is 50% or higher. In some embodiments, the composition or mixture disclosed herein is applied when the wind speed is between 3 and 10 km/h.
- the method comprises diluting any one of the mixtures or compositions described herein prior to application.
- the mixture or composition is diluted with water.
- the mixture or composition is diluted with an agriculturally acceptable carrier.
- the mixture or composition is diluted with an agriculturally acceptable carrier other than water.
- the method comprises applying any one of the mixtures or compositions described herein with one or more additional active ingredient(s). In some embodiments, the method comprises applying any one of the mixtures or compositions described herein with one or more additional non-active ingredient(s).
- the present invention provides use of any one of the mixtures or compositions disclosed herein for controlling nematode, enhancing plant development, regulating plant growth, preventing plant and/or soil disease, and/or controlling plant and/or soil disease.
- the use comprises applying any one of the mixtures or compositions disclosed herein to the plant, a locus of the plant or propagation material of the plant.
- the present invention provides use of (i) an effective amount of fluensulfone, (ii) an effective amount of fipronil, and (iii) an effective amount of azoxystrobin for controlling nematode, enhancing plant development, regulating plant growth, preventing plant and/or soil disease, and/or controlling plant and/or soil disease.
- the use comprises applying the fluensulfone, the fipronil, and the azoxystrobin to the plant, a locus of the plant or propagation material of the plant.
- the invention provides a process for preparing the stable composition described herein, wherein the process comprises the steps of: (1) milling a dispersion of fipronil and azoxystrobin in water, (2) dissolving fluensulfone in an organic carrier to obtain a solution, (3) preparing an emulsion from the solution obtained in step (2), and (4) preparing suspoemulsion composition from the dispersion obtained from step (1) and the emulsion obtained from step (3).
- step (1) is performed in the presence of at least one physically stabilizing additive.
- the physically stabilizing additive is polyvinylpyrrolidone .
- the organic carrier used in step (2) is N, N dimethyl fatty acid amide derivative.
- the invention provides a method for preparing the stable, broad spectrum composition described herein, wherein the method comprises the steps of: (1) milling a dispersion of fipronil and azoxystrobin in water in the presence of polyvinylpyrrolidone; (2) dissolving fluensulfone in N, N dimethyl fatty acid amide derivative to obtain a solution; (3) preparing an emulsion from the solution obtained in step (2) and (4) preparing suspoemulsion composition from the obtained dispersion from step (1) and emulsion of step (3).
- the polyalkylene oxide block copolymer is added in step (1).
- the polyalkylene oxide block copolymer is added in step (3).
- the polyalkylene oxide block copolymer is added in step (1) and
- each of the described steps may further comprise additional additives.
- the N,N -dimethyl fatty acid amide derivative is Genagen® 4296.
- Genagen® 4296 is a dimethylamide based on naturally derived fatty acids from Clariant.
- the N,N-dimethyl fatty acid amide derivative is N,N-dimethyl- decanamide.
- composition embodiments can be used in the mixture (including synergistic mixture), method, use and process embodiments described herein and vice versa.
- Formulating a stable composition comprising fluensulfone, fipronil and azoxystrobin is particularly challenging because fluensulfone has a limited solubility in organic carrier and the fipronil and azoxystrobin should be suspended in the aqueous carrier.
- the unstable suspoemulsion was found to be associated with the partial solubility of fipronil in the organic carrier which leads to crystallization.
- Combining of polyvinylpyrrolidone and polyalkylene oxide block copolymer provided a stable composition.
- Example 1 Ready Mix Composition
- Table 1 Fluensulfone 160 Fipronil 64 Azoxystrobin 19 SE Composition
- Step 1 preparation of the suspension composition
- Soft water was charged to the vessel.
- PVP K-30, Synperonic PE/L 68, Lankropol K02 and half of the Silcolapse 432 were added and mixed until the solution was homogenous and the materials were completely dissolved.
- the fipronil and azoxystrobin were gradually added while mixing.
- a high shear homogenizer was used to obtain a homogenous mixture.
- the dispersion was milled in a bead mill until a particle size distribution of d90 ⁇ 3.5pm was reached.
- the AGRH 23 2% solution was added to the mixture while mixing to prepare the suspension composition.
- Step 2 preparation of the organic carrier
- the fluensulfone was heated until completely melted.
- the Genagen 4296 was charged to the vessel.
- the fluensulfone was added to the vessel while mixing and heating to 40°C.
- the solution was filtered (5 pm filter) to achieve a clear solution.
- Inol and Epoxol were added and mixed until the solution was homogenous to prepare the organic carrier solution.
- Step 3 preparation of an emulsion of Step 2
- the Atlas G-5002L, SynperonicTM PE/L 68, Lankropol K02 and Silcolapse 432 were added and mixed until the solution was homogenous and the materials were completely dissolved.
- the organic carrier solution of step 2 was heated to a temperature of 45-50°C. While applying the high shear, the warmed organic carrier solution of step 2 was add using a gentle stream in three different portions. Shear was applied until a droplet size distribution of d90 ⁇ lpm was reached to prepare the emulsion.
- Step 4 suspoemulsion preparation
- step 3 The emulsion of step 3 was charged into the reactor.
- the suspension of step 1 was added using slow pouring and gentle stirring.
- the AGRH 23 2% and water were added to achieve a viscosity of up to 2200cP (spindle 62 at l2rpm) to prepare the suspoemulsion.
- a tank mix of MIL FI 0437/09 (Fluensulfone 480 g a.i ./ ha EC); MIL FI 0304/05 (Fipronil 800 g a.i./ ha WG) and MIL FF 0357/05 (Azoxystrobin 250 g a.i./ ha SC) and the ready mix composition (Example 1, ADA FI 0017) (Fluensulfone 160 + Fipronil 64 + Azoxystrobin 19.7 g ai / ha SE) were applied (1-2 days after artificial soil infestation with Meloidogyne javanica) to sugarcane culture for controlling Meloidogyne javanica.
- Sugarcane was planted at the time of application in the planting furrow.
- the ready-mix composition or tank mix was applied during the planting of the crop in a jet directed in the furrow of planting, next to the sugar cane sticks.
- the experimental unit consisted of plots 0.2 meters wide and 0.75 meters long (0.15 m 2 ). (Being considered for assessments useful area of the plot of 0.15 m 2 central).
- the ready-mix composition of Example 1 and the tank mix were sprayed in the planting groove once (200.00 L/ha), simulating an application range of 50 cm, before planting, when sugarcane was in the 0 stage of BBCH's overall scale.
- Application equipment Costal pressurized to CO2 with a tip bar of Teejet type A11004VS.
- Agronomic information Early variety with high agroindustrial productivity. No tipping. It has resistance to charcoal, scalding, rust, false red streaks and mosaic; and medium resistance to red streaks, nematodes and the borer-rot complex. 50 days after application (DAT), the number of nematodes per 5 gr of roots were counted.
- the studies were conducted according to IN 36/42, including sending the MAPA worksheet (until the day of each month) to the federation unit.
- Nematodes and eggs in the soil (0 and 50 DAT, days after treatment), nematodes and eggs in the roots (50 DAT), use at least 5 g of root, and report in the results counting the number of J2 + eggs per 5g of roots.
- FR Reproduction Factor
- Tables 3-6 below show the results for the nematode control for tank mix of three active ingredients compared to the ready mix composition comprising the same three active ingredients.
- Example 1 ready mix
- tank mixes for controlling nematode, increasing vigor plant crop and increasing root mass are shown in Table 6 below.
- Table 7 The statistical analysis of variance for the results of Table 6 is shown in Table 7.
- Example 1 Contributing to the analysis of the efficiency and agronomic feasibility of the ready mix composition of Example 1 (Fluensulfone 160 + Fipronil 64 + Azoxystrobin 19.7 g a.i./ha SE), vigor and nematode culture evaluations were carried out. Analyzing the data in Table 6, we observed a significant decrease in nematode count, a significant increase in biomass of roots and a significant increase in relative vigor index in plants treated with the ready mix composition compared to the tank mix of the same three active ingredients when applied at the same rates.
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Abstract
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BR112020025309-0A BR112020025309A2 (en) | 2018-06-13 | 2019-06-12 | STABLE COMPOSITION OF WIDE SPECTRUM, MIXTURE, METHOD FOR INCREASING PLANT DEVELOPMENT, METHOD FOR CONTROLLING NEMATOIDS, METHOD FOR REGULATING PLANT GROWTH AND METHOD FOR PREPARING STABLE COMPOSITION OF WIDE SPECTRUM |
MX2020013170A MX2020013170A (en) | 2018-06-13 | 2019-06-12 | Agricultural composition. |
CN201980038959.5A CN112261872A (en) | 2018-06-13 | 2019-06-12 | Agricultural compositions |
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WO2021064731A1 (en) * | 2019-10-03 | 2021-04-08 | Adama Makhteshim Ltd. | Pesticidal mixtures |
WO2022259159A1 (en) * | 2021-06-10 | 2022-12-15 | Hiteshkumar Anilkant Doshi | Novel pesticidal composition |
US11533910B2 (en) | 2015-12-10 | 2022-12-27 | Adama Makhteshim Ltd. | Polyelectrolyte-layer forming block copolymers and compositions and uses thereof |
WO2023233404A1 (en) * | 2022-06-02 | 2023-12-07 | Adama Makhteshim Ltd. | Method of controlling nematodes |
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2019
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- 2019-06-12 MX MX2020013170A patent/MX2020013170A/en unknown
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- 2019-06-12 CN CN201980038959.5A patent/CN112261872A/en active Pending
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US20170215423A1 (en) * | 2003-05-02 | 2017-08-03 | Adama Makhteshim Ltd. | Active Substance Combination Based on Trifluorobutinyl Compounds and Exhibiting Nematicidal and Insecticidal Properties |
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US11533910B2 (en) | 2015-12-10 | 2022-12-27 | Adama Makhteshim Ltd. | Polyelectrolyte-layer forming block copolymers and compositions and uses thereof |
WO2021064731A1 (en) * | 2019-10-03 | 2021-04-08 | Adama Makhteshim Ltd. | Pesticidal mixtures |
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WO2022259159A1 (en) * | 2021-06-10 | 2022-12-15 | Hiteshkumar Anilkant Doshi | Novel pesticidal composition |
AU2022289516B2 (en) * | 2021-06-10 | 2023-12-21 | Hiteshkumar Anilkant Doshi | Novel pesticidal composition |
WO2023233404A1 (en) * | 2022-06-02 | 2023-12-07 | Adama Makhteshim Ltd. | Method of controlling nematodes |
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CO2021000147A2 (en) | 2021-04-08 |
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